1、G蛋白偶联受体（GPCR）在重大疾病中的作用机制研究及新药开发；

2、小分子药物调控细胞命运

代表性论文

（1）     Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, JunyanWang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, JinpengSun, Jie Zheng, Suwen Zhao, Fei Xu. Cryo-EM structures of orphan GPR21signaling complexes. NATURE COMMUNICATIONS. 2023, 14(1): 1-12.

（2）     Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang,Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie. Small molecule drugspromote repopulation of transplanted hepatocytes by stimulating celldedifferentiation. JHEP REPORTS[J]. 2023, 5(4): 100670-.

（3）     Guo, Ren, Jia, Xiaohui, Ding, Zhenbin, Wang, Gang, Jiang,Mengmeng, Li, Bing, Chen, Shanshan, Xia, Bingqing, Zhang, Qing, Liu, Jian,Zheng, Ruting, Gao, Zhaobing, Xie, Xin. Loss of MLKL amelioratesliver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cellactivation. THERANOSTICS[J]. 2022, 12(11): 5220-5236,

（4）     Zhang, Qing, Chen, Linhai, Yang, Hui, Fang, Youchen,Wang, Siwei, Wang, Min, Yuan, Qianting, Wu, Wei, Zhang, Yangming, Liu, Zhanju,Nan, Fajun, Xie, Xin. GPR84 signaling promotes intestinal mucosal inflammationvia enhancing NLRP3 inflammasome activation in macrophages. ACTAPHARMACOLOGICA SINICA[J]. 2022, 43(8): 2042-2054.

（5）     Guo, Ren, Jiang, Mengmeng, Wang, Gang, Li, Bing, Jia,Xiaohui, Ai, Yan, Chen, Shanshan, Tang, Peilan, Liu, Aijie, Yuan, Qianting, Xie,Xin. IL6 supports long-term expansion of hepatocytes in vitro. NATURECOMMUNICATIONS[J]. 2022, 13(1):http://dx.doi.org/10.1038/s41467-022-35167-8.

（6）     Youwen Zhuang, Yue Wang, Bingqing He, Xinheng He, XEdward Zhou, Shimeng Guo, Qidi Rao, Jiaqi Yang, Jinyu Liu, Qingtong Zhou,Xiaoxi Wang, Mingliang Liu, Weiyi Liu, Xiangrui Jiang, Dehua Yang, HualiangJiang, Jingshan Shen, Karsten Melcher, Hong Chen, Yi Jiang, Xi Cheng, MingWeiWang, Xin Xie, H Eric Xu. Molecular recognition of morphine and fentanylby the human μ-opioid receptor. CELL[J]. 2022, 185(23):4361-4375.e19.

（7）     Duan, Jia, Shen, DanDan, Zhao, Tingting, Guo, Shimeng,He, Xinheng, Yin, Wanchao, Xu, Peiyu, Ji, Yujie, Chen, LiNan, Liu, Jinyu,Zhang, Huibing, Liu, Qiufeng, Shi, Yi, Cheng, Xi, Jiang, Hualiang, Xu, H Eric, Zhang,Yan, Xie, Xin, Jiang, Yi. Molecular basis for allosteric agonism and Gprotein subtype selectivity of galanin receptors. NATURE COMMUNICATIONS[J].2022, 13(1)

（8）     Xu, Peiyu, Huang, Sijie, Guo, Shimeng, Yun, Ying, Cheng,Xi, He, Xinheng, Cai, Pengjun, Lan, Yuan, Zhou, Hu, Jiang, Hualiang, Jiang, Yi,Xie, Xin, Xu, H Eric. Structural identification oflysophosphatidylcholines as activating ligands for orphan receptor GPR119. NATURESTRUCTURAL & MOLECULAR BIOLOGY[J]. 2022, 29(9): 863-

（9）     Cai, Hongmin, Xu, Youwei, Guo, Shimeng, He, Xinheng, Sun,Jun, Li, Xin, Li, Changyao, Yin, Wanchao, Cheng, Xi, Jiang, Hualiang, Xu, HEric, Xie, Xin, Jiang, Yi. Structures of adenosine receptor A(2B)R boundto endogenous and synthetic agonists. CELL DISCOVERY. 2022, 8(1)

（10）  Ji, Sijia, Tu, Wanzhi, Huang, Chenwen, Chen, Ziyang, Ren,Xinyue, He, Bingqing, Ding, Xiaoyan, Chen, Yuelei, Xie, Xin. TheAurora Kinase Inhibitor CYC116 Promotes the Maturation of CardiomyocytesDerived from Human Pluripotent Stem Cells. MOLECULES AND CELLS[J].2022, 45(12): 923-934.

（11）  Suo, Na, He, Bingqing, Cui, Shihao, Yang, Ying, Wang,Min, Yuan, Qianting, Xie, Xin. The orphan G protein-coupled receptorGPR149 is a negative regulator of myelination and remyelination. GLIA[J].2022, 70(10): 1992-2008.

（12）  Zeng, Peng, Hua, Qiuhong, Gong, Junyuan, Shi, Changjie,Pi, Xiaoping, Xie, Xin, Zhang, Ru. Neonatal cortical astrocytes possessintrinsic potential in neuronal conversion in defined media. ACTAPHARMACOLOGICA SINICA[J]. 2021, 42(11): 1757-1768.

