在研课题：

1. ARID1A突变驱动子宫内膜癌多胺代谢重塑的机制，国家自然基金面上课题，47万，2024年-2027年

2. SOX17突变激活YAP/TEAD转录输出：子宫内膜癌恶性转化的新机制，国家自然基金面上课题，54.7万，2022年-2025年.

3. 雌激素通过下调lncRNA-NORAD介导染色体不稳定：子宫内膜癌发病假想和机制.国家自然基金面上课题，55万，2020年-2023年.

4. 分子分型联合手术机器人前哨淋巴结显影新技术精准评估子宫内膜癌淋巴结状况的推广研究，上海申康医院发展中心临床科技创新项目，100万， 2020年-2023年

5. 卵巢癌专病队列数据库与生物样本全息库建设.上海申康医院发展中心促进市级医院临床技能与临床创新三年行动计划临床研究关键支撑项目，790万，2020年-2022年

6. 基于分子分型的子宫内膜癌术后辅助治疗多中心临床研究，浦东新区卫健委卫生行业专项，30万，2021年-2024年

发表SCI论文100余篇，代表性论著：

1. Wen X, Wan J, He Q, Wang M, Li S, Jiang M, Qian Z, Liu B, Lu W, Wang K, Gao K, Wan X. p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer. Signal Transduct Target Ther. 2020 May 27;5(1):81. doi: 10.1038/s41392-020-0170-6. PMID: 32457342; PMCID: PMC7250911.

2. Gao K, Shi Q, Gu Y, Yang W, He Y, Lv Z, Ding Y, Cao W, Wang C, Wan X. SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis. Cell Death Differ. 2023 Feb;30(2):475-487. doi: 10.1038/s41418-022-01097-7. Epub 2022 Dec 8. PMID: 36481790; PMCID: PMC9950446.

3. Han T, Wu Y, Hu X, Chen Y, Jia W, He Q, Bian Y, Wang M, Guo X, Kang J, Wan X. NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis. Cell Death Dis. 2020 Jun 18;11(6):473. doi: 10.1038/s41419-020-2674-y. PMID: 32555178; PMCID: PMC7303217.

4. Song Y, Wang M, Tong H, Tan Y, Hu X, Wang K, Wan X. Plasma exosomes from endometrial cancer patients contain LGALS3BP to promote endometrial cancer progression. Oncogene. 2021 Jan;40(3):633-646. doi: 10.1038/s41388-020-01555-x. Epub 2020 Nov 18. PMID: 33208911.

5. Wang M, Yan Q, Song Y, Zhang Z, Chen X, Gao K, Wan X. Loss-of-function mutations of SOX17 lead to YAP/TEAD activation-dependent malignant transformation in endometrial cancer. Oncogene. 2023 Jan;42(4):322-334. doi: 10.1038/s41388-022-02550-0. Epub 2022 Nov 29. PMID: 36446891.

7. Tan Y, Bian Y, Song Y, Zhang Q, Wan X. Exosome-Contained APOH Associated With Antiphospholipid Syndrome. Front Immunol. 2021 May 4;12:604222. doi: 10.3389/fimmu.2021.604222. PMID: 34040601; PMCID: PMC8143051.

8. Chen G, Liu B, Yin S, Li S, Guo Y, Wang M, Wang K, Wan X. Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA. Oncogenesis. 2020 Sep 11;9(9):81. doi: 10.1038/s41389-020-00265-z. PMID: 32913192; PMCID: PMC7484801.

9. Li BL, Lu W, Qu JJ, Ye L, Du GQ, Wan XP. Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis. J Cell Physiol. 2019 Mar;234(3):2943-2953. doi: 10.1002/jcp.27111. Epub 2018 Aug 26. PMID: 30146796.

10. Li Y, Che Q, Bian Y, Zhou Q, Jiang F, Tong H, Ke J, Wang K, Wan XP. Autocrine motility factor promotes epithelial-mesenchymal transition in endometrial cancer via MAPK signaling pathway. Int J Oncol. 2015 Sep;47(3):1017-24. doi: 10.3892/ijo.2015.3091. Epub 2015 Jul 20. PMID: 26201353.