主持国家自然科学基金项目：

基于dCas9甲基化编辑系统对早期胚胎印记控制区DNA甲基化的调控机制研究，2023-01-01至2025-12-31，在研，主持

参与国家自然科学基金项目：

体细胞核移植胚胎围着床期发育异常的分子机制研究，2024-01-01至2028-12-31，在研，参与

主持其他科研项目/课题：

（1）上海市人力资源和社会保障局，上海市超级博士后，主持，已结题

（2）中国博士后科学基金会，中国博士后科学基金会面上资助，第72批面上资助，主持，已结题

（3）中国博士后科学基金会，2021年度博士后创新人才支持计划，主持，已结题

研究方向：

1. 哺乳动物围着床期胚胎发育过程中的表观调控机制

2. 核移植胚胎异常发育的表观重编程分子机制

3. 基因编辑及表观编辑技术的建立和优化

*第一作者/共同第一作者

1.  Li Y*, Zheng C*, Liu Y, He J, Zhang Q, Zhang Y, Kou X, Zhao Y, Liu K, Bai D, Jia Y, Han X, Sheng Y, Yin J, Wang H, Gao S, Liu W, Gao S. Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos. National Science Review. 2023 Aug 16;10(9): nwad173.

2．Li Y*，Weng Y，Bai D, Jia Y, Liu Y, Zhang Y, Kou X, Zhao Y, Ruan J, Chen J, Yin J, Wang H, Teng X, Wang Z, Liu W, Gao S. Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation. Nature Communications. 2020 Sep 14; 11(1): 0-4593.

3. Yang H*, Bai D*, Li Y*, Yu Z*, Wang C, Sheng Y, Liu W, Gao S, Zhang Y. Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo. Nature Cell Biology. 2022 May; 24(5): 783-792.

4. Wang Y, Li Y*, Luan D, Kang J, He R, Zhang Y, Quan F. Dynamic replacement of H3.3 affects nuclear reprogramming in early bovine SCNT embryos. Theriogenology. 2020 Sep 15; 154:43-52.

5. Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science. 2022 May 27;376(6596):968-973.

6. Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S. N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. Nature Cell Biology. 2022 Jun;24(6):917-927.

7. Chen M, Zhu Q, Li C, Kou X, Zhao Y, Li Y, Xu R, Yang L, Yang L, Gu L, Wang H, Liu X, Jiang C, Gao S. Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos. Nat Communications. 2020 Apr 14;11(1):1813. 

8. Bai D, Sun J, Chen C, Jia Y, Li Y, Liu K, Zhang Y, Yin J, Liu Y, Han X, Ruan J, Kou X, Zhao Y, Wang H, Wang Z, Chen M, Teng X, Jiang C, Gao S, Liu W. Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue cause placental defects and implantation failure in mouse IVF embryos. Cell Reports. 2022 May 3;39(5):110784.

9. Jia Y, Liu W, Bai D, Zhang Y, Li Y, Liu Y, Yin J, Chen Q, Ye M, Zhao Y, Kou X, Wang H, Gao S, Li K, Chen M. Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring. J Pineal Res. 2022 Jan;72(1): e12778. doi: 10.1111/jpi.12778. Epub 2021 Dec 3