团队由刘志强教授领衔，主要从事妇产科麻醉的临床与基础研究，以妇产科危重患者围术期管理、围产期抑郁机制及防治、麻醉药发育神经毒性及阿片药物成瘾机制为主要研究方向。团队现有博士生导师3名，在读博士生11名，硕士生1名，在站博士后2名；已毕业博士9名，硕士1名，出站博士后2名。团队学术成果丰硕，累计获得11项国家自然科学基金面上和青年项目资助，获得20余项市、局、区级课题，2项博士后基金。发表SCI文章50余篇，核心期刊文章60余篇。在Cell Discovery (IF 38.079)、Science Advances（IF 14.957）、Anesthesiology、EJA、AA及中华麻醉学等著名期刊发表论著。主编专著3部，副主编专著5部，以执笔人或编写组成员身份参与制订多部国内临床麻醉指南及专家共识。团队成果获2019上海医学科技进步奖三等奖。团队注重思政教育，师生综合素质高，导师刘志强先后获“优秀党务工作者”、上海市卫生计生系统先进工作者荣誉称号，及上海市医学会上海麻醉事业贡献奖等，带领团队荣获“上海市青年文明号”称号。导师刘志强教授获国家建设高水平大学公派研究生项目（博士生导师短期出国交流项目）在美国哈佛大学医学院交流，多名学生在研究生期间先后获得国家留学基金、上海市第一妇婴保健院优青基金前往美国哈佛医学院、内布拉斯加医学中心学习交流，目前都已学成归国，并逐渐成为科室的医疗和科研骨干。多名学生获上海市优秀毕业生、同济大学优秀学生、同济大学泰禾卓越医学教育奖、国家留学生基金。导学团队氛围融洽，形成了求真、探索、积极向上的团队文化和诚信求实的团队学风。

目前在研课题：

1.国家自然科学基金面上项目，82371533，NRSN2调控突触外δ-GABAAR可塑性介导产后抑郁发生的机制研究，2024.01-2027.12，49万，在研，主持

2.上海市科委，2022年度“科技创新行动计划”优秀学术带头人，22XD1402400，基于突触外GABAA受体亚基功能探究产后抑郁发生的神经微环路机制，2022.9.1-2025.8.31，40万、在研、主持

3.上海市科委自然科学基金，22ZR1449300，七氟烷经选择性抑制GluN2D发挥快速抗抑郁的作用机制研究，2022.04.01-2025.03.31，20万、在研、主持

4.浦东新区卫健委联合攻关项目，PW2021D-01，围产期抑郁“早期筛查-优化管理-联合诊治”一体化防治体系的构建，2021.07.01-2024.06.30，30万、在研、主持

5.横向课题，苯磺酸瑞马唑仑静脉麻醉对宫腔镜手术患者血流动力学及麻醉效果影响的随机对照研究，2022.8.25-2024.8.25，16万、在研、主持

1.国家自然科学基金面上项目，82371533，NRSN2调控突触外δ-GABAAR可塑性介导产后抑郁发生的机制研究，2024.01-2027.12，49万，在研，主持

2.上海市科委，2022年度“科技创新行动计划”优秀学术带头人，22XD1402400，基于突触外GABAA受体亚基功能探究产后抑郁发生的神经微环路机制，2022.9.1-2025.8.31，40万、在研、主持

3.上海市科委自然科学基金，22ZR1449300，七氟烷经选择性抑制GluN2D发挥快速抗抑郁的作用机制研究，2022.04.01-2025.03.31，20万、在研、主持

4.浦东新区卫健委联合攻关项目，PW2021D-01，围产期抑郁“早期筛查-优化管理-联合诊治”一体化防治体系的构建，2021.07.01-2024.06.30，30万、在研、主持

5.横向课题，苯磺酸瑞马唑仑静脉麻醉对宫腔镜手术患者血流动力学及麻醉效果影响的随机对照研究，2022.8.25-2024.8.25，16万、在研、主持

6.上海申康医院发展中心诊疗技术示范推广应用项目，SHDC22020205，多学科融合的加速康复（ERAS）策略在剖宫产围术期应用和推广的规范化管理研究，2020/12/01-2022/11/30，40万、已结题、主持

7.上海市科委医学引导类中医项目基金，19401930500,经皮穴位电刺激全程镇痛改善焦虑产妇宫缩痛及产后情绪的临床对照研究，2019/01/01-2022/03/31，20万、已结题、主持

