个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
王海芸,同济大学生命科学与技术学院生物信息学系教授,同济大学名课优师。1998年毕业于中南大学湘雅医学院,获学士学位;2004年毕业于哈尔滨医科大学,获硕士学位;2009年毕业于同济大学,获博士学位;2012-2014年美国哈佛医学院Dana-Farber癌症研究所访问学者;2022-2023年意大利都灵大学分子生物技术中心访问学者。专注于癌症精准“智疗”与治疗动态优化研究,聚焦癌症异质性、进化与耐药机制的分子特征解析与系统建模。通过整合单细胞与多模态组学数据,发展计算框架与模型,实现肿瘤进化过程的动态感知和治疗策略优化,推动精准医疗的智能化转化。先后主持国家自然科学基金4项,主持企业合作项目2项,作为骨干参与国家精准医学研究重点专项和重大科学计划项目等研究。发表SCI论文50余篇,其中以通讯(共通讯)/第一(共一)作者在Cancer Research、Advanced Science、Nucleic Acids Research、EBioMedicine、Briefings in Bioinformatics、Bioinformatics、GigaScience、PLOS Computational Biology等国际期刊发表,合作成果发表于 Cell、PNAS、Cancer Cell 等国际期刊。近五年培养的研究生多人获得上海市优秀毕业生、同济大学优秀学位论文、国家奖学金等荣誉称号。




上传附件
支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg上传附件
支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg上传附件
支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg(1) 药效关联的癌症单细胞亚群识别与精准联合医疗研究,国家自然科学基金面上项目,主持,在研。
(2) 药物对动植物细胞作用机制研究,横向项目,主持,在研。
(3) 非小细胞肺癌不同KRAS突变型的治疗异质性与精准联合用药研究,国家自然科学基金面上项目,主持,结题。
(4) 基于高通量药物基因组学数据的肺癌个性化联合用药方案筛选和评估,国家自然科学基金面上项目,主持,结题。
(5) 头颈部恶性肿瘤个性化药物评价及临床转化体系建立,精准医学研究重点专项,参与,结题。
(6) 运用比较基因组学基于基因关系传递模式研究基因表达调控的进化机制,国家自然科学基金青年项目,主持,结题。
(7) miRNA在心脏和血管发育过程中的调控作用,973重大专项,参与,结题。
1. Zheng J, Chen S, Zhang Y, Zhang B,Qiao K, Xu J, Fan Y, Feng M, Feng Z, Wang Z, Wang H*. PMADS: anintegrated database of curated and proteomics-inferred associations betweenprotein posttranslational modifications and drug sensitivity. Nucleic Acids Res. 2025 Oct 16:gkaf1033. Epub ahead of print.
2. Liu P#, Zheng J#,Ma W#, Lü J, Zhao Q, Li D, Jiang X, Wang H, Wang H*, Yu Z*. StressPromotes Lung Metastasis in Breast Cancer by Altering Neutrophil Differentiation. Cancer Res. 2025 Sep 24. Epub ahead of print.
3. Tian P#, Zheng J#,Qiao K, Fan Y, Xu Y, Wu T, Chen S, Zhang Y, Zhang B, Ambrogio C, Wang H*.scPharm: Identifying Pharmacological Subpopulations of Single Cells forPrecision Medicine in Cancers. Adv Sci (Weinh). 2024 Nov 19:e2412419.
4. Wu T#, Dai Y#, Xu Y, Zheng J, ChenS, Zhang Y, TianP, Zheng X*, WangH*. ExosomePurity: tumourpurity deconvolution in serum exosomes based onmiRNA signatures. Briefings inBioinformatics. 2023 May 19;24(3):bbad119.
5. Chen S#,Zheng J#, Zhang B, TangX, Cun Y, Wu T, XuY, Ma T, Cheng J, Yu Z*,WangH*. Identification and characterization ofvirus-encoded circular RNAs inhost cells. Microb Genom.2022Jun;8(6):mgen000848.
6. Huang X, Xu Y, Qian L, Zhao Q, Liu P, Lü J, GuoY,Ma W, Wang G, Li S, Luo A, Yang X, Wang H*,Yu Z*. Evolution of geneexpressionsignature in mammary gland stem cells from neonatal to old mice. Cell Death Dis. 2022 Apr 12;13(4):335.
7. Xu Y, Zheng J, Cai Z, Li W, Köhler J, Dai Y,ChengX, Wu T, Zhang F, WangH*. TherapeuticResponse-Based Reclassification of Multiple Tumor SubtypesReveals IntrinsicMolecular Concordance of Therapy Across HistologicallyDisparate Cancers. Front Cell Dev Biol.2021 Nov 12;9:773101.
