2020.01~2023.12  濒死细胞通过Caspases调控Hippo信号通路促进胰腺癌放化疗后再增殖的机制研究（国家自然科学基金面上项目，项目批准号：81972280，资助额度：55万）结题，主持

2016.01~ 2018.12  Merlin/FoxM1 信号轴在PanIN恶性转化中的作用及机制（国家自然科学基金青年项目，项目批准号：81502043，资助额度：18万）已结题，主持

2023.04~2026.03  LDHB介导的肿瘤细胞焦亡激活 CAFs调控胰腺癌免疫微环境的机制研究（上海市自然科学基金，项目批准号：23ZR1452300，资助额度：20万）在研，主持

2019.07~2022.06  MSI1-Hippo信号轴调控胃癌干性特征的机制研究 （上海市自然科学基金，项目批准号：19ZR1441800，资助额度：20万）结题，主持

2019.01~2022.12上海市“医苑新星”青年医学人才，10万，结题，主持

2018.01~2019.12同济大学优秀青年人才培养行动计划，2.5万，结题，主持

2022.12~2025.11上海市浦东新区卫生系统学科带头人培养计划，30万，在研，主持

1. Liu Y, Ding J, Li S, Jiang A, Chen Z, Quan M. LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation. Cell Oncol (Dordr). 2025 Jun;48(3):673. doi: 10.1007/s13402-025-01047-8.

2. Tao Z, Chen Z, Zeng X, Cui J, Quan M. An emerging aspect of cancer neuroscience: A literature review on chemotherapy-induced peripheral neuropathy. Cancer Lett. 2024 Dec 28;611:217433. doi: 10.1016/j.canlet.2024.217433. Online ahead of print.

3. Liu Y, Bischof E, Chen Z, Zhou J, Zhang B, Zhang D, Gao Y, Quan M. Genomic profiling of colorectal cancer in large-scale Chinese patients: amplification and somatic mutations in ERBB2. Oncol Res. 2024 Aug 23;32(9):1429-1438. doi: 10.32604/or.2024.047309. eCollection 2024.

4. Tao Z, Chen Z, Gao Y, Quan M. Influence of cachexia on immunotherapy efficacy and prognosis for malignant tumors of the digestive system.. Cancer Rep (Hoboken). 2024 May;7(5):e2100. doi: 10.1002/cnr2.2100.

5. Ge W, Wang Y, Quan M, Mao T, Bischof EY, Xu H, Zhang X, Li S, Yue M, Ma J, Yang H, Wang L, Yu Z, Wang L, Cui J. Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib. Mol Cancer. 2024 Mar 8;23(1):48. doi: 10.1186/s12943-024-01965-5. PMID: 38459558 Free PMC article.

6. Quan M, Chen J, Chen Z, Hai Y, Zhou Y, Chao Q, Chen C, Li H, Wang M, Gao Y. Cetuximab retreatment plus camrelizumab and liposomal irinotecan in patients with RAS wild-type metastatic colorectal cancer: Cohort B of the phase II CRACK study. Int J Cancer. 2023 May 10. doi: 10.1002/ijc.34531. Online ahead of print.PMID: 37163613

7. Li N, Chen Z, Huang M, Zhang D, Hu M, Jiao F, Quan M. Detection of ROS1 gene fusions using next-generation sequencing for patients with malignancy in China. Front Cell Dev Biol. 2022 Dec 15;10:1035033. doi: 10.3389/fcell.2022.1035033. eCollection 2022.

8. Quan M, Chen Z, Chen J, Hai Y, Gao Y. Preliminary experience of oral fruquintinib-capecitabine as a new maintenance treatment strategy for advanced colorectal cancer in the era of coronavirus disease 2019 (COVID-19): case report and literature review. J Gastrointest Oncol. 2022 Oct;13(5):2660-2666. doi: 10.21037/jgo-22-824.

9. Chong X, Chen J, Zheng N, Zhou Z, Hai Y, Chen S, Zhang Y, Yu Q, Yu S, Chen Z, Bao W, Quan M, Chen ZS, Zhan Y, Gao Y. PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN. Mol Cancer. 2022 May 26;21(1):118. doi: 10.1186/s12943-022-01531-x.PMID: 35619132.

10. Chen Z, Song H, Zeng X, Quan M, Gao Y. Screening and discrimination of optimal prognostic genes for pancreatic cancer based on a prognostic prediction model. G3 (Bethesda). 2021 Oct 19;11(11):jkab296. doi: 10.1093/g3journal/jkab296.PMID: 34499727.

