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魏珂,同济大学生命科学与技术学院教授,附属东方医院再生医学研究所特聘研究员。本科毕业于清华大学生物科学与技术系,于美国加利福尼亚大学洛杉矶分校分子细胞综合生理专业获得博士学位,后在美国桑福德伯纳姆普利贝司医学研究所进行博士后科学研究。入选国家海外高层次人才青年项目,主持并参与多项国家自然科学基金项目及科技部重点研发项目。主要研究方向为心脏发育与再生,通过高内涵筛选发现了影响心肌细胞增殖的旁分泌分子,miRNA以及小分子抑制剂;发现了心肌细胞成熟过程的新颖分子机制,为开发创新性针对心肌细胞再生的药物提供了新的方向。发表SCI论文30余篇,其中以第一作者及通讯作者发表包括Nature, Circulation, Cell Research, Cardiovasc Res, Protein & Cell在内的论文16篇,并获得两项美国专利授权。

Dandan Zhang#, Yansong Tang#, Wen Ye#, Danli Yang, ShengtangQin, Juntao Liu, Nan Su, Rongrong Huang, Guangzheng Shi, Dachun Xu, XiaochenKou, Yanhong Zhao, Hong Wang, Shaorong Gao*, Ke Wei*, Lan Kang*, “Pkm1is required for embryonic cardiomyocyte proliferation through energeticregulation of NFYa stability” (2025) National Science Review https://doi.org/10.1093/nsr/nwaf408
Kuisheng Liu#, Zihui Yan#, Dandan Bai#, Rui Jiang#, Yan Bi#,Xiangjun Ma#, Jiani Xiang, Yifan Sheng, Baoxing Dong, Zhiyuan Ning, Shanru Yi,Yingdong Liu, Xinyi Lei, Yanping Jia, Yan Zhang, Yalin Zhang, Yanhe Li, Tao Wu,Chenxiang Xi, Shanyao Liu, Shuyi Liu, Jiayu Chen, Jiqing Yin, Xiaochen Kou,Yanhong Zhao, Hong Wang, Yixuan Wang*, Ke Wei*, Shaorong Gao*, WenqiangLiu*, “Modeling post-gastrula development via bidirectional pluripotent stemcells” (2025) Cell Research doi.org/10.1038/s41422-025-01172-x
Rui Jiang, Jiayu Chen, Lijuan Pei, Shiqi Huang, MengyingFeng, Zhaohui Ouyang, Min Yuan, Yalin Zhu, Su Yao, Fenglian He, Hongjie Zhang,Xin Dong, Peng Xie*, Ke Wei*, “Myosin inhibition enhances cardiomyocytecell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification” (2025) European Journal of Cell Biology 104(3):151504
Jingjing He#, Yi Yang#, Rui Jiang#, Yanying Zheng#, XianfaYang, Xu Jiang, Xin Xue, Zhongzhou Yang, Naihe Jing, Hailong Cao*, Zhuojuan Luo*, Ke Wei*, PengXie*, Chengqi Lin* “Integration of single-cell andspatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiacprogenitors” (2025) Genome Biology 26(1):158
Yan Bi#*, JindianHu#, Tao Wu#, Zhaohui Ouyang, Tan Lin, Jiaxing Sun, Xinbao Zhang, Xiaoyu Xu,Hong Wang, Ke Wei, Shaorong Gao*,Yixuan Wang* “Optimized derivationand culture system of human naïve pluripotent stem cells with enhanced DNAmethylation status and genomic stability” (2025) Protein & Cell pwaf053,https://doi.org/10.1093/procel/pwaf053
Peng Xie, Xu Jiang, Jingjing He, Qingyun Pan, Xianfa Yang, YanyingZheng, Wenli Fan, Chen Wu, Weiheng Zheng, Ke Fang, Shuhan Si, Shiqi Zhu, YiYang, Tao P Zhong, Zhongzhou Yang, KeWei, Wei Xie, Naihe Jing*, ZhuojuanLuo*, Chengqi Lin* “Epigenetic delineation of theearliest cardiac lineage segregation by single-cell multi-omics” (2024) eLife
Rui Jiang, Lijuan Pei, Hongjie Zhang, Fenglian He, Yuhan Min,Xinhang Li, Ke Wei* “miR-199a-3p suppresses Vldlr expressionto promote cardiomyocyte proliferation” (2024) Acta Biochimica et Biophysica Sinica doi: 10.3724/abbs.2024240
Yihang Zhou#, Jihong Zheng#, Wenqi Song#, Xinyi Yan, Li Du,Zhonglin Ma, Yanbin Fu, Zhaohui Ouyang, Yuchen Xiao, Zhuoqun Liu, Feng Tian,Jason Wing Hon Wong, Jen Hao David Shih, Shikang Liang, Honglei Tian, Liu Liu, Ke Wei*, Chao Zhang*, Jiangtao Li*, XiaozhuWang* “OUTPOST: A comprehensiveanalysis software for whole-metagenome shotgun sequencing incorporating groupstratification” (2024) iMetaOmics 2024:e29
