承担国家级人才项目1项

主持国家国家级项目5项

作为组长和骨干参与国家重点研发项目各1项

1. 原始生殖细胞及早期胚胎发育的调控机制

2. 体细胞重编程（克隆及诱导多能干细胞）的重塑机制

3. 人胎盘发育、母胎互作及妊娠相关疾病研究

4. 基于CRISPR/Cas9基因编辑技术的疾病模型构建与研究

1. 2020年度国家自然科学奖二等奖

2. 2022年度北京市自然科学奖一等奖

3. 2019年度教育部自然科学奖一等奖

4. 2023年度上海市五四奖章集体

5. 2022年“全国高校黄大年式教师团队”成员

6. 2022年同济大学“学生心目中的好导师”

7. 2022年同济大学“青年五四奖章”

8. 2020年同济大学育才教育奖励金优秀教师奖

1.     Mengting Wang#, Liping Wang#, Qingqing Cai#, Yanxin Huang, ShanruYi, Heng Pan, Wenqiang Liu, Hong Wang, Hongjie Yao*, Cizhong Jiang*, ShaorongGao*, Jiayu Chen*. DDX5 orchestrates RNA homeostasis to ensure oocytedevelopmental competence. Nature Communications. 2026 Mar 11.doi: 10.1038/s41467-026-70237-1

2.     Zhang Weiyi#, Le Chunyan#, Yi Shanru#, Liu Wenqiang, Liu Xiaoyu, YinZhen, Wang Hong, Gao Rui*, Gao Shaorong*, Chen Jiayu*. Single-cellAnalysis Reveals Essential lncRNAs Regulating Human Trophoblast LineageDifferentiation. Life Medicine. 2026 DOI:10.1093/lifemedi/lnag010

3.     Li J#, Lu J#, Chen J#, Fu Q, Jiang Z, Gao S*, Tang F*.Multi-omics analysis reveals single-cell meiotic hotspot dynamics andepigenomic regulations in female mammals. Cell Reports. 2025 Jul29;44(8):116082. doi: 10.1016/j.celrep.2025.116082. Online ahead of print.PMID: 40737127 Free article.

4.     Fang J#, Gao Y#, Kang Y#, Li Y, Chen Q*, Chen J*, ZhangP*.Generation and characterization of a pluripotent stem cell line CIPi005-Aderived from a female patient carrying non-canonical splice site c.827 + 1G> A in WDR45. Stem Cell Res. 2025 Apr;84:103686. doi:10.1016/j.scr.2025.103686. Epub 2025 Feb 15.

5.    Kang Y, Liang S*, Gao S*, ChenJ*. Generation of a hiPSC line (TONGJIi001-A) from a 46,XX,ins(1;15)(p13.3;q22.31q26.1),inv(2)(p22.1p16.3),t(2;14)(q34;q12) infertility patient. StemCell Res. 2024 Dec;81:103561. doi: 10.1016/j.scr.2024.103561.

6.    Gao R#*, Yang G#, Wang M#,Xiao J#, Yi S, Huang Y, Guo Z, Kang Y, Fu Q, Wang M, Xu B, Shen S, Zhu Q, LiuM, Wang L, Cui X, Yi S, Kou X, Zhao Y, Gu L, Wang H, Gao S*, Jiang C*, ChenJ*. Defining a TFAP2C-centered transcription factornetwork during murine peri-implantation. Developmental Cell.2024 Apr 1:S1534-5807(24)00185-0. doi:10.1016/j.devcel.2024.03.015.

7.     Wang M#, Wang L#, Huang Y#, Qiao Z, Yi S, Zhang W, Wang J, Yang G,Cui X, Kou X, Zhao Y, Wang H, Jiang C*, Gao S*, Chen J*. Lossof Tet hydroxymethylase activity causes mouse embryonic stem celldifferentiation bias and developmental defects. SCIENCECHINA Life Sciences.2024 Oct;67(10):2132-2148. doi: 10.1007/s11427-024-2631-x

8.    Shen S#, Wang M#, Li X#,Wang B#, Hong W#, Li W, Xu B, Guo Z, Han R, Yi S, Wu Z, He X, Wang L, Zhu Q,Yang G, Wang H, Deng Q, Chen J*（lead contact）, Gao S*, Jiang C*, Gao R*. The gonadal niche safeguards human fetal germline celldevelopment following maternal SARS-CoV-2 infection. Cell ReportsMedicine. 2024 May 21;5(5):101515. doi: 10.1016/j.xcrm.2024.101515.

