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上海市皮肤病医院/同济大学附属皮肤病医院副主任药师、副教授、博士生导师。长期致力于疾病新兴疗法和药物递送领域研究,包括肿瘤免疫治疗新策略、生物与基因创新疗法、皮肤免疫疾病新药开发转化等方向。主持和参与10余项国家级科研项目,主持上海市科委、上海市卫健委、同济大学及院级项目6项,入选上海市东方英才计划,参与国家重大新药创制、国家自然科学基金及上海市级项目13项。近年来在APSB、J Control Release、Chem Eng J、Mater Today Bio、J Adv Res等期刊发表SCI论文60余篇,申请国家发明专利30余项。担任中国医药教育协会皮肤药学专委会秘书长,中国麻风防治协会皮肤病药物治疗学分会委员,中国中西医结合学会临床药理与毒理专委会青年委员,中国抗癌协会纳米肿瘤学专委会青年委员,上海市药理学会皮肤药理专委会委员、青委副主委等学术职务。
1. 国家自然科学基金青年项目,肿瘤细胞和T淋巴细胞双重靶向的功能化外泌体激活前列腺癌特异性免疫研究,2019-01至2021-12,21万元,主持
2. 国家自然科学基金面上项目,基于焦亡诱导-表观遗传调控的仿生微泡肿瘤疫苗新策略及增效转移性黑色素瘤免疫疗法研究,2022-01至2025-12,55万元,主持
3. 东方英才计划青年项目,基于免疫杀伤-表观遗传调控的肿瘤全抗原反应型仿生微泡抗黑色素瘤作用研究,2024-01至2026-12,20万元,主持
4. 上海市科学技术委员会,22S21902700,医疗机构制剂红花平疣颗粒治疗扁平疣的新药临床前研究,2022-04至2025-03,40万元,主持
5. 上海市卫生健康委员会,202240370,新型碘代BDP光敏剂治疗甲真菌病的有效性和安全性研究,2023-01至2025-12,10万元,主持
6. 同济大学自主原创基础研究项目,22120240325,靶向cDC1的衰老黑色素瘤仿生囊泡疫苗多层次抗肿瘤免疫作用机制研究,2024-04至2026-03,12万元,主持
7.上海市卫生健康委员会医学新技术研究与转化种子计划,JAK-HDAC 双靶点抑制剂治疗特应性皮炎的临床转化研究,2026-01至2028-12,20万元,主持
1. 国家自然科学基金青年项目,肿瘤细胞和T淋巴细胞双重靶向的功能化外泌体激活前列腺癌特异性免疫研究,2019-01至2021-12,21万元,主持
2. 国家自然科学基金面上项目,基于焦亡诱导-表观遗传调控的仿生微泡肿瘤疫苗新策略及增效转移性黑色素瘤免疫疗法研究,2022-01至2025-12,55万元,主持
3. 东方英才计划青年项目,基于免疫杀伤-表观遗传调控的肿瘤全抗原反应型仿生微泡抗黑色素瘤作用研究,2024-01至2026-12,20万元,主持
4. 上海市科学技术委员会,22S21902700,医疗机构制剂红花平疣颗粒治疗扁平疣的新药临床前研究,2022-04至2025-03,40万元,主持
5. 上海市卫生健康委员会,202240370,新型碘代BDP光敏剂治疗甲真菌病的有效性和安全性研究,2023-01至2025-12,10万元,主持
6. 同济大学自主原创基础研究项目,22120240325,靶向cDC1的衰老黑色素瘤仿生囊泡疫苗多层次抗肿瘤免疫作用机制研究,2024-04至2026-03,12万元,主持
1.L. Ding, T.R. Zhang, Y.X. Pan, J. Liu, T.Y. Ma, H.X. Zhou, Q.A. Zhu*, Z.G.Tai*, Z.J. Chen*, Extracellular vesicles in chronic wound therapy: engineeringstrategies and advanced delivery systems for enhanced regeneration, MaterialsToday Bio 35, 2025.(IF 10.2共同通讯作者)
2.T.Y. Ma, T.R. Zhang, F.Z. Miao, J. Liu, Q.G. Zhu, Z.J. Chen, Z*. G. Tai*, Z.G.He*, Alopecia Areata: Pathogenesis, Diagnosis, and Therapies, Medcomm 6(5),2025. (IF 10.7共同通讯作者)
3.J. Lu, F. Miao, Y. Zhao, J. Liu, Y. Meng, H. Yan, R. Wang, Q. Zhu*, Z. Tai*, Z.Chen*, Biomimetic nanovesicle vaccines derived from dendritic cells sensitizedwith whole tumor antigens for melanoma immunotherapy, Mater Today Bio35,2025,102409. (IF 10.2共同通讯作者)
4.L. Li, J. Liu, J. Lu, J. Wu, X. Zhang, T. Ma, X. Wu, Q. Zhu*, Z. Chen*, Z.Tai*, Interventions in cytokine signaling: novel horizons for psoriasistreatment, Front Immunol 16,2025,1573905. (IF 5.9共同通讯作者)
5.Zhang X, Bao L, Yu Z, Miao F, Li L, Cui Z, Pan H, Qian Z, Zhang T, Zhao Y, TaiZ*, Zhu Q*, Chen Z*. Nanoengineered M1 macrophages enhance photodynamic therapyof melanoma through oxygen production and subsequent antitumor immunity.Chemical Engineering Journal, 2024, 487: 150153.(IF 13.3共同通讯作者)
6.Zhang X, Huang J, Zhao J, Li L, Miao F, Zhang T, Chen Z, Zhou X*, Tai Z*, ZhuQ*. Exosome-mimetic vesicles derived from fibroblasts carrying matrine forwound healing. Burns & Trauma, 2024, 12: 015.(IF 6.3共同通讯作者)
7.Zhang T#, Tai Z#, Miao F, Zhang X, Li J, Zhu Q, Wei H, Chen Z. Adoptive celltherapy for solid tumors beyond CAR-T: Current challenges and emergingtherapeutic advances. Journal of Controlled Release, 2024, 368: 372-396.(IF 10.5共同第一作者)