Su Yao, Yalin Zhu, Fenglian He, Min Yuan, Rui Jiang, HongjieZhang, Yanbin Fu, Ke Wei* “JAKActivity Regulates Mesoderm Cell Fate by controlling MESP1 expression” (2024) European Journal of Cell Biology 103(4):151452
Miaomiao Chen#, Guoxiu Wu#, Yanli Lu#, Shiwen Sun, Zhao Yu,Xin Pan, Wenjian Chen, Hongyu Xu, Hua Qiu, Weizhi He, Xiuhua Li, Xicheng Wang,Yi Luo, Yuan Du, Jialing Wu, Ke Wei,Wencheng Zhang, Zhongmin Liu, Zhiying He* “A p21-ATD Mouse Model for Monitoringand Eliminating Senescent Cells and Its Application in Liver Regeneration postInjury” (2024) Molecular Therapy S1525-0016(24)00218-1
Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano*, Ke Wei* “Mitochondrial-to-nuclearcommunications through multiple routes regulate cardiomyocyte proliferation”(2024) Cell Regeneration 13(1), 2
Lijuan Pei#, ZhaohuiOuyang#, Hongjie Zhang, Shiqi Huang, Rui Jiang,Bilin Liu, Yansong Tang, Mengying Feng, Min Yuan, Haocun Wang, Su Yao, ShuyueShi, Zhao Yu, Dachun Xu, Guohua, Gong, Ke Wei* “Thrombospondin1 and Reelin act through Vldlr to regulate cardiac growth and repair” (2023) Basic Research in Cardiology 119(1):169-192
Yansong Tang, Mengying Feng, Dachun Xu, Ke Wei* “Response by Tang et al to Letter Regarding Article, “Jmjd4facilitates Pkm2 degradation in cardiomyocytes and is protective againstdilated cardiomyopathy”” (2023) Circulation 148 (24), 1980-1981
Yu Chen#, Shiqi Huang#, Zhen Cui, Xiaoxiang Sun, YansongTang, Hongjie Zhang, Zhixi Chen, Rui Jiang, Weina Zhang, Xue Li, Jiayu Chen,Baohua Liu, Ying Jiang, Ke Wei*,Zhiyong Mao* “Impaired end joining induces cardiac atrophy in aHutchinson–Gilford progeria mouse model” (2023) Proceedings of the National Academy of Sciences 120(47):e2309200120
Yansong Tang#, Mengying Feng#, Yang Su, Teng Ma, HongjieZhang, Hongchun Wu, Xiaoyu Wang, Shuyue Shi, Ying Zhang, Yawei Xu, Shijun Hu, Ke Wei*, Dachun Xu* “Jmjd4 facilitatesPkm2 degradation in cardiomyocytes and is protective against dilatedcardiomyopathy” (2023) Circulation 147(22):1684–1704
Shuangshuang Zhao#, Qiuping Xu#, Yanqin Cui#, Su Yao, SihuiJin, Qian Zhang, Zeyu Wen, Haihua Ruan, Xin Liang, Yanjie Chao, Sitang Gong,Philippe Sansonetti, Ke Wei*, HongTang*, Yaming Jiu* “Salmonella effectorSopB reorganizes cytoskeletal vimentin to maintain replication vacuoles forefficient infection” (2023) Nature Communications 14(1), 478
Jing Zhang#, Zhaohui Ouyang#, Limei Xia, Qi Wang, Feng Zheng,Kun Xu, Yuexian Xing, Ke Wei*,Shaolin Shi*, Chaojun Li*, Jingping Yang* “Dynamic chromatin landscape encodes programs for perinataltransition of cardiomyocytes” (2023) CellDeath Discovery 9(1), 11
王皓存,欧阳兆惠,魏珂* “心肌细胞的成熟及其转录调控” 中国细胞生物学学报 (2022) 44:8 1473–1483
Mengying Feng, YansongTang, Su Yao, Hongjie Zhang, Dachun Xu, KeWei* “PLK inhibitors identified by high content phenotypic screeningpromote maturation of human PSC-derived cardiomyocytes” (2022) Biochemical and Biophysical ResearchCommunications 620 (2022) 113-120
Hongjie Zhang#, Lijuan Pei#, Zhaohui Ouyang, Haocun Wang, XinChen, Kai Jiang, Shiqi Huang, Rui Jiang, Yaozu Xiang, Ke Wei* “AP-1activation mediates postnatal cardiomyocyte maturation” (2022) Cardiovascular Research 119(2), 536-550
Lijuan Pei, Hongjie Zhang, Meihui Zhang, Yixuan Wang*, Ke Wei* “Rcor2 Is Required for SomaticDifferentiation and Represses Germline Cell Fate” (2022) Stem Cells International 2022:5283615
