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张晓明，1988年生，河南林州人，中共党员，博士，同济大学医学院长轨制助理教授，同济大学附属同济医院副研究员，硕士研究生导师。2013至2018年就读于荷兰格罗宁根大学医学院神经科学系并获得博士学位；2018至2023年在美国桑福德-伯纳姆医学研究所和美国哈佛大学医学院从事博士后研究工作；2023年至今任职于同济大学医学院，从事教学科研工作，参与本科生《人体解剖学》和研究生《脑与认知》、《神经生物学》等课程教学。长期开展阿尔茨海默症中小胶质细胞不同表型的表观遗传学研究，相关成果发表在PNAS、Glia、Journal of Neuroinflammation、Journal of Experimental Medicine、Cell Death and Disease、Brain Behavior andImmunity、Frontiers in Cellular Neuroscience、Nature Immunology、Frontiers in MolecularNeuroscience等。目前承担国家自然科学基金1项，累计参与指导硕士研究生7名，提交专利申请2项。现为多个学术杂志的审稿人及Frontiers专刊编辑。
国家自然科学基金青年科学基金项目, 组蛋白H3K9乙酰化在调控小胶质细胞Trem2-ApoE信号通路及治疗阿尔茨海默症中的作用和机制研究, 2023-01-01 至 2025-12-31, 30万元, 主持
1. Zhang X*, Heng Y*, Kooistra SM, van Weering HRJ, Brummer ML, GerritsE, Wesseling EM, Brouwer N, Nijboer TW, Dubbelaar ML, Boddeke EWGM, Eggen BJL.Intrinsic DNA damage repair deficiency results in progressive microglia lossand replacement. Glia. 2021 Mar;69(3):729-745. doi: 10.1002/glia.23925. Epub2020 Oct 17. PMID: 33068332; PMCID: PMC7821301.（共同第一作者）
2. Zhang X*, Kracht L*, Lerario AM*, Dubbelaar ML, Brouwer N, WesselingEM, Boddeke EWGM, Eggen BJL, Kooistra SM. Epigenetic regulation of innateimmune memory in microglia. J Neuroinflammation. 2022 May 14;19(1):111. doi:10.1186/s12974-022-02463-5. PMID: 35568856; PMCID: PMC9107649. （共同第一作者）
3. Lopes JR*, Zhang X*, Mayrink J, Tatematsu BK, Guo L,LeServe DS, Abou-El-Hassan H, Rong F, Dalton MJ, Oliveira MG, Lanser TB, Liu L,Butovsky O, Rezende RM, Weiner HL. Nasal administration of anti-CD3 monoclonalantibody ameliorates disease in a mouse model of Alzheimer's disease. Proc NatlAcad Sci U S A. 2023 Sep 12;120(37):e2309221120. doi: 10.1073/pnas.2309221120.Epub 2023 Sep 5. PMID: 37669383; PMCID: PMC10500187. （共同第一作者）
4. Heng Y*, Zhang X*, Borggrewe M, van Weering HRJ,Brummer ML, Nijboer TW, Joosten LAB, Netea MG, Boddeke EWGM, Laman JD, EggenBJL. Systemic administration of β-glucan induces immune training in microglia.J Neuroinflammation. 2021 Feb 22;18(1):57. doi: 10.1186/s12974-021-02103-4.PMID: 33618716; PMCID: PMC7901224. （共同第一作者）
5. Liu T*, Zhu B*, Liu Y*, Zhang X*, Yin J*, Li X, JiangL, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, TanziRE, Huang TY, Xu H. Multi-omic comparison of Alzheimer's variants in humanESC-derived microglia reveals convergence at APOE. J Exp Med. 2020 Dec7;217(12):e20200474. doi: 10.1084/jem.20200474. PMID: 32941599; PMCID:PMC7953740. （共同第一作者）
6. Li C, Dubbelaar ML, Zhang X*, Zheng JC*. Editorial:Understanding the heterogeneity and spatial brain environment ofneurodegenerative diseases through conventional and future methods. Front CellNeurosci. 2023 May 23;17:1211273. doi: 10.3389/fncel.2023.1211273. PMID:37287510; PMCID: PMC10242171. （共同通讯作者）
7. An J*, Zhang X*, Qin J, Wan Y, Hu Y, Liu T, Li J, DongW, Du E, Pan C, Zeng W. The histone methyltransferase ESET is required for thesurvival of spermatogonial stem/progenitor cells in mice. Cell Death Dis. 2014Apr 24;5(4):e1196. doi: 10.1038/cddis.2014.171. PMID: 24763053; PMCID:PMC4001319. （共同第一作者）
8. McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L,Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H,Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD.Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling.bioRxiv [Preprint]. 2023 Sep 21:2023.07.13.548459. doi:10.1101/2023.07.13.548459. PMID: 37790363; PMCID: PMC10542141.
9. Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W,Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, PittsKM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S,Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, DeikA, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D,Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD,Holtzman DM, Butovsky O. APOE4 impairs the microglial response in Alzheimer'sdisease by inducing TGFβ-mediated checkpoints. Nat Immunol. 2023Nov;24(11):1839-1853. doi: 10.1038/s41590-023-01627-6. Epub 2023 Sep 25. PMID:37749326.
10. Schaafsma W, ZhangX, van Zomeren KC, Jacobs S, Georgieva PB, Wolf SA, Kettenmann H, Janova H,Saiepour N, Hanisch UK, Meerlo P, van den Elsen PJ, Brouwer N, Boddeke HW,Eggen BJ. Long-lasting pro-inflammatory suppression of microglia byLPS-preconditioning is mediated by RelB-dependent epigenetic silencing. BrainBehav Immun. 2015 Aug;48:205-21. doi: 10.1016/j.bbi.2015.03.013. Epub 2015 Apr2. PMID: 25843371.
11. Yin Z, Raj DD,Schaafsma W, van der Heijden RA, Kooistra SM, Reijne AC, Zhang X, MoserJ, Brouwer N, Heeringa P, Yi CX, van Dijk G, Laman JD, Boddeke EWGM, Eggen BJL.Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia ActivationDuring Aging. Front Mol Neurosci. 2018 Mar 12;11:65. doi:10.3389/fnmol.2018.00065. PMID: 29593493; PMCID: PMC5857900.
12. Dong W, ZhangX, Yang C, An J, Qin J, Song F, Zeng W. Iridovirus infection in Chinesegiant salamanders, China, 2010. Emerg Infect Dis. 2011 Dec;17(12):2388-9. doi:10.3201/eid1712.101758. PMID: 22172343; PMCID: PMC3311219.
13. Li X, Li S,Zhang M, Li X, Zhang X, Zhang W, Li C. Protective effects of abacterially expressed NIF-KGF fusion protein against bleomycin-induced acutelung injury in mice. Acta Biochim Biophys Sin (Shanghai). 2010Aug;42(8):548-57. doi: 10.1093/abbs/gmq059. Epub 2010 Jul 5. PMID: 20705596.
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