本团队所在科室胃肠外科为医院重点学科，年完成手术3000台以上，是同济大学癌症中心特色品牌学科。本人每年主刀完成胃肠肿瘤手术300余台，在国际上创新性提出超低位直肠癌精准功能保肛术，获得国际NOSES手术视频大赛亚军；同时在加速康复外科、肿瘤营养等邻域颇有建树，获得全国肿瘤营养先进个人、全国肿瘤营养菁莪奖等荣誉；担任人卫版教材、CACA指南等编委/编者；受邀在2023年亚洲外科代谢与营养学会年会（ASSMN，日本）、2020年国际胃癌会议（KINGCA，韩国）上进行学术汇报。本人及团队成员相关研究发表于《Cell Research》、《Cell Discovery》、《Nature Communications》、《Ageing Res Rev》、《Sci China Life Sci》、《Journal of Cachexia, Sarcopenia and Muscle》、《The American Journal of Clinical Nutrition》、《Clinical Nutrition》等权威SCI期刊。

1.国家自然科学基金面上项目，82371586，Nrf2通过SPNS1调控溶酶体功能改善老年肌少症的作用及机制研究，2024-01至2027-12，49万元

2.国家自然科学基金面上项目，82171565，Nrf2调控OMA1-OPA1通路影响线粒体动力学改善老年肌少症的机制研究，2022-01至2025-12，55万元

3.国家自然科学基金青年项目，81800795，Nrf2调控FoxO1信号通路改善术后骨骼肌功能的机制研究，2019-01至2021-12，21万元

4.上海市卫生和计划生育委员会，20184Y0301，术前锻炼干预肌少症对改善老年胃癌患者术后短期临床结局的有效性研究，2019-01至2021-12，5万元

5.上海市崇明区“可持续发展科技创新行动计划”项目，CKY2021-30，精准功能保肛术治疗超低位直肠癌的临床研究，2021-05至2023-04,4万元

1.国家自然科学基金面上项目，82371586，Nrf2通过SPNS1调控溶酶体功能改善老年肌少症的作用及机制研究，2024-01至2027-12，49万元

2.国家自然科学基金面上项目，82171565，Nrf2调控OMA1-OPA1通路影响线粒体动力学改善老年肌少症的机制研究，2022-01至2025-12，55万元

3.国家自然科学基金青年项目，81800795，Nrf2调控FoxO1信号通路改善术后骨骼肌功能的机制研究，2019-01至2021-12，21万元

4.上海市卫生和计划生育委员会，20184Y0301，术前锻炼干预肌少症对改善老年胃癌患者术后短期临床结局的有效性研究，2019-01至2021-12，5万元

5.上海市崇明区“可持续发展科技创新行动计划”项目，CKY2021-30，精准功能保肛术治疗超低位直肠癌的临床研究，2021-05至2023-04,4万元

近五年发表的代表性论文：

1. Zhang FM, Wu HF, Shi HP, Yu Z, Zhuang CL. Sarcopenia and malignancies: epidemiology, clinical classification and implications. Ageing Res Rev. 2023 Sep 2;91:102057. doi: 10.1016/j.arr.2023.102057. Epub ahead of print. PMID: 37666432.(IF:13.1)，通讯作者

2. Zhuang CL, Zhang FM, Li W, Wang KH, Xu HX, Song CH, Guo ZQ, Shi HP. Associations of low handgrip strength with cancer mortality: a multicentre observational study. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1476-1486. (IF:12.9)，第一作者

3. Zhang FM, Wu HF, Wang KF, Yu DY, Zhang XZ, Ren Q, Chen WZ, Lin F, Yu Z, Zhuang CL. Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity. Cell Death Dis. 2024 Jun 28;15(6):459.(IF:8.1)，通讯作者

4. Zhang X, Zhang F, Wu H, Yu Z, Zhuang C. SPNS1 ablation drives skeletal muscle atrophy by disrupting mitophagy, mitochondrial function, and apoptosis in mice. Genes Dis. 2023 Sep 7;11(5):101083. (IF:6.9)，通讯作者

