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（1）国家自然科学基金委员会, 面上项目，82570611，易感基因NCF1对炎症性肠病肠黏膜中性粒细胞的免疫调节作用及机制研究

, 2026-01-01 至 2029-12-31, 49万元, 在研, 主持。

（2）国家自然科学基金委员会, 面上项目, 82270548, 胆汁酸受体FXR对炎症性肠病肠黏膜中性粒细胞的免

疫调节作用及机制研究, 2023-01-01 至 2026-12-31, 52万元, 在研, 主持。

（3）国家自然科学基金委员会, 青年科学基金项目, 81900491, 生物钟基因Per2对炎症性肠病肠黏膜CD4+T

细胞的调控作用及机制研究, 2020-01-01 至 2022-12-31, 21万元, 结题, 主持。

（1）国家自然科学基金委员会, 面上项目，82570611，易感基因NCF1对炎症性肠病肠黏膜中性粒细胞的免疫调节作用及机制研究

, 2026-01-01 至 2029-12-31, 49万元, 在研, 主持。

（2）国家自然科学基金委员会, 面上项目, 82270548, 胆汁酸受体FXR对炎症性肠病肠黏膜中性粒细胞的免

疫调节作用及机制研究, 2023-01-01 至 2026-12-31, 52万元, 在研, 主持。

（3）国家自然科学基金委员会, 青年科学基金项目, 81900491, 生物钟基因Per2对炎症性肠病肠黏膜CD4+T

细胞的调控作用及机制研究, 2020-01-01 至 2022-12-31, 21万元, 结题, 主持。

[1] Liang Chen; Mingming Sun; Wei Wu;Wenjing Yang; Xiangsheng Huang; Yi Xiao; Chunyan Ma; Leiqi Xu; Suxia Yao;Zhanju Liu; Yingzi Cong ; Microbiota Metabolite Butyrate DifferentiallyRegulates Th1 and Th17 Cells' Differentiation and Function in Induction ofColitis, Inflammatory Bowel Disease, 2019, 25(9): 1450-1461. (期刊论文,第一作者)

[2] Liang Chen;Jiaolan Yang; Leilei Fang; Wei Wu; Baisui Feng; Yanhong Shi; Mingming Sun;Xiaomin Sun; Zhanju Liu; The Degree of Ulcerative Colitis Burden of LuminalInflammation score is superior to predicting medium- to long-term prognosis inpatients with active ulcerative colitis, TherapeuticAdvances in Gastroenterology, 2020, 13: 1756284820981210.(期刊论文,第一作者)

[3] Chen L, Xu CJ, Wu W, et al.Anti-TNF and immunosuppressive combination therapy is preferential to inducingclinical remission in patients with active inflammatory bowel disease: Asystemic review and meta-analysis. J Dig Dis, 2021;22:408-418. (期刊论文,第一作者)

[4] Liang Chen; Zhanjun Lu; Dengfeng Kang;Zhongsheng Feng; Gengfeng Li; Mingming Sun; Zhanju Liu; Wei Wu; Leilei Fang;Distinct alterations of fecal microbiota refer to the efficacy of adalimumab inCrohn’s disease, Frontiers in Pharmacology, 2022, 13: 913720. (期刊论文,第一作者)

[5] Liang Chen; Dengfeng Kang; Leilei Fang;Mingming Sun; Mingsong Li; Guangxi Zhou; Chunjin Xu; Zhi Pang; Yulan Ye; BaisuiFeng; Huili Wu; Jian Lin; Baijing Ding; Changqin Liu; Yanhong Shi; Zhanju Liu;Development and validation of a novel therapeutic drug monitoring-basednomogram for prediction of primary endoscopic response to anti-TNF therapy inactive Crohn’s disease, TherapeuticAdvances in Gastroenterology, 2024, 17: 1-15. (期刊论文,第一作者)

[6] Yulan Ye; Changqin Liu; Ruijin Wu; Dengfeng Kang;Han Gao; Huiying Lv; Zhongsheng Feng; Yanhong Shi; Zhanju Liu; Liang Chen.Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γproduction in ulcerative colitis. Mucosal Immunol. 2024 Aug5:S1933-0219(24)00076-X. (期刊论文，通讯作者)

[7] Wenjing Yang; Liang Chen; LeiqiXu; Anthony J Bilotta; Suxia Yao; Zhanju Liu; Yingzi Cong;MicroRNA-10aNegatively Regulates CD4(+) T Cell IL-10 Production through Suppression ofBlimp1, The Journal of Immunology, 2021, 207(3): 985-995. (期刊论文，共同第一)

[8] Mingming Sun; Wei Wu; Liang Chen; Wenjing Yang; XiangshengHuang; Caiyun Ma; Feidi Chen; Yi Xiao; Ye Zhao; Chunyan Ma; Suxia Yao; VictorH. Carpio; Sara M. Dann; Qihong Zhao; Zhanju Liu; Yingzi Cong;Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 productionto maintain intestinal homeostasis, Nature communications, 2018, 9(1): 3555. (期刊论文，共同第一)

[9] Mingming Sun; Chong He; Liang Chen; Wenjing Yang; Wei Wu; FeidiChen; Anthony T. Cao; SuxiaYao; Sara M. Dann; T. G. Murali Dhar; LuisaSalter-Cid; Qihong Zhao; Zhanju Liu; Yingzi Cong; RORgt Represses IL-10Production in Th17 Cells To Maintain Their Pathogenicity in Inducing IntestinalInflammation, The Journal of Immunology, 2018, 202(1): 79-92.(期刊论文，共同第一)

[10] Shen, Yuting; Chen, Liang; Guan,Xin; Han, Xiaoxia; Bo, Xiaowan; Li, Shaoyue; Sun, Liping;Chen, Yu; Yue, Wenwen;Xu, Huixiong ; Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting TumorGrowth and Metastasis after Incomplete Microwave Ablation, ACS Nano, 2021, 15(12): 20414-20429.(期刊论文，共同第一)