(1) 国家自然科学基金委员会，青年科学基金项目，82201948，USP8激活单核细胞cGAS-STING-IRF3信号通路促进系统性红斑狼疮发病的机制研究，2023-01-01 至 2025-12-31，30万元，在研，主持

(2) 上海市科学技术委员会，“科技创新行动计划”扬帆计划，21YF1438300，E3泛素连接酶TRIM23调控宿主抗病毒免疫的功能与机制研究，2021-05 至 2024-04，20万元，结题，主持

(3) 同济大学附属肺科医院，“优秀青年”人才资助计划，Fkyq2308，NSCLC免疫治疗新靶点筛选与机制探索，2024-01 至 2025-12，20万元，在研，主持

聚焦于固有免疫调控与肺部慢性疾病免疫微环境与免疫调控机制研究，综合运用生物化学与分子生物学、细胞生物学、免疫学、生物信息学手段和疾病动物模型开展系统性研究。1，研究固有免疫信号转导通路的新功能与新机制，阐释固有免疫信号通路在自身免疫性疾病、胸部慢性疾病以及肺癌免疫微环境中的功能与分子调控机理；2，综合运用蛋白质基因组学，单细胞转录组学等多种高通量手段，解析肺癌免疫微环境特征，筛选肺癌免疫逃逸分子以及肺癌免疫治疗耐药的分子机制。

SELECTED PUBLICATIONS AS FIRST/CORRESPONDINGAUTHOR                                                                                          

1.    Chen Y#, Zhu X#, Wang J#, Hu J#, ZhangJ, Zhang X, Han L, Yu H, Hu H, Fei K*, ZhangP*, Zhang L*. MAZ promotes tumor proliferation and immuneevasion in lung adenocarcinoma. Oncogene 2024, 43(50):3619-3632.

2.    Yan Y#, Sun D#, Hu J#, Chen Y#, Sun L,Yu H, Xiong Y, Huang Z, Xia H, Zhu X, Bian D, Sun F, Hou L, Wu C, Fan OR, Hu H,Zeng A*, Zhang L*, Sun YE*, Wang C*, ZhangP*. Multi-omic profilinghighlights factors associated with resistance to immuno-chemotherapy innon-small-cell lung cancer. Nat Genet 2025, 57(1):126-139.

3.    Sun L#, Wang J#, Yu H, Zhu X, Zhang J, Hu J, Yan Y, Zhang X, Zhu Y, Jiang G, Ding M*, Zhang P*, Zhang L*. Selective inhibition of TGF-β-inducedepithelial-mesenchymal transition overcomes chemotherapy resistance inhigh-risk lung squamous cell carcinoma. Commun Biol 2025,8(1): 152.

4.    Yi C#, Bian D#, Wang J#, Hu S#, Sun L,Yan Y, Wang S, Shen Z, Yu H, Yang Y, Zhou Y, Liu X, Song N, Zhu Y, Zhao D,Jiang G, Duan L, He W, Xie D*, Dai J*, ZhangL*, Zhang P*. Anti-PD1 based precision induction therapy inunresectable stage III non-small cell lung cancer: a phase II umbrella clinicaltrial. Nature communications 2025, 16(1): 1932.

5.    Hu Q#, Dai J,# Zhang Z#, Yu H,Zhang J, Zhu X, Qin Y, Zhang L*, Zhang P*. ASS1-MediatedReductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistancein Cancer Cells. Cancerresearch 2023, 83(10): 1646-1665.

6.    Hu J#, Zhang L#, Xia H#,Yan Y#, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H,Chen Y, Fan P, Ma Q, Jiang G, Wang C*, Zhang P*. Tumormicroenvironment remodeling after neoadjuvant immunotherapy in non-small celllung cancer revealed by single-cell RNA sequencing. Genome Med 2023,15(1): 14.

7.    Shen Z#, Teng M#, Han L#, Bian D, Zhang J,Zhu X, Qing Y, Hu S, Chen Y, Yao W, Yu H, Zhang L*, Zhang P*. The impact of oncogenic driver mutations on neoadjuvantimmunotherapy outcomes in patients with resectable non-small cell lung cancer.Cancer Immunol Immunother 2023, 72(12): 4235-4247.

8.    Song J#, Zhang L#*, Li C#,Maimaiti M, Sun J, Hu J, Li L, Zhang X, Wang C*, Hu H*. m(6)A-mediated modulation coupled with transcriptional regulationshapes long noncoding RNA repertoire of the cGAS-STING signaling. Comput Struct Biotechnol J 2022, 20: 1785-1797.

