上海市肺科医院药剂科现有博士后及博士4人，硕士8人，人才队伍健全，学科发展潜力较大。近年来获得国家自然基金青年项目1项，省部级课题2项，市级人才计划1项；荣获全国药学信息工作先进集体1项，上海市优秀信息管理奖1项，上海药学信息工作先进个人2项，上海市优秀临床药师提名1项，上海市临床药师师资培训优秀学员奖2项。并获得上海市优秀服务示范窗口、上海市卫生健康行业青年文明号、上海市合理用药系列宣传教育活动先进集体、上海市合理用药示范单位等光荣称号。近5年发表论文三十余篇，SCI论文约二十篇，合计影响因子40.605分，形成了以吸入药物、肺移植药物、肺部肿瘤药物、结核药物临床使用评价及药物服务为方向的专业特色。

主持和参与，曾主持国家自然基金、上海市自然基金和上海市创新药械产品应用示范等课题。目前的主要研究方向为肺癌靶向仿生纳米制剂研究和肺部疾病创新药品的临床应用评价。

1、主持 国家自然科学基金青年项目：不同亲脂性Pluronic修饰的多烯紫杉醇PCL纳米粒抗多药耐药研究，22万

2、主持 上海市自然基金面上项目：程序化释药仿生纳米载药系统助力“代谢+免疫”联合调控策略抗NSCLC的作用及机制研究，20万

3、主持 上海市2024年度“科技创新行动计划”创新药械产品应用示范项目：盐酸右美托咪定鼻喷雾剂在CT引导下的肺部肿瘤消融术围术期镇静的安全性和有效性评价研究，20万

4、主持 上海市2025年度“科技创新行动计划”创新药械产品应用示范项目：阿得贝利单抗注射液在广泛期小细胞肺癌的应用示范项目：一项多中心的真实世界报告结局、安全性与经济性研究，120万

5、参与 国家自然科学基金青年项目：基于微针给药的主动靶向黑素细胞纳米粒的构建及其抗色素沉着效果评价，20万

6、参与 国家自然科学基金面上项目：基于MMP-2、CD44双重介导的miR-145靶向纳米复合物构建及抗乳腺癌转移作用的研究，58万

1. 1.     Wei Zhang#, Chunai Gong#,Ziqiang Chen#, Ming Li, Yuping Li, Jing Gao.Tumor microenvironment‑activatedcancer cell membrane‑liposome hybrid anoparticle‑mediated synergistic metabolictherapy and chemotherapy for non‑small cell lung cancer.J Nanobiotechnology.2021 Oct 24;19(1):339. (JCR Q1, IF=10.435)

   2.     Chunai Gong#, Xiaoyan Yu#, WeiZhang#, Lu Han, Rong Wang, Yujie Wang, Shen Gao*, Yongfang Yuan*. Regulatingthe immunosuppressive tumor microenvironment to enhance breast cancerimmunotherapy using pH-responsive hybrid membrane-coated nanoparticles. J Nanobiotechnology.2021 Feb 25;19(1):58. (JCR Q1, IF=10.435)

   3.     Xiujuan Han#; Chunai Gong#;Qingru Yang; Kaile Zheng; Zhuo Wang*; Wei Zhang*. Biomimetic Nano-Drug DeliverySystem: An Emerging Platform for Promoting Tumor Treatment, Int J Nanomedicine,2024, 19(1): 571-608. (JCR Q1, IF=8.0)

   4.     Yu-E Guo#, Jie Lv#, Ping Shu#,Xi Li, Ying Li, Junhong Guo, Guo fang Chen, Yuping Li , Bo Lu , Wei Zhang*, YinLiu*. Drug screening identifies pyrrolidinedithiocarbamate ammoniumameliorating DSS-induced mouse ulcerative colitis via suppressing Th17 differentiation.Cell Immunol. 2024 Nov-Dec:405-406:104887. (JCR Q2, IF=3.7）

   5.      Qiaoli Chen#, Ping Shu#, Xia Yuan# , WeiZhang*.Levels of serum lipids predict responses to PD-L1 inhibitors asfirst-line treatment in small cell lung cancer: an observational study. Int JClin Pharm. 2024 Dec;46(6):1464-1471. (JCR Q2, IF=3.2）

