1、女性下生殖道上皮内病变临床诊疗体系的优化和关键技术研究，十四五国家重点研发计划“生育健康及妇女儿童健康保障”（首席），2025YFC2708400，在研；

2、缺氧TAMs调控TME中滤泡树突状细胞转化抑制三级淋巴结构成熟介导宫颈癌免疫治疗抵抗的作用及机制，国家自然科学基金面上项目，82573002，在研；

3、HPV16整合源性exoCircE7远程诱导宫颈癌淋巴结免疫抑制性转移前微环境形成的机制研究，国家自然科学基金面上项目，82173227，在研；

4、腹腔内窥镜手术导航和自动手术系统，国家工信部揭榜挂帅项目，在研；

5、靶向阻遏HPV持续性感染恶性转化的治疗策略研究，十四五国家重点研发计划“生育健康及妇女儿童健康保障”（课题负责人），2021YFC2701205，结题；

6、HPV16整合强化宫颈微环境中M2型巨噬细胞SIRPα-CD47信号促进宫颈上皮内瘤变进展的作用机制，国家自然科学基金面上项目，81971341，结题；

7、宫颈癌筛查与干预新技术及方案的研究，国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项（骨干成员），2016YFC1302901，结题；

8、缺氧促进肿瘤微环境中NRP-1+肿瘤相关巨噬细胞募集诱导宫颈癌淋巴管生成的作用及机制研究，国家自然科学基金面上项目，81672589，结题；

9、miR-221在TWIST2调控下通过ARID1A和Wnt/β-catenin信号通路参与宫颈癌侵袭转移的分子机制，国家自然科学基金面上项目，81372781，结题；

10、Twist在HPV介导的宫颈癌细胞衰老逃逸中的作用机制研究，国家自然科学基金面上项目，81072132，结题；

11、女性下生殖道上皮内病变智能诊疗辅助决策系统研究，上海市卫生健康委员会智慧医疗专项，2025ZHYL032，在研；

12、基于患者结局（PRO）建立妇科恶性肿瘤术后症状智能管理康复队列，上海市卫健委面上项目，202540099，在研；

13、尼拉帕利一线维持治疗真实世界治疗安全性研究，上海科委创新药械应用示范项目，24SF1900503，在研；

14、外泌体miR-142-5p介导淋巴内皮细胞参与宫颈癌微环境免疫逃逸形成及其机制研究，广东省自然科学基金，2019A1515010872，结题；

15、外泌体促进肿瘤微环境中miR-221-3p的肿瘤细胞-淋巴管上皮细胞间转运诱导宫颈癌淋巴管生成的作用及其机制研究，广东省教育厅基础研究重大项目及应用研究重大项目（自然科学类），2017KZDXM065，结题；

16、肿瘤微环境局部缺氧促进TAMs 募集对宫颈癌发生淋巴转移的作用机制研究，深圳市科技计划项目，JCYJ202160429161218745，结题；

17、HPV整合相关的CNVs变异与TRIO基因扩增在宫颈癌发生中的作用机制研究，广东省自然科学基金，S2013010014663，结题；

18、人乳头瘤病毒致癌及宫颈癌发生发展机制，教育部“新世纪优秀人才支持计划（2012 年度）”，NECT-12-0646，结题；

19、包载反义cFLIP的溶瘤腺病毒治疗宫颈癌的实验研究，湖北省卫生厅临床研究中心科研基金，JX4D10，结题；

20、新型溶瘤腺病毒选择封闭FLIP基因治疗宫颈癌的研究，湖北省自然科学基金，2008CDB213，结题。

1. Xiangguang Wu#,Mingfu Wu#, Huawen Li#, Yang Yang#, Huimin Shen#, Siyuan Huang, Yuha Pan, LiwenTao, Shuangshuang Guo, Jinjiao Chen, Yu Wu, Xiaoqing Zhong, Shuangdi Li, Binya Liu,Wenliang Zhang, Ruixin Zhu*, Liangsheng Fan*, Wei Wang*. Intraperitoneal Translocation of Gut Microbiota InducesNETosis and Promotes Endometriosis. Gut. 2025 Nov30:gutjnl-2025-336185. doi: 10.1136/gutjnl-2025-336185. Epub ahead ofprint. PMID: 41320323

2. Haoran Hu#,Meiqin Yang#, Baoyou Huang#, Jianyi Ding, Yashi Zhu, Xinxin Xu, Bo Yin, HuijuanZhou, Tiefeng Huang, Mengjie Li, Yifan Kou, Zilale Rahim, Ang Li, Wei Wang*,Lingfei Han*. Tumor cells promote immunosuppression inovarian cancer via a positive feedback loop with MDSCs through the SAA1-IL-1βaxis. J Exp Clin Cancer Res. 2025 Sep 30;44(1):277.  doi:10.1186/s13046-025-03536-y.PMID: 41029721.

