1.上海市卫生局, 2008151,钙降素基因相关肽在宫颈癌中的蛋白表达特点及其作用的研究，2009.1-2011.12，3万元，已结题，主持

2.上海交大科技基金项目，11XJ21030，神经标记物在人乳腺癌中的表达特点及其临床意义，2011.06-2013.05，5万元，已结题，主持

3.上海市科委，12ZR1417500，乳腺癌组织中神经分布特点及其分子调控机制研究，2012.07-2015.06，10万元，已结题，主持   

4.上海市教委，13YZ038，大麻素CB1受体调控子宫内膜异位症病灶中神经发生的分子机制，2013.01-2015.12，8万元，已结题，主持

5.国家自然科学基金面上项目，81272927，乳腺癌组织中神经新生的生物学意义及其分子调控机制，2013.01-2013.12，16万元，已结题，主持

6.上海交大085工程，肿瘤学科建设，2013.2-2014.12，15万元，已结题，主持

7.上海市宝山区科委，12-E-4，乳腺癌组织中神经新生的临床意义及其分子调控机制研究，2013.01-2014.12,已结题，主持

8.上海交通大学医学院附属第九人民医院，syz2015-020，神经标记物在人口腔癌组织中的表达特点及其临床意义，2016.01-2019.12，已结题，主持

9.国家自然科学基金面上项目，81770533，5-HT抑制坏死性凋亡信号通路改善糖尿病胃肠神经病变的机制研究，2018.01-2021.12，已结题，第一参与人

10.同济大学附属同济医院，国自然培育项目，2021.11-2022.10，已结题，主持

11.上海市自然科学基金，23ZR1457700，乳腺癌TME交感神经基于PKM2/COX-2重塑肿瘤相关巨噬细胞功能和抑制免疫反应的机制研究，2023.4.1-2026.3.31，在研，主持

1. 第一作者论文

(1) Hongxiu Han #, Xizi Liang #, Juan Wang, Qianqian Zhao, Mei Yang, Weifang Rong, Guohua Zhang*, Cannabinoid receptor 1 contributes to sprouted innervations in endometrial ectopic growth through mitogen-activated protein kinase, Brain Research, 2017,1663:132-140 (IF: 3.125)

    (2) Hongxiu Han, Kyu-sang Lee, Weifang Rong*, Guohua Zhang*, Different roles of peripheral mitogen-activated protein kinases in carrageenan-induced arthritic pain and arthritis in rats, Anesthesia & analgesia, 2012, 115(5): 1221-1227 (IF: 3.3)

    (3) Hongxiu Han, Chan-Kum Park*, The expression of apolipoprotein D in hepatocellular carcinoma, Korean Journal of Pathology, 2010, 44: 187-190 (IF: 0.6)

    (4) Hongxiu Han, Si-Hyong Jang, Chan-kum Park*, Enhanced protein expression of signal transducer and activator transcription 3 and protein kinase substrate p36 in hepatocellular carcinoma, Korean Journal of Pathology, 2009, 43: 393-399 (IF: 0.6)

2．通讯作者论文

(1) Yingying Cheng,Yueting Kou, Juan Wang, Yue Wang, Weifang Rong, Hongxiu Han*, Guohua Zhang*, 5-hydroxytryptamine 4 receptor agonist attenuates diabetic enteric neuropathy through inhibition of the receptor-interacting protein kinase 3 pathway. The American Journal of Pathology, 2024, 194(5):785-795.

(2) Shasha Hu, Yueting Kou, Xiaochen Liu, Weifang Rong, Hongxiu Han*, Guohua Zhang*, Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice. 2023, 55(12): 1874–1883.

(3) Hongxiu Han*, Chunxue Yang, Yuan Zhang, Changhao Han, Guohua Zhang*, Vascular endothelial growth factor mediates the sprouted axonogenesis of breast cancer in rat. The American Journal of Pathology, 2021, 191(3): 515-526. (IF: 5.77)

(4) Juanhong Shi, Xue Chen, Long Zhang, Xia Fang, Yuting Liu, Xuyou Zhu, Haoyang Zhang, Lichao Fan, Jun Gu, Suxia Zhang, Bin She, Hongxiu Han*, Xianghua Yi*, Performance evaluation of SHOX2 and RASSF1A methylation for the aid in diagnosis of lung cancer based on the analysis of FFPE specimen. Frontiers in Oncology, 2020, 10. (IF: 6.244)

(5) Changhao Han, Yuanyuan Wang, Hongxiu Han*, Occult metastasis in subserosal leiomyoma of uterus from SCC of uterine cervix: a case report. Human Pathology Case report, 2020, 21: 200399

(6) 杨春雪，张圆，汪园圆，韩洪秀*,肿瘤内神经新生在口腔鳞状细胞癌进展中的作用及其潜在机制，同济大学学报(医学版)，2019,40(2):162-168

(7) 梁茜子, 赵倩倩, 韩洪秀*, 肿瘤组织内神经新生的生物学意义及其分子调控机制研究进展，中华病理学杂志, 2015,44(11): 825-827.

