主持 青年科学基金项目（82402233）基于多种超高场磁共振血管影像标志物的脑小血管病进展预测模型研究  2025.01-2027.12

主持 中国博士后科学基金第74批面上资助（2023M740685）超高场多模态磁共振评估脑小血管病动脉血管周围间隙

参与 国家自然科学基金面上项目 基于水交换量化成像方法的脑卒中血脑屏障破坏机制及取栓治疗后出血转化预警模型研究 2026.01-2028.12

参与 国家自然科学基金面上项目（82271956） 基于五维血流成像和高分辨弥散影像组学技术的肝硬化门静脉高压症无创评估研究  2023.01-2026.12 

参与 国家自然科学基金面上项目（81971583）  基于多尺度磁共振血管成像的血管性认知障碍机制研究 2020.01-2023.12

1. 基于高场磁共振影像的脑血管疾病风险预测研究

依托7T/5T高场磁共振成像平台，构建脑血管疾病（包括脑小血管病、卒中、认知障碍等）的多维影像生物标志物体系，实现疾病早期识别与风险预测。通过引入高空间分辨率结构像、先进扩散成像、脑灌注与血流动力学影像等序列，提取脑血管结构、管腔状态、血流动力学参数与脑组织微结构指数，并结合深度学习与机器学习模型进行特征融合分析。探索脑血管损伤发生—进展—功能代偿的影像学机制，建立可推广的个体化脑血管风险评估框架，为脑血管疾病的早筛、早治和精准干预提供科学依据。

 2. 脑卒中多模态磁共振影像研究

围绕急性与慢性脑卒中的机制、诊断与预后评估展开，采用多模态磁共振成像技术，系统刻画卒中组织损伤程度、血管病变性质、脑灌注与能量代谢状态以及功能网络重组特征。探讨缺血半暗带的可逆性影像特征、血管壁不稳定斑块的影像生物标志物、卒中后脑网络可塑性变化与功能恢复的关系。通过影像-临床-功能随访数据的多维整合，建立卒中精准分型与预后预测模型，为临床制定个体化溶栓/取栓策略及康复方案提供支持。

 3. 静息态脑功能影像研究

聚焦静息态功能磁共振成像在脑网络功能评估中的应用，揭示脑疾病发生发展过程中神经网络连接模式的改变。采用多种定量方法，分析正常脑功能组织架构、疾病相关网络失衡以及认知功能变化的影像特性。重点研究脑小血管病、认知障碍、情绪障碍、卒中后康复等人群，探索脑功能网络代偿机制及其干预可塑性。为脑疾病表征、早期检测和疗效监测提供新的影像学证据和功能生物标志物。

发表论文
1. Zhang Shi, Boyu Zhang, Xiyin Miao, Shujie Zhang, Jing Li, Qi Liu,Mengsu Zeng, Jiang Lin, Jianping Lu, He Wang. High-risk characteristics ofrecurrent ischemic stroke after intensive medical management for 6-monthfollow-up: a histogram study on vessel wall MRI. European Radiology. (2025)

2. Bei Wang, Cen Guo, Ying-Hua Chu, YajingHuo, Boyu Zhang, Guanshu Liu, Yan Han, He Wang. Differential impact ofcerebral small vessel disease on thalamic regulation of anxiety: insights from7T MRI. Molecular Psychiatry. (2025)

3. Wei Tang, Yuxiang Dai, Boyu Zhang,Zhang Shi, Ying-Hua Chu, Peixian Zhuang, Dinggang Shen, Chengyan Wang, He Wang.Aleatoric-Uncertainty-Aware Maximum Intensity Projection-Based GAN for 7T-LikeGeneration From 3T TOF-MRA. IEEE Journal of Biomedical and Health Informatics.(2025)

4. Yu Cheng, Yuxiang Dai, Rencheng Zheng,Beini Fei, Hui Zhang, Xinran Wu, Boyu Zhang, Haoran Peng, Yuchen Liu,Chun-Yi Zac Lo, Chengyan Wang, He Wang. Federated Spatial Prior-BasedSource-Free Domain Adaptation for White Matter Hyperintensities Segmentation. IEEEJournal of Biomedical and Health Informatics. (2025)

