吴兴教授科研临床团队有副教授1名：李文俊副教授（骨科教学部主任、教学名师）、主治医师、讲师1名：刘葛君博士，博士研究生2名：林增博士（现在美国哈弗大学留学），唐果博士（在职博士生）、硕士研究生1名：郭新珂。

主持国家自然科学基金面上项目3项：

1.模拟微重力环境Hedgehog 调控MSCs 成软骨分化的信号串话机制。（81371950)（2013年面上项目）

2.力学环境miRNA-365协同Ihh调控MSCs成软骨分化的分子机制。（81772324）（2017年面上项目）

3. 力学刺激诱导的人脐带间充质干细胞外泌体中FOXO3A促进软骨修复的分子作用机制研究。（82372383）（2023年面上项目）

1.模拟微重力环境Hedgehog 调控MSCs 成软骨分化的信号串话机制。（81371950)（2013年面上项目）

2.力学环境miRNA-365协同Ihh调控MSCs成软骨分化的分子机制。（81772324）（2017年面上项目）

3. 力学刺激诱导的人脐带间充质干细胞外泌体中FOXO3A促进软骨修复的分子作用机制研究。（82372383）（2023年面上项目）

另外主持市科委、卫健委、同济大学科研项目6项。

第一完成人国家级专利2项：

1.一种细胞培养装置（专利号：201720595640.0）

2.一种新型细胞培养装置（专利号：201720595639.8）

吴兴教授在国际核心期刊（SCI收录）及国内中华牌核心期刊以第一作者或通讯作者发表代表性论著34篇（累计影响因子121.78分），具体如下：

(1) Li-tao Yan; Ge-jun Liu; Xing Wu(correspondingauthor). Exosomes derived from umbilical cord mesenchymal stem cells inmechanical environment show improved osteochondral  activity viaupregulation of LncRNA H19. Journal of Orthopaedic Transalation,2021,26:111-120. (IF:6.11) 

(2) Li-tao Yan; XingWu(corresponding author). Exosomes produced from 3D cultures of umbilical cordmesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondralregeneration activity. Cell Biology and Toxicology 2020,36:165-178. (IF:6.42)

(3) Li-tao Yan; Ge-jun Liu; Xing Wu(corresponding author)..The umbilical cord mesenchymal stem cell-derived exosomal IncRNA H19 improvesosteochondral activity through miR-29b-3p/FoxO3 axis, Clinical andTranslational Medicine, 2021, 11: e255. (IF:10.69)

(4) Chao-qing Huang, XingWu(corresponding author).. SurgicalSelection of Unstable Intertrochanteric Fracture : PFNA Combined with or withoutCerclage Cable. BioMed Research International.2021,12.（IF：3.39）

(5) Li-yang Chen; Ge-jun Liu; Wen-jun Li; Xing Wu(corresponding author).. Synergistic efects of Indian hedgehog and sonichedgehog on chondrogenesis during cartilage repair. Journal of MolecularHistology, 2021 52:407–418. (IF:3.38)

(6) Li-yang Chen; Ge-jun Liu; Wen-jun Li; Xing Wu(corresponding author).. Chondrogenicdifferentiation of bone marrow-derived mesenchymal stem cells followingtransfection with Indian hedgehog and sonic hedgehog using a rotarycell culture system. Cellular and Molecular Biology Letters 2019 24: 16.(IF:9.76)

(7) Li-yang Chen; Ge-jun Liu; Wen-jun Li; Xing Wu(corresponding author).. Sonichedgehog promotes chondrogenesis of rabbit bone marrow stem cells in a rotarycell culture system. BMC Developmental Biology 2019 19: 18. (IF:3.1).

(8) Jian Chen; XingWu(corresponding author). Cyclic tensile strain promotes chondrogenesis ofbone marrow-derived mesenchymal stem cells by increasing miR-365 expression0-UNSP 116625.  Life Sciences 2019 232:116625. (IF:6.51).

(9) Jian Chen; XingWu (corresponding author). MicroRNA-103 contributes to osteoarthritis developmentby targeting Sox6. Biomedicine &Pharmacotherapy 118 (2019) 109186. (IF: 7.66)

(10) Jun-feng Liu, Peng-cheng Liu, Kuo Xia, Li-yang Chen, Xing Wu(corresponding author).IliacVein Compression Syndrome (IVCS):An Under-Recognized Risk Factor forLeft-SidedDeep Venous Thrombosis (DVT) in Old Hip Fracture Patients. Med SciMonit, 2017 May 1;23:2078-2082. (IF: 3.1)

(11). Peng-cheng Liu, Jun-feng Liu, Kuo Xia, Li-yang Chen,Xing Wu(corresponding author). Clinical Outcome Evaluation of Primary TotalKnee Arthroplasty in Patients with Diabetes Mellitus. Med Sci Monit, 2017 May9;23:2198-2202. (IF: 3.1)

(12). Peng-cheng Liu, Jun-feng Liu, Kuo Xia, Li-yang Chen, Xing Wu (corresponding author).Intermittent pneumatic compression devices combined with anticoagulants for preventionof symptomatic deep vein thrombosis after total knee arthroplasty: a pilotstudy. Therapeutics and Clinical Risk Management, 2017 Feb 14;13:179-183. (IF:2.74)

(13) Peng-cheng Liu, Kuan Liu, Jun-feng Liu, Kuo Xia,Li-yang Chen, Xing Wu(correspondingauthor). Transfection of the IHH gene into rabbit BMSCs in a simulatedmicrogravity environment promotes chondrogenic differentiation and inhibitscartilage aging. Oncotarget, 2016 Sep 27;7(39):62873-62885.

