神经干细胞与大脑发育的研究。寨卡病毒暴发以后，在寨卡病毒的细胞侵嗜性上有重要发现。第一个发现了寨卡病毒能够突破母体的胎盘屏障，靶向胎鼠脑内的神经干细胞-放射状胶质细胞，进而造成小头畸形。

        室管膜细胞分化和纤毛形成的研究。室管膜细胞是脑实质和脑脊液间的重要屏障，研究发现囊泡蛋白分选相关蛋白VPS35决定了管膜细胞的分化成熟，并在纤毛的发育形成中起着关键作用。

曾主持或参与国家自然科学基金，国家重大科学研究计划等项目。入选2022年上海领军（海外）项目。

1.    Tsai NY, Wang F, Toma K, Yin C,Takatoh J, Pai EL, Wu KY, Matcham AC, Yin L, Dang EJ, Marciano DK,Rubenstein JL, Wang F, Ullian EM, Duan X. (2022) Trans-Seq maps a selective mammalian retinotectal synapseinstructed by Nephronectin. Nature Neuroscience 25(5):659-674.

2.      Zhao MY, Toma K, Kinde B, Li L, Patel AK,Wu KY, Lum MR, Tan CX, Hooper JE, Kriegstein AR, Torre AL, LiaoYJ, Welsbie DS, Hu Y, Han Y, Duan X. (2023) Osteopontin drivesretinal ganglion cell resiliency in glaucomatous optic neuropathy. CellRep. 42(9): 113038

3.    Zheng C. H. , Zhang H. N., Cui Y. L., Mu Y. C.,Jiang K., Zhou L. Q., Wang J. B., Liu J. P., Deng Y. X., Zhang C. X., Zhu W.M.,Wu K.Y. , Sun Y. E. (2022)Bio-C (Modified Hyaluronic Acid -Coated- Collagen Tube) implants enable functional recovery after complete spinal cordinjury. Pharmaceutics 14(3):596.

4.    WuK.Y., Tang F. L.,  Lee D., Zhao Y., Song H., Zhu X.J., Mei L., Xiong W. C. (2020) Ependymal VPS35 promotes ependymal celldifferentiation and survival, suppresses microglial activation, and preventsneonatal hydrocephalus. J. Neurosci.40 (19): 3862-3879. 

5.    WuK.Y., Zuo G.L., Li X.F., Ye Q., Deng Y.Q.,Huang X.Y., Cao W.C., Qin C.F., Luo Z.G. (2016) Vertical transmission of Zika virus targeting the radial glial cells affectscortex development of offspring mice. CellRes. 26(6): 645-654.

6.    Wu K.Y., He M., Hou Q.Q.,Sheng A. L., Yuan L., Liu F., Liu W.W., Li G., Jiang X.Y., Luo Z. G. (2014)Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growthcone collapse and organize callosal axon projections. Sci. Signal. 7, ra81. 

7.    Wu K.Y., ZhouX.P., Luo Z.G. (2010) Geranylgeranyltransferase I is essential for dendriticdevelopment of cerebellar Purkinje cells. Mol.Brain 2010, 3:18.

8.    Zhou X.P., Wu K.Y, Liang B., Fu X.Q., Luo Z.G.(2008) TrkB-mediated activation of geranylgeranyltransferase I promotesdendritic morphogenesis. Proc. Natl.Acad. Sci. USA. 105(44):17181-17186.

9.    Ju X.C., Hou Q.Q., Sheng A.L., Wu K.Y., Zhou Y., Jin Y., Wen T., Yang Z., Wang X., Luo Z.G. Thehominoid-specific gene TBC1D3 promotes generation of basal neural progenitorsand induces cortical folding in mice. eLife2016;5:e18197

10. Wang T., Liu Y., Xu X. H., Deng C. Y., Wu K. Y., ZhuJ., Fu X. Q., He M., Luo Z. G. (2011) Lgl1 activation of rab10 promotes axonalmembrane trafficking underlying neuronal polarization. Dev. Cell. 21(3):431-444.