5.Shanhua Han, Quan Tao, Boyu Zhang,Yifan Lv, Zhihao Li, Yu Luo. Probing Neural Compensation in Rehabilitation ofAcute Ischemic Stroke with Lesion Network Similarity Using Resting StateFunctional MRI. Brain Sciences. (2025)

6. Zhang Shi, Xueying Zhao, Shuo Zhu, XiyinMiao, Yunfei Zhang, Shihong Han, Bei Wang, Boyu Zhang, Xiaodan Ye,Yongming Dai, Caizhong Chen, Shengxiang Rao, Jiang Lin, Mengsu Zeng, He Wang.Time-of-Flight Intracranial MRA at 3 T versus 5 T versus 7 T: Visualization ofDistal Small Cerebral Arteries. Radiology. (2023)

7. Boyu Zhang, Yajing Huo, ZidongYang, Huihui Lv, Yilin Wang, Jianfeng Feng, Yan Han, He Wang. Day to Day BloodPressure Variability Associated With Cerebral Arterial Dilation and WhiteMatter Hyperintensity. Hypertension. (2022)

8. Boyu Zhang, Zidong Yang, Jing Li,Bei Wang, Huazheng Shi, He Wang#, Yuehua Li#. Modification of cerebrovascularmorphologies during different stages of life. Journal of Cerebral Blood Flow& Metabolism. (2022)

9. Boyu Zhang, Yingzhe Wang, BeiWang, Ying‐Hua Chu, Yanfeng Jiang, Mei Cui, He Wang#, Xingdong Chen. MRI‐BasedInvestigation of Association Between Cerebrovascular Structural Alteration andWhite Matter Hyperintensity Induced by High Blood Pressure. Journal of MagneticResonance Imaging. (2021)

10. Qiaoyu Liu, Boyu Zhang, LunaWang, Rencheng Zheng, Jinwei Qiang, He Wang, Fuhua Yan, Ruokun Li. Assessmentof Vascular Network Connectivity of Hepatocellular Carcinoma Using Graph-BasedApproach. Frontiers in Oncology. (2021)

11. Xueying Zhao, Jingjing Shi, Fei Dai,Lei Wei, Boyu Zhang, Xuchen Yu, Chengyan Wang, Wenzhen Zhu, He Wang.Brain Development From Newborn to Adolescence: Evaluation by NeuriteOrientation Dispersion and Density Imaging. Frontiers in human neuroscience. (2021)

12. Xianfu Meng, Boyu Zhang, Yan Yi,Hui Cheng, Baoming Wang, Yanyan Liu, Teng Gong, Wei Yang, Yefeng Yao, He Wang,Wenbo Bu. Accurate and real-time temperature monitoring during MR imagingguided PTT. Nano letters. (2020)

申请国家发明专利

1. 王鹤，张博宇。脑血管形态特征定量分析方法(CN112790741A)。

2. 张博宇，王鹤，赵雪莹。一种磁共振肝癌疗效评估方法和系统(CN108538399A)。

3. 赵雪莹，王鹤，张博宇。一种基于磁共振指纹的动态增强磁共振成像方法(CN108375747A)。

4. 王鹤，张博宇。一种脑血管血流动力学特征定量分析方法(CN117582199A)。

发表ISMRM会议摘要

1. Association of MRI-derived GlymphaticFunction with Cognition and Cerebral Small Vessel Disease. 2024

2. MRA Derived Cerebral Arterial FlowFeatures Associated with White Matter Hyperintensity. 2024

3. Middle Cerebral Artery Morphologies Associatedwith White Matter Hyperintensities. 2023

4. Assessing Focal Cortical Dysplasia UsingAdvanced Diffusion Imaging Sequences. 2021

5. Cerebrovascular Atlas: A Novel Frameworkto Detect Structural Alterations Using MRA. 2021

6. Accurate and Real-Time TemperatureMonitoring during MR Imaging Guided Photothermal therapy. 2021