同济大学附属第十人民医院眼科是一所拥有近百张床位的上海市 重点学科，目前拥有齐全的临床检查和治疗设备如拍摄眼底疾病的所 有影像学设备包括眼底血管造影仪器可拍摄视网膜造影（FFA），脉络 膜造影（ICGA）和自发荧光等眼底图像，另外还拥有血流 OCT， 3D-OCT 和宽视野眼底照相机器等；另外我院眼科日门诊平均病人的 数量可达 500 余人次，每月进行眼内抗 VEGF 药物注射的患者数量 达 100 余人次。另外, 我科是上海市复明重点学科，白内障手术病人每年 3000 余人。

课题组当前在读学生，四证合一专业型硕士三名，专业型博士三名，学术型直博生两名

当前有多个项目在研

包括：上海市科委项目1项：题目：“科学-城市-生活”系列科普活动——眼底疾病防治。经费：20万，项目编号：22DZ2300200

上海市卫健委重点学科经费：CBA技术检测黄斑变性（AMD）患者房水中细胞因子表达

十院引进人才科研经费：CNV患者房水中靶因子的变化与疾病发病机制的相关性

另作为项目负责人（PI）负责4项全球药物临床试验（GCP）项目，作为Sub-I负责1项GCP项目，所有项目进展顺利。

从事眼科临床、科研和教学工作20余年，曾留学美国洛杉矶 UCLA大学附属Doheny眼科研究所和澳大利亚多年，完成博士后深造。擅长玻璃体视网膜疾病和白内障的诊治，尤其擅长眼底黄斑疾病、糖尿病性视网膜病变、眼底血管阻塞性疾病和视神经疾病的诊治；熟练运用眼科激光技术、玻璃体内药物注射技术及手术方法治愈上万例眼底疾病患者。主持并完成多项科研项目包括国家自然基金面上项目、市科委及卫健委项目等，已发表SCI学术论文50余篇，培养研究生近20名。

以下为近几年科研项目（均为项目负责人）：

1. 主持上海市科委项目1项：题目：“科学-城市-生活”系列科普活动——眼底疾病防治。经费：20万，项目编号：22DZ2300200，时间：2022-8至2023年

2. 主持并完成国家自然基金面上项目1项：题目“基于SPR技术研究房水中靶因子在新生血管AMD疾病中的致病机理”，项目编号：81470025， 30万

3. 主持一项申康科研项目。题目：《促进市级医院临床技能与临床创新三年行动计划》关键支撑项目，2020-2022年，经费：50万， 项目编号：SHDC2020CR5014

4. 主持4项厅局级和院级项目：

(1) 上海市卫健委：“视神经萎缩性疾病的中西医结合临床体系研究”

编号：No. ZY（2018-2020)--FWTX-3010

(2) 上海市卫健委：“糖尿病视神经网膜病变的中西医结合治疗”

编号：No. ZY (2018-2020)-ZWB-1001-CPJS10

(3) 上海市卫健委重点学科经费：CBA技术检测黄斑变性（AMD）患者房水中细胞因子表达

(4) 十院引进人才科研经费：CNV患者房水中靶因子的变化与疾病发病机制的相关性

5. 作为项目负责人（PI）负责4项全球药物临床试验（GCP）项目，作为Sub-I负责1项GCP项目，所有项目进展顺利。

[1] Jin Wei, Yifan Zhou, Kaiweisa Abuduxukuer, et al. Association of Socioeconomic Position with Sensory Impairment Among Chinese Population: a nationally representative cohort and Mendelian randomization study [J]. Frontiers in Public Health, 2024, 12: 1371825.

[2] H. Chen, R. Wang, X. Wang, et al. Unsupervised Local Discrimination for Medical Images [J]. IEEE Transactions on Pattern Analysis and Machine Intelligence, 2023, 45(12): 15912-15929.

