主持项目

1.高龄雄性精子tsRNA通过调控早期胚胎基因表达介导子代焦虑样行为发生的机制研究. 国家自然科学基金 面上项目    

2.高龄父亲精子miRNA表达谱异常及其在子代自闭症谱系障碍（ASD）发生中的作用和机制研究.国家自然科学基金 青年项目  

3.比较纺锤体观察法与传统极体法对短时授精后部分受精失败患者的治疗结局:一项随机双盲对照研究. 中华医学会  

4.基于人工智能的精子优选系统的研发. 上海市第一妇婴保健院 

1.高龄雄性精子tsRNA通过调控早期胚胎基因表达介导子代焦虑样行为发生的机制研究. 国家自然科学基金 面上项目    

2.高龄父亲精子miRNA表达谱异常及其在子代自闭症谱系障碍（ASD）发生中的作用和机制研究.国家自然科学基金 青年项目  

3.比较纺锤体观察法与传统极体法对短时授精后部分受精失败患者的治疗结局:一项随机双盲对照研究. 中华医学会  

4.基于人工智能的精子优选系统的研发. 上海市第一妇婴保健院 

近五年发表文章及专利:

1.Junting Xu #, Qiaoling Wang #, Xianting Jiao #, Pengcheng Kong, Siyu Chen,  Wanli Yang, Wenqiang Liu, Kunming Li*, Xiaoming Teng*, Yi Guo*. Association betweenperfluorooctanoic acid-related poor embryo quality and metabolite alterationsin human follicular fluid during IVF:A Cohort Study. Environmental HealthPerspectives. 2025 Jun;133(6):67017.

2.   Li J#, Liu Y#,Kong P, Chang Q, Chen S, Yang W, Liu W*, Teng X*, Guo Y*: Impact ofDNAH3 Deficiency on Sperm Energy Metabolism and Motility Leading toAsthenozoospermia. Biol Reprod. 2025,112:501-512

3.     WangQ#, Chi F#, Liu Y#, Chang Q, Chen S, Kong P,Yang W, Liu W, Teng X*, Zhao Y*,Guo Y*: Polyethylene microplasticexposure adversely affects oocyte quality in human and mouse. Environ International. 2025, 195:109236.

4.   Liu Y#,Teng X#, Bai D#, Xing F, Chang Q, Li J, Gao S,* Liu W*, GuoY*:Inhibition of aging-induced DNA hypermethylation by si-Dnmt3a_3b inpre-implantation embryos improves aberrant social behavior in offspring. InternationalJournal of Biological Macromolecules. 2025 Mar 17;307(Pt 4):142130. 

5.   Liu Y,Hao F, Liang H, Liu W, Guo Y*. Exposure to polystyrenenanoplastics impairs sperm metabolism and pre-implantation embryo developmentin mice. Frontiers in Cell and Developmental Biology. 2025,13: 1562331

6.   Jinli Li#, Tangzhen Zhao#, Mengmeng Ma, Pengcheng Kong, Yuping Fan,Xiaoming Teng*,Yi Guo*. Metabolomic profiling and machinelearning-based biomarker identification for oligoasthenozoospermia. Metabolomics. 2025 Sep 17;21(5):137.

7.  Yi Guo#, Mengxun Rong#, YupingFan, Xiaoming Teng, Liping Jin* and Yan Zhao*: The Presence of Microplastics in Human Semen and TheirAssociations with Semen Quality. Toxics. 2025 Jul 3;13(7):566.

8.  Jie Zhang#, Shuwen Qiu#, Hongyuan Gao#, Xiaoyan Mao, Yi Guo* andLing Wu*:Pregnancy and perinatal outcomes after modified naturalcycle-frozen embryo transfers according to size of the dominant follicle on thehCG trigger day. Human Reproduction Open. 2025 Jul 16;2025(3).

9.     YangH#, Ma M#, Chen X, Chen G, Shen Y, Zhao L, Wang J, Yan F,Huang D, Gao H, Chen Y, Guo Y*, Liang B*, Teng X*:Multidimensional morphological analysis of live sperm based on multiple-targettracking. Comput Struct Biotechnol J. 2024,24:176-184.

10.   GuoY#, Li J#, Hao F, Yang Y, Yang H, Chang Q, Kong P,Liu W, Jiao X*, Teng X*: A new perspective on semen quality of aged male: Thecharacteristics of metabolomics and proteomics. Front Endocrinol (Lausanne). 2023, 13:1058250.

11.  Guo Y#, Bai D#, Liu W, Liu Y, Zhang Y, Kou X, ChenJ, Wang H, Teng X*, Zuo J*, Gao S*. Alteredsperm tsRNAs in aged male contribute to anxiety-like behavior in offspring. AgingCell. 2021, 20(9):e13466.

12.  Li M, Chang Q, Luo Y, Pan J, HuY, Liu B, Ma M, Wang Q, Guo Y*, Wang Q*: The gut microbial composition in polycysticovary syndrome with hyperandrogenemia and its association with steroid hormones.Front Cell Dev Bio.l 2024, 12:1384233.

13. Yi Guo#, Zhijuan Cao#,Xianting Jiao, Dandan Bai, Yalin Zhang, Jing Hua,Wenqiang Liu,Xiaoming Teng*Pre-pregnancy exposure to fine particulate matter (PM2.5) increases reactiveoxygen species production in oocytes and decrease litter size and weight inmice. Environmental Pollution. 2021 Jan 1;268(Pt A):115858

14.Guo Y#, Liu W#, Wang Y, Pan J, Liang S, RuanJ, Teng X: Polarization microscopy imaging for the identification ofunfertilized oocytes after short-term insemination. Fertility and sterility.2017,108(1):78-83.

15. Niu J, Chang Q,Xu J, Li J, Liu W, Chen Z, Jiao X, Guo Y*, Teng X*: Relationship of thelevels of reactive oxygen species in the fertilization medium with the outcomeof in vitro fertilization following brief incubation. Front Endocrinol(Lausanne). 2023, 14:1133566.

(1)精子优选和检测方法、装置、电子设备及存储介质, 2023-09-29, 中国, 202310244206.8 (国家发明专利)

(2) DNAH3 在制备弱精症诊断试剂或试剂盒以及治疗药物中的应用, 2023-10-20, 中国, 202311364449.1 (国家发明专利)