团队主要聚焦肿瘤发生发展分子机制并开展相关临床转化研究，上海三甲医院病理学科竞争力持续上升， 2020-2021连续两年排名第五，2022年排名第三，2023年排名第二。近年共获批课题及人才资助50项，累计经费近2000万元，其中国家自然科学基金项目22项。以第一或通讯作者在国际重要学术期刊Signal Transduction and Targeted Therapy（IF38）、Nature Communications（IF17.694）等发表SCI论文40余篇。申请发明专利30项，授权10项，科技成果转化1项（100万元）。在医院支持下，科室建成符合国际标准的临床生物样本全息库，形成样本库动态存储和使用的模式，样本库的两大特色平台基于类器官的耐药基因筛选平台和细菌分离平台目前已正式投入使用，具有特征性致病因素及发病特点的恶性肿瘤PDO及耐药基因筛选已申请技术准入，细菌分离平台已获得三百余株纯培养分离株，涵盖一百余个菌种，目前已完成中国典型培养物保藏中心7株菌的保藏，已建成“结直肠癌信息库系统”，目前共收录病例信息5000万余例。

国自然面上项目，白介素13在甲状腺乳头状癌发生中的作用与调控机制，75万元

国自然面上项目，IL-13调控一种新颖小RNA分子：PIWI蛋白结合RNA在甲状腺乳头状癌发生中的作用机制，55万元

国自然面上项目，具核梭杆菌增强整合素α5β1介导细胞迁移在结直肠癌转移中的作用机制研究，55万元

国自然面上项目，具核梭杆菌通过短链脂肪酸调控结直肠癌微卫星不稳定 的分子机制研究，66万元

第二轮《促进市级医院临床技能与临床创新三年行动计划（2020-2022年）》重大临床研究项目二类，基于梭杆菌精准检测的结直肠癌分子分型临床研究，240万元

国自然面上项目，白介素13在甲状腺乳头状癌发生中的作用与调控机制，75万元

国自然面上项目，IL-13调控一种新颖小RNA分子：PIWI蛋白结合RNA在甲状腺乳头状癌发生中的作用机制，55万元

国自然面上项目，具核梭杆菌增强整合素α5β1介导细胞迁移在结直肠癌转移中的作用机制研究，55万元

国自然面上项目，具核梭杆菌通过短链脂肪酸调控结直肠癌微卫星不稳定 的分子机制研究，66万元

第二轮《促进市级医院临床技能与临床创新三年行动计划（2020-2022年）》重大临床研究项目二类，基于梭杆菌精准检测的结直肠癌分子分型临床研究，240万元

1.       HuiyuanZhu,Dexi Bi,Youhua Zhang,Cheng Kong,Jiahao Du,Xiawei Wu,Qing Wei and HuanlongQin.Ketogenic diet for human diseases: the underlying mechanisms and potentialfor clinical implementations. Signal Transduction and Targeted Therapy.2022 Jan17;7(1):11.

2.       Dexi BiYin Zhu,Yaohui Gao,Hao Li,Xingchen Zhu,Rong Wei,Ruting Xie,Chunmiao Cai

QingWei, Huanlong Qin. Profiling Fusobacterium infection at high taxonomicresolution reveals lineage-specific correlations in colorectal cancer.NatureCommunications. 2022 Jun 9;13(1):3336.

3.       FeifeiSong, Youhua Zhang, Qi Chen, Dexi Bi, Muqing Yang, Ling Lu, Man Li, HuiyuanZhu, Ying Liu, Qing Wei, Huanlong Qin, Jiyu Li.Mast cells inhibit colorectal cancerdevelopment by inducing ER stress through secreting Cystatin C. Oncogene. 2023 Jan;42(3):209-223.

4.       Man Li,Qunqun Bao, Jing Guo, Ruting Xie, Chao Shen, Qing Wei, Ping Hu,Huanlong Qin,andJianlin Shi.Low Colorectal Tumor Removal by E-Cadherin Destruction-EnabledTumor Cell Dissociation. Nano Letters.2022 Apr 13;22(7):2769-2779.

5.       HongshengLu, Chumeng Zhu, Yanyun Ruan, Lilong Fan, Zhengying Ruan, Qi Chen, Jiuyun Yuan,Yang Xu, Hongwei Wang, Qing Wei. hsa-miR-206b Involves in the Development ofPapillary ThyroidCarcinoma via Targeting LMX1B. Biomed Res Int. 2022 Mar15;2022:7488708.

