近5年主持科研项目6项（包含3项国自然基金）：

1、国家自然科学基金项目“牙髓感觉神经通过CGRP/Ramp1轴调控DPSCs定向迁移促牙髓损伤修复及机制研究”，48万。项目编号：82370950（2024-2027）

2、国家自然科学基金项目“牙髓基质细胞线粒体转移在消退素E1介导的牙髓炎症消退及损伤修复中的作用和机制研究”，55万。项目编号：82170945（2022-2025）

3、上海市申康医院发展中心2020年临床“五新”创新研发项目“人工智能牙体牙髓病诊疗辅助系统的研发和临床应用”，100万。项目编号：SHDC2020CR3058B（2021-2022）

4、上海市卫生健康委员会面上项目“基于CBCT实现患牙三维可视化与微创开髓设计的应用研究”，10万。项目编号：202040282 （2021-2023）

5、国家自然科学基金项目“牙周膜成纤维细胞外泌体递送的骨保护素对再植牙根吸收的保护作用及机制研究”，57万。项目编号：81870760 （2019-2022）

6、同济大学2019年重点领域学科交叉重大项目“沉浸式牙体牙髓病治疗临床模拟训练系统的研发”，60万。项目编号：22120190217（2019-2021）

近5年主持科研项目6项（包含3项国自然基金）：

1、国家自然科学基金项目“牙髓感觉神经通过CGRP/Ramp1轴调控DPSCs定向迁移促牙髓损伤修复及机制研究”，48万。项目编号：82370950（2024-2027）

2、国家自然科学基金项目“牙髓基质细胞线粒体转移在消退素E1介导的牙髓炎症消退及损伤修复中的作用和机制研究”，55万。项目编号：82170945（2022-2025）

3、上海市申康医院发展中心2020年临床“五新”创新研发项目“人工智能牙体牙髓病诊疗辅助系统的研发和临床应用”，100万。项目编号：SHDC2020CR3058B（2021-2022）

4、上海市卫生健康委员会面上项目“基于CBCT实现患牙三维可视化与微创开髓设计的应用研究”，10万。项目编号：202040282 （2021-2023）

5、国家自然科学基金项目“牙周膜成纤维细胞外泌体递送的骨保护素对再植牙根吸收的保护作用及机制研究”，57万。项目编号：81870760 （2019-2022）

6、同济大学2019年重点领域学科交叉重大项目“沉浸式牙体牙髓病治疗临床模拟训练系统的研发”，60万。项目编号：22120190217（2019-2021）

1.      Wang C, Liu X, Zhou J, Zhang X, Zhou Z, Zhang Q*. Sensory nerves drivemigration of dental pulp stem cells via the CGRP-Ramp1 axis in pulp repair.Cell Mol Life Sci. 2024 Aug 28;81(1):373. doi: 10.1007/s00018-024-05400-2.PMID: 39196292; PMCID: PMC11358583.

2.      Yufei Chen*, Xiaoyu Yang, Xiaodong Yue, XiangLin, Qi Zhang*, Hamido Fujita. Ageneral variation-driven network for medical image synthesis. Applied Intelligence(2024)54:3295–3307. Doi:10.1007/s10489-023-05017-1.

3.      Wang C, Liu X, Zhou J, Zhang Q*. The Role of Sensory Nerves inDental Pulp Homeostasis: Histological Changes and Cellular Consequences afterSensory Denervation. Int J Mol Sci. 2024 Jan 17;25(2):1126. doi:10.3390/ijms25021126. PMID: 38256202; PMCID: PMC10815945.

4.      Zhang X, Wang C, Zhou Z, Zhang Q*. The mitochondrial-endoplasmicreticulum co-transfer in dental pulp stromal cell promotes pulp injury repair.Cell Prolif. 2024 Jan;57(1):e13530. doi: 10.1111/cpr.13530. Epub 2023 Jul 26.PMID: 37493094; PMCID: PMC10771100.

5.      Tao S, Yang T, Yin Y, Zhang Q*. Mitochondrial reactive oxygen species promotemitochondrial damage in high glucose-induced dysfunction and apoptosis of humandental pulp cells. J Dent Sci. 2024 Jan;19(1):292-302. doi:10.1016/j.jds.2023.04.008. Epub 2023 Apr 21. PMID: 38303803; PMCID:PMC10829553.

6.      Tao S, Yang T, Zhou JN, Zhang Q*. Impaired pulp healingassociated with underlying disorders in the dental pulp of rats with type 2diabetes. J Dent Sci. 2024 Jan;19(1):310-320. doi: 10.1016/j.jds.2023.03.021.Epub 2023 Apr 10. PMID: 38303798; PMCID: PMC10829554.

7.      Liu X, Wang C, Pang L, Pan L, Zhang Q*. Combination of resolvin E1and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF-κBactivation through upregulating sirtuin 7 in dental pulp fibroblasts. CellProlif. 2022 May;55(5):e13227. doi: 10.1111/cpr.13227. Epub 2022 Apr 11. PMID:35411569; PMCID: PMC9136498.

8.      Lin X, Fu Y, Ren G, Yang X, Duan W, ChenY*, Zhang Q*. Micro-ComputedTomography Guided Artificial Intelligence for Pulp Cavity and ToothSegmentation on Cone-beam Computed Tomography. J Endod. 2021 Sep11:S0099-2399(21)00642-7. Epub ahead of print.

9.      Duan W, Chen Y*, Zhang Q*, Lin X, Yang X. Refinedtooth and pulp segmentation using U-Net in CBCT image. Dentomaxillofac Radiol.2021 Sep 1;50(6):20200251. doi: 10.1259/dmfr.20200251. Epub 2021 Jan 15. PMID:33444070; PMCID: PMC8404523.