   6.     Dandan Zhang#, Wenwen Zhang#,Ping Hu, Wei Zhang*. Dipeptidyl peptidase 1 inhibitors for inflammatoryrespiratory diseases: mechanisms, clinical trials, and therapeutic prospects. FrontPharmacol. 2025 Aug 22:16:1656316. (IF=4.8)

   7.     Ping Shu#, Wei Zhang#, YanfeiZhang, Yanfeng Zhao, Yuping Li*, Xiaoqing Zhang*. Interleukin-18: A NovelParticipant in the Occurrence, Development, and Drug Therapy of ObliterativeBronchiolitis Postlung Transplantation. Dis Markers. 2021 Jul 27;2021:5586312.(IF=3.434)

   8.     Nan Ding#, Wei Zhang #, ZhuoWang, Chong Bai, Qian He, Yuchao Dong, Xiumin Feng, Jingxi Zhang*, Shen Gao*.Prevalence and Associated Factors of Suboptimal Daily Peak Inspiratory Flow andTechnique Misuse of Dry Powder Inhalers in Outpatients with Stable ChronicAirway Diseases. Int J Chron Obstruct Pulmon Dis. 2021 Jun 23;16:1913-1924.(IF=3.355）

   9.     Wei Zhang#, Jing Gao#, QuangangZhu, Min Zhang, Xueying Ding, Xiaoyu Wang, Xuemei Hou, Wei Fan, Baoyue Ding,Xin Wu, Xiying Wang, Shen Gao*. Penetration and distribution of PLGAnanoparticles in the human skin treated with microneedles. Int J Pharm. 2010Dec 15;402(1-2):205-12.（IF=3.871）

   10.   Bao-yue Ding#, Wei Zhang#, XinWu, Xiang Wang, Wei fan, Shen Gao*, Jing Gao, Lu-lu Ma, Xue-ying Ding and QiangHao. Biodegradable methoxy poly (ethylene glycol)-poly(lactide) nanoparticlesfor controlled delivery of dacarbazine: Preparation, characterization andanticancer activity evaluation，African Journal ofPharmacy and Pharmacology，2011，5（11）：1369-1377 （IF=0.839）

   11.   Wei Zhang#, Baoyue Ding#,Renjie Tang, Xueying Ding, Xuemei Hou, Xiaoyu Wang, Shengying Gu, Lei Lu, YiZhang, Shen Gao* and Jing Gao*. Combination of Microneedles with PLGANanoparticles as a Potential Strategy for Topical Drug Delivery，Current Nanoscience,2011,7:545-551.（IF=1.776）

   12.   Lei Lu#, Wei Zhang#, Xin Wu,Xiaoyu Wang, Min Zhang, Quangang Zhu, Xueying Ding, Zhiyun Xu, Shen Gao*, JingGao*. A novel ropivacaine-loaded in situ forming implant prolongs the effect oflocal analgesia in rats，Archives of Medical Science，2013，9（4）：614-621( IF=1.89）

   13.   Baoyue Ding#, Wei Zhang#, XinWu#, Jeffrey Wang, Chen Xie, Xuan Huang, Shuyu Zhan, Yongxia Zheng, YueyanHuang, Ningyin Xu, Xueying Ding*, Shen Gao*. DR5 mAb-conjugated, DTIC-loadedimmuno-nanoparticles effectively and specifically kill malignant melanoma cellsin vivo. Oncotarget. 2016 Aug 30;7(35):57160-57170.（IF=5.01）

   14.   Wei Zhang#, Xiaoyu Wang#, MinZhang, Min Xu, Wenyan Tang, Yi Zhang , Lei Lu, Jing Gao*, Shen Gao*. Intranasaldelivery of microspheres loaded with 20 (R)-ginsenoside Rg3 enhancesanti-fatigue effect in mice. Curr Drug Deliv. 2017 Sep 6;14(6):867-874. (IF=1.45)

   15.   Wei Zhang#, Lili Xu#, Shen Gao,Nan Ding, Ping Shu, Zhuo Wang*, Yuping Li*. Technical Evaluation of Soft MistInhaler Use in Patients with Chronic Obstructive Pulmonary Disease: ACross-Sectional Study. Int J Chron Obstruct Pulmon Dis. 2020 Jun 22;15:1471-1479.(IF=2.772）