同济大学脊柱脊髓损伤再生修复教育部重点实验室，发展起自2012年同济大学脊柱脊髓损伤研究所建成，依托同济大学附属同济医院建设，于2018年3月5日正式立项，同年9月通过建设计划论证，并于2021年9月正式通过验收。目前实验室围绕脊柱脊髓损伤再生修复研究，凝练了四个研究方向，建成八大实验平台。实验室分为两个工作区，一是同济大学附属同济医院科研楼，已建成脊柱生物力学实验室、脊柱运动学实验室、动物实验中心、智能康复实验室、中心实验室、细胞治疗 GMP 实验室、干细胞与再生修复实验室、基因测序与生物信息中心。二是同济大学沪北校区汇峰楼 5-7 楼，已建成再生修复生物材料实验室、脊髓电生理实验室、脊柱脊髓物理调控实验室、动物行为学评价实验室等。

      教育部重点实验室主要聚焦脊柱脊髓损伤再生修复研究，以国家重大基础及应用研究项目为龙头, 动和支持实验室的快速发展，旨在揭示脊柱脊髓损伤结构和功能重建的生理和病理学机制，构建神经功能重塑的关键科学理论和体系，研制运动与神经系统修复的系列新药物、新材料、新设备，形成核心修复技术的新理论、新方法、新策略，以期打破基础与临床转化瓶颈，引领国际、国内脊柱脊髓损伤修复领域研究发展，增强我国脊柱脊髓修复学科国际竞争力。

1. 国家自然科学基金青年项目（2023）

2. 上海市“超级博士后”激励计划（2022）

3. 博士后特别资助（2024）

4. 博士后面上资助（2023）

1. 国家自然科学基金青年项目（2023）

2. 上海市“超级博士后”激励计划（2022）

3. 博士后特别资助（2024）

4. 博士后面上资助（2023）

1. Zhaojie Wang#, Yuxin Bai#, Xu Xu, Yanjing Zhu, Xioalie He, Ruiqi Huang, Liqun Yu, Runzhi Huang, Liming Cheng*, Rongrong Zhu*.Two-Way Regulation of MgFe-LDH on ESC Cell Fate via Temporal Selective Activation of Different Cell Membrane Receptors. Advanced Functional Materials, 2024, 2314112. 

2. Zhaojie Wang#, Huiyi Yang#, Xu Xu#, Hongxing Hu, Yuxin Bai, Jian Hai, Liming Cheng*, Rongrong Zhu*. Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway. Bioactive Materials, 2023, 22, 75-90.  

3. Zhaojie Wang, Ziping Xu, Guoxin Jing, Qingxiu Wang, Li Yang, Xiaolie He, Lijuan Lin, Jintong Niu, Linnan Yang, Kun Li, Zhongmin Liu,; Yechang Qian*, Shilong Wang*, Rongrong Zhu*. Layered double hydroxide eliminate embryotoxicity of chemotherapeutic drug through BMP-SMAD signaling pathway, Biomaterials, 2020, 230: 119602.

4. Zhaojie Wang, Peng Liang, Xiaolie He, Bin Wu, Qiang Liu, Ziping Xu, Huijun Wu, Zhongmin Liu, Yechang Qian*, Shilong Wang*, Rongrong Zhu*. Etoposide loaded layered double hydroxide nanoparticles reversingchemoresistance and eradicating human glioma stem cells in vitro and in vivo. Nanoscale, 2018, 10: 13106-13121.

5. Zhaojie Wang#, Huiyi Yang#, Yuxin Bai, Liming Cheng*, Rongrong Zhu*. rBMSC osteogenic differentiation enhanced by graphene quantum dots loaded with immunomodulatory layered double hydroxide nanoparticles. Biomedical Materials, 2022, 17, 024101. 

6. Xiao Hu#, Wei Xu#, Yilong Ren#, Zhaojie Wang#, Xiaolie He#, Runzhi Huang, Bei Ma, Jingwei Zhao, Rongrong Zhu*, Liming Cheng*, Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduction And Targeted Therapy, 2023, 8 (1): 245. 

7. Yiming Chen#, Huiyi Yang#, Zhaojie Wang#, Rongrong Zhu, Liming Cheng* and Qian Cheng*. Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway. Stem Cell Research & Therapy, 2023, 14: 93. 

8. Hongxing Hu#, Zhaojie Wang#, Huiyi Yang, Yuxin Bai, Rongrong Zhu*, Liming Cheng*, Hypoxic Preconditional Engineering Small Extracellular Vesicles Promoted Intervertebral Disc Regeneration by Activating Mir-7-5p/NF-Κb/Cxcl2 Axis. Advanced Science, 2023, 202304722. 

9. Yuxin Bai#, Zhaojie Wang#, Xiaolie He, Yanjing Zhu, Xu Xu, Huiyi Yang, Guangyu Mei, Shengguang Chen *, Bei Ma*, Rongrong Zhu*, Application of Bioactive Materials for Osteogenic Function in Bone Tissue Engineering. Small Methods, 2023, smtd.202301283. 

10. Bolin Zheng, Yijing He, Shuai Yin, Xu Zhu, Qing Zhao, Huiyi Yang, Zhaojie Wang*, Rongrong Zhu*, Liming Cheng*.Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury. Research, 2023, 0135.

11. Yadong Qian#, Huiyi Yang#, Yuxin Bai#, Hongxing Hu, Li Yang, Guangyu Mei, Zhaojie Wang*, Rongrong Zhu*, Liming Cheng*. Bioactive layered double hydroxide nanoparticles loaded calcein under GelMA scaffolds promoted osteogenesis and angiogenesis for bone regeneration. Materials & Design, 2024, 238, 112621.

12. Yuxin Bai, Yanjing Zhu, Xiaolie He, Xu Xu, Li Yang, Zhaojie Wang*, Rongrong Zhu*. Size-Optimized Layered Double Hydroxide Nanoparticles Promote Neural Progenitor Cells Differentiation of Embryonic Stem Cells Through the Regulation of M6A Methylation. International Journal of Nanomedicine, 2024, 19, 4181-4197.