Jianyong Du#, Lixia Zheng#, Peng Gao, Hang Yang, Wan-JieYang, Fusheng Guo, Ruqi Liang, Mengying Feng, Zihao Wang, Zongwang Zhang, LinluBai, Ye Bu, Shijia Xing, Wen Zheng, Xuelian Wang, Li Quan, Xinli Hu, Haosen Wu,Zhixing Chen, Liangyi Chen, Ke Wei,Zhe Zhang, Xiaojun Zhu, Xiaolin Zhang, Qiang Tu, Shi-Min Zhao*, Xiaoguang Lei*, Jing-Wei Xiong* “A small-molecule cocktail promotes mammaliancardiomyocyte proliferation and heart regeneration” (2022) Cell Stem Cell 29 (4), 545-558. e13
Zhaohui Ouyang, Ke Wei* “miRNA incardiac development and regeneration” (2021) Cell Regeneration 10 (1):1-21
Zhaohui Ouyang#, Shuangshuang Zhao#, SuYao#, Jing Wang, Yanqin Cui, Ke Wei*, Yaming Jiu* “Multifaceted Functionof Myosin-18, an Unconventional Class of the Myosin Superfamily” (2021) Frontiersin Cell and Developmental Biology 9;9:632445
Lei Gao#, Hongjie Zhang#, Jingyi Cui,Lijuan Pei, Shiqi Huang, Yaning Mao, Zhongmin Liu*, Ke Wei*, HongmingZhu* “Single-cell transcriptomics of cardiac progenitors reveals functionalsubpopulations and their cooperative crosstalk in cardiac repair” (2021) Protein& Cell 12(2):152-157
Weina Zhang, Yu Chen, Jiaqing Yang, JingZhang, Jiayu Yu, Mengting Wang, Xiaodong Zhao, Ke Wei, Xiaoping Wan,Xiaojun Xu, Ying Jiang, Jiayu Chen, Shaorong Gao, Zhiyong Mao* “Ahigh-throughput small molecule screen identifies farrerol as a potentiator ofCRISPR/Cas9-mediated genome editing” (2020) Elife e56008
Ying Tao, Hongjie Zhang, Shiqi Huang, Lijuan Pei, MengyingFeng, Xiaodong Zhao, Zhaohui Ouyang, Su Yao, Rui Jiang, Ke Wei* “miR-199a-3p PromotesCardiomyocyte Proliferation by Inhibiting Cd151Expression” (2019) Biochemical and Biophysical Research Communications 516(1):28-36
Ke Wei#, Vahid Serpooshan#, Cecilia Hurtado, Marta Diez-Cuñado, MingmingZhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, KazutoNakamura, Xueying Tian, Qiaozhen Liu, Andrew Wang, Yuka Matsuura, Paul Bushway,Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J.B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou,Daniel Bernstein, Mark Mercola & Pilar Ruiz-Lozano* “Epicardial FSTL1 Reconstitution Regenerates the Adult Mammalian Heart”(2015) Nature 525(7570): 479-485
Marta Diez-Cuñado, Ke Wei,Paul J Bushway, Mano R Maurya, Ranjan Perera, Shankar Subramaniam, PilarRuiz-Lozano, Mark Mercola* “miRNAs that Induce Human CardiomyocyteProliferation Converge on the Hippo Pathway” (2018) Cell Reports 23/7 2168-2174
Rosana Crespo, Ke Wei,Boris Rodenak-kladniew, Mark Mercola, Pilar Ruiz-Lozano, Cecilia Hurtado* “Effectof geraniol on rat cardiomyocytes and its potential use as a cardioprotectivenatural compound” (2017) Life Sciences172, 8-12
Ke Wei#,Ramon Díaz-Trelles#, Qiaozhen Liu, Marta Diez-Cuñado, Maria-CeciliaScimia, Wenqing Cai, Junko Sawada, Masanobu Komatsu, Joseph J. Boyle, Bin Zhou,Pilar Ruiz-Lozano*, and Mark Mercola* “Developmental origin of age-relatedcoronary artery disease” (2015) CardiovascularResearch 107 (2): 287-294
VahidSerpooshan, Morteza Mahmoudi, Mingming Zhao, Ke Wei, Senthilkumar Sivanesan, Khatereh Motamedchaboki, Andrey V.Malkovskiy, Andrew.B. Gladstone, Jeffrey Cohen, Phillip C. Yang, JayakumarRajadas, Daniel Bernstein, Y. Joseph Woo, Pilar Ruiz-Lozano* “Protein coronainfluences cell-biomaterial interactions in nanostructured tissue engineeringscaffolds.” (2015) Advanced FunctionalMaterials 25 (28): 4379-4389
