同济大学医学院光医学研究所在学科带头人王秀丽教授的带领下，依托上海市皮肤病医院/同济大学附属皮肤病医院光医学治疗科团队，聚焦“光老化/老年斑/皮肤肿瘤、痤疮、瘢痕、血管瘤”四大专病以及“光医学无创诊断中心”，并已逐步形成光医学特色诊疗平台。

    团队成员先后荣获上海市启明星、浦江、扬帆、新百人、新优青等人才培养项目；承担包括科技部国家重点研发计划、国自然等省部级及以上课题70余项；发表SCI论文100余篇，包括Journal of the American Academy of Dermatology，Journal of Investigative Dermatology，British Journal of Dermatology，Journal of the European Academy of Dermatology & Venereology，ACS NANO， Protein Cell，Cell Death & Disease等国际有影响力的杂志；获省部级科技奖9项；相关研究成果在全国3000余家医院推广应用。

作为项目负责人先后主持上海市皮肤病医院学术骨干项目，上海市科委面上项目，国自然青年基金,中国博士后基金，作为项目骨干参与科技部国家重点研发计划皮肤肿瘤专项课题和多项国自然面上项目。在Protein Cell，J Am Acad Dermatol，J Eur Acad Dermatol Venereol ，Cell Mol Life Sci，Cancer Letters，Cell Death Disease，Oncoimmunology等杂志发表多篇论文。

主持：

2025-2028 国自然面上项目 49万

2022-2024 上海市皮肤病医院学术骨干项目 30万

2021-2024 上海市科委面上项目 20万

2019-2021 国自然青年项目 20万

2018-2020 中国博士后基金

作为项目负责人先后主持上海市皮肤病医院学术骨干项目，上海市科委面上项目，国自然青年基金,中国博士后基金，作为项目骨干参与科技部国家重点研发计划皮肤肿瘤专项课题和多项国自然面上项目。在Protein Cell，J Am Acad Dermatol，J Invest Dermatol，J Eur Acad Dermatol Venereol 等皮肤科权威杂志发表多篇论文。

1.        Wu Y#, Liu X#, Zhang L, Wang P, Zhang H, Yan J, Yan Y, LiuP, Zhao J, Zeng Q*, Wang X*. 5-Aminolevulinic Acid Photodynamic TherapyModulates Lipid Production by Akt/JunD-mediated NR4A1 Activation in theTreatment of Acne Vulgaris. J Invest Dermatol. 2025 Feb6:S0022-202X(25)00090-9. doi: 10.1016/j.jid.2025.01.018. （共同通讯作者）Q1；IF 5.7

2.        Yan J#, Zhang L#, Zeng Q,Qian Y, Li K, Liu X, Wu Y, Yan Y, Zhang H, Cheung S, Liu J, Sroka R*, Wang X*, Shi L*. Mechanistic insightsinto 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targetinglipogenesis via the OLR1-Wnt/β-catenin pathway. Mol Med. 2025 Feb 4;31(1):41.doi: 10.1186/s10020-025-01104-w Q1；IF 6.0

3.        Lu F#, Yan G#, Zhao Z, Zheng Z, Wu Y, Wen L, Liu Y, Zeng Q*, Zhang G*. TDO2 + cancer-associated fibroblasts mediate cutaneoussquamous cell carcinoma immune escape via impeding infiltration of CD8 + Tcells. Cancer Immunol Immunother. 2025 Jan 3;74(2):67. doi:10.1007/s00262-024-03921-0 （共同通讯作者）Q1；IF 4.6

4.        Li C#, Wan Y#, Yang J, Feng C, Liu J, Cao Z, Li C, Wang P,Wang X*, Zeng Q*. Ultra-small platinum nano-enzymatic spray with ROSscavenging and anti-inflammatory properties for photoaging treatment. Int JBiol Macromol. 2024 Nov;280(Pt 2):135743. doi: 10.1016/j.ijbiomac.2024.135743 （通讯作者）Q1；IF 7.7

5.        Wu Y, YanY, Zhang L, Liu X, Yang J, Cao Y, Chang Q, Yan J, Zeng Q, Wang P*, Wang X*. Positive results of intense pulsedlight-photodynamic therapy for moderate-to-severe rosacea: A prospective,single-arm study. J Am Acad Dermatol. 2024 Nov;91(5):943-945. doi:10.1016/j.jaad.2024.06.063. Q1；IF 12.8

