同济大学
导师风采
陈炳地
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个人信息

Personal Information

  • 导师类别:硕士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

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Contact Information

  • 所属院系:医学院
  • 所属专业: 生物医学工程
  • 邮箱 : inanochen@tongji.edu.cn
  • 工作电话 : -

个人简介

Personal Profile

陈炳地,博士,现任同济大学医学院副研究员,上海市分子诊断创新技术研究所CTC中心主任。重点从事肿瘤液体活检、AI+细胞病理和癌症康复治疗研究。与海外特聘教授、美籍华人科学家崔征教授合作,在全世界首创粒细胞抗癌疗法。通过医工交叉,结合纳米技术,开展癌症的诊断、治疗、康复研究。目前在癌症检测、粒细胞抗癌免疫治疗、营养抗癌等方向已取得突破性进展。部分科研项目已进入临床转化阶段,是致慧医疗科技(上海)有限公司创始人。

作为项目负责人承担十余项国家及省部级科研项目,包括国家自然科学基金面上项目、教育部博士点基金、上海市科委生物医药科技支撑项目、上海市卫健委优青计划等。迄今在Adv.Mater.、ACSNano、Theranostics等国际知名学术期刊发表SCI论文60余篇,总引用次数超过3000多次(H因子23),申请国家发明专利30 余项,已授权10余项。

荣获上海市卫健委优秀青年医学人才,同济大学“青年岗位能手”,福建省“百人计划”专家,台州“500精英计划”A类人才等称号。兼任白求恩精神研究会检验医学分会理事、中国抗癌协会肿瘤标志物委员会CTC专家委员会委员、上海市医师协会肿瘤精准诊疗专业委员会委员、中国人体健康科技促进会临床检验科学技术转化专业委员会常委、全国卫生产业企业管理协会转化医学专家委员会委员、全国抗衰老协会肿瘤风险评估与系统康复专委会委员,国家自然科学基金评审专家,教育部学位论文评审专家等。


  • 研究方向Research Directions
精准医学与系统生物学,肿瘤液体活检,癌症免疫治疗
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
团队展示

微信图片_20231007115838



微信图片_20231007115848


科研项目

1. 国家自然科学基金面上项目:批准号:81772285;基于癌细胞表面电荷特性的循 环肿瘤细胞高效捕获与无损释放纳米技术在临床诊断中的应用研究;起止时间: 2018/01~2021/12

2. 上海市科委生物医药科技支撑项目:批准号:18441900300;基于新型纳米技术 的循环肿瘤细胞检测试剂盒的研发;起止时间:2018/04~2021/06

3. 上海市卫计委优秀青年医学人才计划:批准号:2017YQ051;新型循环肿瘤细胞 检测纳米技术在临床诊断中的应用研究;起止时间:2017/07~2020/06

4. 上海市科委西医引导项目:批准号:17411968700;基于癌细胞表面电荷特性新型循环肿瘤细胞检测技术在临床诊断中的应用研究;起止时间:2017/06~2020/06

5. 国家自然科学基金青年项目:批准号:51302190;新型单壁碳纳米管集成系统在 乳腺癌诊疗中的应用基础研究;起止时间:2014/01~2016/12

6. 教育部博士点基金:批准号:20130072120029;新型单壁碳纳米管集成系统在乳 腺癌诊疗中的应用基础研究;起止时间:2014/01~2016/12

7. 上海市卫计委青年科研项目:批准号:20144Y0248;用于循环肿瘤细胞快速灵 敏检测的多功能纳米试剂盒的研发;起止时间:2015/01~2017/12

8. 硅材料国家重点实验室开放课题:批准号:SKL2014-11;基于微/纳复合结构的 新型柔性纤维状光伏器件的构筑及应用研究;起止时间:2014/08~2016/07

9. 同济大学青年优秀人才培养计划:批准号:2012KJ022;基于新型非对称纳米结 构的痕量肿瘤细胞检测方法研究;起止时间:2012/12~2014/12

10. 中国博士后基金特别资助:批准号:2012T50435;基于新型非对称纳米结构的 痕量肿瘤细胞检测方法研究;起止时间:2012/06~2013/06

11:中国博士后基金面上项目:批准号:20100480618;基于单壁碳纳米管的纳米 集成系统的构建及其在乳腺癌诊疗中的应用研究;起止时间:2010/12~2012/12


研究成果

1.          Xiao Y, Chen K, Hu T, Wang Y, Wang J,Lv C, Xu J, Zhang X, Li A, Chen B* . A bionic “trojan horse”-like nanovesicledelivery system hybridized with BCG cytoplasmic membrane and melanoma cellmembrane for cancer immunotherapy[J]. Pharmaceutics, 2025, 17(4): 507.