8. Zheng J, Wang H*. Pharmaco-omics data sheds light ontherapy-orientedprospects of precision medicine. EBioMedicine.2021 Aug;70:103493(Commentary).
9. Dai Y, Cao Y, Köhler J, Lu A, Xu S*, Wang H*.UnbiasedRNA-Seq-driven identification and validation of reference genes forquantitativeRT-PCR analyses of pooled cancer exosomes. BMCGenomics. 2021 Jan6;22(1):27.
10. Cai Z#, Xue H#,Xu Y, Köhler J, Cheng X, Dai Y,Zheng J, WangH*.Fcirc: Acomprehensive pipeline for the exploration of fusion linear andcircular RNAs. GigaScience.2020Jun 1;9(6):giaa054.
11. Esteban-Burgos L, Wang H, Nieto P, Zheng J, Blanco-Aparicio C,Varela C, Gómez-LópezG, Fernández-García F, Sanclemente M, Guerra C, Drosten M,Galán J, Caleiras E,Martínez-Torrecuadrada J, Fajas L, Peng SB, Santamaría D,Musteanu M*, Barbacid M*. Tumor regression andresistance mechanisms upon CDK4and RAF1 inactivation in KRAS/P53 mutant lungadenocarcinomas. Proc Natl Acad Sci U S A. 2020 Sep29;117(39):24415-24426.
12. Luo A#, Xu Y#,Li S#, Bao J, Lü J, DingN, Zhao Q,Fu Y, Liu F, Cho WC, Wei X*, WangH*, Yu Z*. Cancer stem cell property and gene signature inbone-metastaticBreast Cancer cells. Int J Biol Sci.2020 Jul19;16(14):2580-2594.
13. WangH*, Lv Q, Xu Y, Cai Z, Zheng J,Cheng X, Dai Y, Jänne P, Ambrogio C*, KöhlerJ*. An integrativepharmacogenomics analysis identifies therapeutic targets inKRAS-mutant lungcancer. EbioMedicine.2019 Nov;49:106-117.
14. Chen W, Wang J,Shi J, Yang X, Yang P, Wang N, YangS, XieT, Yang H, Zhang M, WangH*, Fei J*. Longevity Effect of Liuwei Dihuang in Both CaenorhabditisElegans andAged Mice. Aging and Disease.2019 Jun 1;10(3):578-591.
15. Liu R#,Wang J#, Ukai M, Sewon K,Chen P, Suzuki Y, Wang H*, AiharaK*, Okada-Hatakeyama M*, Chen L*. Hunt for the tipping point duringendocrineresistance process in breast cancer by dynamic network biomarkers. J Mol Cell Biol. 2018 Nov 1.
16. Ambrogio C*, Köhler J, Zhou ZW, Wang H, Paranal R,Li J, Capelletti M, Caffarra C, Li S, Lv Q,Gondi S, Hunter JC, Lu J, Chiarle R,Santamaría D, Westover KD*, Jänne PA*. KRAS Dimerization Impacts MEKInhibitorSensitivity and Oncogenic Activity of Mutant KRAS. Cell.2018 Feb 8;172(4):857-868.e15.
17. Liu Y, Fei T, Zheng X, Brown M, Zhang P*, Liu X*, Wang H*. Anintegrative pharmacogenomic approach identifiestwo-drug combination therapiesfor personalized cancer medicine. SciRep. 2016, 26:6.
18. Zhang N#, Wang H#,Fang Y, Wang J*, Zheng X*, LiuX*.Predicting anticancer drug responses using a dual-layer integratedcellline-drug network model. PlosComputational Biology. 2015 Sep29;11(9).
19. WangH*#,Zheng X#, Fei T, Wang J, Li X, LiuY, Zhang F. Towards pathway-centric cancertherapies via pharmacogenomicprofiling analysis of ERK signalling pathway. Clin Transl Med. 2015Dec;4(1):66.
20. Wang J#,Zhang Y#, Wang H#, Dong N, Bao L, SunX, Xu M, Wang X*.Global analyses of subtype- or stage-specific genes onchromosome 7 in patientswith lung cancer. Cancer Metast Rev.2015 Jun;34(2).
21. WangH*,Meyer C, Fei T, Wang G, Zhang F*, Liu X. A systematic approachidentifies FOXA1as a key factor in the loss of epithelial traits duringtheepithelial-to-mesenchymal transition in lung cancer. BMC Genomics. 2013, 14:680.
22. WangH*,Wang Q, Shen B and Li X*.Systematic investigation of global coordination amongmRNA and protein incellular society. BMCGenomics. 2010, 11:364
23. WangH*#,Wang Q*#,Li X, Shen B, Ding M and Shen Z. Towards patterns tree of genecoexpression ineukaryotic species. Bioinformatics.2008,24(11):1367-1373.

文件上传中...