个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
同济大学附属第十人民医院病理科副主任技师，同济大学医学院讲师、硕士生导师，上海市预防医学会微生态专业委员会委员。目前从事分子病理与肿瘤内微生物研究，致力于解析肠道细菌与宿主互作的遗传基础及分子机制，探索新型诊疗靶点及策略。主持国家自然科学基金项目3项，入选上海市“医苑新星”青年医学人才；发表SCI论文41篇，其中以第一/通讯作者在Nature Communications、Nucleic Acids Research、SignalTransduction and Targeted Therapy等杂志发表论文18篇；获8项发明专利授权；作为参与人获上海市科技进步一等奖；担任SCI期刊编委、客座编辑；参编英文专著1部、中文专著2部、科普书籍2部。
1. 国家自然科学基金（National Natural Science Foundation of China），82572576，2026/01-2029/12，主持/PI
2. 国家自然科学基金（National Natural Science Foundation of China），82072236，2021/01-2024/12，主持/PI
3. 国家自然科学基金（National Natural Science Foundation of China），81702037，2018/01-2020/12，主持/PI
4. 上海市“医苑新星”青年医学人才培养资助计划（Shanghai “Rising Stars of Medical Talent” Youth Development Program），2021-2024
5. 同济大学附属第十人民医院攀登人才计划（Pandeng Research Foundation of Shanghai Tenth People’s Hospital），2018SYPDRC015，2018/09-2020/08
1. 国家自然科学基金（National Natural Science Foundation of China），82572576，2026/01-2029/12，主持/PI
2. 国家自然科学基金（National Natural Science Foundation of China），82072236，2021/01-2024/12，主持/PI
3. 国家自然科学基金（National Natural Science Foundation of China），81702037，2018/01-2020/12，主持/PI
4. 上海市“医苑新星”青年医学人才培养资助计划（Shanghai “Rising Stars of Medical Talent” Youth Development Program），2021-2024
5. 同济大学附属第十人民医院攀登人才计划（Pandeng Research Foundation of Shanghai Tenth People’s Hospital），2018SYPDRC015，2018/09-2020/08
代表性论文/Representative Papers
1. Wu Y, Ji G, Han D, Zhu X, Li H, Li M,Zhang Y, Gao Y, Xie R, Xu M, Lu L, Deng Z, Wei Q, Qin H, Bi D*. Fusobacteriumlineage profiling facilitates clarification of the associations between non-nucleatumFusobacterium and colorectal cancer. npj Biofilms and Microbiomes,2025, 11: 197.
2. Yang R, Yang Y*, Lin W, He K, Bi D*,Teng L*. Lactobacillus paracasei ZJUZ2-3 inhibits gastrointestinaltumors via the IAA-induced AHR/MTDH/NF-κB axis. International Journal ofBiological Sciences, 2025, 21: 6522-6541. (* co-corresponding author)
3. Wang W, Li H, Qian Y, Li M, Deng M, BiD*, Zou J*. ALKBH5 regulates corneal neovascularization by mediatingFOXM1 m6A demethylation. Investigative Ophthalmology & Visual Science,2024, 65: 34. (* co-corresponding author)
4. BiD*, Zhu Y, Gao Y, Li H, Zhu X, Wei R, Xie R, Cai C, Wei Q, Qin H.Profiling Fusobacterium infection at high taxonomic resolution revealslineage-specific correlations in colorectal cancer. NatureCommunications. 2022, 13:3336
5. Zhu H#,Bi D#, Zhang Y#, Kong C#,Du J, Wu X, Wei Q, Qin H. Ketogenic diet for human diseases: the underlyingmechanisms and potential for clinical implementations. Signal Transduction and Targeted Therapy, 2022, 7:11. (Review; # joint-first author)
6. BiD, Zhu Y, Gao Y, Li H,Zhu X, Wei R, Xie R, Wei Q, Qin H. Anewly developed PCR-based method revealed distinct Fusobacterium nucleatum subspeciesinfection patterns in colorectal cancer. Microbial Biotechnology,2021, 14, 2176-2186.
