1. 多能干细胞（iPSC/ESC）向NK细胞和T细胞分化，以及肿瘤免疫细胞疗法的开发。

2. iPSC/ESC向抑制性神经元分化，以及癫痫、亨廷顿病等细胞疗法开发。

3. 阿尔茨海默病（AD）大脑类器官模型构建和发病机制研究。

1. 1. Zhu X*, Bai Z*, Ren Y*, Chang Z*, Wang Y, Li P, Liang Y, Zhao Z, Zhu Y, Gao S#, Gao Y#, Chen X#. Generating LGE/CGE Organoids from Human Pluripotent Stem Cell-derived Brain Organoids Without External Signal Induction. Cell Rep. 2026 Jan 27;45(1):116780.  

   2. Chen X*, Sun G*, Feng L, Tian E, Shi Y#. Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids. Commun Biol. 2025 Jan 9;8(1):30.

   3. Chen X*, Shi Y#. Generating Homogeneous Brain Organoids from Human iPSCs. Methods Mol Biol. 2024;2794:157-167.

   4. Chen X*, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y#. Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure. Adv Sci. 2021 Sep;8(18):e2101462.

   5. Chen X*, Yang Q, Liu Z, Shi Y#. Chapter 2 - Human induced pluripotent stem cell–based modeling of Alzheimer’s disease, a glial perspective. Editor(s): Alexander Birbrair. In Advances in Stem Cell Biology, iPSCs for Modeling Central Nervous System Disorders, Academic Press, Volume 6, 2021, Pages 21-35.

   6. Sun G*, Chiuppesi F*, Chen X*, Wang C, Tian E, Nguyen J, Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ, Wussow F#, Shi Y#. Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids. Cell Rep Med. 2020 Mar 25;1(1):100002.

   7. Chen X*, Zhu Y, Wang Z, Zhu H, Pan Q, Su S, Dong Y, Li L, Zhang H, Wu L#, Lou X#, Liu S#. mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances. J Proteomics. 2016 Mar 16;136:13-24. doi: 10.1016/j.jprot.2016.01.021. Epub 2016 Feb 2. PMID: 26844761.

   8. Chen X*, Guo D, Zhu Y, Xian F, Liu S, Wu L#, Lou X#. Nuclear phosphoproteomics analysis reveals that CDK1/2 are involved in EGF-regulated constitutive pre-mRNA splicing in MDA-MB-468 cells. J Proteomics. 2016 Jun 1;141:77-84.