8. 国家自然科学基金面上项目，81771188，氯胺酮快速抗抑郁的潜在靶点和神经微环路机制研究，2018/01/01– 2021/12/31，54万、已结题、主持

9.浦东新区妇产科医疗联合项目，PDYLT201901-2，多层次、多渠道科普分娩镇痛，让更多准妈妈享受“无痛福利”，2019/1-2019/12，20万、已结题、主持

10.上海市卫计委面上项目，201740072，氯胺酮在产后抑郁症模型中的快速抗抑郁作用及药理学机制研究，2018/01/01- 2020/12/31，20万、已结题、主持

11.上海市科委医学引导项目基金，16411967400，围产期全程优化镇痛策略改善产后抑郁情绪行为的研究，2016/06- 2019/06, 20万元、已结题、主持

12.上海市科委医学引导项目基金，14411966700，多模式全产程分娩镇痛方案的设计与应用研究，2015/01- 2017/12，20万、已结题、主持

13.浦东新区卫计委课题，PW2016D-10，回收式自体输血在高危出血性剖宫产术中的应用研究，2016/10/1-2019/09/30,20万、已结题、主持

14.上海申康医院发展中心市级医院新兴前沿技术联合攻关项目，SHDC12016102，老年患者围术期喉罩应用与肺部并发症的多中心、随机对照临床研究，2016/09/30- 2019/09/30，30万、已结题、主持

15.上海市科委重要疾病的多中心研究项目分中心，16411950302，老年病人围术期喉罩应用与肺部并发症的多中心随机对照临床研究，2016/07/01- 2019/09/30、20万、已结题、主持

16.上海市科委产学研课题子课题，16DZ1930305，维迪欧视频喉镜在新生儿气管插管中的应用，2016/09/01- 2019/09/30，25万、已结题、主持