9.    Wang L#, Yi S#, Cui X#, GuoZ, Wang M, Kou X, Zhao Y, Wang H, Jiang C, Gao S*, Yang G*, Chen J*, GaoR*. Chromatin landscape instructs precise transcriptionfactor regulome during embryonic lineage specification. Cell Reports.2024 Apr 20;43(5):114136. doi: 10.1016/j.celrep.2024.114136.

10.  Yi S#, Wang L#, Wang M#, Hong W#, Xu B#, He X, Yang M, Wu Z, Wang B,Yang G, Shen S, Cui X, Wang R, Wang K, Wang H, Li X*, Gao S*, Jiang C*, ChenJ*. Effect of SARS-CoV-2 infection in earlypregnancy on placental development. SCIENCE CHINA Life Sciences.2024 Mar;67(3):622-625. doi: 10.1007/s11427-023-2437-x.

11.  Gao R#, Zeng S#, Yang D#, Li X#, Liu W, Gao Y, Bai D, Zhang L, ChenC, Kang Y, Wang B, Hong W, Wang M, Yin J, Wang H, Deng Q, Gao S*, Zhang Y*, ChenJ*. Resetting histone modifications during human prenatal germlinedevelopment. Cell Discovery. 2023 Feb 3;9(1):14. doi:10.1038/s41421-023-00519-1.

12.  Wang M#, Zhao K#, Liu M#, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, ZhaoY, Yin J, Li T, Wang H, Jiang C*, Gao S*, ChenJ*. BMP4 preserves the developmental potential of mESCs through Ube2s- andChmp4b-mediated chromosomal stability safeguarding. Protein Cell. 2022Aug;13(8):580-601. doi: 10.1007/s13238-021-00896-x. （封面）

13.  Zhao K#, Wang M#, Gao S*, ChenJ*. Chromatin architecture reorganization during somatic cellreprogramming. Current Opinion in Genetics & Development. 2021 Oct70:104-113. https://doi.org/10.1016/j.gde.2021.07.006

14.  Yang G#, Zhang L#, Liu W#, Qiao Z, Shen S, Zhu Q, Gao R, Wang M,Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, LiangZ, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S*, Chen J*, Jiang C*.Dux-mediated corrections of aberrant H3K9ac during 2-cell genome activationoptimized efficiency of somatic cell nuclear transfer. Cell Stem Cell.2021 Oct 5:S1934-5909(20)30452-5. doi: 10.1016/j.stem.2020.09.006.

15.  Zhang W#, Chen Y#, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, WanX, Xu X, Jiang Y, Chen J*, Gao S*, Mao Z*. A high-throughput smallmolecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediatedgenome editing. Elife. 2020 Jul 9;9:e56008. doi:10.7554/eLife.56008.

16.  Chen Y#, Chen J#, Sun X#, Yu J, Qian Z, Wu L, Xu X, Wan X,Jiang Y, Zhang J*, Gao S*, Mao Z*. The SIRT6 activator MDL-800 improves genomicstability and pluripotency of old murine-derived iPS cells. Aging Cell. 2020Aug;19(8):e13185. doi: 10.1111/acel.13185.

17.  He W#, Chen J#*, Gao S*. Mammalianhaploid stem cells: establishment, engineering and applications. CellMol Life Sci. 2019Jun;76(12):2349-2367. doi: 10.1007/s00018-019-03069-6. (#co-firstauthors, *Co-correspondence)

18.  Gao H#, Gao R#, Zhang L#, Xiu W, Zang R, Wang H, Zhang Y, Chen J*, Gao Y*, Gao S*. Esrrb plays important roles in maintainingself-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cellsto induced TSCs. Journal of Molecular Cell Biology. 2019 Jun 1;11(6):463-473. doi:10.1093/jmcb/mjy054. (*Co-correspondence)

19.  Li Y#, Zhang Z#, Chen J#,Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y,Zhang P, Fan G, Wong J, Xu G, Wang Z, Wang H, Gao S, Zhu B*. Stella safeguardsthe oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature.2018 Dec;564(7734):136-140. doi: 10.1038/s41586-018-0751-5. (#co-firstauthors)