（13）  Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu,Xinheng He, Jia Guo, Wanchao Yin, H Eric Xu, Xin Xie, Yi Jiang. Molecularrecognition of an acyl-peptide hormone and activation of ghrelin receptor. NATURECOMMUNICATIONS[J]. 2021, 12(1):

（14）  Yang, Fan, Mao, Chunyou, Guo, Lulu, Lin, Jingyu, Ming,Qianqian, Xiao, Peng, Wu, Xiang, Shen, Qingya, Guo, Shimeng, Shen, DanDan, Lu,Ruirui, Zhang, Linqi, Huang, Shenming, Ping, Yuqi, Zhang, Chenlu, Ma, Cheng,Zhang, Kai, Liang, Xiaoying, Shen, Yuemao, Nan, Fajun, Yi, Fan, Luca, VincentC, Zhou, Jiuyao, Jiang, Changtao, Sun, JinPeng, Xie, Xin, Yu, Xiao,Zhang, Yan. Structural basis of GPBAR activation and bile acid recognition. NATURE[J].2020, 587(7834): 499-+.

（15）  Lin, Xi, Li, Mingyue, Wang, Niandong, Wu, Yiran, Luo,Zhipu, Guo, Shimeng, Han, GyeWon, Li, Shaobai, Yue, Yang, Wei, Xiaohu, Xie,Xin, Chen, Yong, Zhao, Suwen, Wu, Jian, Lei, Ming, Xu, Fei. Structuralbasis of ligand recognition and self-activation of orphan GPR52. NATURE[J].2020, 579(7797): 152-+

（16）  Tu, Wanzhi, Fu, Yanbin, Xie, Xin. RepSox, a smallmolecule inhibitor of the TGF beta receptor, induces brown adipogenesis andbrowning of white adipocytes. ACTA PHARMACOLOGICA SINICA[J].2019, 40(12): 1523-1531.

（17）  Suo, Na, Guo, Yue, He, Bingqing, Gu, Haifeng, Xie, Xin.Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation andrecovery of demyelinating diseases. GLIA[J]. 2019, 67(7):1320-1332.

（18）  Cui Xue, Guo Yue, Fang Jiahui, Shi Changjie, Suo Na,Zhang Ru, Xie Xin. Donepezil, a drug for Alzheimer's disease, promotesoligodendrocyte generation and remyelination. ACTA PHARMACOLOGICA SINICA[J].2019, 40(11): 1386-1393, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888883/.

（19）  Tang Wei, Guo Ren, Shen Shijun, Zheng Yang, Lu Yuting,Jiang Mengmeng, Cui Xue, Jiang Cizhong, Xie Xin. Chemical cocktails enablehepatic reprogramming of human urine-derived cells with a single transcriptionfactor. ACTA PHARMACOLOGICA SINICA[J]. 2019, 40(5): 620-629.

（20）  Guo, Yue, Suo, Na, Cui, Xue, Yuan, Qianting, Xie, Xin.Vitamin C promotes oligodendrocytes generation and remyelination. GLIA[J].2018, 66(7): 1302-1316.

（21）  Huang, Chenwen, Tu, Wanzhi, Fu, Yanbin, Wang, Jinxi, Xie,Xin. Chemical-induced cardiac reprogramming in vivo. CELL RESEARCH[J].2018, 28(6): 686-689.

（22）  Fu, Yanbin, Huang, Chenwen, Xu, Xinxiu, Gu, Haifeng, Ye,Youqiong, Jiang, Cizhong, Qiu, Zilong, Xie, Xin. Direct reprogramming ofmouse fibroblasts into cardiomyocytes with chemical cocktails. CELLRESEARCH[J]. 2015, 25(9): 1013-1024.

（23）  Zhang, Shuyong, Ma, Yuyong, Li, Jing, Ma, Junjun, Yu,Biao, Xie, Xin. Molecular matchmaking between the popular weight-lossherb Hoodia gordonii and GPR119, a potential drug target for metabolicdisorder. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITEDSTATES OF AMERICA[J]. 2014, 111(40): 14571-14576.

（24）  Xu, Xinxiu, Wang, Quan, Long, Yuan, Zhang, Ru, Wei,Xiaoyuan, Xing, Mingzhe, Gu, Haifeng, Xie, Xin. Stress-mediated p38activation promotes somatic cell reprogramming. CELL RESEARCH[J].2013, 23(1): 131-141.

（25）  Wei, Wei, Du, Changsheng, Lv, Jie, Zhao, Guixian, Li,Zhenxin, Wu, Zhiying, Hasko, Gyoergy, Xie, Xin. Blocking A(2B) AdenosineReceptor Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitisvia Inhibition of IL-6 Production and Th17 Differentiation.JOURNALOFIMMUNOLOGY[J]. 2013, 190(1): 138-146.

（26）  [82] Du, Changsheng, Xie, Xin. G protein-coupledreceptors as therapeutic targets for multiple sclerosis. CELL RESEARCH[J].2012, 22(7): 1108-1128.

（27）  Wang, Quan, Xu, Xinxiu, Li, Jun, Liu, Jing, Gu, Haifeng,Zhang, Ru, Chen, Jiekai, Kuang, Yin, Fei, Jian, Jiang, Cong, Wang, Ping, Pei,Duanqing, Ding, Sheng, Xie, Xin. Lithium, an anti-psychotic drug,greatly enhances the generation of induced pluripotent stem cells. CELLRESEARCH[J]. 2011, 21(10): 1424-1435.