近5年发表论文
1.     Bing Zhang(#), Sensen Zhang(#), Maya M. Polovitskaya(#),Jingbo Yi(#), Binglu Ye(#), Ruochong Li, Xueyin Huang, Jian Yin, SebastianNeuens, Tom Balfroid, Julie Soblet, Daphné Vens, Alec Aeby, Xiaoling Li, JinjinCai, Yingcai Song, Yuanxi Li, Marco Tartaglia(*), Yang Li(*), Thomas J.Jentsch(*), Maojun Yang(*) and Zhiqiang Liu(*). Molecular basis of ClC-6function and its impairment in human disease. Science Advances (2023,Accepted).（通讯作者）IF: 13.6006
2.     Yuanxi Li, Bing Zhang, Zhiqiang Liu(*) and Rubin Wang(*).Neural energy computations based on Hodgkin-Huxley models bridge abnormalneuronal activities and energy consumption patterns of major depressivedisorder. Computers in Biology and Medicine (2023, Accepted).（共同通讯）IF: 7.7002
3.     Fuyi Shen, Xianjin Zhou, Fei Guo, Kechen Fan, Yilu Zhou,Jianhua Xia, Zhendong Xu, Zhiqiang Liu. Increased risk of postpartum depressionin women with lactational mastitis: a cross-sectional study. Front Psychiatry.2023, 14:1229678.（通讯作者） IF: 4.7003
4.     Binglu Ye, Yawei Yuan, Rui Liu, Haitao Zhou, Yujie Li, ZhihaoSheng, Tianyu Li, Bing Zhang, Zhendong Xu, Yang Li, Zhiqiang Liu. Restoring Wntsignaling in a hormone-simulated postpartum depression model remediatedimbalanced neurotransmission and depressive-like behaviors. Mol Med. 2023, 29(1):101.（通讯作者） IF: 6.3821
5.     Yujie Li, Weijia Du, Rui Liu, Guiying Zan, Binglu Ye, QianLi, Zhihao Sheng, Yawei Yuan, Yujie Song, Jinggen Liu, Zhiqiang Liu.Paraventricular nucleus-central amygdala oxytocinergic projection modulatespain-related anxiety-like behaviors in mice. CNS Neurosci Ther. 2023. doi:10.1111/cns.14282. Online ahead of print.（通讯作者） IF: 7.034
6.     Shuangqiong Zhou, Xiuhong Cao, Yao Zhou, Zhendong Xu,Zhiqiang Liu. Ultrasound assessment of gastric volume in parturients afterhigh-flow nasal oxygen therapy. Anesth Analg. 2023, 137(1):176-181.（通讯作者） IF: 6.627
7.     Yuanxi Li, Bing Zhang, Xiaochuan Pan, Yihong Wang, Xuying Xu,Rubin Wang, Zhiqiang Liu. Dopamine Mediated Major Depressive Disorder in theNeural Circuit of VTA-NAc-mPFC: From Biological Evidences to ComputationalModels. Front Cell Neurosci. 2022, 16: 923039.（通讯作者）IF: 6.147
8.     Yi J, Li Y, Yuan Y, Xu Z, Song Y, Ye B, Zhao Q, Yang Y, Du W,Liu Z. Comparison of labor analgesia efficacy between single-orifice andmultiorifice wire-reinforced catheters during programmed intermittent epiduralboluses: a randomized controlled clinical trial. Reg Anesth Pain Med. 2023,48(2):61-66.（通讯作者） IF: 5.564
9.     Lin R, Lu Y, Luo W, Zhang B, Liu Z, Xu Z. Risk factors forpostpartum depression in women undergoing elective cesarean section: Aprospective cohort study. Front Med (Lausanne). 2022 Sep 28;9:1001855.（共同通讯）IF: 5.058
10.  Weijia Du#; Lulong Bo#; Zhendong Xu; Zhiqiang Liu. ChildbirthPain, Labor Epidural Analgesia, and Postpartum Depression: Recent Evidence andFuture Directions. J Pain Res. 2022:15 3007–3015.（通讯作者） IF: 2.832
11.  Yilu Zhou, Zhendong Xu; Zhiqiang Liu. Impact of NeutrophilExtracellular Traps on Thrombosis Formation: New Findings and FuturePerspective. Front Cell Infect Microbiol. 2022, 12: 910908.（通讯作者）IF: 6.073 (Review)
12.  Chen X, Zhang Y, Ni X, Liu Z. Effects of labour analgesiawith different concentrations of ropivacaine on maternal body temperature andinflammatory factor: A randomised controlled study. Anaesth Crit Care Pain Med.2022, 41(2): 101030. （通讯作者）IF: 7.025
13.  Xiuhong Cao, Ye Luo, Shuangqiong Zhou, Qingsong Zhao, XueweiQin, Zhendong Xu, Zhiqiang Liu. Twin growth discordance and risk of postpartumhemorrhage: A retrospective cohort study. Front Med (Lausanne). 2022, 9:876411.（通讯作者）IF: 5.058