3. Jianyi Ding#, Haoran Hu#, Yashi Zhu#, XinxinXu, Bo Yin, Meiqin Yang, Huijuan Zhou, Tiefeng Huang, Mengjie Li, Yifan Kou, ZilaleRahim, Baoyou Huang, Ang Li, Wei Wang*, Lingfei Han*. Inhibiting CMTM4 reverses the immunosuppressive functionof myeloid-derived suppressor cells and augments immunotherapy response incervical cancer. J Immunother Cancer. 2025 Jun13;13(6):e011776. doi:10.1136/jitc-2025-011776. PMID: 40514067;

4. Chenfei Zhou#, Yanmei Zhang#, RuimingYan#, Lei Huang, Andrew L. Mellor, Yang Yang, Xiaojing Chen, Wenfei Wei,Xiangguang Wu, Lan Yu, Luojiao Liang, Dan Zhang, Sha Wu*, Wei Wang*.Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO topromote immune privilege in the tumour microenvironment. Cell Death Differ.2021 Feb; 28(2): 715–729.  doi:10.1038/s41418-020-00618-6. PMID: 32929219

5. Wenfei Wei#, Huiling Zhou#, Peiyu Chen#,Xiaolan Huang, Long Huang, Luojiao Liang, Chuhong Guo, Chenfei Zhou, Lan Yu,Liangsheng Fan*, Wei Wang*. Cancer-associated fibroblast-derived PAI-1promotes lymphatic metastasis via the induction of EndoMT in lymphaticendothelial cells. J Exp Clin Cancer Res. 2023 Jul 6;42(1):160. doi:10.1186/s13046-023-02714-0. PMID: 37415190; PMCID: PMC10324144.

6. Xiaojing Chen#, Wenfei Wei#, Zici Wang,Nisha Wang, Chuhong Guo, Chenfei Zhou, Luojiao Liang, Sha Wu*, Li Liang*, WeiWang*. A novel lymphatic pattern promotes metastasis of cervical cancer ina hypoxic tumour‑associated macrophage‑dependent manner. Angiogenesis. 2021 Aug; 24(3): 549–565. doi:10.1007/s10456-020-09766-2. Epub 2021 Jan 23.

7. Xiaojing Chen#, Yuanrun Deng#, ZiciWang, Wenfei Wei, Chenfei Zhou, Yanmei Zhang, Ruiming Yan, Luojiao Liang, MeiZhong, Li Liang, Sha Wu*, Wei Wang*. Hypoxia-induced ZEB1 promotescervical cancer progression via CCL8-dependent tumour-associated macrophagerecruitment. Cell Death Dis. 2019 Jul 1;10(7):508. doi:10.1038/s41419-019-1748-1. PMID: 31263103.

8. Zheng Hu#, Da Zhu#, Wei Wang#,Weiyang Li#, Wenlong Jia#, Xi Zeng#, Wencheng Ding, Lan Yu, Xiaoli Wang, LimingWang, Hui Shen, Changlin Zhang, Hongjie Liu, Xiao Liu, Yi Zhao, Xiaodong Fang,Shuaicheng Li, Wei Chen, Tang Tang, Aisi Fu, Zou Wang, Gang Chen, Qinglei Gao,Shuang Li, Ling Xi, Changyu Wang, Shujie Liao, Xiangyi Ma, Peng Wu, Kezhen Li,Shixuan Wang, Jianfeng Zhou, Jun Wang, Xun Xu*, Hui Wang*, Ding Ma*.Genome-wide profiling of HPV integration in cervical cancer identifiesclustered genomic hot spots and a potential microhomology-mediated integrationmechanism. Nature Genetics. 2015. 47(2): 158–163. doi:10.1038/ng.3178. Epub 2015 Jan 12. PMID: 25581428.