6.       H Lu, CZhu, Y Chen, Y Ruan, L Fan, Q Chen, Q Wei. LncRNA ABHD11-AS1promotes tumor progression in papillary thyroid carcinoma by regulatingEPS15L1/EGFR signaling pathway. Clin Transl Oncol. 2022Jun;24(6):1124-1133.

7.       Zhang Y#,Xie R#, Zhang H#, Zheng Y, Lin C, Yang L, Huang M, Li M,Song F, Lu L, Yang M, Liu Y, Wei Q*, Li J*, Chen J*. Integrin β7 inhibitscolorectal cancer pathogenesis via maintaining anti-tumor immunity. CancerImmunology Research, 2021, 9, 967-980.

8.       Bi D, ZhuY, Gao Y, Li H, Zhu X, Wei R, Xie R, Wei Q*, Qin H*. A newly developedPCR-based method revealed distinct Fusobacterium nucleatum subspeciesinfection patterns in colorectal cancer. Microbial Biotechnology, 2021, 14,2176-2186. 

9.       Gao Y#,Bi D#, Xie R#, Li M, Guo J, Liu H, Guo X, Fang J, Ding T,Zhu H, Cao Y, Xing M, Zheng J, Xu Qing, Xu Qian, Wei Q*, Qin H*. Fusobacteriumnucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer.Signal Transduction and Targeted Therapy, 2021, accepted.

10.    Cai C#,Bi D#, Bick G#, Wei Q, Liu H, Lu L, Zhang X*, Qin H*. HNF1Aserves as a potential regulator in shaping super-enhancer landscape incolorectal cancer liver metastasis. FEBS Letters, 2021, accepted.

11.   Dexi Bi, Jiayi Zheng, Ruting Xie, Yin Zhu, Rong Wei,Hong-Yu Ou, Qing Wei, Huanlong Qin, ComparativeAnalysis of AbaR-Type Genomic Islands Reveals Distinct Patterns of GeneticFeatures in Elements with Different Backbones, MSPHERE,2020. 5(3):e00349-20.

12.   Xiaoli Huan,, Yang Yan, Rong Wei, Hu Liu, Xingchen Zhu,Dexi Bi, Qing Wei, Xudong Yao，CentrosomeProtein 78 Is Overexpressed in Muscle-Invasive Bladder Cancer and Is Associatedwith Tumor Molecular Subtypes and Mutation Signatures, MedSci Monit, 2020 Oct 29;26:e925197

13.   Zhengyan Chang,* Guo Ji1, Runzhi Huang, Hong Chen, YaohuiGao, Weifeng Wang, Xuechen Sun, Jie Zhang, Jiayi Zheng, Qing Wei. PIWI-interacting RNAs piR-13643 and piR-21238 arepromising diagnostic biomarkers of papillary thyroid carcinoma. Agingus. 2020.12: 9292-9310.

14.   Zhengyan Chang, Runzhi Huang, Wanting Fu, Jiehan Li, GuoJi, Jinglei Huang, Weijun Shi, Huabin Yin, Weifeng Wang, Tong Meng, ZongqiangHuang, Qing Wei and Huanlong Qin.The Construction and Analysis of ceRNA Network and Patterns of ImmuneInfiltration in Colon Adenocarcinoma Metastasis. Frontiersin cell and developmental biology. 2020. doi: 10.33089/1-18.

15.   Ling Lu, Ruting Xie, Rong Wei, Chunmiao Cai, Dexi Bi,Dingzi Yin, Hu Liu, Jiayi Zheng, Youhua Zhang, Feifei Song, Yaohui Gao, LinhuaTan, Qing Wei*, Huanlong Qin*. Integrinα5 subunit is required for the tumor supportive role of fibroblasts incolorectal adenocarcinoma and serves as a potential stroma prognostic marker. MolecularOncology. doi: 10.1002/1878-0261

16.   Yaohui Gao*,  YangYan*,  Jing Guo,  Qian Zhang, Dexi Bi,  Fen Wang,  Zhengyan Chang,  Ling Lu, Xudong Yao  and  QingWei. HNF‑4α downregulation promotes tumor migration and invasion byregulating E‑cadherin in renal cell carcinoma. Oncology Reports. 2019. 42:1066-1074. 

17.   Sheng Zhang#, Qing Wei#, Yongzhi Yang,Huanlong Qin, Xinxiang Li*, SanjunCai1*, Yanlei Ma1. Loss of Yes-associatedProtein Represents an Aggressive Subtype of Colorectal Cancer. Journalof Cancer. 2019, 10(3):689-696.