[3] Shengyong Diao, Jinzhu Su, Changqing Yang, et al. Classification and segmentation of OCT images for age-related macular degeneration based on dual guidance networks [J]. Biomedical Signal Processing and Control, 2023, 84: 104810.

[4] Yuanyuan Zhang, Tianyu Wang, Zhongqi Wan, et al. Alterations of the intestinal microbiota in age-related macular degeneration [J]. Frontiers in Microbiology, 2023, 14: 1069325.

[5] Yifan Zhou, Yan Lu, Ye Liu, et al. Sensory impairments and subjective well-being status in middle-aged and older Chinese population: Cross-sectional and longitudinal analyses of a nationally representative survey [J]. Frontiers in Public Health, 2023, 11: 1099754.

[6] Yifan Zhou, Jin Wei, Ning Wang, et al. The prevalence, incidence, and persistence of self-reported visual impairment among Chinese population with diabetes mellitus: evaluation from a nationally representative survey [J]. Frontiers in Public Health, 2023, 11: 978457.

[7] Jianhao Bai, Zhongqi Wan, Ping Li, et al. Accuracy and feasibility with AI-assisted OCT in retinal disorder community screening [J]. Frontiers in Cell and Developmental Biology, 2022, 10: 1053483.

[8] Jianhao Bai, Zhongqi Wan, Minli Wang, et al. Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye [J]. Frontiers in Aging Neuroscience, 2022, 14: 1027705.

[9] Jianhao Bai, Zhongqi Wan, Yuanyuan Zhang, et al. Composition and diversity of gut microbiota in diabetic retinopathy [J]. Frontiers in Microbiology, 2022, 13: 926926.

[10] Tingting Sun, Jianhao Bai, Minli Wang, et al. Cytokine profiling in patients with polypoidal choroidal vasculopathy before and after intravitreal injection of ranibizumab [J]. American Journal of Translational Research, 2022, 14(10): 7147-7155.

[11] Tianyu Wang, Tong Zhu, Yuanyuan Zhang, et al. Pan-cancer analysis of the prognostic and immunological role of BRCA1-associated protein 1 gene (BAP1): Friend or foe? [J]. Gene, 2022, 840: 146765.

[12] Yaoyan Qiu, Tingting Sun, Feijia Xu, et al. Correlation of vascular change and cognitive impairment in age-related macular degeneration patients [J]. American Journal of Translational Research, 2021, 13(1): 336-348.

[13] Tingting Sun, Qingquan Wei, Peng Gao, et al. Cytokine and Chemokine Profile Changes in Patients with Neovascular Age-Related Macular Degeneration After Intravitreal Ranibizumab Injection for Choroidal Neovascularization [J]. Drug Design, Development and Therapy, 2021, 15: 2457-2467.

[14] Tianyu Wang, Yuanyuan Zhang, Jianhao Bai, et al. MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma [J]. BMC Cancer, 2021, 21(1): 1068.

[15] Yinghua Fu, Yao Wang, Yin Zhong, et al. Change detection based on tensor RPCA for longitudinal retinal fundus images [J]. Neurocomputing, 2020, 387: 1-12.

[16] Qingquan Wei, Tingting Sun, Zhongqi Wan, et al. Cytokine and chemokine profile changes in patients after intravitreal conbercept injection for center macular edema due to branch retinal vein occlusion [J]. American Journal of Translational Research, 2020, 12(7): 4001-4008.

[17] Qingquan Wei, Tingting Sun, Zhongqi Wan, et al. Cytokine and Chemokine Profile Changes in Patients After Intravitreal Conbercept Injection for Diabetic Macular Edema [J]. Drug Design, Development and Therapy, 2019, 13: 4367-4374.

[18] Kaijie Ma, Le Liu, Pengfei Zhang, et al. Optimization of angle-pixel resolution for angular plasmonic biosensors [J]. Sensors and Actuators B: Chemical, 2019, 283: 188-197.