6.        Kang Z,Wang P, Wang B, Yan Y, Zhao Z, Li C, Wen L, Wu M, Yan G, Wang X*, Zhang G*, Zeng Q*. Echinatin suppresses cutaneous squamous cell carcinoma bytargeting GSTM3-mediated ferroptosis. Phytomedicine. 2024 Aug;131:155752. doi:10.1016/j.phymed.2024.155752 （通讯作者）Q1；IF 6.7

7.        Feng C,Zhang H, Wang P, Zhang L, Liu X, Yan G, Yan Y, Yang J, Liu J, Tan F, Wang X*, Zeng Q*. Oroxylin A suppress LL-37 generatedrosacea-like skin inflammation through the modulation of SIRT3-SOD2-NF-κBsignaling pathway. Int Immunopharmacol. 2024 Mar 10;129:111636. doi:10.1016/j.intimp.2024.111636 （通讯作者）Q1；IF 4.8

8.        Zeng Q#, Chen C,Chen D, Zhang G, Wang X. Non-Surgical Therapeutic Strategies for Non-MelanomaSkin Cancers. Curr Treat Options Oncol. 2023 Dec;24(12):1978-1993. doi:10.1007/s11864-023-01154-4. （第一作者）Q2；IF 3.8

9.        KangZ, Jiang L, Chen D, Yan G, Zhang G, Lai Y, Zeng Q*, Wang X*. Wholegenome methylation sequencing reveals epigenetic landscape and abnormalexpression of FABP5 in extramammary Paget's disease. Skin Res Technol. 2023Oct;29(10):e13497. doi: 10.1111/srt.13497. （共同通讯作者）Q3；IF 2.2

10.     ChenD, Wang B, Zhao Z, Zhang G, Wang P, Zhang L, Liu X, Zhang H, Zeng Q*,Wang X*. Modified 5-aminolevulinic acid photodynamic therapy induces cutaneoussquamous cell carcinoma cell pyroptosis via the JNK signaling pathway. BiochimBiophys Acta Mol Cell Res. 2023 Oct 5;1871(1):119603. doi:10.1016/j.bbamcr.2023.119603. （共同通讯作者）Q2；IF 5.1

11.     Chen,C.; Wang, P.; Zhang,L.; Liu, X.; Zhang, H.; Cao, Y.; Wang,X*.; Zeng, Q*.Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea:Previous Understanding and Updates. Biomedicines. 2023, 11, 2153. （通讯作者）Q2；IF 4.7

12.     YangJ, Liu X, Cao Y, Wang P, Zhang H, Chen Q, Yang Y, Zeng Q*, Zhang L*,Wang X*. 5-Aminolevulinic acid photodynamic therapy versus minocycline formoderate-to-severe rosacea: A single-center, randomized, evaluator-blindcontrolled study. J Am Acad Dermatol. 2023 Jun 24. （共同通讯作者）Q1；IF 13.8

13.     LiuP#, Liu X#, Zhang L, Yan G, Zhang H, Xu D, Wu Y, Zhang G, Wang P, ZengQ*, Wang X*. ALA-PDT augments intense inflammation in the treatment of acnevulgaris by COX2/TREM1 mediated M1 macrophage polarization. BiochemPharmacol. 2023 Feb;208:115403. （共同通讯作者）Q1；IF 5.8

14.     ZengQ#, Liu J#, Yan Y, Zhang G, Wang P,Zhang H, Liu X, Zhang L*, Wang X*. Modified 5-aminolevulinic acid photodynamictherapy suppresses cutaneous squamous cell carcinoma through blockingAkt/mTOR-mediated autophagic flux. Front Pharmacol. 2023 Mar 17;14:1114678. （第一作者）Q1；IF 5.6

15.     ChengY, Lu X, Li F, Chen Z, Zhang Y, Han Q, Zeng Q, Wu T, Li Z, Lu S,Williams C, Xia W. NDFIP1 limits cellular TAZ accumulation via exosomal sortingto inhibit NSCLC proliferation. Protein Cell. 2023 Mar 16;14(2):123-136.Q1；IF 21.1

16.     ZengQ#, Yang J#, Ji J, Wang P, Zhang L, YanG, Wu Y, Chen Q, Liu J, Zhang G*, Wang X*. PD-L1 blockade potentiates theantitumor effects of ALA-PDT and optimizes the tumor microenvironment incutaneous squamous cell carcinoma. Oncoimmunology. 2022 Apr 3;11(1):2061396. （第一作者）Q1；IF 7.2