18.   Feifei Song, Qi Chen, Wei Rao, Renfeng Zhang, YingWang,Hailiang Ge, QingWei. OVA66 promotestumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2signalling. EBioMedicine. 2019 Mar;41:156-166. 

19.   Dexi Bi, Ruting Xie, Jiayi Zheng, Huiqiong Yang, XingchenZhu, Hong-Yu Ou, Qing Wei.Identification of AbaR-Type Genomic Islands in Acinetobacter baumannii RevealsDiverse Insertion Sites and Clonal Lineage-Specific Antimicrobial ResistanceGene Profiles. Antimicrob Agents Chemother. 2019, 63(4):2526-18. 

20.   Ruting Xie#, YongzhiYang#, Huizhen Zhang, HuLiu1, Jing Guo, Huanlong Qin, Yanlei Ma, Ajay Goel, Xinxiang Li, Qing Wei. c-Myb and its Effector COX-2as an Indicator Associated with Prognosis and Therapeutic Outcome in ColorectalCancer. Journal of Cancer. 2019; 10(7):1601-1610.

21.   Yingdi Liu, Kangsheng Peng, Ruting Xie, Jiayi Zheng, JingGuo, Rong Wei, Huiqiong Yang, Chunmiao Cai, Qing Wei. Protocadherin gamma A7 is down-regulated in colorectalcancer and associated with the prognosis in patients with wild-type KRAS. HumanPathology. 2018, 83: 14-21. 

22.   Bi D, Zheng J, Li JJ, Sheng ZK, Zhu X, Ou HY, Li Q, Wei Q. Large-scale in silico typing andcomparative genomic analysis of IncFIIK plasmids: insights into the evolutionof replicons, plasmid backbones and resistance determinant profiles.Antimicrobial Agents and Chemotherapy. 2018, 62(10): e00764-18. 

23.   Wenhao Weng*, QingWei*, Shusuke Toden1, Kazuhiro Yoshida1,Takeshi Nagasaka, ToshiyoshiFujiwara, Sanjun Cai, Huanlong Qin,Yanlei Ma, and Ajay Goel. Circular RNA ciRS-7—APromising Prognostic Biomarker and a Potential Therapeutic Target in ColorectalCancer. Clin Cancer Res. 2017,23(14):3918-3928.

24.   Chang Z, Cai C, Han D, Gao Y, Li Q, Feng L, Zhang W, Zheng J, Jin J, Zhang H, WeiQ. Anoctamin5 regulates cell migration andinvasion in thyroid cancer. Int J Oncol. 2017, 51(4): 1311-1319.

25.    Ma YY, Yang MQ, He ZG, Fan MH, Huang M, Teng F, Wei Q, Li JY. Pregulation of heme oxygenase-1 in Kupffer cellsblocks mast cell degranulation and inhibits dendritic cell migration in vitro. Mol Med Rep. 2017, 15(6):3796-3802.

26.   G Li, M Li, J Hu, R Lei, H Xiong, H Ji, HYin, Q Wei and G Hu. ThemicroRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvatedehydrogenase and lipogenesis. Oncogene.2017, 36, 989–998.

27.   Yanlei Ma, Yongzhi Yang, Feng Wang, Qing Wei* and Huanlong Qin*. Hippo-YAP signaling pathway: A newparadigmfor cancer therapy. Int. J. Cancer.2015, 137: 2275–2286.

28.   Dongyan Han, Da Fu, Hao Xi, Qianyu Li, LijinFeng, WeiZhang, GuoJi, Jiacheng Xiao*, Qing Wei*.Genomic expression profiling and bioinformatics analysis of pancreatic cancer.Mol Med Rep. 2015, 12(3): 4113-40.

29.   QingWei, Rong Lei*,Guohong Hu*.Roles of miR-182 in sensory organ development and cancer. ThoracCancer. 2015, 6(1): 2-9.

30.   Hao Xi, YaohuiGao,Dongyan Han,Qianyu Li, LijinFeng, WeiZhang, GuoJi,Jiacheng Xiao*, HuizhenZhang*, Qing Wei*. Hypoxia inducible factor-1a suppresses Peroxiredoxin 3expressionto promote proliferation of CCRCC cells. FEBS Lett. 2014, 588(18):3390-4.

31.   Gao YH, Li CX, Shen SM, Li H, Chen GQ, Wei Q*, Wang LS*. Hypoxia-induciblefactor 1α mediates the down-regulation of superoxide dismutase 2 in vonHippel-Lindau deficient renal clear cell carcinoma. Biochem Biophys Res Commun.2013, 435(1): 46-51.