VahidSerpooshan, Mingming Zhao, Scott A Metzler, Ke Wei, Parisha B Shah, Andrew Wang, Morteza Mahmoudi, Andrey VMalkovskiy, Jayakumar Rajadas, Manish J Butte, Daniel Bernstein, PilarRuiz-Lozano* (2014) “Use of bio-mimetic three-dimensional technology intherapeutics for heart disease” Bioengineered5:3, 193-197
WenqingCai, Sonia Albini, Ke Wei, ErikWillems, Rosa M Guzzo, Masanao Tsuda, Lorenzo Giordani, Sean Spiering, LeoKurian, Gene W Yeo, Pier Lorenzo Puri, Mark Mercola* (2013) “Coordinate Nodaland BMP inhibition directs Baf60c-dependent cardiomyocyte commitment” Genes & Development 27(21):2332-44
Vahid Serpooshan, Mingming Zhao, Scott AMetzler, Ke Wei, Parisha B Shah,Andrew Wang, Morteza Mahmoudi, Andrey V Malkovskiy, Jayakumar Rajadas, Manish JButte, Daniel Bernstein, Pilar Ruiz-Lozano* (2013) “The effect of bioengineeredacellular collagen patch on cardiac remodeling and ventricular function postmyocardial infarction” Biomaterials 34(36):9048-55
Wenqing Cai,Rosa M. Guzzo, Ke Wei, Erik Willems,Herman Davidovics and Mark Mercola* (2012) “A Nodal to TGFβ Cascade ExertsBiphasic Control Over Cardiopoiesis” CirculationResearch 111: 876-881
MariaCecilia Scimia, Cecilia Hurtado, Saugata Ray, Scott Metzler, Ke Wei, Jianming Wang, Chris E. Woods,Nicole H. Purcell, Daniele Catalucci, Takeshi Akasaka, Orlando F. Bueno, GeorgeP. Vlasuk, Perla Kaliman, Rolf Bodmer, Layton H. Smith, Euan Ashley, MarkMercola, Joan Heller Brown & Pilar Ruiz-Lozano* (2012) “APJ acts as a dual receptor in cardiac hypertrophy”. Nature488: 394–398
RobertaNoberini, Sayantan Mitra, Ombretta Salvucci, Fatima Valencia, SrinivasDuggineni, Natalie Prigozhina, Ke Wei,Giovanna Tosato, Ziwei Huang, and Elena B. Pasquale* (2011) “PEGylationPotentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4Receptor with Nanomolar Affinity” PlosOne 6(12): e28611
Natalie L.Prigozhina, Andrew Heisel, Ke Wei,Roberta Noberini, Edward A. Hunter, Diego Calzolari, Jordan R. Seldeen, ElenaB. Pasquale, Pilar Ruiz-Lozano, Mark Mercola and Jeffrey H. Price* (2011)“Characterization of a novel angiogenic model based on stable, fluorescentlylabeled endothelial cell lines amenable to scale-up for high content screening”Biology of the Cell 103(10): 467-81
Minqi Hao, Kevan Akrami, Ke Wei, Carlos De Diego, Nam Che, Jeong-Hee Ku, James Tidball,Michael C. Graves, Perry B. Shieh, Fabian Chen* (2008) “Muscleblind-like 2(Mbnl2) -deficient mice as a model for myotonic dystrophy” Developmental Dynamics 237(2): 403-10.
Ke Wei, JiyuanChen, Kevan Akrami, Gary C. Galbraith, Ivan A. Lopez, and Fabian Chen (2007) “NeuralCrest Cell Deficiency of c-myc Causes Skull and Hearing Defects” Genesis 45(6): 382-390
Ke Wei, Jiyuan Chen, Kevan Akrami, and Fabian Chen* (2007)“Generation of mice deficient for Lbx2,a gene expressed in the urogenital system, nervous system and Pax3 dependent tissues” Genesis 45(6): 361-368
Ke Wei, Nam Che, and Fabian Chen* (2007). “Myocardin-related transcription factor B is required for normalmouse vascular development and smooth muscle gene expression” Developmental Dynamics 236(2): 416-425.
Xiao-Nan Dong, Ke Wei,Zu-Qiang Liu, and Ying-Hua Chen* (2002). “Candidate peptide vaccine inducedprotection against classical swine fever virus” Vaccine 21(3-4): 167-173.

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