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主要从事微生物感染与神经免疫相关研究，重点关注白念珠菌感染的免疫识别及应答机制，探讨白念珠菌、牙龈卟啉单胞菌和隐球菌等微生物对神经系统的影响机制。相关研究成果以第一作者或通讯作者身份发表在在Nature Communications、Cell Host & Microbe、Trends in Microbiology、Proceedings of the National Academy of Sciences (PNAS)等杂志。作为项目负责人，承担国家自然科学基金、上海市科委项目等科研项目。现为同济大学高等研究院副研究员、同济大学附属第十人民医院兼聘副研究员；上海市扬帆人才，《中国真菌学杂志》编委、高等教育出版社“十四五”医学规划新形态教材《微生物学与免疫学》数字编委；日本矫正齿科学会会员、九州矫正齿科学会会员、日本齿科基础医学会会员、日本药理学会会员、亚洲神经精神药理学会会员。
国家自然科学基金, 青年科学基金项目（2025.01-2027.12）,主持，30万元
上海市科委, “科技创新行动计划”启明星项目（扬帆专项）（2022.05-2025.04）,主持，20万元
科技部, 国家重点研发计划“国家质量基础设施体系”重点专项（2023.11-2028.10），课题骨干，55万元
科技部, 国家重点研发计划“病原学与防疫技术体系研究”重点专项（2022.12-2025.11）, 课题骨干, 32万元
同济大学自主原创基础研究项目(2024.04-2026.03), 主持，12万元
Research projects:
Grants from the National Natural Science Foundation of China;
Grants from the Shanghai Sailing Program, the Science and Technology Commission of Shanghai;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “National Quality Infrastructure System” Key Special Project;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “Research on Pathogen and Preventive Technology Systems” Key Special Project;
Grants from Tongji University Original Basic Research Project
国家自然科学基金, 青年科学基金项目（2025.01-2027.12）,主持，30万元
上海市科委, “科技创新行动计划”启明星项目（扬帆专项）（2022.05-2025.04）,主持，20万元
科技部, 国家重点研发计划“国家质量基础设施体系”重点专项（2023.11-2028.10），课题骨干，55万元
科技部, 国家重点研发计划“病原学与防疫技术体系研究”重点专项（2022.12-2025.11）, 课题骨干, 32万元
同济大学自主原创基础研究项目(2024.04-2026.03), 主持，12万元
Research projects:
Grants from the National Natural Science Foundation of China;
Grants from the Shanghai Sailing Program, the Science and Technology Commission of Shanghai;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “National Quality Infrastructure System” Key Special Project;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “Research on Pathogen and Preventive Technology Systems” Key Special Project;
Grants from Tongji University Original Basic Research Project
代表性论文：
Representative publications：
Yi-Heng Yang, Ke-Fang Xie, Shuai Yang, Huan Wang, Hui-Hui Ma, Min Zhou, Zhong-Wei Wang, Yebo Gu*, Xin-Ming Jia*. BLNK negatively regulates C-type lectin receptor-mediated antifungal immunity through inhibiting macrophage migration. .Proc Natl Acad Sci U S A (PNAS). 2024; 2024 Oct 22;121(43):e2400920121. (*Corresponding author)
Fan Li, Hui Wang, Yan-Qi Li, Yebo Gu*, Xin-Ming Jia*. C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity. Nature Communications 2023; 14(1): 6718. (*Corresponding author, Featured article at Nature Communications)
Yebo Gu#, Xin-Ming Jia*. STING negatively regulates antifungal immunity. Trends in Microbiology 2023; 31(11): 1090-1092.
Yebo Gu#, Xin-Ming Jia*. Stealth strategies of Candida albicans to evade host immunity. Cell Host & Microbe 2024 Sep 11;32(9):1459-1461.
Yebo Gu#, Zhou Wu, Fan Zeng, Muzhou Jiang, Jessica L Teeling, Junjun Ni, Ichiro Takahashi. Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis Induces Bone Loss-Correlated Alzheimer's Disease-Like Pathologies in Middle-Aged Mice. Journal of Alzheimer’s Disease 2020; 78(1):61-74.
Wang Y, Zhao J, Gu Y#, Wang H, Jiang M, Zhao S, Qing H, Ni J. Cathepsin H: Molecular characteristics and clues to function and mechanism. Biochem Pharmacol. 2023 Jun;212:115585. doi: 10.1016/j.bcp.2023.115585. Epub 2023 May 5.
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同济大学