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2006年毕业于石河子大学，获学士学位；2011年毕业于华东师范大学，获得硕士学位；2018年毕业于中国科学院大学，获博士学位。2018年2月起在同济大学附属妇产科医院（上海市第一妇婴保健院）工作至今。主要从事体细胞重编程以及干细胞定向分化过程中的机制研究以及女性生殖系统的发育和疾病的体外模拟和机制研究。应用多能干细胞以及类器官模型模拟女性生殖系统的生理和病理过程（包括卵巢和子宫的发育、胚胎植入过程以及卵巢早衰、子宫腺肌症、反复植入失败等疾病过程），探索相关疾病治疗的新策略，并以此为基础开展细胞治疗以及相关药物筛选的转化医学研究。相关成果发表在Stem Cell Reports，Cell Proliferation，Protein & Cell等杂志上等杂志上；主持完成或在研国家自然科学基金2项。
（#共同一作，*共同通讯）
1. Xu Y#, ChengT#, Wang J#, Qiu Z, Guan X, Yu Y, Shen J, Xu F, Jiang X, Bai D, Wang M, Mei S,Wang H, Xu X*, Wu L*, Gao S*,Che X*. Decoding adenomyosis pathogenesis using an assembloid model. Sci ChinaLife Sci. 2025 Aug 28; Online ahead print.
2. Wu L, Shen J,Hou Z, Zhang Y, Bi Y, Zhang R, Bai H, Ye W, Chen K, Zhu J, Xi C, Xu Y, Kou X,Zhao Y, Li C, Fan H, Le R, Wang Y, Xu X, Xu S, Wang H, Gao S*, Kang L*. Obox1deficiency impairs fertility in female mice. Fundam Res. 2025 Apr 19;5(4):1570-1580.
3. Chen T#,Xu Y#, Xu X#, Wang J#, Qiu Z, Yu Y, Jiang X,Shao W, Bai D, Wang M, Mei S, Cheng T, WuL*, Gao S*, Che X*. Comprehensive transcriptional atlas of humanadenomyosis deciphered by the integration of single-cell RNA-sequencing andspatial transcriptomics. Protein Cell. 2024 Jul 1;15(7):530-546.
4. Shen J#,Wu L#*, Shi X, Chen G,Liu T, Xu F, Xu X, Kou X, Zhao Y, Wang H, Wang C, Gao S*, Xu S*.Transplantation of the LRP1high subpopulation of human umbilical cord-derivedmesenchymal stem cells improves ovarian function in mice with premature ovarianfailure and aged mice. Stem Cell Res Ther. 2024 Mar 5;15(1):64.
5. Xi C#,Yan Z#, Bai D#, Zhang Y#, Wang B#,Han XX#, Wu L, Shi X, HuZ, Tang M, Su Z, Liu Y, Liu B, Yin J, Wang H, Li X*, Zhang Y*, Gao S*, Liu W*.Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2infection during early pregnancy. Protein Cell. 2024 Mar 5: pwae006.
6. Liu D#,Guan X#, Liu W, Jia Y, Zhou H, Xi C, Zhao M, Fang Y, Wu L*, Li K*. Identificationof transcriptome characteristics of granulosa cells and the possible role ofUBE2C in the pathogenesis of premature ovarian insufficiency. J OvarianRes. 2023 Oct 17;16(1):203.
7. Tu Z#,Bi Y#, Zhu X, Liu W, Hu J, WuL, Mao T, Zhou J, Wang H, Wang H, Gao S*, Wang Y*. Modeling humanpregastrulation development by 3D culture of blastoids generated fromprimed-to-naïve transitioning intermediates. Protein Cell. 2023 May8;14(5):337-349.
8. Li H#,Sun J#, Dong Y, Huang Y, Wu L,Xi C, Su Z, Xiao Y, Zhang C, Liang Y, Li Y, Lin Z, Shen L, Zuo Y, AbudurehemanA, Yin J, Wang H, Kong X, Le R*, Gao S*, Zhang Y*. Remodeling of H3K9me3 duringthe pluripotent to totipotent-like state transition. Stem Cell Reports. 2023Feb 14;18(2):449-462.
9. Zhu J#,Chen K#, Sun YH, Ye W, Liu J, Zhang D, Su N, Wu L, Kou X, Zhao Y, Wang H, Gao S*, Kang L*. LSM1-mediated MajorSatellite RNA decay is required for nonequilibrium histone H3.3 incorporationinto parental pronuclei. Nat Commun. 2023 Feb 21;14(1):957.
10. Xi C#, Sun J#, Xu X, Wu Y, Kou X, ZhaoY, Shen J, Dong Y, Chen K, Su Z, Liu D, Ye W, Liu Y, Zhang R, Xu Y, Wang H, HaoL*, Wu L*, Gao S*. Mettl14-drivensenescence-associated secretory phenotype facilitates somatic cellreprogramming. Stem Cell Reports. 2022 Aug9;17(8):1799-1809.
11. Zhao K#, Sun X#, Zheng C#,Wang M, Xu Z, Wang M, Chen J, Guo M, Le R, WuL, Wang Y, Kou X, Zhao Y, Yin J, Wang H, Mao Z*, Gao S*, Gao S*. Enhancement ofXrcc1-mediated base excision repair improves the genetic stability andpluripotency of iPSCs. Sci Bull(Beijing). 2022 Jun 15;67(11):1126-1130.
12. Wu L#, He S#, Ye W, Shen J,Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, WangH, Kang L*, Gao S*. Surf4 facilitates reprogramming by activating the cellular responseto endoplasmic reticulum stress. CellProlif. 2021 Nov;54(11):e13133.
13. Chen Y#,Chen J, Sun X, Yu J, Qian Z, Wu L,Xu X, Wan X, Jiang Y, Zhang J, Gao S*, Mao Z*. The SIRT6 activator MDL-800improves genomic stability and pluripotency of old murine-derived iPS cells.Aging Cell. 2020 Aug;19(8):e13185.
14. Li J#, Shen S#, Chen J#,Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L,Wang M, Gu L, Wang H, Yin J, Jiang C*, Gao S*. Accurate annotation of accessiblechromatin in mouse and human primordial germ cells. Cell Res. 2018 Oct 10.
15. Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M,Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R*, Kang L*, Gao S*. Oocyte-SpecificHomeobox 1, Obox1, Facilitates Reprogramming by PromotingMesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation. StemCell Reports. 2017 Nov 14;9(5):1692-1705.
16. Zhang L, Wang JC, Hou L, Cao PR, Wu L, Zhang QS, Yang HY, Zang Y*, DingJP*, Li J*. FunctionalRole of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core ofProtein Kinases. Sci Rep. 2015 May 11;5:10115.
17. Wu L, Yang C, Deng S, Zhou Y, Qian M, Zang Y*. Screeningof AMPK interacted proteins by yeast two hybrid system. China Biotechnology.2012 Feb 32(2):1-7.
18. Wu L, Huang XJ, Yang CH, Deng SS, Qian M, Zang Y*, Li J*.5'-AMP-activatedprotein kinase (AMPK) regulates progesterone receptor transcriptional activityin breast cancer cells. Biochem BiophysRes Commun. 2011 Dec 9;416(1-2):172-7.
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