1、细胞信号转导研究，衰老与阿尔茨海默症发病机制研究及相关创新药物发现

2、干细胞命运调控机制研究及相关小分子药物的发现

代表性论文：

1、  Chang-Jie Shi,Jun-Jiang Lian, Bo-Wen Zhang , Jia-Xue Cha , Qiu-Hong Hua  , Xiao-Ping Pi,Yu-Jun Hou, Xin Xie , Ru Zhang*.TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition andinfluences gastrointestinal mobility in adult mice. Acta Pharmacol Sin.2022 Jul 6. doi: 10.1038/s41401-022-00932-4

2、  Changjie Shi,Jiaxue Cha, Junyuan Gong, Shaodeng Wang, Peng Zeng, Junjiang Lian, Bowen Zhang,Qiuhong Hua, Jie Lv, Changsheng Du, Xin Xie, Ru Zhang*. Amelioration of Experimental AutoimmuneEncephalomyelitis in Alzheimer's Disease Mouse Models: A Potential Role for Aβ.Cells. 2022 Mar 16;11(6):1004.

3、  Zeng P, Hua QH,Gong JY, Shi CJ, Pi XP, Xie X, Zhang R*.Neonatalcortical astrocytes possess intrinsic potential in neuronal conversion indefined media. Acta Pharmacol Sin. 2021Nov;42(11):1757-1768

4、  Lu Deng, Dandan Wang, Shouzhen Chen, Weiguo Hu, Ru Zhang*. Epiphycan Predicts Poor Outcomes andPromotes Metastasis in Ovarian Cancer. Front Oncol. 2021 Nov23;11: 653782.

5、  Li Y, Sun X, LiuH, Huang L, Meng G, Ding Y, Su W, Lu J, Gong S, Terstappen GC, Zhang R*, Zhang W. Developmentof Human in vitro Brain-blood Barrier Model from Induced Pluripotent StemCell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs. Neurosci Bull. 2019Dec;35(6):996-1010. (*co-correspondingauthor）

6、  Cui X, Guo YE,Fang JH, Shi CJ, Suo N, Zhang R*,Xie X. Donepezil,a drug for Alzheimer's disease, promotes oligodendrocyte generation andremyelination. Acta Pharmacol Sin. 2019Nov;40(11):1386-1393. (*co-corresponding author)

7、  SuD, Wang M, Ye C, Fang J, Duan Y, Zhang Z, Hua Q, Shi C, Zhang L, Zhang R*, XieX. One-step generation of mice carrying a conditional allele together with anHA-tag insertion for the delta opioid receptor. Sci Rep. 2017 Mar16;7:44476. （*co-corresponding author）

8、  ZhangL, Hua Q, Tang K, Shi C, Xie X, Zhang R*.CXCR4 activation promotes differentiation of human embryonic stem cells toneural stem cells. Neuroscience.2016 Nov 19;337:88-97.

9、  Wang,Junjie; Wang, Zhilong; Zhang, Zhenghong; Hua, Qiuhong; Wang, Min; Shi,Changjie; Xue, Lei; *Zhang, Ru;*Xie, Xin. Methuselah regulates longevity via dTOR: a pathway revealed bysmall-molecule ligands. Journal of Molecular Cell Biology,2015,7(3) :280-282. ( *co-correspondingauthor)

10、        Ye C, Zhang Z, Wang Z, Hua Q, ZhangR*, Xie X. Identification of a novel small-molecule agonist for human Gprotein-coupled receptor 3. JPharmacol Exp Ther. (2014);349(3):437-43. (*co-corresponding author)

11、        Yongyu Xu, Xiaoyuan Wei, Min Wang, RuZhang*, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie. Proliferation rateof somatic cells affects reprogramming efficiency. The Journal of Biological Chemistry. (2013), 288(14):9767-9778 ( *co-corresponding author)

12、        Ru Zhang, Lihong Zhang, Xin Xie. iPSCs and small molecules:a reciprocal effort towards better approaches for drug discovery. Acta Pharmacalogica Sinica，(2013) 34(6):765-76

13、        Ru Zhang, Guizhen Xue, Shaodeng Wang, Lihong Zhang,Changjie Shi, Xin Xie. Novel Object Recognition as a Facile Behavior Test forEvaluating Drug Effects in A PP/PS1 Alzheimer’s Disease Mouse Model. Journal of alzheimer's disease, 31(2012) 801–812

14、        Xinxiu Xu, Quan Wang, Yuan Long, RuZhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie. Stress-mediated p38activation promotes somatic cell reprogramming. Cell Research, 23(2012):131-41

15、        Ru Zhang, Xin Xie. Tools for GPCR Drug Discovery. Acta Pharmacalogica Sinica，(2012) 33:372-384