2.          Liu M, Han Y, Wang J, Zhu Y, Zhang Y,Chu Q, Yang C, Chen B* and Sun G. Skeletal muscle-derived IL-33 mediatesmuscle-to-bone crosstalk and regulates bone metabolism via CD8+ T cell-secretedCCL5 [J]. eBioMedicine, 2025;122: 106024.

3.          Du Y, Wang Y, Kong M, Liang T, Long Q,Chen B*, Zhu Q. Confidence calibration for multimodal LLMs: an empirical studythrough medical VQA, MICCAI, 2025[J].

4.          Lin C, Wang J, Zhu Y, Zhang D, HuangX, Wang J, Ren J, Hou M, Wu M, Shen B, Chen B*. Enhancing cancer-killingactivity of PMN transfusion therapy via apoptotic modulation function ofselenium nanoparticles[J]. Chemical Engineering Journal, 2025, 514: 162764.

5.          Ninghan Fan, Ming Kong, Jing Huang,Qiang Zhu, Bingdi Chen*. Explainable ADHD diagnostic framework usingweakly-supervised action recognition, MICCAI,2025[J].

6.          Wang, Jiaming, Mingchong Liu, ChensongYang, Xixi Huang, Chenyu Lin, Yuqian Zhu, Jing Wang, Hongyi Zhang, Bingdi Chen*and Guixin Sun. Photocrosslinked gelatin methacryloyl/hyaluronic acidmethacryloyl composite hydrogels loaded with bone morphogenetic protein 2-blackphosphorus nanosheets for bone regeneration[J]. Journal of BiomaterialsScience, Polymer Edition, 2025, 36(14): 1962-1984.

7.          Chen X, Chen B, Zhao H. Role ofneutrophils in anti-tumor activity: characteristics and mechanisms ofaction[J]. Cancers, 2025, 17(8): 1298.

8.          Shuyuan Hu, Jingyao Chen, Yihui Hu,Wenjun Le, Pengbo Zhang, Wenwen Jia, Quanhu Sun, Tao Chen, Wei Bao, Zheng Cui,Bingdi Chen*. The intensity of cell surface charge defines the malignancy ofcancer cells[J]. Chemical Engineering Journal, 2025, 519: 164948.

9.          Wenjun Le, Shuyuan Hu, Pengbo Zhang,Yanqi Wang, Yihui Hu, Zheng Cui, Bingdi Chen*. Capture of live circulatingtumor cells via unique surface charges from cancer patients by a novelnanotechnology[J]. Interdisciplinary Medicine, 2024, 2(4): e20240045.

10.        Jun Li , Jutang Li , Jingyao Chen , WeiCao , Bingdi Chen*. Comprehensive analysis of ATP6V1s family member, ATP6V1C2,with prognostic and drug development values in colorectal cancer[J]. Pathology,Research and Practice, 2024, 258: 155357.

11.        Gang Liu , Jinfeng Zhu , Pengbo Zhang ,Tingting Zhang , Zheng Cui , Fanglei Jiao , Wenjun Le , Xiaofeng Li , BingdiChen*. Exploring the diagnostic and prognostic significance of circulatingtumor cells in stage II-IV colorectal cancer using a nano-based detectionmethod[J]. Journal of the Chinese Medical Association, 2024, 87(10): 945-952.

