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朱炳博士,同济大学医学院特聘研究员,浙江大学神经生物学博士(美国内布拉斯加医学中心联培),从事阿尔茨海默症和干细胞研究15 年,主要应用病人来源干细胞培养和分化技术, 新型蛋白质组学技术,单细胞空间转录组以及三光子高级显微成像技术研究携带遗传突变基因的阿尔茨海默症病人的发病机制。
代表性论文:
(1) Bing Zhu#; Yan Liu#; Spring Hwang; Kailey Archuleta; Huijie Huang; Alex Campos; Rabi Murad;Juan Piña-Crespo; Huaxi Xu; Timothy Y. Huang ; Trem2 deletion enhances tau dispersion andpathology through microglia exosomes, Molecular Neurodegeneration, 2022, 17(1)
(2) Bing Zhu#; LuLin Jiang#; Timothy Huang; Yingjun Zhao; Tongfei Liu; Yongwang Zhong;Xiaoguang Li; Alexandre Campos; Kenneth Pomeroy; Eliezer Masliah; Dongxian Zhang; Huaxi Xu ; ER associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity, NATURE COMMUNICATIONS, 2017, 8(1472)
(3) Tongfei Liu#; Bing Zhu#; Yan Liu#; Xiaoming Zhang#; Jun Yin; Xiaoguang Li; LuLin Jiang; Andrew P. Hodges; Sara Brin Rosenthal; Lisa Zhou; Joel Yancey; Amanda McQuade; Mathew BlurtonJones; Rudolph E. Tanzi; Timothy Y. Huang; Huaxi Xu ; Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE, Journal of experimental medicine, 2020, 217(12)
(4) Lu-Lin Jiang; Bing Zhu#; Yingjun Zhao#; Xiaoguang Li#; Tongfei Liu; Juan Pina-Crespo; Lisa Zhou; Wenxi Xu; Maria J. Rodriguez; Haiyang Yu; Don W. Cleveland; John Ravits; Sandrine Da Cruz;Tao Long; Dongxian Zhang; Timothy Y. Huang; Huaxi Xu ; Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment, The Journal of Clinical Investigation, 2019, 129(8): 3103-3120
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