14.  Weijia Du, Yujie Song, Jiang L, Xianjin Zhou, Zhendong Xu,Zhiqiang Liu. Comparison of Prophylactic Norepinephrine and PhenylephrineInfusions During Spinal Anaesthesia for Primary Caesarean Delivery in TwinPregnancies: A Randomized Double-Blinded Clinical Study. Drug Des Devel Ther.2022, 16: 789-798.（通讯作者）IF: 4.319
15.  Weijia Du, Yujie Song, Qingsong Zhao, Zhendong Xu, ZhiqiangLiu. The effect of open-end versus closed-end epidural catheter design oninjection pressure and dye diffusion under various programmed intermittentepidural delivery rates: an in vitro study. Int J Obstet Anesth. 2022, 51:103252.（通讯作者）IF: 3.282
16.  Yujie Song, Weijia Du, Yiyi Tao, Qian Li, Fuyi Shen, ZhendongXu, Zhiqiang Liu. Optimum programmed intermittent epidural bolus interval timebetween 8 mL boluses of Ropivacaine 0.1% with sufentanil 0.3 μg/mL with duralpuncture epidural technique for labor analgesia: A biased-coin up-and-downsequential allocation trial. J Clin Anesth, 2022, 79:110698.（通讯作者）IF: 9.375
17.  Gui-Ying Zan, Xiang Sun, Yu-Jun Wang, Rui Liu, Chen-Yao Wang,Wei-Jia Du, Liu-Bin Guo, Jing-Rui Chai, Qing-Lin Li, Zhi-Qiang Liu, Jing-GenLiu. Amygdala dynorphin/κ opioid receptor system modulates depressive-likebehavior in mice following chronic social defeat stress. Acta Pharmacol Sin.2022, 43(3): 577-587.（通讯作者）IF: 7.169
18.  Zhendong Xu, Zhiqiang Liu. In Response. Anesth Analg. 2021,133(3):e40-e41.（通讯作者）IF: 6.627 (Comment)
19.  Xudong Chen, Mingze Zhou, Sensen Zhang, Jian Yin, Ping Zhang,Xujun Xuan, Peiyi Wang, Zhiqiang Liu, Boda Zhou, Maojun Yang. Cryo-EMstructures and transport mechanism of human P5B type ATPase ATP13A2. CellDiscov. 2021, 7(1):106. （共同通讯）IF: 38.079
20.  Yilu Zhou, Weimin Tao, Fuyi Shen, Weijia Du, Zhendong Xu,Zhiqiang Liu. The Emerging Role of Neutrophil Extracellular Traps in Arterial,Venous and Cancer-Associated Thrombosis. Front Cardiovasc Med. 2021, 8: 786387.（通讯作者）IF: 5.846 (Review)
21.  Gui-Ying Zan, Yu-Jun Wang, Xue-Ping Li, Jun-Fan Fang, Song-YuYao, Jun-Ying Du, Qian Wang, Xiang Sun, Rui Liu, Xiao-Mei Shao, Jian-Dong Long,Jing-Rui Chai, Ying-Zhi Deng, Ye-Qing Chen, Qing-Lin Li, Jian-Qiao Fang,Zhi-Qiang Liu, Jing-Gen Liu. Amygdalar κ-opioid receptor-dependentupregulating glutamate transporter 1 mediates depressive-like behaviors ofopioid abstinence. Cell Rep. 2021, 37(5): 109913. （共同通讯）IF: 9.995
22.  Yujie Song, Weijia Du, Shuangqiong Zhou, Yao Zhou, Yibing Yu,Zhendong Xu, Zhiqiang Liu. Effect of Dural Puncture Epidural Technique CombinedWith Programmed Intermittent Epidural Bolus on Labor Analgesia Onset andMaintenance: A Randomized Controlled Trial. Anesth Analg.2021, 132(4): 971-978.（通讯作者）IF: 6.627
23.  Yilu Zhou, Wei Chen, Shuangqiong Zhou, Yiyi Ta, Zhendong Xu,Zhiqiang Liu. Comparison of different approaches to combined spinal epiduralanesthesia (CSEA) under the guidance of ultrasound in cesarean delivery ofobese patients: a randomized controlled trial. Eur J Med Res. 2021, 26(1): 106.IF: 4.981
24.  Bing Zhang, Xili Yang, Luyu Ye, Rui Liu, Binglu Ye, WeijiaDu, Fuyi Shen, Qian Li, Fan Guo, Jinqi Liu, Fei Guo, Yang Li, Zhendong Xu,Zhiqiang Liu. Ketamine Activated Glutamatergic Neurotransmission by GABAergicDisinhibition in the Medial Prefrontal Cortex. Neuropharmacology. 2021,194:108382.（通讯作者）IF: 5.273
25.  Xiu Ni, Meng-Zhu Li, Shuang-Qiong Zhou, Zhen-Dong Xu, Yue-QiZhang, Yi-Bing Yu, Jing Su, Li-Min Zhang, Zhi-Qiang Liu. Accuroultrasound-based system with computer-aided image interpretation compared totraditional palpation technique for neuraxial anesthesia placement in obeseparturients undergoing cesarean delivery: a randomized controlled trial. JAnesth. 2021, 35(4):475-482. （通讯作者）IF: 2.931
26.  Rong Lin, Peng Shi, Haibing Li, Zhiqiang Liu, Zhendong Xu.Association between epidural analgesia and indications for intrapartumcaesarean delivery in group 1 of the 10-group classification system at atertiary maternity hospital, Shanghai, China: a retrospective cohort study. BMCPregnancy Childbirth. 2021, 21(1):464.（共同通讯）IF: 3.105
