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主要从事结核病/非结核分枝杆菌病分子流行病学、治疗药物监测和临床诊疗相关研究。以第一作者/共同第一作者累计发表学术论文14篇,包括European Respiratory Journal、Clinical Infectious Diseases、Clinical Microbiology and Infection、Emerging Microbes & Infections等权威期刊,累计影响因子90余分,单篇最高影响因子33.8。目前主持国家自然科学基金青年项目、国家重点研发计划任务、上海市卫健委临床研究专项青年项目各1项,入选上海市公共卫生优秀青年人才培养计划和上海市肺科医院优秀青年人才资助计划。
| 项目名称 | 经费来源 | 起止年月 | 角色 | |
| 1 | 基于药物代谢与动力学的鸟-胞内分枝杆菌复合群肺病治疗药物监测策略的队列研究 | 国家自然科学基金委员会(青年项目) | 2023.01-2025.12 | PI |
| 2 | 结核病多维时序标志物和精准预警诊断技术研究 | 国家卫生健康委医药卫生科技发展研究中心(国家重点研发计划) | 2023.12-2026.11 | 任务负责人 |
| 3 | 上海地区耐多药结核潜伏感染现况和疗效相关新型生物标志物研究 | 上海市卫生健康委员会(上海市公共卫生优秀青年人才培养计划) | 2023.07-2025.06 | PI |
| 4 | 上海地区鸟-胞内分枝杆菌复合群临床分离株的泛基因组和耐药表型研究 | 上海市卫生健康委员会(临床研究专项青年项目) | 2023.07-2026.06 | PI |
| 5 | 鸟-胞内分枝杆菌复合群遗传特征与临床表型关联研究 | 上海市肺科医院(“优秀青年”人才培育计划) | 2024.01-2025.12 | PI |
1.Zheng X#, Gui X#, Yao L#,Ma J, He Y, Lou H, Gu J, Ying R, Chen L, Sun Q, Liu Y, Ho C-M, Lee B-Y, ClemensDL, Horwitz MA, Ding X, Hao X, Yang H, Sha W. Efficacy and safety of aninnovative short-course regimen containing clofazimine for treatment ofdrug-susceptible tuberculosis: a clinical trial. Emerging Microbes &Infections. 2023:2187247.
2.Zheng X, Davies Forsman L, Bao Z, Xie Y, Ning Z, Schön T, Bruchfeld J, XuB, Alffenaar J-W, Hu Y. Drug exposure and susceptibility of second-line drugscorrelate with treatment response in patients with multidrug-resistanttuberculosis: a multi-centre prospective cohort study in China. The EuropeanRespiratory Journal. 2022:2101925.
3.Zheng X, Wang J, Cai E, Jiang Y, Tang H, Xu B. Integrated Approaches forCOVID-19 Case Finding and Their Impact on Timeliness for Disease Containment -Changning District, Shanghai Municipality, China, January-July, 2020. ChinaCDC weekly. 2021;3(27):576-80.
4.Zheng X#, Bao Z#, Forsman LD, HuY, Ren W, Gao Y, Li X, Hoffner S, Bruchfeld J, Alffenaar J-W. Drug Exposure andMinimum Inhibitory Concentration Predict Pulmonary Tuberculosis TreatmentResponse. Clinical Infectious Diseases. 2021;73(9):e3520-e8.
5.Hu Y#, Zheng X#,Davies Forsman L, Ning Z, Chen C, Gao Y, Zhang Z, Lu W, Werngren J, BruchfeldJ, Hoffner S, Xu B. Emergence of additional drug resistance during treatment ofmultidrug-resistant tuberculosis in China: a prospective cohort study. ClinicalMicrobiology and Infection. 2021;27(12):1805-13.
6.Zheng X-B, Diwan VK, Zhao Q, Hu Y, Bruchfeld J, Jiang W-L, Hoffner S, Xu B.Treatment quality and outcome for multidrug-resistant tuberculosis patients infour regions of China: a cohort study. Infectious Diseases of Poverty.2020;9(1):97.

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