在研项目

国家自然科学基金：GMFB调控星形胶质细胞CARM1/PPARG通路改善损伤轴突再髓鞘化的机制研究（82471073）2025.1-2028.12 49万 (主持）

1.  国家自然科学基金：GMFB调控星形胶质细胞CARM1/PPARG通路改善损伤轴突再髓鞘化的机制研究（82471073）2025.1-2028.12 49万 (主持）

2. 中央高校研究基金：胶质细胞成熟因子beta 控制视神经损伤后内源性干细胞动员的微环境（22120220009）2022.1-2022.30（主持）

3. 国家重点研发计划:开发人胚胎干细胞向视网膜细胞分化关键技术、种子细胞优化及组织工程化视网膜片构建（2017YFA0104103）2017-2021 （骨干）

4.上海市自然科学基金:胶质成熟因子beta在早期糖尿病视网膜病变的作用机制及干预策略研究（17ZR1431300） 2017-2019（主持）

5.上海卫计委 (201640229) GMFB作为糖尿病视网膜病变早期神经变性标记物的研究2016-2017 （主持）

6.863子课题：临床级干细胞分离培养、扩增诱导和保存运输等产业化关键技术研发（2011AA020109） 92万（2013-2015）（骨干）

7.973课题（2011CB965102）ES和iPS细胞向RPE分化，治疗视网膜变性眼病有效性和临床安全性间的差异及预编程机制 121万（2011-2015) （骨干）

1. Sun W, Wang J, Liu C, Gao F, Ou Q, Tian H, Xu J, Zhang J, Li J, Xu J, Jia S, Zhang J, Xu G, Huang J, Jin C, Lu L. SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia. Int J Biol Macromol. 2024;268(Pt2):131678. doi: 10.1016/j.ijbiomac.2024.131678.

2. Shi S, Gu H, Xu J, Sun W, Liu C, Zhu T, Wang J, Gao F, Zhang J, Ou Q, Jin C, Xu J, Chen H, Li J, Xu G, Tian H, Lu L. Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity. Exp Mol Med. 2023 ;55(5):898-909. doi: 10.1038/s12276-023-00980-8.

3. Zhu T, Li Y, Zhu L, Xu J, Feng Z, Chen H, Shi S, Liu C, Ou Q, Gao F, Zhang J, Jin C, Xu J, Li J, Zhang J, Bi Y, Xu GT, Wang J, Tian H, Lu L*.GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model.Glia. 2023 Oct 31. doi: 10.1002/glia.24486.

4. Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L.Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.Redox Biol. 2022 Jun;52:102292. doi: 10.1016/j.redox.2022.102292. Epub 2022 Mar 18.

5. Xu J, Zhu L, Xu J, Lin K, Wang J, Bi YL, Xu GT, Tian H, Gao F, Jin C, Lu L. The identification of a novel shared therapeutic target and drug across all insulin-sensitive tissues under insulin resistance.Front Nutr. 2024 Mar 26;11:1381779. doi: 10.3389/fnut.2024.1381779. eCollection 2024.

6. Liu C, Zhu T, Zhang J, Wang J, Gao F, Ou Q, Jin C, Xu JY, Zhang J, Tian H*, Xu GT*, Lu L*.Identification of novel key molecular signatures in the pathogenesis of experimental diabetic retinopathy.IUBMB Life，2021 Nov;73(11):1307-1324. doi: 10.1002/iub.2544.

7. Gao F, Wang L, Wu B, Ou Q, Tian H, Xu J, Jin C, Zhang J, Wang J, Lu L*, Xu GT*. Elimination of senescent cells inhibits epithelial-mesenchymal transition of retinal pigment epithelial cells. Exp Eye Res. 2022 Aug 2;223:109207. 

8. Sun W, Hu C, Wang T, Wang J, Zhang J, Gao F, Ou Q, Tian H, Jin C, Xu J, Zhang J, Xu GT*, Lu L*. Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular Carcinoma. Front Oncol. 2021 Nov 2;11:744331. 

9. Zhu T, Wang T, Feng Z, Gao F, Zhang J, Jin C, Tian H, Xu J, Chen H, Ou Q, Wang J, Xu G*, Lu L*. Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma. Front Oncol.2022 Jul 4;12:880100.

10. Diao M, Wu Y, Yang J, Liu C, Xu J, Jin H, Wang J, Zhang J, Gao F, Jin C, Tian H, Xu J, Ou Q, Li Y, Xu G*, Lu L*. Identification of Novel Key Molecular Signatures in the Pathogenesis of Experimental Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2022 Mar 30;13:843721.

11. Tianyu Wang, Tong Zhu , Yuanyuan Zhang, Jianhao Bai, Yawen Xue, Guotong Xu*, Lixia Lu*, Qing Peng*.Pan-cancer analysis of the prognostic and immunological role of BRCA1-associated protein 1 gene (BAP1): Friend or foe?. Gene. 840 (2022) 146765

12. Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L*, Xu GT*. Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis. Stem Cell Res Ther. 2022 Apr 1;13(1):136.

13. Gao F#, Li Z#, Kang Z, Liu D, Li P, Ou Q, Xu JY, Li W, Tian H, Jin C，Lu L*, Xu GT*: Inhibition of PARP activity improves therapeutic effect of ARPE-19 transplantation in RCS rats through decreasing photoreceptor death. Experimental eye research 2021, 204:108448.

14. Chen Y, Wu B, He JF, Chen J, Kang ZW, Liu D, Luo J, Fang K, Leng X, Tian H, Xu J, Jin C, Zhang J, Wang J, Zhang J, Ou Q, Lu L*, Gao F*, Xu GT*. Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-βSignaling Inhibitors.Invest Ophthalmol Vis Sci. 2021 Apr 1;62(4):21. doi: 10.1167/iovs.62.4.21.PMID: 33861322 (IF=4.799)

15. Gu H, Shi S, Xiao F, Huang Z, Xu J, Chen G, Zhou K, Lu L*, Yin X*.MiR-1-3p regulates the differentiation of mesenchymal stem cells to prevent osteoporosis by targeting secreted frizzled-related protein 1. Bone. 2020 May 21;137:115444. doi: 10.1016/j.bone.2020.115444.

14 .Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu*, Caixia Jin*, Guo-Tong Xu*, Jingjun Zhao*. BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs. Stem Cell Res Ther 2021 Jun 5;12(1):327. doi: 10.1186/s13287-021-02400-y.

15..Haibin Tian, Zhiyang Chen, Xiaoman Zhu, Qingjian Ou, Zhe Wang, Binxin Wu, Jing-Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Lixia Lu*, Guo-Tong Xu*. Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration. iScience.2022 Sep 2;25(10):105050. doi: 10.1016/j.isci.2022.105050. eCollection 2022 Oct 21.

16. Zhu X, Chen Z, Wang L, Ou Q, Feng Z, Xiao H, Shen Q, Li Y, Jin C, Xu JY, Gao F, Wang J, Zhang J, Zhang J, Xu Z, Xu GT, Lu L, Tian H.Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration.Cell Death Dis. 2022 Sep 12;13(9):785. doi: 10.1038/s41419-022-05199-5.