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医学博士,中华医学会急诊医学分会青年委员,中国医疗保健国际促进会急诊医学分会全国委员,Critical Care Med中文版第二届编委秘书,中华重症医学电子杂志第一届通讯编委,中国感染控制杂志编委,湘雅期刊社中青年编委。曾赴美国芝加哥大学医学中心学习深造。主要从事严重感染和感染性休克,急性呼吸窘迫综合症,急性肾功能衰竭,多器官功能障碍综合症等多种危重病的治疗工作,擅长机械通气、血液净化、ECMO等多种高级生命支持治疗手段
[1] CRTC1-p300-EGR2转录复合物调控急性呼吸窘迫综合征的分子机理研究;国家自然科学基金(82470070);资助金额62万元
[2] 靶向CtBP2-p300相互作用小分子化合物筛选及其在急性肺损伤中抑制炎症反应的机理研究;国家自然科学基金(82160020);资助金额35万元
[1] Chen Z, Dong W H, Chen Q, et al. Downregulation of miR-199a-3p mediated by the CtBP2-HDAC1-FOXP3 transcriptional complex contributes to acute lung injury by targeting NLRP1. International journal of biological sciences, 2019, 15(12):2627-2640.(第一作者,JCR分区Q1,IF=4.858)
[2] Chen Z, Dong W H, Wu Q, et al. Two-layer regulation of TRAF6 mediated by both TLR4/NF-kB signaling and miR-589-5p increases proinflammatory cytokines in the pathology of severe acute pancreatitis[J]. American Journal of Translational Research, 2020, 12(6).(第一作者,JCR分区Q2,IF=4.06)
[3] Chen Z, Hua S. Transcription factor-mediated signaling pathways' contribution to the pathology of acute lung injury and acute respiratory distress syndrome. American Journal of Translational Research, 2020, 12(9):5608-5618.(第一作者,JCR分区Q2,IF=4.06)
[4] Chen Z, Dong W H, Qiu Z M, et al. The Monocyte-Derived Exosomal CLMAT3 Activates the CtBP2-p300-NF-κB Transcriptional Complex to Induce Proinflammatory Cytokines in ALI. Molecular Therapy: Nucleic Acids Vol. 21 September 2020.(第一作者,JCR分区Q2,IF=8.886)
[5] Zeng J, Chen J Y, Meng J, Chen Z. Inflammation and DNA methylation coregulate the CtBP-PCAF-c-MYC transcriptional complex to activate the expression of a long non-coding RNA CASC2 in acute pancreatitis[J]. International journal of biological sciences, 2020, 16(12):2116-2130.(通讯作者,JCR分区Q1,IF=6.582)
[6] Chen Z. The transrepression and transactivation roles of CtBPs in the pathogenesis of different diseases. Journal of Molecular Medicine, 2021:1-13.(第一作者,JCR分区Q2,IF=4.599)
[7] Lou LQ, Zhou WQ, Song X, Chen Z. Elevation of hsa-miR-7-5p level mediated by CtBP1-p300- AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response, Journal of Molecular Medicine, 2023. (通讯作者,JCR分区Q1,IF=4.8)
[8] Zhou WQ, Song X, Dong WH, Chen Z. Independent effect of the triglyceride-glucose index on all-cause mortality in critically ill patients with chronic obstructive pulmonary disease and asthma: A retrospective cohort study, Chronic Respiratory Disease, 2024, 21(1): 1-13. (通讯作者,JCR分区Q2,IF=3.5)
[9] Li F, Yan WQ,Dong WH, Chen ZP, Chen Z. PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome. Biology Direct, 2024, 19(1): 1-16. (通讯作者,JCR分区Q1,IF=5.7)

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