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博士毕业于中国科学院上海药物研究所，长期致力于骨髓瘤等肿瘤领域的蛋白质结构与功能的研究，并综合运用结构生物学、计算机辅助药物设计等多学科交叉的技术手段开展大分子与小分子药物的早期研发。以第一/通讯作者发表SCI论文15篇，包括Cell Discov（2022，2020，2017）以及计算化学经典老牌杂志J Chem Inf Model（2023，2017）和药物化学经典杂志Eur J Med Chem（2015）等。授权化合物发明专利两项。主持国家自然科学基金两项（国自然面上、国自然青年）。
国自然面上项目，主持，DDRGK1与USP5竞争结合HNRNPC抑制骨髓瘤细胞增殖的分子和结构机制研究，2025年1-2028年12月
近五年代表性论文
[1]X. Gao, Q. Feng, Q. Zhang, Y. Zhang, C. Hu, L. Zhang, H. Zhang, G. Wang, K. Hu,M. Ma, Z. Wang, Y. Liu, D. An, H. Yi, Y. Peng, X. Wu, G. Chen, X. Jia, H. Cai,J. Shi, Targeting enolase 1 reverses bortezomib resistance in multiple myelomathrough YWHAZ/Parkin axis, J Biomed Sci, 32 (2025) 9.
[2]K. Hu, Y. Lai, J. Zhou, C. Hu, S. Guo, H. Zhang, G. Wang, Q. Zhang, X. Gao, Z.Wang, Y. Liu, Q. Feng, H. Yi, Y. Peng, Y. Zhang, X. Wu, H. Cai, J. Shi,Aberrant activation of adenine nucleotide translocase 3 promotes progressionand chemoresistance in multiple myeloma dependent on PINK1 transport, Int JBiol Sci, 21 (2025) 233-250.
[3]Y. Lai, S. Guo, Q. Tang, G. Chang, H. Zhang, B. Li, Q. Feng, K. Hu, Z. Xu, X.Gao, Q. Zhang, H. Yi, D. Song, Y. Zhang, Y. Peng, H. Cai, W. Zhu, J. Shi,Dihydrocelastrol induces cell death and suppresses angiogenesis throughBCR/AP-1/junb signalling in diffuse large B cell lymphoma, Arch BiochemBiophys, 754 (2024) 109929.
[4]S. Jacob Bunu, H. Cai, L. Wu, H. Zhang, Z. Zhou, Z. Xu, J. Shi, W. Zhu, TRIP13- a potential drug target in cancer pharmacotherapy, Bioorg Chem, 151 (2024)107650.
[5]S. Guo, Q. Tang, X. Gao, L. Hu, K. Hu, H. Zhang, Q. Zhang, Y. Lai, Y. Liu, Z.Wang, S. Chang, Y. Zhang, H. Hu, D. An, Y. Peng, H. Cai, J. Shi, EZH2inhibition induces senescence via ERK1/2 signaling pathway in multiple myeloma,Acta Biochim Biophys Sin (Shanghai), 56 (2024) 1055-1064.
[6]H. Cai, Y. Wang, J. Zhang, Z. Wei, T. Yan, C. Feng, Z. Xu, A. Zhou, Y. Wu,Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against HumanLeukemia Cells, J Chem Inf Model, 63 (2023) 4780-4790.
[7]J. Zhang, X. Jiang, H. Gao, F. Zhang, X. Zhang, A. Zhou, T. Xu, H. Cai,Structural Basis of a Novel Agonistic Anti-OX40 Antibody, Biomolecules, 12(2022).
[8]Z. Shu, J. Zeng, L. Xia, H. Cai, A. Zhou, Structural mechanism of VWF D'D3dimer formation, Cell Discov, 8 (2022) 14.
[9]H. Cai, P. Sasikumar, G. Little, D. Bihan, S.W. Hamaia, A. Zhou, J.M. Gibbins,R.W. Farndale, Identification of HSP47 Binding Site on Native Collagen and ItsImplications for the Development of HSP47 Inhibitors, Biomolecules, 11 (2021).
[10]H. Gao, H. Cai, J. Liu, X. Wang, P. Zheng, M. Devenport, T. Xu, F. Dou, Y. Liu,A. Zhou, Structure of CTLA-4 complexed with a pH-sensitive cancerimmunotherapeutic antibody, Cell Discov, 6 (2020) 79.
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