20.  Li J#, Shen S#, Chen J#,Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, JiangC*, Gao S*. Accurate annotation of accessible chromatin in mouse and humanprimordial germ cells. Cell Research. 2018Nov;28(11):1077-1089. doi: 10.1038/s41422-018-0096-5. (#co-first authors)

21.  He W#, Zhang X#, Zhang Y, Zheng W, Xiong Z, Hu X, Wang M, Zhang L,Zhao K, Qiao Z, Lai W, Lv C, Kou X, Zhao Y, Yin J, Liu W, Jiang Y, Chen M, XuR, Le R, Li C, Wang H, Wan X, Wang H, Han Z, Jiang C*, Gao S*, Chen J*. Reduced Self-Diploidization and Improved Survival ofSemi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cellsthrough Overexpression of Dnmt3b. Stem Cell Reports. 2018 Feb13;10(2):477-493. doi: 10.1016/j.stemcr.2017.12.024. (*Co-correspondence)

22.  Liu W#, Bai D#, Chen J*,Gao S*. Additive-effect pattern of both ZP2 and ZP3 in human and mouse. HumGenet. 2017Nov;136(11-12):1493-1495. doi: 10.1007/s00439-017-1848-x. (*Co-correspondence)

23.  Liu W#, Li K#, Bai D#, Yin J#, Tang Y, Chi F, Zhang L, Wang Y, PanJ, Liang S, Guo Y, Ruan J, Kou X, Zhao Y, Wang H, Chen J*, Teng X*, Gao S*. Dosage effects of ZP2 and ZP3heterozygous mutations cause human infertility. Hum Genet. 2017Aug;136(8):975-985. doi: 10.1007/s00439-017-1822-7. (*Co-correspondence)

24.  Gao R#, Xiu W#, Zhang L, Zang R, Yang L, Wang C, Wang M, Wang M, YiL, Tang Y, Gao Y, Wang H, Xi J, Liu W, Wang Y, Wen X, Yu Y, Zhang Y, Chen L*, Chen J*, Gao S*. Direct induction ofneural progenitor cells transiently passes through a partially reprogrammedstate. Biomaterials. 2017 Mar;119:53-67. doi:10.1016/j.biomaterials.2016.12.007. (*Co-correspondence)

25.  Xu K#, Chen X#, Yang H, Xu Y, He Y, Wang C, Huang H, Liu B, Liu W,Li J, Kou X, Zhao Y, Zhao K, Zhang L, Hou Z, Wang H, Wang H, Li J, Fan H, WangF, Gao Y, Zhang Y, Chen J*, Gao S*.Maternal Sall4 Is Indispensable for Epigenetic Maturation of Mouse Oocytes. JBiol Chem. 2017 Feb 3;292(5):1798-1807. doi: 10.1074/jbc.M116.767061.(*Co-correspondence)

26.  Chen J#*, Gao Y#, Huang H, Xu K, Chen X, Jiang Y, Li H, Gao S, Tao Y, WangH, Zhang Y, Wang H, Cai T, Gao S*. The combination of Tet1 with Oct4generates high-quality mouse induced pluripotent stem cells (iPSCs).Stem Cells. 2015 Mar;33(3):686-98. doi:10.1002/stem.1879. (#co-first authors, *Co-correspondence)

27.  Liu X#,Chen J#,Liu W,Li X,Chen Q,Liu T,Gao S*,Deng M*.The fused in sarcoma protein forms cytoplasmic aggregates in motor neuronsderived from integration-free induced pluripotent stem cells generated from apatient with familial amyotrophic lateral sclerosis carrying the FUS-P525Lmutation. Neurogenetics. 2015 Jul;16(3):223-31.doi: 10.1007/s10048-015-0448-y. (#co-first authors)

28.  Gao Y#, Chen J#, Li K, WuT, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z,Kang L, Chen J, Wang H, Cai T and Gao S. Replacement of Oct4 by Tet1 duringiPSC induction reveals an important role of DNA methylation andhydroxymethylation in reprogramming. Cell Stem Cell, 2013 Apr4;12(4):453-69. doi: 10.1016/j.stem.2013.02.005. (Cover Story; Previewed by Cell Stem Cell; Selected as Best of 2013 byCell Stem Cell) (#co-first authors)