27.  Shuang-Qiong Zhou, Yao Zhou, Xiu-Hong Cao, Xiu Ni, Wei-JiaDu, Zhen-Dong Xu, Zhi-Qiang Liu. The efficacy of high flow nasal oxygenationfor rapid sequence induction in pregnancy: a prospective randomised clinicaltrial. Eur J Anaesthesiol. 2021, 38(10): 1052-1058.（通讯作者）IF: 4.183
28.  Wei Liu, Qian Li, Binglu Ye, Hang Cao, Fuyi Shen, ZhendongXu, Weijia Du, Fei Guo, Jinqi Liu, Tianyu Li, Bing Zhang, Zhiqiang Liu.Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects ThroughNeuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex.Front Psychiatry. 2020, 11:837.（通讯作者）IF: 5.435
29.  Yan Lu, Zhendong Xu, Fuyi Shen, Rong Lin, Haibing Li, XiangLv, Zhiqiang Liu. Propofol protects against TNF-α-induced blood-brain barrierdisruption via the PIM-1/eNOS/NO pathway. Curr Neurovasc Res. 2020,17(4):471-479.（通讯作者）IF: 2.294
30.  Xiubin Chen, Xiu Ni, Yueqi Zhang, Hong Liu, Zhiqiang Liu. Theassociation of labor epidural analgesia with low concentration of ropivacaineand maternal fever: A retrospective study. J Clin Anesth. 2020, 65:109613.（通讯作者）IF: 9.375
31.  Yao Zhou, Weimin Tao, Xuewei Qin, Rong Lin, Zhiqiang Liu,Zhendong Xu. Evaluating coagulation status with thromboelastography in a womanwith antiphospholipid syndrome and sepsis: a case report. J Anesth. 2020,34(5):781-785.（共同通讯） IF: 2.931
32.  Sensen Zhang,Yang Liu,Bing Zhang, Jun Zhou, Tianyu Li,Zhiqiang Liu, Yang Li, Maojun Yang. Molecular insights into the humanCLC-7/Ostm1 transporter. Science Advances. Sci Adv. 2020, 6(33):eabb4747.（共同通讯）IF: 14.957
33.  Qian Li, Bing Zhang, Hang Cao, Wei Liu, Fei Guo, Fuyi Shen,Binglu Ye, Huan Liu, Yang Li, Zhiqiang Liu. Oxytocin Exerts Antidepressant-likeeffect by potentiating dopaminergic synaptic transmission in the mPFC.Neuropharmacology. 2020, 162:107836.（通讯作者）IF: 5.273
34.  Zhi-Qiang Liu, Wei-Jia Du, Shang-Long Yao. Enhanced recoveryafter cesarean delivery: a challenge for anesthesiologists. Chin Med J (Engl).2020, 133(5):590-596.（第一作者）IF:2.624
35.  Shuang-Qiong Zhou, Jing Wang, Wei-Jia Du, Yu-Jie Song,Zhen-Dong Xu, Zhi-Qiang Liu. Optimum interval time of programmed intermittentepidural bolus of ropivacaine 0.08% with sufentanyl 0.3 μg/mL for laboranalgesia: a biased-coin up-and-down sequential allocation trial. Chin Med J(Engl). 2020, 133(5):517-522.（通讯作者）IF: 6.133
36.  Zhou X, Li J, Deng S, Xu Z, Liu Z. Ropivacaine at differentconcentrations on intrapartum fever, IL-6 and TNF-α in parturient withepidural labor analgesia. Exp Ther Med. 2019, 17(3):1631-1636.（通讯作者）IF: 2.751
37.  Li M, Ni X, Xu Z, Shen F, Song Y, Li Q, Liu Z. UltrasoundAssisted Technology Versus the Conventional Landmark Location Methodin SpinalAnesthesia for Cesarean Delivery in Obese Parturients: A Randomized ControlledTrial. Anesth Analg. 2019, 129(1):155-161.（通讯作者）IF: 6.627
38.  Chen X, Chen F, Zhao Q, Zhang L, Liu Z. Ultrasonographicmeasurement of antral area for estimating gastric fluid volume in pregnantwomen. J Clin Anesth. 2019, 53:70-73.（通讯作者）IF: 9.375
39.  Shen FY, Song YC, Guo F, Xu ZD, Li Q, Zhang B, Ma YQ, ZhangYQ, Lin R, Li Y, Liu ZQ. Cognitive Impairment and Endoplasmic Reticulum StressInduced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats.Front Psychiatry. 2018, 9:332.（通讯作者）IF: 5.435
40.  Du W, Xu Z, Wang W, Liu Z. A case of anosmia and hypogeusiaas a complication of propofol. J Anesth. 2018, 32(2):293-296.（通讯作者）IF: 2.931
41.  Xu Z, Liu Z, Zhang Y, Jin C, Shen F, Yu Y, Cheek T, Onuoha O,Liang G, Month R, Atkins J, Tran KM, Wei H. S100β in Newborns after C-Sectionwith General versus Epidural Anesthesia: a prospective observational study.Acta Anaesthesiol Scand. 2018, 62(3):293-303.（共同通讯）IF: 2.274