9. Xiaojing Chen#, Chuhong Guo#, Zici Wang,Yang Yang, Yuhua Pan, Jieying Liang, Meige Sun, Liangsheng Fan*, Li Liang*, WeiWang*. Hypoxia-induced ZEB1 promotes cervical cancer immune evasion bystrengthening the CD47-SIRPα axis. Cell Commun Signal.2024 Jan 5;22(1):15. doi: 10.1186/s12964-023-01450-4. PMID: 38183060

10. Xiaojing Chen#, Chuhong Guo#, YangYang#, Zici Wang, Yunyi Liang, Yongqi Cai, Xiaofeng Cui, Liangsheng Fan*, WeiWang*. HPV16 integration regulates ferroptosis resistance via thec-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis. CellBiosci. 2024 Oct 17;14(1):129. doi: 10.1186/s13578-024-01309-2. PMID: 39420439.

11. Shuangshuang Guo#, Peiyu Chen#, YangYang#, Wenfei Wei, Yuhua Pan, Fanke Zeng, Liangsheng Fan*, Wei Wang*. Tumor-to-stromaCD8+T cells ratio combined with cancer-associated fibroblasts: an innovative approachto predicting lymph node metastases of cervical cancer. J Cancer Res ClinOncol. 2024 Feb 19;150(2):93. doi: 10.1007/s00432-023-05578-1. PMID: 38369672.

12. Xiangguang Wu#, Yu Wu#, Yuhua Pan#,Jinjiao Chen, Siyuan Huang, Xiaoxia Zhou, Xiaoqing Zhong, Ziang Ding, YangzhiQiu, Wei Wang*, Liangsheng Fan*. Elevated expression of ECT2 as adiagnostic marker and prognostic indicator in endometrial cancer. Gene. 2024Nov;927:148756.  doi: 10.1016/j.gene.2024.148756. Epub 2024 Jul 6. PMID:38977110.

13. Chenfei Zhou#, Wenfei Wei#, Jing Ma#,Yang Yang, Luojiao Liang, Yanmei Zhang, Zici Wang, Xiaojing Chen, Lei Huang, WeiWang*, Sha Wu*. Cancer-secreted exosomal miR-1468-5p promotes tumor immune escapevia the immunosuppressive reprogramming of lymphatic vessels. Mol Ther. 2022Feb 2; 30(2): 976–977. doi:10.1016/j.ymthe.2021.12.014. PMID: 33388421.

14. Shuangshuang Guo#, Xiaojing Chen, ChuhongGuo, Wei Wang*. Tumour-associated macrophages heterogeneity drives resistanceto clinical therapy. Expert Rev Mol Med. 2022;24:e17. doi: 10.1017/erm.2022.8.PMID: 35400355.

15. Luojiao Liang#, Yang Yang#, Wenfei Wei#,Xiangguang Wu, Ruiming Yan, Chenfei Zhou, Xiaojing Chen, Sha Wu, Wei Wang*,Liangsheng Fan*. Tumor-secreted exosomal Wnt2B activates fibroblasts to promotecervical cancer progression. Oncogenesis. 2021 Mar 17;10(3):30.  doi:10.1038/s41389-021-00319-w. PMID: 33731705.

16. Xiangguang Wu#, Jinjiao Chen#, Huiling Zhou#,Yu Wu, Fei Lin, Jing Shi, Hongzhen Wu, Haiqun Xiao*, Wei Wang*.Identification and Validation of the Signatures of Infiltrating Immune Cells inthe Eutopic Endometrium Endometria of Women With Endometriosis. Front Immunol.2021 Sep 3;12:671201. doi: 10.3389/fimmu.2021.671201. PMID: 34539624.

17. Peiyu Chen#, Wenfei Wei#, Hongzhen Wu, LiangshengFan*, Wei Wang*. Cancer-Associated Fibroblast Heterogeneity: A FactorThat Cannot Be Ignored in Immune Microenvironment Remodeling. Front Immunol.2021 Jul 8;12:671595. doi: 10.3389/fimmu.2021.671595. PMID: 34305902.

18. Wenfei Wei#, Xiaojing Chen#, LuojiaoLiang, Lan Yu, Xiangguang Wu, Chenfei Zhou, Zici Wang, Liangsheng Fan, Zheng Hu*,Li Liang*, Wei Wang*. Periostin+ cancer‐associatedfibroblasts promote lymph node metastasis by impairing the lymphaticendothelial barriers in cervical squamous cell carcinoma. Molecular Oncology.2021 Jan;15(1):210–27. doi: 10.1002/1878-0261.12837.Epub 2020 Nov 12. PMID: 33124726.