    (8) 赵倩倩，韩洪秀*, 大麻素受体1参与神经生长调控的研究进展, 上海交通大学学报(医学版), 2015, 35(8): 1225-1228.

    (9) Qianqian Zhao#, Yan Yang#, Xizi Liang, Guangye Du, Liwei Liu, Lingjuan Lu, Junbo Dong, Hongxiu Han*, Guohua Zhang*, The clinicopathological significance of neurogenesis in breast cancer, BMC Cancer, 2014, 14: 484 (IF: 3.36)

(10) 赵倩倩，梁茜子，韩洪秀*，大麻素1型受体在大鼠子宫内膜异位病灶神经生长中的作用，中华病理学杂志, 2014, 43(12): 827-830.

(11) 刘立伟, 赵倩倩, 梁茜子, 杜光烨, 陆玲娟, 董君波, 韩洪秀*, 神经标志物蛋白基因产物9.5在乳腺癌组织中的表达及其临床意义, 中华病理学杂志, 2014, 43(5): 318-320. 

    (12) Hongxiu Han*, Yan Yang, Zhouping Lu, Qizhi He, Zhenhua Lin, Decreased D2-40 and increased p16NK4A immunireactivities correlate with higher grade of cervical intraepithelial neoplasia, Diagn Pathol, 2011, 6: 59.

    (13) 韩洪秀*，杨敏，李向红，肿瘤组织库的建立与规范化管理，中华病理学杂志，2008, 37(12): 849-850.

   3.其它

    (1) Ziling Huang, Siqi Wang, Yuting Liu, Lichao Fan, Yu Zeng, Hongxiu Han, Haoyang Zhang, Xiaoting Yu, Yudong Zhang, Dandan Huang, Yunjin Wu, Wnxia Jiang, Peipei Zhu, Xuyou Zhu, Xianghua Yi*. GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients, Sci Total Environ, 2020, 739:139923.

    (2) Yongbin Wang, Guifang Gan, Bocheng Wang, Jinliang Wu, Yuan Cao, Dan Zhu, Yan Xu, Xiaona Wang, Hongxiu Han, Xiaoling Li, Ming Ye, Jiangmin Zhao, Jun Mi*, Cancer-associated fibroblasts promote irradiated cancer cell recovery through autophagy, EBioMedicine, 2017, 17: 45-56

    (3) 陆宙萍,蔡旭,杨春雪,汪圆圆,韩洪秀,张圆*,采用切缘标记子宫颈冷刀锥切标本辅助诊断, 中华病理学杂志, 2017, 46(11): 789-790

    (4) Ming-Jue Si, Shuang Gui, Qin Fan, Hong-xiu Han, Qian-Qian Zhao, Zhi-Xin Li, Jiang-Min Zhao*, Role of MRI in the early diagnosis of tubal ectopic pregnancy, European Radiology, 2016, 26(7): 1970-1980

    (5) Hong-Jiang Li, Hongxiu-Han, Dong-fu Feng*, Rapid increase in cystic volume of an anaplastic astrocytoma misdiagnosed as neurocysticercosis: A case report, Oncology Letters, 2016, 12(4): 2825-2827

    (6) Li Dong, Xizi Liang, Biying Sun, Xiaowei Ding, Hongxiu Han, Guohua Zhang*, Weifang Rong*, Impairments of the primary afferent nerves in a rat model of diabetic visceral hyposensitivity, Molecular Pain, 2015, 11(1): 74

    (7) 刘立伟*，韩洪秀，杜光烨，陆玲娟，董君波，肾脏平滑肌瘤1例及临床病理分析，现代肿瘤医学，2013，11：2517-2519

    (8) Seung Sam Paik, Ki-Seok Jang, Young Soo Song, Si-Hyong Jang, Kyueng-Whan Min, Hongxiu Han, Woong Na, Kang Hong Lee, Dongho Choi, Se Jin Jang*, Reduced expression of Apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype, Annals of Surgical Oncology, 2007, 14(12): 3453-3459

(9) Ki-Seok Jang, Hongxiu Han, Seung Sam Paik, Powel H Brown, Gu Kong*, Id-1 overexpression in invasive ductal carcinoma cells is significantly associated with intratumoral microvessel density in ER-negative/node-positive breast cancer, Cancer Letters, 2006, 244(2): 203-210.