5. Liu L, He J, Sun G, et al. The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma. Clin Transl Med. 2022;12(5):e778. (IF: 10.6)，共同通讯作者

6. Cai Y, Song W, Li J，et al. The landscape of aging. Sci China Life Sci. 2022 Dec;65(12):2354-2454. (IF:9.1)，共同第一作者

7. Zhang FM, Zhuang CL, Dong QT, Yu Z, Cheng J, Shen X, Wang SL. Characteristics and prognostic impact of cancer cachexia defined by the Asian Working Group for Cachexia consensus in patients with curable gastric cancer. Clin Nutr. 2024 Jun;43(6):1524-1531.(IF:6.6)，共同第一作者

8. Zhang FM, Zhuang CL, Dong QT, et al. Characteristics and prognostic impact of cancer cachexia defined by the Asian Working Group for Cachexia consensus in patients with curable gastric cancer. Clin Nutr. 2024 May 10;43(6):1524-1531. (IF:6.3)，共同第一作者

9. Wang SL, Zhang FM, Chen CB, et al. Comparison between AWGC-cachexia and GLIM-malnutrition in patients with gastric cancer. European Journal of Surgical Oncology.(IF:3.5)，通讯作者

10. Zhuang CL, Wu HF al.Metabolomic analysis of circulating tumor cells derived liver metastasis of colorectal cancer. Heliyon.Nutrition. (IF:4.4)，第一作者

11. Wu HF, Yan JP, Wu Q, Yu Z, Xu HX, Song CH, Guo ZQ, Li W, Xiang YJ, Xu Z, Luo J, Cheng SQ, Zhang FM, Shi HP, Zhuang CL; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group. Discovery of distinct cancer cachexia phenotypes using an unsupervised machine-learning algorithm. Nutrition. 2023 Nov 29;119:112317. (IF:4.4)，通讯作者

12. Zhang FM, Song CH, Guo ZQ, Yu Z, Weng M, Zhou FX, Liu M, Cong MH, Li T, Li ZN, Chen JQ, Cui JW, Xu HX, Li W, Shi HP, Zhuang CL; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group. Sarcopenia prevalence in patients with cancer and association with adverse prognosis: A nationwide survey on common cancers. Nutrition. 2023 Oct;114:112107.(IF:4.4)，通讯作者

13. Chen WZ, Zhang XZ, Zhang FM, Yu DY, Chen WH, Lin F, Dong QT, Zhuang CL, Yu Z. Coexistence of GLIM-defined malnutrition and sarcopenia have negative effect on the clinical outcomes in the elderly gastric cancer patients after radical gastrectomy. Front Nutr. 2022 Aug 19;9:960670. doi: 10.3389/fnut.2022.960670. PMID: 36061885; PMCID: PMC9437552.(IF:5.0)，共同通讯作者

14. Zhuang CL, Zhang FM, Xu HX, et al. Reference values of low body mass index, mid-upper arm circumference, and calf circumference in cancer patients: A nationwide multicenter observational study Nutrition. 2022;99-100:111688. (IF: 4.4)，第一作者

15. Zhuang CL, Dong QT, Shi HP, et al. Cachexia Versus Sarcopenia in Clinical Characteristics and Prognostic Value After Radical Gastrectomy for Gastric Cancer: A Large-Scale Prospective Study. Ann Surg Oncol. 2022;29(4):2348-2358. (IF: 3.7)，第一作者

16. Zhang FM, Zhang XZ, Zhu GL, Lv LQ, Yan XL, Wu WX, Wang SL, Chen XL, Zhuang CL, Yu Z. Impact of sarcopenia on clinical outcomes of patients with stage I gastric cancer after radical gastrectomy: A prospective cohort study [published online ahead of print, 2021 Aug 17]. Eur J Surg Oncol. 2021;S0748-7983(21)00693-4. doi:10.1016/j.ejso.2021.08.021 (IF:3.8)，共同通讯作者