7. Gao Y#, Bi D#,Xie R#, Li M, Guo J, Liu H, Guo X, Fang J, Ding T, Zhu H, Cao Y,Xing M, Zheng J, Xu Qing, Xu Qian, Wei Q, Qin H. Fusobacterium nucleatum enhancesthe efficacy of PD-L1 blockade in colorectal cancer. Signal Transduction andTargeted Therapy, 2021, 6:398. (# joint-first author)
8. Cai C#, Bi D#, Bick G#, Wei Q, Liu H, Lu L,Zhang X, Qin H. HNF1A serves as a potential regulator in shaping super-enhancerlandscape in colorectal cancer liver metastasis. FEBS Letters, 2021, 595:3056–3071. (# joint-first author)
9. BiD, Zheng J, Xie R, ZhuY, Wei R, Ou HY, Wei Q, Qin H. Comparativeanalysis of AbaR-type genomic islands reveals distinct patterns of geneticfeatures in elements with different backbones. mSphere, 2020,5:e00349-20.
10. Bi D, Xie R, Zheng J,Yang H, Ou HY, Wei Q. Large-scale identification of AbaR-type genomic islandsin Acinetobacter baumannii reveals diverse insertion sites and clonallineage-specific antimicrobial resistance gene profiles. AntimicrobialAgents and Chemotherapy, 2019, 63:e02526-18.
11. Bi D, Zheng J, Li JJ,Sheng ZK, Zhu X, Ou HY, Li Q, Wei Q. In silico typing and comparativegenomic analysis of IncFIIK plasmids and insights into the evolutionof replicons, plasmid backbones and resistance determinant profiles. AntimicrobialAgents and Chemotherapy, 2018, 62:e00764-18.
12. Dong X#, Bi D#,Wang H, Zou P, Xie G, Wan X, Yang Q, Zhu Y, Chen M, Guo C, Liu Z, Wang W, HuangJ. pirABvp-Bearing Vibrio parahaemolyticus and Vibriocampbellii pathogens isolated from the same AHPND-affected pond possesshighly similar pathogenic plasmids. Frontiers in Microbiology, 2017,8:1859. (# joint-first author)
13. Bi D, Jiang X, Sheng ZK,Tai C, Wang M, Deng Z, Rajakumar K, Ou HY. Mapping the resistance-associatedmobilome of a carbapenem-resistant Klebsiella pneumoniae strain revealsinsights into factors shaping these regions and facilitates generation of a‘resistance-disarmed’ model organism. Journal of Antimicrobial Chemotherapy,2015, 70: 2770-4.
14. Li G#, Zhang Y#, BiD#, Shen P, Ai F, Liu H, Tian Y, Ma Y, Wang B, Rajakumar K,Ou HY, Jiang X. First report of a clinical, multidrug-resistant Enterobacteriaceaeisolate coharboring fosfomycin resistance gene fosA3 and cabarpenemasegene blaKPC-2 on the same transposon, Tn1721. AntimicrobialAgents and Chemotherapy, 2015, 59:338-343. (# joint-first author)
15. Bi D, Liu L; Tai C, DengZ, Rajakumar K, Ou HY. SecReT4: a web-based bacterial type IV secretion systemresource. Nucleic Acids Research, 2013, 41: D660-5.
16. Bi D, Xu Z, Harrison EM,Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K, Ou HY. ICEberg: a web-basedresource for integrative and conjugative elements found in Bacteria. NucleicAcids Research, 2012, 40: D621-6.
17.Bi D, Chu D, Zhu P, Lu C,Fan C, Zhang J, Bao J. Utilization of dry distiller's grain and solubles asnutrient supplement in the simultaneous saccharification and ethanolfermentation at high solids loading of corn stover. Biotechnology Letters,2011, 33: 273-276.
文件上传中...
同济大学