10.   Deng S, Fan L, Wang Y, Zhang Q*. Constitutive activation ofβ-catenin in odontoblasts induces aberrant pulp calcification in mouseincisors. J Mol Histol. 2021 Jun;52(3):567-576. doi:10.1007/s10735-021-09965-1. Epub 2021 Mar 10. PMID: 33689044.

11.   Chen J, Xu H, Xia K, Cheng S, Zhang Q*. Resolvin E1 accelerates pulprepair by regulating inflammation and stimulating dentin regeneration in dentalpulp stem cells. Stem Cell Res Ther. 2021 Jan 22;12(1):75. doi:10.1186/s13287-021-02141-y. PMID: 33482900; PMCID: PMC7821538.

12.   Xia K, Chen Z, Chen J, Xu H, Xu Y, Yang T,Zhang Q*. RGD- and VEGF-MimeticPeptide Epitope-Functionalized Self-Assembling Peptide Hydrogels PromoteDentin-Pulp Complex Regeneration. Int J Nanomedicine. 2020 Sep 8;15:6631-6647.doi: 10.2147/IJN.S253576. PMID: 32982223; PMCID: PMC7495350.

13.   Xu H, Chen J, Ge J, Xia K, Tao S, Su Y, Zhang Q*. Resolvin E1 AmelioratesPulpitis by Suppressing Dental Pulp Fibroblast Activation in a ChemerinReceptor 23-dependent Manner. J Endod. 2019 Sep;45(9):1126-1134.e1.

14.   Sui X, Deng S, Liu M, Fan L, Wang Y, Xu H,Sun Y, Kishen A, Zhang Q*.Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces BoneLoss in Mice. Cell Physiol Biochem. 2018;48(5):2091-2102. doi:10.1159/000492549. Epub 2018 Aug 14. PMID: 30107384.

15.   Fan L, Deng S, Sui X, Liu M, Cheng S, WangY, Gao Y, Chu CH, Zhang Q*.Constitutive activation of ß-Catenin in ameloblasts leads to incisor enamelhypomineralization. J Mol Histol. 2018 Oct;49(5):499-507.

16.   Liu M, Sun Y, Zhang Q*. Emerging Role of Extracellular Vesicles in BoneRemodeling. J Dent Res. 2018 Jul;97(8):859-868.

17.   Wang Y, Liu M, Deng S, Sui X, Fan L, Zhang Q*. Osteoprotegerin deficiencycauses morphological and quantitative damage in epithelial rests of Malassez. JMol Histol. 2018 Jun;49(3):329-338.

18.   Han N, Chen Z, Zhang Q*. Expression of KLF5 in odontoblastic differentiation ofdental pulp cells during in vitro odontoblastic induction and in vivo dentalrepair. Int Endod J. 2017 Jul;50(7):676-684.

19.   Chen Z, Zhang Q#, Wang H, Li W, Wang F, Wan C, Deng S, Chen H, Yin Y, Li X,Xie Z, Chen S.KLf5 Mediates Odontoblastic Differentiation through RegulatingDentin-Specific Extracellular Matrix Gene Expression during Mouse ToothDevelopment. Sci Rep. 2017 Apr 25;7:46746.

20.   Zhang L, Liu M, Zhou X, Liu Y, Jing B,Wang X, Zhang Q*, Sun Y. Role ofOsteoprotegerin (OPG) in Bone Marrow Adipogenesis. Cell Physiol Biochem.2016;40(3-4):681-692. doi: 10.1159/000452580. Epub 2016 Nov 30. PMID: 27898403.

21.   Zhang Q#, Lin S, Liu Y, Yuan B, Harris SE, Feng JQ. Dmp1 NullMice Develop a Unique Osteoarthritis-like Phenotype. Int J Biol Sci. 2016;12(10): 1203–1212.

22.   Liu Y, Wang Y, Du H, Liu M, Deng S, Fan L,Zhang L, Zhang Q*. Osteoprotegerin-Knockout MiceDeveloped Early Onset Root Resorption. J Endod. 2016 Oct;42(10):1516-1522.

23.   Liu Y, Ge J, Chen D, Weng Y, Du H, Sun Y, Zhang Q*. Osteoprotegerin deficiencyleads to deformation of the articular cartilage in femoral head. J Mol Histol.2016 Oct;47(5):475-483.

24.   Li R, Zhang Q*. HtrA1 may regulate theosteogenic differentiation of human periodontal ligament cells by TGF-β1. J MolHistol. 2015 Apr;46(2):137-144. 被引频次：11

25.  Lin SX, Zhang Q#, Zhang H, Yan K,Ward L, Lu YB, Feng JQ. Nucleus-targeted Dmp1 transgenefails to rescue dental defects in Dmp1 null mice. Int J Oral Sci.2014 Sep;6(3):133-141. 被引频次：5

26.  Lin S, Zhang Q#, Cao Z, Lu Y, ZhangH, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ. ConstitutiveNuclear Expression of Dentin Matrix Protein 1 Fails to Rescuethe Dmp1-null Phenotype. J Biol Chem. 2014 Aug 1;289(31):21533-21543. 被引频次：10

27.  Han N, Zheng Y, Li R, LiX, Zhou M, Niu Y, Zhang Q*. β-catenin enhancesodontoblastic differentiation of dental pulp cells through activation of Runx2.PLoS One. 2014 Feb 10;9(2):e88890. 被引频次：51

28.   Zhou M, Rong R, Munro D, Zhu C, Gao X, Zhang Q*, Dong Q.Investigation of the effect of type 2 diabetes mellitus on subgingival plaquemicrobiota by high-throughput 16S rDNA pyrosequencing. PLoS One.2013;8(4):e61516. 被引频次：49