1. Wolfram综合征人脑类器官疾病模型的建立和神经发育缺陷的研究，2022，国自然面上项目，主持；

2. 利用WFS1基因编辑多能干细胞研究人Wolfram综合征神经病变发病机制，2020，国自然面上项目，主持；

3. 开发诱导多能干细胞定向分化为胶质细胞的新方案促进髓鞘修复再生，2017，国家重点研发计划干细胞及转化研究专项，骨干；

4. 上海市青年科技启明星计划（A类），2017，主持；

5. 利用三维多层水凝胶系统研究Rett综合症中星型胶质细胞的作用及其机制，2017，国自然面上项目，主持。

1.  Gong M(#), Fang Y(#), Yang K, Yuan F, Hu R,Su Y, Yang Y, Xu W, Ma Q, Cha J, Zhang R, Zhang ZN(*), Li W(*).The WFS1-ZnT3-Zn2+ Axis Regulates the Vicious Cycle of Obesity andDepression. Adv Sci (Weinh). 2024 Nov;11(41):e2403405.

2. Rui Hu(#), Xiangyi Chen(#), Qiang Su(#), Zhaoyue Wang, Xushu Wang, Mengting Gong, Minglu Xu, Rongrong Le, Yawei Gao, Peng Dai, Zhen-Ning Zhang(*), Li Shao(*), Weida Li(*). ISR inhibition reversespancreatic β-cell failure in Wolfram syndrome models. Cell Death Differ.2024 Mar;31(3):322-334. doi: 10.1038/s41418-024-01258-w. Epub 2024 Feb 6. PMID:38321214; PMCID: PMC10923889.

3. Fei Yuan(#), Yana Li(#), Rui Hu(#), Mengting Gong, Mengyao Chai, Xuefei Ma, Jiaxue Cha, Pan Guo, Kaijiang Yang, Mushan Li, Minglu Xu, Qing Ma, Qiang Su, Chuan Zhang, Zhejin Sheng, Heng Wu, Yuan Wang, WenYuan, Shan Bian, Li Shao, Ru Zhang, Kaicheng Li, Zhen Shao(*), Zhen-Ning Zhang(*), Weida Li(*). Modeling disrupted synapseformation in wolfram syndrome using hESCs-derived neural cells and cerebralorganoids identifies Riluzole as a therapeutic molecule. Molecular Psychiatry, 2023 Apr;28(4):1557-1570. doi: 10.1038/s41380-023-01987-3. Epub 2023 Feb 7.

4. Gang Liu(#), Yana Li(#), Mushan Li(#), Sheng Li, Qing He , Shuxin Liu, Qiang Su, Xiangyi Chen, Minglu Xu, Zhen-Ning Zhang(*), Zhen Shao(*), Weida Li(*). Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells. Science Advances, 2023 May 24;9(21):eadg2183. doi: 10.1126/sciadv.adg2183. Epub 2023 May 24.

5. Xin Zhang(#), Sihan Lv(#),Zhenhuan Luo(#), Yongfei Hu, Xin Peng, Jie Lv, Shanshan Zhao, JianqiFeng, Guanjie Huang, Qin-Li Wan, Jun Liu, Hongxin Huang, Bing Luan, Dong Wang,Xiaoyang Zhao, Ying Lin, Qinghua Zhou(*), Zhen-Ning Zhang(*),and Zhili Rong(*) . MiniCAFE, a CRISPR/Cas9-based compact and potenttranscriptional activator, elicits gene expression in vivo. Nucleic Acids Research, 2021 Apr 19;49(7):4171-4185. doi: 10.1093/nar/gkab174.

6. Sihan Lv, Jian Li, Xinchen Qiu,Weida Li, Chao Zhang, Zhen-Ning Zhang(*), Bing Luan(*). A negative feedback loop of ICER and NF-kappa B regulates TLR signaling ininnate immune responses. Cell Death and Differentiation, 2017.3,24(3): 492~499

7. Jian Li, Sihan Lv, Xinchen Qiu,Jiamin Yu, Junkun Jiang, Yalan Jin, Wenxuan Guo, Ruowei Zhao, Zhen-Ning Zhang(*), Chao Zhang(*), Bing Luan(*).BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepaticgluconeogenesis. Protein & cell, 2018.11, 9(11),976-980.

8. Xinchen Qiu, JianLi, Sihan Lv, Jiamin Yu, Junkun Jiang, JindongYao, Yang Xiao, Bingxin Xu, Haiyan He, Fangfei Guo, Zhen-Ning Zhang(*), Chao Zhang(*), Bing Luan(*). HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acidoxidation. Journal of lipid research, 2018.2, 59(2),330-338.

9. Sihan Lv, Xinchen Qiu, Jian Li,Jinye Liang, Weida Li, Chao Zhang, Zhen-Ning Zhang(*), Bing Luan(*). Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. Journal of Endocrinology, 2017.8, 234(2): 73~87

10. Sihan Lv, Xinchen Qiu, Jian Li,Weida Li, Chao Zhang, Zhen-Ning Zhang(*), Bing Luan(*). Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes tohypoglycemia in septic shock. Cell Discovery, 2016.12, 2

11. Zhen-Ning Zhang, Beatriz C Freitas, Hao Qian, Jacques Lux, Allan Acab, Cleber A Trujillo, Roberto H Herai, Viet Anh Nguyen Huu, Jessica H Wen, Shivanjali Joshi-Barr, Jerome V Karpiak, Adam J Engler, Xiang-Dong Fu, Alysson R Muotri(*), Adah Almutairi(*).Layered hydrogels accelerate iPSC-derived neuronal maturation and revealmigration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A, 2016 Mar 22;113(12):3185-90.

12. Tongbiao Zhao(#), Zhen-Ning Zhang(#), Peter DWestenskow(#), Dilyana Todorova, Zheng Hu, Tongxiang Lin, Zhili Rong, Jinchul Kim, Jingjin He, Meiyan Wang, Dennis O Clegg, Yong-guang Yang, Kun Zhang, MartinFriedlander, Yang Xu(*).Humanized Mice Reveal Differential Immunogenicity of Cells Derived fromAutologous Induced Pluripotent Stem Cells. Cell Stem Cell, 2015Sep 3;17(3):353-9. doi: 10.1016/j.stem.2015.07.021. Epub 2015 Aug 20.

13. Shao-Qiu He(#), Zhen-Ning Zhang(#), Ji-Song Guan(#), Hong-Rui Liu, Bo Zhao, Hai-Bo Wang, Qian Li, Hong Yang, Jie Luo, Zi-Yan Li, Qiong Wang, Ying-Jin Lu, Lan Bao(*), Xu Zhang(*). Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 2011Jan 13;69(1):120-31. doi: 10.1016/j.neuron.2010.12.001.