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金佳丽,同济附属第十人民医院,癌症中心,研究员。
营养状态对细胞命运决定极为关键。氨基酸、葡萄糖等匮乏造成的营养应激在调控细胞增 殖、死亡等命运决定中发挥着重要作用。申请人致力于营养应激与细胞命运的机制与功能研究 ,取得如下原创成果:1)发现物种特异的缬氨酸感应器,并阐明缬氨酸限制通过重塑表观修 饰诱导细胞死亡的新机制,提出细胞内存在非经典氨基酸感应通路的新理论;2)揭示了胆固 醇合成中间代谢物7-DHC抵抗胱氨酸匮乏所致的肿瘤细胞死亡的新机制;3)揭示翻译后修饰调 控营养应激在细胞命运决定中的作用。研究成果以第一作者/通讯作者(含共同)发表在Nature、Nature Communications、 Development Cell、Signal Transduction and Targeted Therapy、Neuro Oncology等杂志。论文被包括Nature、Cell Stem Cell、Molecular Cell等杂志引用。围绕“营养微环境在肿瘤恶性进展中的机制与功能研究”这一方向获得3项国家自然科学基金,1项启明星项目。入选东方英才计划、上海高校青年科研骨干培养计划(“晨光”计划)、“科技创新行动计划”青年科技英才扬帆计划。目前担任肿瘤抗癌协会肿瘤微环境专业委员会青年委员及Tissue and Cell、JPM等期刊审稿人。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg主持项目:
1. 项目来源:国家自然科学基金面上项目;项目名称:缬氨酸限制促进DNA去甲基化抑制肿瘤的机制与功能研究
2. 项目来源:国家自然科学基金面上项目;项目名称:酰基转移酶SAT1通过调控组蛋白琥珀酰化影响肿瘤免疫微环境的机制与功能研究
3. 项目来源:国家自然科学基金青年项目;项目名称:TGF-β/SPOP负反馈环路在肿瘤转移中的调控作用及分子机制研究
4. 项目来源:上海市东方英才计划青年项目;项目名称:营养代谢应激与肿瘤细胞命运
5. 项目来源:上海市“科技创新行动计划”启明星项目;项目名称:营养代谢感应调控肿瘤代谢稳态的机制与功能研究
6. 项目来源:上海市青年科技英才扬帆计划;项目名称:TGFβ信号通路调控肿瘤干细胞在肿瘤转移与复发中的功能与机制研究
5. 项目来源:上海高校青年科研骨干培养计划(“晨光”计划);项目名称:氨基酸感应体的鉴定及其功能与机制的研究
1. Jiali Jin*, Tong Meng*, Yuanyuan Yu*, Shuheng Wu*, …Ping Wang#. Human HDAC6 senses valine abundancy to regulate DNA damage. Nature, 2025, 637(8044): 215-223.
2. Yaxu Li*, Qiao Ran*,Qiuhui Duan*, Jiali Jin* ,Yanjin Wang, Lei Yu, Chaojie Wang, Zhenyun Zhu, XinChen, Linjun Weng, Zan Li, Jia Wang, Qi Wu, Hui Wang, Hongling Tian, SihuiSong, Zezhi Shan, Qiwei Zhai, Huanlong Qin, Shili Chen, Lan Fang, Huiyong Yin,Hu Zhou, Xuejun Jiang, Ping Wang#. 7-Dehydrocholesterol dictates ferroptosissensitivity and surveillance. Nature, 2024Feb;626(7998):411-418.
3. Chenchen Jiao, Tong Meng, Chenyu Zhou, Xinbo Wang, Ping Wang, MeilingLu, Xiao Tan, Qing Wei, Xin Ge, Jiali Jin. TGF-β signaling regulates SPOP expression and promotes prostate cancercell stemness. Aging. 2020 May 1;12(9):7747-7760.
4. Tong Meng*, Runzhi Huang*, Jiali Jin*,Jianxuan Gao, Fuyan Liu, Ziheng Wei, Xiaowen Xu, Zhengyan Chang, Jun Lin, NaTa, Zongqiang Huang, Huabin Yin, Wang Zhou, Dianwen Song. The comparativeintegrated multi-omics analysis identifies CA2 as a novel target for chordoma. Neuro Oncol. 2021 Jul 2;noab156. doi: 10.1093/neuonc/noab156.
5.Wen Zhang*, Jiali Jin*, Yanjin Wang*, Lan Fang, Min Liu, Xinbo Wang, Lin Ding,Linjun Weng, Xiao Tan, Tianhua Zhou, Ping Wang#. PD-L1 regulatesgenomic stability via interaction with Cohesin-SA1 in the Nucleus. SignalTransduction and Targeted Therapy, 2021 Feb 25;6(1):81.doi: 10.1038/s41392-021-00463-0.
6. Xinbo Wang*, Jiali Jin*, Fangning Wan*, Linlin Zhao*, Hongshang Chu, Cong Chen,Guanghong Liao, Jian Liu, Yue Yu, Hongqi Teng, Lan Fang, Cong Jiang, WeijuanPan, Xin Xie, Jia Li, Xiaolin Lu, Xuejun Jiang, Xin Ge,* Dingwei Ye,* and PingWang. AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate CancerCell Stemness. Developmental Cell.2019 Feb 11;48(3):345-360.
7. Tong Meng*, Jiali Jin*, Cong Jiang, Runzhi Huang,Huabin Yin, Dianwen Song and Liming Cheng. Molecular Targeted Therapy in theTreatment of Chordoma: A Systematic Review. Front Oncol. 2019 Feb1;9:30. doi: 10.3389/fonc.2019.00030. eCollection 2019.
8. Jiali Jin*, Jian Liu*, Cong Chen, Zhenping Liu, CongJiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, CizhongJiang, Xin Ge, Xin Xie & Ping Wang. The deubiquitinase USP21 maintains thestemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications. 2016 Nov25; 7:13594.
9. Peng Liao*,Weichao Wang*, Yu Li*, Rui Wang*, Jiali Jin*,Weijuan Pan,Yunfei Chen, Mingyue Shen, Xinbo Wang, Dongyang Jiang, Jinjiang Pang, MingyaoLiu, Xia Lin, Xin-Hua Feng, Ping Wang & Xin Ge. Palmitoylated SCP1 istargeted to the plasma membrane and negatively regulates angiogenesis. eLife. 2017 Mar31;6:e22058. doi: 10.7554/eLife.22058.
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