(14). Peng-cheng Liu, Kuan Liu, Jun-feng Liu, Kuo Xia,Li-yang Chen, Xing Wu (correspondingauthor). Effect of  leptin combined withCoCl2 on healing in Sprague Dawley Rat fracture model. Sci Rep, 2016 Jul29;6:30754.

(15) Kuan Liu, Peng-cheng Liu, Run Liu, Xing Wu(corresponding author).Advantage of minimally invasivelateral approach relative to conventional deltopectoral approach for treatmentof proximal humerus fractures. Med Sci Monit, 2015 Feb 15;21:496-504. (IF: 3.1)

(16) Kuan Liu, Peng-cheng Liu, Run Liu, Xing Wu(corresponding author).Steroid for epidural injection inspinal stenosis: a systematic review and meta-analysis. Drug Des DevelTher,2015 Jan 30;9:707-16. (IF: 3.3)

(17) Kuan Liu, Peng-cheng Liu, Run Liu, Xing Wu(corresponding author).Relationship between serum leptinlevels and bone mineral density: a systematic review and meta-analysis. ClinicaChimica Acta. 2015 Apr 15;444:260-3.(IF:5.6)

(18) Xing Wu,Ming Cai, Fang Ji* and Lie-ming Lou. The impact of COX-2 on invasion ofosteosarcoma cell and its mechanism of regulation. Cancer Cell International2014, 14:27. (IF:6.03)

(19) Peng-Cheng, Yu-Ji Yang, Run Liu, He-xi Shu, Jing-pengGong, Qi Sun, Xing Wu(correspondingauthor),, Cai M . A study on the mechanical characteristics of the EBM-printedTi-6Al-4V LCP plates in vitro. .J Orthop Surg Res, 2014 Nov 5;9:106. (IF:2.5)

(20) Biao Cheng, XingWu(Co-first author) , Heng’an Ge, Ye qing Sun and Qiang Zhang. Operativeversus conservative treatment for patellar dislocation:a meta –analysis of 7randomized controlled trials. Diagnostic Pathology 2014,9:60.(IF:3.01)

(21) Xing Wu ,Zheng-Dong Cai , Lei-Ming Lou , Zheng-Rong Chen. The effects of inhibitingHedgehog signaling pathways by using specific antagonist cyclopamine on thechondrogenic differentiation of mesenchymal stem cells. International journalof molecular science. 2013, 14:5966-5977. (IF:6.21)

(22) Xing Wu,Shao-Hua Li, Lie-Ming Lou and Zheng-rong Chen. The Effect of the MicrogravityRotating Culture System on the Chondrogenic Differentiation of Bone MarrowMesenchymal Stem Cells. Molecular Biotechnology ,2013,54:331-336. (IF:2.45)

(23) Xing Wu,Biao Cheng, Zheng-dong Cai and Lie-ming Lou. Determination of the apoptoticindex in osteosarcoma tissue and its relationship with patients prognosis.Cancer cell international, 2013,4;13(1):56.(IF:6.03)

(24) Xing Wu,Shao-Hua Li, Zheng-Dong Cai and Lie-Ming Lou. Modified hemiarthroplasty forfour-part fractures of the proximal humerus. ANZ Journal ofSurgery,2013,83(3):165-170. (IF:2.22)

(25) Xing Wu,Zheng-dong Cai, Zheng-rong Chen, Zhen-jun Yao, Guang-jian Zhang. A PreliminaryEvaluation of Limb Salvage Surgery for Osteosarcoma around Knee Joint. PLOS ONE2012 , Volume 7, Issue 3 . E33492. (3.75)

(26) Xing Wu ,Shao-hua Li , Lie-ming Lou, Zheng-dong Cai. The techniques of soft tissuerelease and true socket reconstructionin total hip arthroplasty for patientswith severe developmental dysplasia of the hip. International Orthopaedics.2012,36:1795-1801. (2.71)

(27) Xing Wu ,Zheng-Dong Cai , Lei-Ming Lou and Yanbo Zhu. Expressions of P53, C-myc, Bcl-2and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. CancerEpidemiology , 2012,36,212–216. (2.67)

(28) Xing Wu,Zheng-dong Cai, Lie-ming Lou, Zheng-rong Chen, Zhen-jun Yao,Treatments foracute and old distal radius fracture with lunate dislocation. Eur J Orthop SurgTraumatol, 2013,23(2):191-196. (IF:1.12)

(29) Xing Wu,Lie-ming Lou, Shao-hua Li.Soft tissue balancing in total hip arthroplasty forpatients with adult dysplasia of the hip. Orthopaedic Surgery (2009), Volume 1,No. 3, 211–214.(IF:2.02)

(30) Kuan Liu, Peng-cheng Liu, Run Liu, Xing Wu(corresponding author).Dual AO/EB staining to detectapoptosis in osteosarcoma cells compared with flow cytometry. Med Sci MonitBasic Res, 2015 Feb 9;21:15-20.(IF:3.1)

(31) 吴兴等。肱骨近端四部分骨折半肩置换术中的软组织重建与平衡。中华外科杂志，2008，46（19）：1876-1879。

(32) 吴兴等。转染环氧合酶-2反义寡核苷酸对骨肉瘤细胞侵袭性的抑制作用。中华实验外科杂志，2008，25（12）：1649-1651。

(33) 吴兴等。桡骨远端骨折合并月骨脱位的治疗。中华手外科杂志，2008，24（3）：175-177。

(34) 吴兴，陈峥嵘，张光健。骨肉瘤凋亡相关基因的表达及临床意义。中华肿瘤杂志，2004, 26（11）：678-680