8.Xu H#, Zheng Q#, Tai Z#, Jiang W, Xie S, Luo Y, Fei X, Luo Y, Ma X, Kuai L,Zhang Y, Wang R, Li B, Zhu Q, Song J. Formononetin attenuates psoriasiforminflammation by regulating interferon signaling pathway. Phytomedicine, 2024,128: 155412.(IF 6.7共同第一作者)
9.Wu J, Li L, Zhu Q, Zhang T, Miao F, Cui Z, Dong G*, Tai Z*, Chen Z*. JAK1/JAK2degraders based on PROTAC for topical treatment of atopic dermatitis.Biomedicine & Pharmacotherapy, 171, 2024, 116167.(IF 6.9共同通讯作者)
10.Wu J, Li L, Zhang T, Lu J, Tai Z*, Zhu Q*, Chen Z*. The epidermallipid-microbiome loop and immunity: Important players in atopic dermatitis.Journal of Advanced Research, 2024.(IF 11.4共同通讯作者)
11.Wang J, Ma J, Xie F, Miao F, Lv L, Huang Y, Zhang X, Yu J, Tai Z*, Zhu Q*, BaoL*. Immunogenic cell death-based cancer vaccines: promising prospect in cancertherapy. Frontiers in Immunology, 2024, 15: 1389173.(IF 5.7共同通讯作者)
12.Ma J#, Tai Z#, Li Y, Li Y, Wang J, Zhou T, Shen M, Xin R, Shen C, Zhu Q, ChenZ. Dissolving Microneedle-Based Cascade-Activation Nanoplatform for EnhancedPhotodynamic Therapy of Skin Cancer. International Journal of Nanomedicine,2024, 19: 2057-2070.(IF 6.6共同第一作者)
13.Liu J, Lu J, Wu L, Zhang T, Wu J, Li L, Tai Z*, Chen Z*, Zhu Q*. Targetingtumor-associated macrophages: Novel insights into immunotherapy of skin cancer.Journal of Advanced Research, 2024.(IF 11.4共同通讯作者)
14.Li L, Wu X, Wu J, Zhang X, Miao F, Wang J, Lu J, Liu J, Chen Z*, Tai Z*, ZhuQ*. Transdermal delivery of Fn14 siRNA using a novel composite ionic liquid fortreatment of psoriasis-like skin lesions. Journal of Controlled Release, 2024,365: 818-832.(IF 10.5共同通讯作者)
15.Han T, Tang H, Lin C, Yan D, Zhou Z, Yang Y, Cai L, Zhu J, Gao B, Si Y, Fu W,Tai Z*, Tang X*, Guo D*. Costunolide mitigates inflammation and promotesextracellualr matrix integrity of thoracic aortic dissection by inhibitingNF-κB signaling. International Immunopharmacology, 2024, 131: 111784.(IF 4.8共同通讯作者)
16.Wang J#, Ma J#, Tai Z#, Li L, Zhang T, Cheng T, Yu J, Zhu Q, Bao L, Chen Z.Nanocarrier-Mediated Immunogenic Cell Death for Melanoma Treatment.International Journal of Nanomedicine, 2023, 18: 7149-7172.(IF 6.6共同第一作者)
17.Song Z, Tu D, Tang G, Liu N, Tai Z*, Yang J*, Wang Y*. Hemophagocyticlymphohistiocytosis and disseminated intravascular coagulation areunderestimated, but fatal adverse events in chimeric antigen receptor T-celltherapy. Haematologica, 108, 2023, 2067-2079.(IF 8.2共同通讯作者)
18.Lu J#, Tai Z#, Wu J, Li L, Zhang T, Liu J, Zhu Q, Chen Z. Nanomedicine-inducedprogrammed cell death enhances tumor immunotherapy. Journal of AdvancedResearch, 2023.(IF 11.4共同第一作者)
19.Li Y#, Tai Z#, Ma J, Miao F, Xin R, Shen C, Shen M, Zhu Q, Chen Z. Lycorinetransfersomes modified with cell-penetrating peptides for topical treatment ofcutaneous squamous cell carcinoma. Journal of Nanobiotechnology, 2023, 21: 139.(IF 10.6共同第一作者)
20. Li L, Lu J, Liu J, WuJ, Zhang X, Meng Y, Wu X, Tai Z*, Zhu Q*, Chen Z*. Immune cells in theepithelial immune microenvironment of psoriasis: emerging therapeutic targets.Frontiers in Immunology, 2023, 14: 1340677.(IF 5.7共同通讯作者)

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