围绕“DNA损伤修复如何调控衰老”这一关键科学问题，系统识别参与DNA损伤修复的新型衰老相关因子以及探究DNA修复相关蛋白在衰老调控中的新机制，从而为延缓衰老、促进健康衰老提供坚实的理论依据和潜在干预靶标。（1）阐释了促衰老因子cGAS细胞核内调控DNA修复的全新功能 ( Nature,2018; Cell Death and Differentiation, 2024 )；（2）揭示了DNA修复是增龄相关基因组稳定性下降的关键因素 ( Aging Cell,2020 )；（3）开发了新型DNA修复检测系统并助力衰老相关疾病研究 ( Nucleic Acids Research,2019; Cell Death and Disease, 2025 ) 。

（1）国家自然科学基金委员会, 面上项目, 82571784 , 叶酸靶向其代谢酶TYMS调控DNA修复抑制衰老的新功能及机制研究 , 2026-01 至 2029-12, 47万 元, 主持。

（2）国家自然科学基金委员会, 青年科学基金项目, 82101634, cGAS调控非同源末端连接修复的机制研究,2022-01-01 至 2024-12-31, 30万 元, 主持。

（3）上海市科学技术委员会, 自然科学基金青年项目, 25ZR1402434, 长寿相关XRCC1变体通过促进基因组稳定性抑制细胞衰老的机制研究 , 2025-07 至 2028-06, 25万元, 主持。

（4）上海市“东方英才计划”青年项目，长寿相关LIG4变体提升DNA修复延缓卵巢衰老的机制研究，2026.01至2028.12，主持。（人才项目）

（5）上海市科学技术委员会, 扬帆计划, 21YF1435900, XRCC1调控脂肪干细胞衰老相关基因组稳定性的机制研究, 2021-05 至 2024-04, 20万元, 主持。（人才项目）

(1) Haipeng Liu #,Haiping Zhang #, Xiangyang Wu #,Dapeng Ma, Juehui Wu, Lin Wang, Yan Jiang, Yiyan Fei, Chenggang Zhu, Rong Tan,Peter Jungblut, Gang Pei, Anca Dorhoi, Qiaoling Yan, Fan Zhang, Ruijuan Zheng,Siyu Liu, Haijiao Liang, Zhonghua Liu, Hua Yang, Jianxia Chen, Peng Wang,Tianqi Tang, Wenxia Peng, Zhangsen Hu, Zhu Xu, Xiaochen Huang, Jie Wang, HaohaoLi, Yilong Zhou, Feng Liu, Dapeng Yan, Stefan H E Kaufmann, Chang Chen, ZhiyongMao*, Baoxue Ge*, Nuclear cGAS suppresses DNA repairand promotes tumorigenesis, Nature, 2018, 563(7729): 131-6. ( IF: 50.5 )

(2) Zhang, Haiping #; Jiang Lijun #; Du Xinyi; Qian zhen; Wu Guizhu*; Jiang Ying*; Mao Zhiyong*; The cGAS-Ku80 complex regulates the balance between two end joining subpathways, Cell Death & Differentiation, 2024, 31:792–803. ( IF: 15.4 )

(3) Wenge Dong #, Haiping Zhang #, Zhigang Zhuang *, Ying Jiang *.PIPKIgamma promotes non-homologous end joining through LIG4 to enhanceradiotherapy resistance in triple-negative breast cancer. Cell Death and Disease，2025，16, 578. ( IF: 9.6 )

(4) Yu Chen #; Haiping Zhang #; Zhu Xu #; Huanyin Tang; Anke Geng; Bailian Cai; Tao Su; Jiejun Shi;Cizhong Jiang; Xiao Tian; Andrei Seluanov; Jun Huang; Xiaoping Wan; Ying Jiang*; Vera Gorbunova*;Zhiyong Mao* ; A PARP1–BRG1–SIRT1 axis promotes HR repair by reducing nucleosome density at DNAdamage sites, Nucleic Acids Research, 2019, 47(16): 8563-8580 . ( IF: 16.1 )

(5) Haiping Zhang #; Bailian Cai #; Anke Geng; Huanyin Tang; Wenjun Zhang; Sheng Li; Ying Jiang;Rong Tan*; Xiaoping Wan*; Zhiyong Mao* ; Base excision repair but not DNA double-strand break repairis impaired in aged human adipose-derived stem cells, Aging Cell, 2020, 19(2) . ( IF: 11.07 )

(6) Zhang Haiping #; Chen Yu #; Jiang Ying; Mao Zhiyong* ; DNA double-strand break repair and nucleic acid-related immunity, Acta Biochimica et Biophysica Sinica, 2022, 54(6): 828-835.  (Invited Review)