团队成员介绍：

实验室负责人：王海坤 研究员

副研究员：刘元花（生物信息学）

助理研究员：任甲子（免疫学）

科研助理：杜凤雪

博士后：刘秋月   翟云泽（免疫学）

博士研究生：张羽、张娟

1. 自然科学基金项目, “Foxp1 调控滤泡辅助性 T 细胞分化的机制研究”

2. 科技部重点研发计划项目, “CD4+ T细胞转录调控机制”  

3. 科技部重点研发计划项目,“ 抗病毒免疫个体差异的适应性免疫基础”

4. 中科院先导B项目, “滤泡辅助性T细胞和抗体免疫应答的调控机制研究”

近期通讯作者论文:

1. Deng X, Wang L, Zhai Y, LiuQ, Du F, Zhang Y, Zhao W, Wu T, Tao Y, Deng J, Cao Y, Hao P, Ren J, Shen Y, YuZ, Zheng Y, Zhang H, Wang H. RIPK1plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibitingboth RIPK3- and FADD-mediated cell death. Cell Mol Immunol. 2024 Jan;21(1):80-90. doi:10.1038/s41423-023-01113-x.

2. Gu W, Zhang J, Li Q, Zhang Y, Lin X, Wu B, Yin Q, Sun J, Lu Y, Sun X,Jia C, Li C, Zhang Y, Wang M, Yin X, Wang S, Xu J, Wang R, Zhu S, Cheng S, ChenS, Liu L, Zhu L, Yan C, Yi C, Li X, Lian Q, Lin G, Ling Z, Ma L, Zhou M, XiaoK, Wei H, Hu R*, Zhou W*, Ye L*, Wang H*, Li J*, Sun B*. The TRIM37 variants inMulibrey nanism patients paralyze follicular helper T cell differentiation. CellDiscov. 2023 Aug 1;9(1):82. doi: 10.1038/s41421-023-00561-z. PMID:37528081; PMCID: PMC10394018.

3. Ao YQ, Jiang JH, Gao J, Wang H*, Ding J*. Recentthymic emigrants as the bridge between thymoma and autoimmune diseases. BiochimBiophys Acta Rev Cancer. 2022 May;1877(3):188730. doi:10.1016/j.bbcan.2022.188730.

4. Zang J, Yin Y, Xu S, Qiao W, Liu Q, LavilletteD, Zhang C, Wang H*, Huang Z*.Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against OmicronVariant. Front Immunol. 2022 Jun 30;13:908478. doi:10.3389/fimmu.2022.908478. PMID: 35844601; PMCID: PMC9280631.

5. Gao S, Jiang J, Jin C, Gao J, Xiong D, Yang P,Cui S, Yang W, Leng Q, Dong J, Chen G, Liu J, Wang L, Ke A, Wang H*, Ding J*. Interleukin-8 as acandidate for thymoma identification and recurrence surveillance. NatCommun. 2020;11(1):4881. doi: 10.1038/s41467-020-18697-x. PMID:32985506 （第一完成单位）.

6. Cao Y,Wang X, Yang Q, Deng H, Liu Y, Zhou P, Xu H, Chen D, Feng D, Zhang H, Wang H*, Zhou J. Critical Role ofIntestinal Microbiota in ATF3-Mediated Gut Immune Homeostasis. JImmunol. 2020 Aug 1;205(3):842-852. doi: 10.4049/jimmunol.1901000.

7. Wang, M., Huang, Y., Gu, W., Wang, H. Evaluation of T FollicularHelper Cells and Germinal Center Response During Influenza A Virus Infection inMice. J Vis Exp. 2020;(160). doi: 10.3791/60523.

8. Liang H, Tang J, Liu Z, Liu Y, Xu Y, HaoP, Yin Z, Zhong J, Ye L, Jin X, Wang H. ZIKVinfection induces robust Th1-like Tfh cell and long-term protective antibodyresponses in immunocompetent mice. NatCommun. 2019;10(1):3859. doi: 10.1038/ s41467-019-11754-0.

9. Ren J, Han L, Tang J, Liu Q, Deng X, LiuQ, Hao P, Feng X, Li B, Hu H, Wang H.Foxp1 is critical for the maintenance of regulatory T-cell homeostasis andsuppressive function. PLoS Biol. 2019; doi.org/10.1371/journal.pbio.3000270.

10. He L, Gu W, Wang M, Chang X, Sun X,ZhangY, Lin X, Yan C, FanW, Su P, Wang Y, Yi C, Lin G, Li L, Lu J, Wang H*and Sun B*. ECM1 promotes differentiation of follicular helper T cells andantibody production. Proc Natl AcadSci USA. 2018; 115(34):8621-8626.