17.     ZengQ#, Yang J#, Yan G, Zhang L, Wang P,Zhang H, Chen Q, Cao Y, Liu X*, Wang X*. Celastrol inhibits LL37-inducedrosacea by inhibiting Ca2+/CaMKII-mTOR-NF-κB activation. Biomed Pharmacother.2022 Sep;153:113292. （第一作者）Q2；IF 7.5

18.     ZengQ, Zhou C, Zhang Y, Yan G, Wang X*.Modified 5-aminolevulinic acid photodynamic therapy reduces pain and improvestherapeutic effects in cutaneous squamous cell carcinoma mouse model. LasersSurg Med. 2022 Jul;54(5):804-812. （第一作者）Q3；IF 2.4

19.     WuM, Huang J, Shi J, Shi L, Zeng Q*, Wang H*. Ruyi Jinhuang Powderaccelerated diabetic ulcer wound healing by regulating Wnt/β-catenin signalingpathway of fibroblasts In Vivo and In Vitro. JEthnopharmacol. 2022 Jul 15;293:115321. （共同通讯作者）Q2；IF 5.4

20.     WuYH#, Wu F#, Yan GR#, Zeng QY, Jia N, Zheng Z, Fang S, Liu YQ*, ZhangGL*, Wang XL*. Features and clinical significance of tertiary lymphoidstructure in cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol.2022 Nov;36(11):2043-2050.Q1；IF 9.2

21.     LiuJ#, Yan G#, Chen Q, Zeng Q*, Wang X*. Modified 5-aminolevulinicacid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinomacell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway. IntJ Biochem Cell Biol. 2021 Aug;137:106036. (共同通讯作者）Q2；IF 5.7

22.     ZhangL#, Yang J#, Liu X, Xu D, Shi L, Liu J, Zeng Q*, Wang X*.5-Aminolaevulinic acid photodynamic therapy amplifies intense inflammatoryresponse in the treatment of acne vulgaris via CXCL8. Exp Dermatol. 2021Jul;30(7):923-931.  （共同通讯作者）Q2；IF 4.5

23.     YangJ, Shi L, Xu D, Liu J, Zhang L, Liu X, Zeng Q*, Wang X*.5-Aminolaevulinic acid photodynamic therapy suppresses lipid secretion ofprimary sebocytes through AMPK/SREBP-1 pathway. Photodiagnosis Photodyn Ther.2021 Dec;36:102537. (共同通讯作者）Q4；IF 3.6

24.     ZengQ#, Zhou Z#, Qin S, Yao Y, Qin J, ZhangH, Zhang R, Xu C, Zhang S, Huang S*, Chen L*. Rapamycin inhibits B-cellactivating factor (BAFF)-stimulated cell proliferation and survival bysuppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normaland neoplastic B-lymphoid cells. Cell Calcium. 2020 May;87:102171.  （第一作者）Q2；IF 6.8

25.     ChengY#, Zeng Q#, Han Q, Xia W*. Effect of pH, temperature andfreezing-thawing on quantity changes and cellular uptake of exosomes. ProteinCell. 2019 Apr;10(4):295-299. (共同第一作者）Q1；IF 10.1

26.     ZengQ#, Hong S#, Wang X#, Cheng Y, Sun J*,Xia W*. Regulation of exosomes secretion by low-intensity pulsed ultrasound inlung cancer cells. Exp Cell Res. 2019 Oct 1;383(1):111448. (第一作者）Q3；IF 3.4

27.     ZengQ#, Qin S#, Zhang H, Liu B, Qin J, WangX, Zhang R, Liu C, Dong X, Zhang S, Huang S*, Chen L*. Rapamycin attenuatesBAFF-extended proliferation and survival via disruption of mTORC1/2 signalingin normal and neoplastic B-lymphoid cells. J Cell Physiol. 2018Jan;233(1):516-529. （第一作者）Q2；IF 4.5

28.     ZengQ, Zhang H, Qin J, Xu Z, Gui L, Liu B,Liu C, Xu C, Liu W, Zhang S, Huang S*, Chen L*. Rapamycin inhibitsBAFF-stimulated cell proliferation and survival by suppressing mTOR-mediatedPP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells. CellMol Life Sci. 2015 Dec;72(24):4867-84. （第一作者）Q1；IF 5.7