12.        Yilong Huang, Shasha Shen, Jie Xiao,Cici Luo, Jiyao Ma, Xin Huang, Tianfu Qi, Chao Gao, Guiyun Li, Fan Li, Bo He,Bingdi Chen, Dan Han. Mesothelin-targeted MRI for assessing migration,invasion, and prognosis in malignant pleural mesothelioma[J]. CancerNanotechnology, 2024, 15(1) 1.

13.        Wenjia Guo , Yu’e Liu , Bingdi Chen ,Lieying Fan.Target prediction and potential application of dihydroartemisininon hepatocarcinoma treatment[J]. Naunyn-Schmiedeberg’s Archives ofPharmacology, 2024, 397(10): 7711-7724.

14.        Li X, Zheng J, Zhu J,Huang X, Zhu X,Chen B* . Circulating tumor cells: biological features and survivalmechanisms[J]. Biocell, 2023, 47(8): 1771-1781.

15.        Qidong Wang, Meng Li, Tianming Cui,RuiWu, Fangfang Guo, Mei Fu, Yuqian Zhu, Chensong Yang, Bingdi Chen* and GuixinSun*. A Novel Zwitterionic Hydrogel Incorporated with Graphene Oxide for BoneTissue Engineering Synthesis Characterization and Promotion of OsteogenicDifferentiation of Bone Mesenchymal Stem Cells. Int. J. Mol. Sci. 2023, 24,2691 

16.        Yuqian Zhu, Jingyao Chen, Jun Li, ChenqiZhou, Xin Huang*and Bingdi Chen*. Ginsenoside Rg1 as a promising adjuvant agentfor enhancing the anti-cancer functions of granulocytes inhibited bynoradrenaline. Frontiers in Immunology, 2023, 14:1070679. 

17.        Jingyao Chen#, Dan Li#, Chenqi Zhou,Yuqian Zhu, Chenyu Lin, Liting Guo, Wenjun Le, Zhengrong Gu* and Bingdi Chen*.Principle Superiority and Clinical Extensibility of 2D and 3D Charged NanoprobeDetection Platform Based on Electrophysiological Characteristics of CirculatingTumor Cells. Cells 2023, 12, 305.

18.        Jun Li#, Chenjie Qin#, Yicheng Wu, ShengCheng,Yuanqing Wang, Huijie Chen, Fangli Chen*, Bingdi Chen* and Jutang Li*.Targeting LRRC41 as a potential therapeutic approach for hepatocellularcarcinoma. Frontiers in Molecular Biosciences, 10:1300294.

19.        Jun Li#, Chenyu Lin#, Yuqian Zhu,Chengwei Shao, Tiegong Wang* and Bingdi Chen*. Colorectal cancer cell membranebiomimetic ferroferric oxide nanomaterials for homologous bio-imaging andchemotherapy application. Medical Oncology, 2023, 40:322. 

20.        Mei Fu, Jun Li, Mingchong Liu, ChensongYang, Qidong Wang, Hongrui Wang, Bingdi Chen, Qingge Fu*, Guixin Sun*.Sericin/Nano-Hydroxyapatite Hydrogels Based on Graphene Oxide for EffectiveBone Regeneration via Immunomodulation and Osteoinduction. InternationalJournal of Nanomedicine, 2023:18 1875–1895.

21.        Huixiao Yuan#, Xin Huang#, Qingqing Li#,Cici Luo, Chenyu Lin, Shuxian Zhang, Yaguang Zhang, Zhilin Yan, Ning Du,Zhongmin Liu*, Hua Jiang*, Bingdi Chen*. SiRNA-circFARSA-loaded porous siliconnanomaterials for pancreatic cancer treatment via inhibition of CircFARSAexpression, Biomedicine & Pharmacotherapy, 2022, 147, 112672.

22.        Jinshan Xu#, Shuxiong Zeng#, Jun Li#, LiGao, Wenjun Le, Xin Huang, Guandan Wang, Bingdi Chen*, Zhengsheng Zhang*,Chuanliang Xu*. Novel Non Invasive Diagnosis of Bladder Cancer in Urine Basedon Multifunctional Nanoparticles, Frontiers in Cell and Developmental Biology,2022, 9, 813420.