19. Yanmei Zhang#, Nisha Wang#, Meilin Ding#,Yang Yang, Zhimin Wang, Lei Huang, Wei Zhu, Andrew L Mellor, Xiaorui Hou,Chenfei Zhou, Ruiming Yan, Wei Wang*, Sha Wu*. CD40 Accelerates the Antigen-SpecificStem-Like Memory CD8+ T Cells Formation and Human Papilloma Virus(HPV)-Positive Tumor Eradication. Front Immunol. 2020 May 27;11:1012.  doi:10.3389/fimmu.2020.01012. PMID: 32536922.

20. Xiaotao Jiang#, Jiang Xu#, MingfengLiu#, Hui Xing, Zhiming Wang, Lei Huang, Andrew L Mellor, Wei Wang*, ShaWu*. Adoptive CD8+ T cell therapy against cancer: Challenges and opportunities.Cancer Letters. 2019. 462: 23–32. doi:10.1016/j.canlet.2019.07.017. Epub 2019 Jul 26. PMID: 31356845.

21. Chenfei Zhou#, Jing Ma#, Lei Huang#,Hongyan Yi, Yanmei Zhang, Xiangguang Wu, Ruiming Yan, Li Liang, Mei Zhong,Yanhong Yu, Sha Wu*, Wei Wang*. Cervical squamous cell carcinoma-secretedexosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targetingVASH1. Oncogene.2019 Feb 21;38(8):1256–68. doi:10.1038/s41388-021-02165-x. PMID: 30254211.

22. Xiaojing Chen#, Sha Wu#, Ruiming Yan#, LiangshengFan, Lan Yu, Yanmei Zhang, Wenfei Wei, Chenfei Zhou, Xiangguang Wu, Mei Zhong,Yanhong Yu, Li Liang*, Wei Wang*. The role of the hypoxia‐Nrp‐1 axis in the activation of M2‐like tumor‐associated macrophages in the tumormicroenvironment of cervical cancer. Molecular Carcinogenesis. 2019Mar;58(3):388–97. doi: 10.1002/mc.22936. Epub 2018 Nov18. PMID: 30362630.

23. Yuanrun Deng#, Xiaojing Chen#, WeiChen, Lanfang Wu, Huiping Jiang, Dan Lin, Lijing Wang, Wei Wang*, SuiqunGuo*. Sp1 contributes to radioresistance of cervical cancer through targetingG2/M cell cycle checkpoint CDK1. CMAR. 2019 Jun;Volume 11:5835–44. doi: 10.2147/CMAR.S348374. PMID: 31303791.

24. Fan Xu#, Yanfang Li#, Liangsheng Fan#,Jing Ma, Lan Yu, Hongyan Yi, Xiaojing Chen, Wenfei Wei, Peng Wu, Li Liang,Huiquan Hu, Hui Xing*, Wei Wang*. Preoperative SCC-Ag and thrombocytosisas predictive markers for pelvic lymphatic metastasis of squamous cervicalcancer in early FIGO stage. J Cancer. 2018;9(9):1660–6.doi: 10.7150/jca.24049. PMID: 29760805.

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26. Lanfang Wu#, Lingfei Han#, Chenfei Zhou#,Wenfei Wei, Xiaojing Chen, Hongyan Yi, Xiangguang Wu, Xiangyang Bai, Suiqun Guo,Yanhong Yu, Li Liang*, Wei Wang*. TGF‐β1‐induced CK17 enhances cancer stem cell‐likeproperties rather than EMT in promoting cervical cancer metastasis via theERK1/2-MZF1 signaling pathway. The FEBS Journal. 2017 Sep;284(18):3000–17. doi: 10.1111/febs.14162. Epub 2017 Jul 31. PMID: 28703907.

27. Wenfei Wei#, Lingfei Han#, Dan Liu#,Lanfang Wu, Xiaojing Chen, Hongyan Yi, Xiangguang Wu, Mei Zhong, Yanhong Yu, LiLiang*, Wei Wang*. Orthotopic Xenograft Mouse Model of Cervical Cancer forStudying the Role of MicroRNA-21 in Promoting Lymph Node Metastasis.International Journal of Gynecological Cancer. 2017 Oct;27(8):1587–95. doi: 10.1097/IGC.0000000000001059. PMID: 28945212.

28. Xiaojing Chen#, Lingfei Han#, XiangguangWu#, Wenfei Wei, Lanfang Wu, Hongyan Yi, Ruiming Yan, Xiangyang Bai, Mei Zhong,Yanhong Yu, Li Liang*, Wei Wang*. Clinical Significance of CD163+ and CD68+Tumor-associated Macrophages in High-risk HPV-related Cervical Cancer. J Cancer.2017;8(18):3868–75. doi: 10.7150/jca.21444. PMID:29151975.