11. Chen Z, Chen J, Gao Y, Quan M. Heterogeneous clinical and pathological landscapes of HER2 positive colorectal cancer. Expert Rev Anticancer Ther. 2021 Jun 16. doi: 10.1080/14737140.2021.1944108. Online ahead of print.

12. Xie D, Yu S, Li L, Quan M, Gao Y. The FOXM1/ATX signaling contributes to pancreatic cancer development. Am J Transl Res. 2020 Aug 15;12(8):4478-4487. eCollection 2020.

13. Yang H, Hu J, Chen J, Chen Z, Jiao F, Cui J, Quan M, Wang L. RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. Med Oncol. 2020 Aug 11;37(9):84. doi: 10.1007/s12032-020-01384-8.

14. Liu S, Huang M, Chen Z, Chen J, Chao Q, Yin X, Quan M. FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13. Exp Cell Res. 2020 Feb 6:111894. doi: 10.1016/j.yexcr.2020.111894. [Epub ahead of print]

15. Chen J, Quan M, Chen Z, Zeng T, Li Y, Zhou Y, Hai Y, Gao Y. Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial. J Cancer Res Clin Oncol. 2020 Oct;146(10):2651-2657. doi: 10.1007/s00432-020-03251-5. Epub 2020 Jul

16. Quan M, Chen Z, Jiao F, Xiao X, Xia Q, Chen J, Chao Q, Li Y, Gao Y, Yang H, Wang L, Cui J. Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression.  J Exp Clin Cancer Res. 2020 Jan 15;39(1):13. doi: 10.1186/s13046-019-1489-0.

17. Cui J, Quan M, Xie D, Gao Y, Guha S, Fallon MB, Chen J, Xie K. A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. Oncogene. 2020 Jan;39(5):1140-1151. doi: 10.1038/s41388-019-1051-8. Epub 2019 Oct 22.

18. Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, Wang L, Chen J, Quan M. MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Mol Cancer Res. 2019 Jun;17(6):1316-1325. doi: 10.1158/1541-7786.MCR-18-0910. Epub 2019 Feb 22.

19. Guo K, Cui J, Quan M Xie D, Jia Z, Wei D, Wang L, Gao Y, Ma Q, Xie K.A novel KLF4-MSI2 signaling pathway regulates growth and metastasis of pancreatic cancer.Clin Cancer Res. 2017 Feb 1;23(3):687-696.

20. Ming Quan, Jiu-jie Cui, Xiao Feng, Qian Huang. The Critical Role and Potential Target of the ATX/LPA Axis in Pancreatic Cancer. Tumor Biology2017 Mar;39(3):1010428317694544. doi: 10.1177/1010428317694544.

21. Jiujie Cui,Tian Xia, DachengXie, Yong Gao, ZhiliangJia, Daoyan Wei, Liang Wang, Suyun Huang, Ming Quan, KepingXie. HGF/Met and FoxM1 form a positive feedback loop and render pancreatic cancer cells proliferation to Met inhibition and aggressive phenotypes. Oncogene. 2016 Sep 8;35(36):4708-18

22. Quan M ,Jiujie Cui, Tian Xia, ZhiliangJia, DachengXie, Daoyan Wei, SuyunHuang, Qian Huang, Shaojiang Zheng, KepingXie. Merlin/NF2 Suppresses Pancreatic Cancer Growth and Metastasis by Attenuating FOXM1-mediated Wnt/β-Catenin Signaling Pathway.Cancer Res. 2015 Nov 15;75(22):4778-89.

23. DachengXie, Jiujie Cui, Tian Xia, ZhiliangJia, Liang Wang, Wenfei Wei, Anna Zhu, Yong Gao, KepingXie, Ming Quan.Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression. Oncotarget, 2015 Nov 3;6(34):35949-63.

24. Jiujie Cui, Ming Quan, Weihua Jiang, Hai Hu, Feng Jiao,Ning Li, ZiliangJin, Lei Wang, Yu Wang, Liwei Wang. Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype. Medical Oncology, 2015, 32:143 DOI: 10.1007/s12032-015-0589-8

25. Quan M , Wang P, Cui J, Gao Y, Xie K. The roles of FOXM1 in pancreatic stem cells and carcinogenesis.Mol Cancer. 2013 Dec 10;12:159. doi: 10.1186/1476-4598-12-159