课题组现有秘书1名，博士后1名，博士研究生4名，硕士研究生2名；已毕业硕士生1名。

课题组每年提供活动经费，不定期举行聚餐+团建。

1.国家自然科学基金——面上项目，2023.01-2026.12，课题负责人

2.上海市自然科学基金——面上项目，2023.04-2026.03，课题负责人

3.国家重点研发计划，骨骼与血液干细胞休眠和激活调控，2022.12-2027.11，项目骨干

4.上海市海外高层次人才引进计划，2022.01-2024.12

代表性论文：(* Co-first authors; # Corresponding authors)

1. Xue JH*, Chen GD*, Hao F*, Chen H*, Fang Z, Chen FF, Pang B, Yang QL, Wei X, Fan QQ, Xin C, Zhao J, Deng X, Wang BA, Zhang XJ, Chu Y, Tang H, Yin H, Ma W, Chen L, Ding J, Weinhold E, Kohli RM, Liu W, Zhu ZJ, Huang K#,Tang H#, Xu GL#. A vitamin-C-derived DNA modification catalysed by analgal TET homologue Nature 2019 May;569(7757):581-585.

2. Meng WY*, Wang ZX*, Zhang Y, Hou Y#, Xue JH#. Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes J Biol Chem. 2024 Feb 23:106791.

3. Chen Z*, Zhou K*, Xue J*, Small A*, Xiao G, Nguyen LXT, Zhang Z, Prince E, Weng H, Huang H, Zhao Z, Qing Y, Shen C, Li W, Han L, Tan B, Su R, Qin H, LiY, Wu D, Gu Z, Ngo VN, He X, Chao J, Leung L, Wang K, Dong L, Qin X, Cai Z, Sheng Y, Chen Y, Wu X, Zhang B, Shi Y, Marcucci G, Qian Z, Xu M, Müschen M, Chen J#, Deng X#. Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B-cell acute lymphoblastic leukemia Sci Transl Med. 2023 Mar 29;15(689):eabq8513.

4. Xue JH*, Xu GF*, Gu TP, Chen GD, Han BB, Xu ZM, BjøråsM, Krokan HE, Xu GL, Du YR#. Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation J Biol Chem. 2016 Jan8;291(2):731-8.

5. Xue JH, Xu GL#.RNA Pol II as a sensor of 5caC Cell Research 2015 Oct;25(10):1089-90.

6. Zhao Z*, Qing Y*, Dong L*, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q#, Su R#, Chen J#. QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism Cell 2023 Jul 20;186(15):3208-3226.

7. Li Y, Xue M, Deng X, Dong L, Nguyen LXT, Ren L, Han L, Li C, Xue J, Zhao Z, Li W, Qing Y, Shen C, Tan B, Chen Z, Leung K, Wang K, Swaminathan S, Li L, Wunderlich M, Mulloy JC, Li X, Chen H, Zhang B, Horne D, Rosen ST, Marcucci G, Xu M, Li Z, Wei M, Tian J, Shen B, Su R, Chen J. TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal Cell Stem Cell 2023 Aug 3;30(8):1072-1090.

8. Han L*, Dong L*, Leung K*, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Wunderlich M, Zhang B, Mulloy JC, Marcucci G, Chen CW, Wei M#, Su R#, Chen J#, Deng X#. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism Cell Stem Cell. 2023 Jan 5;30(1):52-68.

9. Su R*, Dong L*, Li Y*, Gao M*, He PC*, Liu W*, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C#, Chen J#. METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis Nat Cell Biol. 2022 Feb;24(2):205-216.

10. Dou X*, Boyd-Kirkup JD*, McDermott J*, Zhang X*, Li F, Rong B, Zhang R, Miao B, Chen P, Cheng H, Xue J, Bennett D, Wong J, Lan F, Han JJ#.The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A Genome Res. 2019 Oct;29(10):1622-1634.