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刘晓雨博士,长聘教授,博导,第六批国家高层次人才特殊支持计划青年拔尖人才计划获得者,获多项科技部、基金委及上海市项目支持。主要研究方向为哺乳动物胚胎发育过程中的表观遗传调控机制。表观遗传修饰的重塑在全能性的建立过程中发挥重要作用,但具体调控机制尚不清楚。近年来,课题组通过对小鼠和人早期胚胎发育过程中表观遗传修饰重编程机制的研究,1)建立了植入前胚胎发育多种核心组蛋白修饰的图谱,鉴定了多个表观调控因子并初步解析了其作用机制,揭示了早期胚胎逆转座子沉默的表观调控机制;2)解析了核移植胚胎的组蛋白修饰和染色质高级结构重编程机制,并通过改变表观修饰显著提高核移植胚胎发育率。相关成果发表在Nature、Cell Stem Cell、Nature Cell Biology、Cell Research等国际著名学术期刊上,这些研究拓展了对哺乳动物早期表观修饰重编程过程的认识,一篇论文入选ESI高被引论文,一项成果入选2016年“中国生命科学领域十大进展”。未来的研究中,课题组将继续围绕全能性重建这一核心问题,深入探究转录调控因子协同表观修饰发挥作用的分子机制,为表观修饰调控胚胎发育机制的研究提供新的理论基础。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1,细胞谱系分化的分子机制与类胚胎构建,主持,500万元 ,2022 年12月至2027 年11 月,科技部国家重点研发计划青年科学家项目(国家级)2022YFA1106000 ,在研;
2,国家高层次人才支持计划青年拔尖人才,主持, 180万元 ,2022年1月至2024年12月,中组部青年拔尖人才(国家级),在研;
3,细胞全能性获得的表观调控机制及基于干细胞的类胚胎构建,骨干,500万元,2021年12月至 2026年6月, 国家重点研发计划青年科学家项目(国家级)2021YFA1102900 ,在研;
4,组蛋白H3.3变体在小鼠早期胚胎组蛋白修饰遗传与重编程中的作用与机制研究,主持,58万,2021年1月至2024年12月,国自然面上(国家级)32070802 ,结题;
5,胚胎基因组激活过程中关键转录因子的筛选及其机制研究,主持,40万,2020年6月至2023年5月,上海市科委启明星计划(省部级),20QA1409700 ,结题;
6,植入前胚胎发育的调控网络研究,骨干,2732万元,2018年12月至2021年12月, 国家重点研发计划(国家级)2018YFC1004000,结题;
7,小鼠早期胚胎发育过程中组蛋白H3K4me3修饰长度变化的调控机制及其作用,主持,25万元,2018.01-2020.12,国自然青年项目(国家级)31701262,结题。
1, Ruimin Xu1, Qianshu Zhu 1, Yuyan Zhao, Mo Chen, Lingyue Yang, Shijun Shen, Guang Yang, Zhifei Shi, Xiaochen Kou, Yanhong Zhao, Hong Wang, Cizhong Jiang*, Chong Li*, Sharong Gao*, Xiaoyu Liu*. (2023). Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos. Nature communications, 14(1), 4807
2,Xiaolei Zhang1, Ruimin Xu1, Yuyan Zhao, Yijia Yang, Qi Shi, Hong Wang, Xiaoyu Liu*, Shaorong Gao*, Chong Li*, Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA, Protein & Cell, 2025;, pwaf010
3,Ruimin Xu1, Sen Li1, Qiu Wu1, Chong Li1, Manxi Jiang1, Lei Guo, Mo Chen, Lingyue Yang, Xin Dong, Hong Wang, Chenfei Wang*, Xiaoyu Liu*, Xianghong Ou*, Shaorong Gao*. Stage-specific H3K9me3 allocations ensure retrotransposon silencing in human preimplantation embryos. Cell Stem Cell, 2022.
4, Chenfei Wang1, Chuan Chen1, Xiaoyu Liu1, Chong Li1, Qiu Wu, Xiaolan Chen, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yawei Gao*, Yong Zhang*, Shaorong Gao*.Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation. Cell Research, 2022
5, Lingyue Yang1, Xiaocui Xu1, Ruimin Xu, Chuan Chen, Xiaolei Zhang, Mo Chen, Xiaochen Kou, Yanhong Zhao, Hong Wang, Xiaoyu Liu*, Shaorong Gao*, Chong Li*.Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq. Stem Cell Reports, 2022
6, Xu Rumin1, Li Chong1, Liu Xiaoyu*, Gao Shaorong*. Insights into epigenetic patterns in mammalian early embryos. Protein & Cell. 2021
7, Xiaolei Zhang, Shaorong Gao*, Xiaoyu Liu*, "Advance in the Role of Epigenetic Reprogramming in Somatic Cell Nuclear Transfer-Mediated Embryonic Development", Stem Cells International, vol. 2021,
8,Chen, Mo1; Zhu, Qianshu1; Li, Chong1; Kou, Xiaochen; Zhao, Yanhong; Li, Yanhe; Xu, Ruimin; Yang, Lei; Yang, Lingyue; Gu, Liang; Wang, Hong; Liu, Xiaoyu*; Jiang, Cizhong*; Gao, Shaorong*; Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos, Nature Communications,2020.
9, Tiegang Meng1, Qian Zhou1, Xueshan Ma1, Xiaoyu Liu1, Qingren Meng, Xianju Huang, Honglin Liu, Wenlong Lei , Zhenghui Zhao, Yingchun Ouyang, Yi Hou, Heide Schatten, Xianghong Ou*, Zhenbo Wang *, Shaorong Gao* & Qingyuan Sun *.PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome. Nature Communications, 2020
10,Chenfei Wang1, Xiaoyu Liu1, Yawei Gao*1, Lei Yang1, Chong Li, Wenqiang Liu, Chuan Chen, Xiaochen Kou, Yanhong Zhao, Jiayu Chen, Yixuan Wang, Rongrong Le, Hong Wang, Tao Duan, Yong Zhang*, Shaorong Gao*. Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development. Nature Cell Biology,2018,20(5):620-631 (co-first author)
11, Yawei Gao1, Xiaoyu Liu1, Bin Tang1, Chong Li1, Zhaohui Kou, Lin Li, Wenqiang Liu, You Wu, Xiaochen Kou, Jingyi Li, Yanhong Zhao, Jiqing Yin, Hong Wang, She Chen, Lujian Liao*, Shaorong Gao*. Protein expression landscape of mouse embryos during pre-implantation development. Cell Reports, 2017, 21(13):3957-3969 (co-first author)
12,Xiaoyu Liu1, Chenfei Wang1, Wenqiang Liu1, Jingyi Li1, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang*, Yawei Gao*, Shaorong Gao*. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature, 2016. 537: p.558-562.
13,Wenqiang Liu1, Xiaoyu Liu1, Chenfei Wang1, Yawei Gao1*, Rui Gao, Xiaochen Kou, Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Wei Liu, Tao Cai, Hong Wang, Yong Zhang*, Shaorong Gao*. Identification of key factors releasing cloned embryo arrests by combining embyo biopsy and single-cell sequencing. Cell Discovery, (2016) 2, 16010; doi:10.1038/celldisc.2016.10. (co-first author)

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