17. Zhang FM, Zhang XZ, Shi HP, Zhang Z, Wang SL, Shen ZL, Chen XL, Shen X, Yu Z, Zhuang CL. Comparisons and Impacts of the Basic Components of Sarcopenia Definition and Their Pairwise Combinations in Gastric Cancer: A Large-Scale Study in a Chinese Population. Front Nutr. 2021;8:709211. Published 2021 Oct 20. doi:10.3389/fnut.2021.709211 (IF:5.0) ，通讯作者

18. Zhuang CL, Zhang FM, Wang Z, Jiang X, Wang F, Liu ZC. Precision functional sphincter-preserving surgery (PPS) for ultralow rectal cancer: a natural orifice specimen extraction (NOSE) surgery technique. Surg Endosc. 2021 Jan;35(1):476-485. doi: 10.1007/s00464-020-07989-4. Epub 2020 Sep 28. PMID: 32989539，(IF: 3.1)，第一作者

19. Zhang FM, Chen XL, Wu Q, Dong WX, Dong QT, Shen X, Shi HP, Yu Z, Zhuang CL. Development and validation of nomograms for the prediction of low muscle mass and radiodensity in gastric cancer patients. Am J Clin Nutr. 2021 Feb 2;113(2):348-358. doi: 10.1093/ajcn/nqaa305. PMID: 33300037. (IF:7.1)，通讯作者

20. Zou HB, Yan XL, Dong WX, Yu DY, Zhang FM, Zhou LP, Shen ZL, Cai GJ, Zhuang CL, Yu Z. Sarcopenia is a predictive factor of poor quality of life and prognosis in patients after radical gastrectomy. Eur J Surg Oncol. 2021 Aug;47(8):1976-1984. doi: 10.1016/j.ejso.2021.03.004. Epub 2021 Mar 6. PMID: 33714648. (IF:3.8)，共同通讯作者

21. Zhang F. M., Ma B.W., Huang Y. Y., Chen W. Z., Chen J. J., Dong Q. T., Chen W. S., Chen X.L., Shen X., Yu Z., Zhuang C.L., Laparoscopic colorectal cancer surgery reduces the adverse impacts of sarcopenia on postoperative outcomes: A propensity score-matched analysis. Surgical Endoscopy. 2020 Oct;34(10):4582-4592. Epub 2019 Nov 18. (IF:3.1)，通讯作者

22. Zhuang C. L., Shen X., Huang Y. Y., Zhang F. M., Chen X. Y., Ma L. L., Chen X. L., Yu Z., Wang S. L. Myosteatosis predicts prognosis after radical gastrectomy for gastric cancer: A propensity score-matched analysis from a large-scale cohort. Surgery. 2019,166(3):297-304. (IF:3.8)，第一作者

23. Chen X.Y., Zhang X.Z., Ma B.W., Li B., Zhou D.L., Liu Z.C., Chen X.L., Shen X., Yu Z., Zhuang C.L., A comparison of four common malnutrition risk screening tools for detecting cachexia among patients with curable gastric cancer. Nutrition. 2020 Feb;70:110498. Epub 2019 Apr 26. Doi: org/10.1016/j.nut.2019.04.009 (IF: 4.4)，通讯作者

24. Zhou LP, Yu DY, Ma BW, Shen ZL, Zou HB, Zhang XZ, Yan XL, Zhuang CL, Yu Z. Feasibility of substituting handgrip strength for muscle mass as a constituent standard in the Global Leadership Initiative on Malnutrition for diagnosing malnutrition in patients with gastrointestinal cancers. Nutrition. 2020 Oct 30;84:111044. doi: 10.1016/j.nut.2020.111044. Epub ahead of print. PMID: 33517155. (IF: 4.4)，共同通讯作者