[1] 国家自然科学基金面上项目， 82171288

[2]  国家自然科学基金青年项目，31801167

[3] 上海市东方英才计划/青年项目 QNWS2024062

[4] 上海市青年科技英才扬帆计划项目，17YF1424200

[5] 上海市卫生健康委员会青年科学基金，20214Y0238

[6] 上海市科委自然科学基金/ 面上项目，22ZR1458100

[7] 同济大学自主原创基础研究项目，22120240384

[8] 同济大学附属杨浦医院攀登计划，Ye2002101

[9] 同济大学附属杨浦医院人才引进项目

[10] 同济大学附属杨浦医院转化专项，zhyxzx202201

[11] 同济大学附属杨浦医院转化专项，zhyxzx202202

[1]Moubin Lin, Juan Wang, Yongshuai Chai, Xin Chen, Danyang Zhao, Zhangdan Xie, Jiebang Jiang, Hong Li, Li Huang, Siwei Xing, Dashi Qi*, Xinyu Mei*(通讯作者). Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation. Cell Metabolism , 2025

反向代谢组发现新型抗炎代谢物同康酸，鉴定了其合成酶AHCY，揭示了其靶向MARS调控炎症N-Hcy修饰时序开关的机制，验证了补充同康酸或通过NAD+增强其生物合成对炎症相关疾病的干预潜力

[2] Yi Liu, Jingjing Guo, HaoCheng, Juan Wang, Yanfeng Tan, Jingjing Zhang, Hongxun Tao, Hongyan Liu, JianboXiao*, Dashi Qi*, Xinyu Mei* (通讯作者).Methionine restriction diets: Unravelling biological mechanisms and enhancingbrain health. Trends in Food Science & Technology，2024

甲硫氨酸限制饮食降低同型半胱氨酸修饰对健康的影响和机制

[3] Xinyu Mei (第一作者,共同通讯作者),Dashi Qi, Ting Zhang, Ying Zhao, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, YuXue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, JianhongYe, Richard H Finnell, Hexige Saiyin, Hongyan Wang, Jianyuan Zhao, Shimin Zhao,Wei Xu. Inhibiting MARSs reduceshyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Molecular Medicine, 2020

建立了N-Hcy修饰检测技术；在神经管畸形和先天性心脏病中检测到MARS拷贝数变异，并发现机制在于增加了SOD的N-Hcy修饰从而抑制了活性氧解毒代谢；靶向MARS设计N-Hcy修饰抑制剂AHT，并验证了AHT预防神经管畸形和先天性心脏病的作用

[4] Xinyu Mei (第一作者), Yuan Guo, Zhangdan Xie, Xiaofen Wu, DaichaoXu, Ying Li , Nan Liu, Zhengjiang Zhu*. RIPK1 regulates starvationresistance through modulating aspartate catabolism. Nature Communications，2021

饥饿应激情况下（如肿瘤、缺血性脑卒中、出生后哺乳期）的代谢调控机制

[5] ZhangdanXie, Moubin Lin, Beizi Xing, Hongmiao Wang, Haosong Zhang, Xinyu Mei*, Zheng-Jiang Zhu*. Citrulline regulates macrophage metabolism and inflammation tocounter aging. Science Advances，2025

衰老和慢性炎症过程中的代谢调控机制

[6] Chuantao Fang†, Xiaodan Zhang†, Lin Yang†, Licheng Sun †, Yujia Lu†, Yi Liu, Jingjing Guo, Min Wang, Yanfeng Tan, Jinsen Zhang, Xin Gao, Guoping Liu, Jianbo Xiao, Fayong Zhang, Shaojie Ma, Rui Zhao*, Xinyu Mei*, Dashi Qi* Transcriptomic and morphologic vascular aberrations underlying FCDIIb etiology. Nature Communications, 2025

血管平滑肌细胞异常所致缺氧环境激活mTOR信号通路促癫痫的发病机制

[7] Licheng Sun; Liu Ping ; GuoJingjing; Fang Chuantao; Li Li; Tang Yanfeng ; Zhao Rui; Dong Rui ; Ma Shaojie;Xinyu Mei*; Dashi Qi* Deciphering the temporal transcriptional landscape of humanfetal leptomeninges. Brain, 2024

人类胚胎期软脑膜免疫细胞、成纤维细胞及血管相关细胞的发育轨迹

[8] Qin Zhang, Baoling Bai, XinyuMei (共同第一作者),Chunlei Wan, Haiyan Cao, Dan Li, Shan Wang, Min Zhang, Zhigang Wang, JianxinWu, Hongyan Wang, Junsheng Huo, Gangqiang Ding, Jianyuan Zhao, Qiu Xie, LiWang, Zhiyong Qiu, Shiming Zhao, Ting Zhang. ElevatedH3K79 homocysteinylation causes abnormal gene expression during neuraldevelopment and subsequent neural tube defects. Nature Communications, 2018

组蛋白N-Hcy修饰调控神经管发育相关基因的表达

[9] Dan Wang, Rui Zhao, Yuanyuan Qu, Xinyu Mei (共同第一作者),  Xuan Zhang, Qian Zhou, Yang Li, Shaobo Yang, Zhigui Zuo, Yiming Chen, Yan Lin, WeiXu, Chao Chen, Shimin Zhao, and Jianyuan Zhao. Coloniclysine homocysteinylation induced by high fat diet suppresses DNA damageRepair. Cell Reports, 2018

建立了基于蛋白互作的N-Hcy修饰蛋白检测技术，并发现高脂饮食上调Hcy和N-Hcy修饰水平，上调DNA损伤修复蛋白ATR的N-Hcy修饰，是高脂饮食诱发结直肠癌的机制之一

[10] XinyuMei (第一作者),Xiadi He, Lei Huang, Dashi Qi, Ji Nie, Yang Li, Wen Si and Shimin Zhao. Dehomocysteinylation is catalysed by the sirtuin-2-like bacteriallysine deacetylase CobB. FEBS Journal, 2016

首次发现了N-Hcy修饰的自发去修饰现象，并揭示了N-Hcy自发去修饰机制，另外发现N-Hcy去修饰反应可以被酶促加速，并鉴定到了N-Hcy去修饰酶cobB

[11] Rong Yin, Jie Xue, Yanfeng Tan, Chuantao Fang, Chunchun Hu, QianYang, Xinyu Mei*, Dashi Qi*, The Positive Role and mechanismof Herbal Medicine in Parkinson's disease. Oxidative Medicine and CellularLongevity, 2021.

植物代谢物通过AMPK通路调控帕金森疾病进展的作用和机制

[12] NwobodoAlexander Kenechukwu, Man Li, Lei An, Miaomiao Cui, Cailin Wang, Aili Wang,Yulin Chen, Saijun Du, Chenyao Feng, Sijin Zhong, Yuying Gao, Xueyan Cao, LiWang, Ezenwali Moses Obinna, Xinyu Mei*,Yuanjian Song*, Zongyun Li*, Dashi Qi* Comparative Analysis of the Complete MitochondrialGenomes for Development Application. Frontiers in Genetics, 2018

线粒体与发育