23.        Jing Wang, Wenjun Le, Tinghua Yan,Jinhua Jiang*, Bingdi Chen*. Usage of Nanoparticles to Alter Neutrophils’Function for Therapy, ACS Biomaterials Science & Engineering, 2022,8,3676 

24.        Yao Yao#; Jingyao Chen#; Yuhan Guo; TianLv; Zilin Chen; Ning Li; Shaokui Cao; Bingdi Chen*; Tao Chen*; Integration ofinterstitial fluid extraction and glucose detection in one device for wearablenon-invasive blood glucose sensors, Biosensors and Bioelectronics, 2021, 179:113078.

25.        Xin Huang#, Chenyu Lin#, Cici Luo, YuhanGuo, Jun Li, Yiping Wang, Jiahong Xu, Yuwen Zhang, He Wang*, Zhongmin Liu*,Bingdi Chen*. Fe3O4@M nanoparticles for MRI-targeted detection in the earlylesions of atherosclerosis, Nanomedicine: Nanotechnology, Biology, andMedicine, 2021, 33, 102348.

26.        Jing Wang#, Tianxiao Mei#, Yang Liu,Yifan Zhang, Ziliang Zhang, Yihui Hu, Yibin Wang, Minliang Wu, Chuanxue Yang,Xiangdong Zhong, Bingdi Chen*, Zheng Cui, Wenjun Le*, Zhongmin Liu*.Dual-targeted and MRI-guided photothermal therapy via iron-based nanoparticles-incorporatedneutrophils, Biomaterials Science, 2021, 9, 3968. 

27.        Chen, Xin#; Wang, Tiegong#; Le, Wenjun;Huang, Xin; Gao, Minghui; Chen, Qian; Xu,Shuogui; Yin, Detao; Fu, Qingge; Shao, Chengwei; Bingdi Chen*;Shi, Donglu; Smart Sorting of Tumor Phenotype with Versatile Fluorescent AgNanoclusters by Sensing Specific Reactive Oxygen Species, Theranostics, 2020,10(8): 3430. 

28.        M. L. Wu, T. X. Tian, C. Y. Lin, Y. C.Wang, J. Y. Chen, W. J. Le*, M. Y. Sun, J. G. Xu, H. Y. Dai, Y. F. Zhang, C. Y.Xue*, Z. M. Liu, B. D. Chen*, Melanoma Cell Membrane Biomimetic Versatile CuSNanoprobes for Homologous Targeting Photoacoustic Imaging and PhotothermalChemotherapy, ACS Applied Materials & Interfaces, 2020, 1214:16031

29.        M. L. Wu, W. J. Le, T. X. Mei, Y. C.Wang, B. D. Chen*, Z. M. Liu, C. Y. Xue*, Cell membrane camouflagednanoparticles: a new biomimetic platform for cancer photothermal therapy.International Journal of Nanomedicine 2019, 14:4431-4448

30.        X. Huang, W. J. Le, Q. Chen, J. Y. Chen,Y. Q. Zhu, D. L. Shi, B. D. Chen*, Z. Cui*, Suppression of the innatecancer-killing activity in human granulocytes by stress reaction as a possiblemechanism for affecting cancer development. Stress 2019, DOI: 10.1080/10253890.2019.1645112.

31.        W. J. Le, B. D. Chen, Z. Cui, Z. M.Liu*, D. L. Shi*, Detection of cancer cells based on glycolytic-regulatedsurface electrical charges. Biophysics Reports 2019,5, 1:10-18

32.        H. H. Zhu, X.F. Li, J.F.Zhu, X.Huang, Q.He, B. D. Chen, W.Cao, Circulating tumor cells detected by surface-enhancedRaman scattering technique based on graphene oxide/gold nanorods. Journal ofthe Second Military Medical University, 2019, 40(6): 643-650.

33.      B. D. Chen, W. J. Le, Y. L. Wang, Z. Q.Li, D. Wang, L. Lin, S. B. Cui, J. J. Hu, Y. H. Hu, P. Y.Yang, R. C. Ewing, D.L. Shi*, Z. Cui* Targeting Negative Surface Charges of Cancer Cells byMultifunctional Nanoprobes. Theranostics 2016, 6, 11:1887-1898.


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