1. 国家自然科学基金委员会, 青年项目, 82103768, ALA光动力通过募集天然淋巴样细胞重建皮脂腺稳态治疗痤疮的机制研究, 2022-01至2024-12, 30万, 在研, 主持

2. 同济大学“中央高校基本科研业务费”专项资金，ALA光动力通过激活cGAS-STING通路诱导抗肿瘤免疫反应治疗皮肤鳞癌的机制研究（22120180344），经费：3万元，2018.9—2019.8，项目负责人。

3. 院内国家自然基金培育项目(A 类)，卡泊三醇增强 ALA-PDT 治疗皮 肤鳞癌的疗效及分子机制研究（17GZRPY04），经费：10万元，2018.1-2019.12，项目负责人。

4. 上海市卫生健康委员会，ALA光动力激活cGAS-STING通路诱导抗肿瘤免疫治疗皮肤鳞癌的机制研究（20194Y091），经费：5万元，2020.1.1-2022.12.31

5. 国家重点研发计划子课题-常见多发病防治研究，2023YFC2508202，局部温热和光动力技术治疗几种慢性皮肤黏膜感染和上皮内瘤变的临床研究，2023/11-2026/10，138万，在研，分中心负责人：张国龙，本人重要参与

1.Zhang H, Yan Y, Zhao Y,Zhou Z, Gao J, Sroka R, Zhang L, Wang X. Efficacy of ALA-PDT for epidermoidcyst on the face: A retrospective study. Photodiagnosis Photodyn Ther. 2025Aug;54:104641. 

2.Zhang HY, Zhao Y, Tao H, FengCM, Wang PR, Zhang LL, Liu XJ, Chen YM, Wang XL. A chlorin e6derivative-mediated photodynamic therapy for mild to moderate acne: Aprospective, single-blind, randomized, split-face controlled study.Photodiagnosis Photodyn Ther. 2024 Sep 2; 49:104304.

3.Feng CM#, Zhang HY#,Wang PR, Zhang LL, Liu XJ, Yan GR, Yan Y, Yang J, Liu J, Tan F*, Wang XL*, ZengQY*. Oroxylin A suppress LL-37 generated rosacea-like skin inflammation throughthe modulation of SIRT3-SOD2-NF-κB signaling pathway. Int Immunopharmacol.2024 Mar 10; 129:111636. (Co-first author)

4.Gao JW#, Zhang HY#,Zhou ZX, Sun XF, Zhang GL, Wang PR*, Wang XL*. The combination of holmium laserand ALA-PDT for Bowenoid Papulosis with diffuse large B-cell lymphoma. PhotodiagnosisPhotodyn Ther. 2024 Feb; 45:103953. (Co-first author)

5. Wu Y, Sun XF, Yan Y, Zhou ZX,Chang QH, Chen DY, Yan J, Zhang HY*, Wang XL*. Successful treatment by achlorin e6 derivative mediated photodynamic therapy combined holmium laser forcervical and vaginal giant condyloma acuminata and low-grade intraepithelialneoplasia: A case report. Photodiagnosis Photodyn Ther. 2024 Feb22; 46:104022. (Co-corresponding author)

6.Tao H#, Zhang HY#, Xu DT, Yan GR, Wu YH,Zhang GL, Zeng QY*, Wang XL*. A chlorin e6 derivative-mediated photodynamictherapy inhibits cutaneous squamous cell carcinoma cell proliferation viaAkt/mTOR signaling pathway. Photodiagnosis Photodyn Ther. 2023Feb 14; 42:103332. doi: 10.1016/j.pdpdt.2023.103332（3.577）(Co-first author)

7.Yao HX#, Yan J#, Zhou ZX, Shen SZ, Wu Y, Liu P, ZhangHY*, Wang XL*. A chlorin e6 derivative-mediated photodynamic therapy forpatients with cervical and vaginal low-grade squamous intraepithelial lesions:a retrospective analysis. Translational Biophotonics. 2022.DOI:10.1002/tbio.202200006IF: NA NA NA. (Co-corresponding author)

8.Zhang YF#, Zhang HY#, Zhang LL, Wang PR, ShiL, Zhang GL, Zhou ZX, Marcus S, Wang XL, Modified 5-aminolevulinic acidphotodynamic therapy to reduce pain in the treatment of moderate to severe acnevulgaris: A prospective, randomized split-face study, J Am Acad Dermatol，2021Jan;84(1):218-220.（IF 15.487） (Co-first author)