9.    Li D#, Yu H#, Hu J#, Li S, Yan Y,Li S, Sun L, Jiang G, Hou L*, Zhang L*, Zhang P*. Comparative profiling of single-cell transcriptomereveals heterogeneity of tumor microenvironment between solid and acinar lungadenocarcinoma. J Transl Med2022, 20(1): 423.

10.  Li C#, Zhang L#, Qian D#,Cheng M, Hu H, Hong Z, Cui Y, Yu H, Wang Q, Zhu J, Meng W, Xu JF, Sun Y*, ZhangP*, Wang C*. RNF111-facilitated neddylationpotentiates cGAS-mediated antiviral innate immune response. PLoS pathogens 2021, 17(3): e1009401.

11.  Zhang L#, Wei N#, Cui Y, Hong Z, Liu X, Wang Q, Li S, Liu H, YuH, Cai Y, Wang Q, Zhu J, Meng W, Chen Z*, Wang C*. Thedeubiquitinase CYLD is a specific checkpoint of the STING antiviral signalingpathway. PLoS pathogens 2018, 14(11): e1007435.

12.  Liu H#, Zhang L#, Sun J#,Chen W, Li S, Wang Q, Yu H, Xia Z, Jin X*, Wang C*. EndoplasmicReticulum Protein SCAP Inhibits Dengue Virus NS2B3 Protease by Suppressing ItsK27-Linked Polyubiquitylation. Journalof virology 2017, 91(9).

# First/Co-first author. *Corresponding/Co-corresponding author

SELECTED PUBLICATIONS ASCONTRIBUTING AUTHOR                                                                     

1.    Liu Q, Zhang J, Guo C, Wang M,Wang C, Yan Y, Sun L, Wang D, Zhang L, Yu H, Hou L, Wu C, Zhu Y, JiangG, Zhu H, Zhou Y, Fang S, Zhang T, Hu L, Li J, Liu Y, Zhang H, Zhang B, Ding L,Robles AI, Rodriguez H, Gao D, Ji H, Zhou H, Zhang P. Proteogenomiccharacterization of small cell lung cancer identifies biological insights andsubtype-specific therapeutic strategies. Cell 2024,187(1): 184-203.e128.

2.    Liu NN, Yi CX, Wei LQ, Zhou JA,Jiang T, Hu CC, Wang L, Wang YY, Zou Y, Zhao YK, Zhang LL, Nie YT, ZhuYJ, Yi XY, Zeng LB, Li JQ, Huang XT, Ji HB, Kozlakidis Z, Zhong L, Heeschen C,Zheng XQ, Chen C, Zhang P, Wang H. The intratumormycobiome promotes lung cancer progression via myeloid-derived suppressorcells. Cancer cell 2023.

3.    Bian D, Sun L, Hu J, Duan L, XiaH, Zhu X, Sun F, Zhang L, Yu H, Xiong Y, Huang Z, Zhao D, Song N, YangJ, Bao X, Wu W, Huang J, He W, Zhu Y, Jiang G, Zhang P. Neoadjuvant Afatinib for stage III EGFR-mutant non-small cell lungcancer: a phase II study. Nature communications 2023,14(1): 4655.

4.    Pan M, Yin Y, Wang X, Wang Q, ZhangL, Hu H, Wang C. Mice deficient in UXT exhibitretinitis pigmentosa-like features via aberrant autophagy activation. Autophagy2021, 17(8): 1873-1888.

5.    Hong Z, Mei J, Li C, Bai G,Maimaiti M, Hu H, Yu W, Sun L, Zhang L, Cheng D, Liao Y, Li S, You Y,Sun H, Huang J, Liu X, Lieberman J, Wang C. STINGinhibitors target the cyclic dinucleotide binding pocket. Proceedingsof the National Academy of Sciences of the United States of America 2021,118(24).

6.    Sun B, Zeng H, Liang J, Zhang L,Hu H, Wang Q, Meng W, Li C, Ye F, Wang C, Zhu J. NSUN5Facilitates Viral RNA Recognition by RIG-I Receptor. Journal ofimmunology 2020, 205(12): 3408-3418.

7.    Wang Q, Huang L, Hong Z, Lv Z, MaoZ, Tang Y, Kong X, Li S, Cui Y, Liu H, Zhang L, Zhang X, Jiang L, WangC, Zhou Q. The E3 ubiquitin ligase RNF185facilitates the cGAS-mediated innate immune response. PLoSpathogens 2017, 13(3): e1006264.