9.Tu P#, Zhang HY#, Zheng HY, Gu H, Xu JH, TaoJN, Wang HW, Zhu XJ, Wang XL. 5-aminolevulinic photodynamic therapy vs. carbondioxide laser therapy for small genital warts: a multicenter, randomized,open-label trial. J Am Acad Dermatol.2021 Mar;84(3):779-781.（IF 15.487）(Co-first author)

10.Zhang HY#, Shi L#, Zhang YF, Wang PR, Zhang GL, Cao YJ, ZhouZX, Wang XL. Modified photodynamic therapy to minimize pain in the treatment ofcondylomata acuminata: a prospective, randomized, self-controlled study. PhotodiagnosisPhotodyn Ther.2020 Dec;32:10191（IF 3.631）

11. Yao HX#, Zhang HY#, Pu XW, Shi L, Zhang YF,Wang PR, Zhang GL,ZhouZX,Zhou WQ,Wang XL. Photodynamic therapy combined with carbon dioxide laser forlow-grade vaginal intraepithelial neoplasia: A retrospective analysis.PhotodiagnosisPhotodyn Ther. 2020 Jun;30:101731.（IF 3.631）(Co-first author)

12.Zhao ZJ#, Zhang HY#, Zeng QY, Wang PR, Zhang GL,Ji J,Li M,ShenSZ,Wang XL. Exosomes from 5-aminolevulinic acid photodynamic therapy-treatedsquamous carcinoma cells promote dendritic cell maturation.PhotodiagnosisPhotodyn Ther.2020 Jun;30:101746.（IF 3.631）(Co-first author)

13.Lai YX#, Zhang HY#, Wei ML, Ji J, Shi L, Wang PR, Wang B, Huang Z,Wang XL. Can red-light 5-aminolevulinic photodynamic therapy cure port winestains on comb animal model? Photodiagnosis Photodyn Ther. 2018Jun; 22:253-262.（IF 2.895）(Co-first author)

14.Zhang HY, Wang PR,Wang XJ, Shi L, Fan ZX, Zhang GL, Yang DG, Bahavar CF, Zhou FF, Chen WR, WangXL. Antitumor effect of DC vaccine with ALA-PDT induced immunogenic apoptoticcells for skin squamous cell carcinoma in mice. Technol Cancer Res Treat.2018 Jan 1;17:1533033818785275.（IF 1.646）

15.Zhang HY, Ji J,Tan YM, Zhang LL, Wang XJ, Wang PR, Yang DG, Shi L, Huang Z, Chen SY, Wang XL*.Evaluation of 5-aminolevulinic acid-mediated photorejuvenation of neck skin.Photodiagnosis Photodyn Ther, 2014; 11: 498 – 509．（IF 2.524）

1. 2022年上海市“医苑新星”青年医学人才培养资助计划

2. 2023年上海市皮肤病医院“院内学科骨干”人才项目

3.2024年上海市东方英才计划青年项目

1.张海艳（5/9） 5-氨基酮戊酸光动力治疗难治性皮肤病关键技术的建立及推广应用。获2017年华夏医学科技奖二等奖（5/9）；（王秀丽、王宏伟、石磊、张玲琳、张海艳、张国龙、王佩茹、张云凤、吉杰）2017年11月18日。证书编号：201702091U0205。

2. 张海艳（11/11）皮肤恶性肿瘤5-氨基酮戊酸光动力诊疗与康复体系的创建与应用，中国康复医学会，中国康复医学会科学技术奖，一等奖，2020（王秀丽、方方、李智铭、张国龙、王宏伟、黄鹏、石磊、张玲琳、周忠霞、王佩茹、张海艳）

3. 张海艳（6/11）“难治性皮肤疾病的5-氨基酮戊酸光动力诊疗与康复体系的创建与应用”，中国康复医学会，中国康复医学会科学技术奖，一等奖，2021（王秀丽、王宏伟、石磊、张玲琳、周忠霞、张海艳、张云凤、张国龙、王佩茹、柳小婧、曹智）

1.《紫外线皮肤科实战口袋书》，人民卫生出版社，书刊号：ISBN 978-7-117-29562-8,138千字（2020/05第一版）

2.《光动力皮肤病治疗学》，同济大学出版社，ISBN978-7-5765-1266-3，2024.10

3.《Photodynamic Therapy in Dermatology》Springer出版社，同济大学出版社，ISBN 978-981-96-8914-9     ISBN 978-981-96-8915-6 (eBook)  Springer Nature Singapore Pte Ltd.  2025