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1.同济大学附属第十人民医院院长
Tenth Peoples Hospital of TONGII University Dean
2.中国生物医学工程学会透析移植分会 副主任委员
Deputy Director of the Dialysis and Transplantation Branch, Chinese Society of Biomedical Engineering
3.中华医学会泌尿外科分会尿控学组 委员
Member of the Urinary Incontinence Study Group, Urology Branch, Chinese Medical Association
4.中华医学会器官移植分会移植感染学组委员、器官捐献学组委员
Member of the Transplant Infection Study Group and Organ Donation Study Group, Organ Transplant Branch, Chinese Medical Association
5.全国卫生产业企业管理协会卫生与防疫耗材分会副会长
Vice President of the Health and Epidemic Consumables Branch, National Health Industry Enterprise Management Association
6.上海市医院协会第四届理事会 理事
Director, 4th Council of the Shanghai Hospital Association
7.上海市免疫学会第十三届理事会 理事
Director, 13th Council of the Shanghai Immunology Society
8.上海医学会器官移植分会 委员
Member of the Organ Transplant Branch, Shanghai Medical Association
9.上海市中西医结合学会肿瘤微创医学专委会 副主委
Deputy Director of the Tumor Minimally Invasive Medicine Committee, Shanghai Society of Integrated Traditional Chinese and Western Medicine
团队长期从事泌尿外科临床和科研工作，一直关注膀胱癌发病机制与诊疗技术的研究。课题组发表相关 SCI 学术论文 33篇，申请专利3项，授权专利2项。申请人完成国家自然科学基金面上项目2项。另有科技部子课题1项，国家自然科学基金面上项目1项（在研）。所在单位为同济大学附属的最大的三甲综合医院，同济大学癌症中心的依托单位，拥有国家临床重点专科3个，上海市工程中心2个，上海市技术创新中心1个，上海市技术服务中心1个，上海市医学研究中心2个，“一带一路”国际联合实验室1个。所在泌尿外科的主要科研方向之一为膀胱癌基础研究，近5年发表相关论文60余篇。
近三年科研课题
1. 肿瘤来源Wnt7a重塑转移小生境成纤维细胞促进膀胱癌肺转移的机制研究
国家自然科学基金委员会面上项目2021.1-2024.12（55万）
2. 基于膀胱灌注双靶向金纳米探针实现膀胱微小病灶可视化诊疗的研究
国家自然科学基金委重大研发计划培育项目2021.1-2023.12（60万）
3.基于交互式诊疗系统的医疗能力评估体系构建（《标准化儿童患者模型关键技术与应用》2021ZD0113501子课题）
国家科技部科技创新2030-“新一代 人工智能”重大项目子课题2021.12-2024.11（159万）
4. IGF2BP2 通过 m6A 依赖方式调控TXNDC12/B-catenin 信号轴影响膀胱癌进展的机制研究
上海市科委自然科学基金2023.4.1-2026.3.31（20万）
| 23ZR1446000 | IGF2BP2 通过 m6A 依赖方式调控TXNDC12/B-catenin 信号轴影响膀胱癌进展的机制研究 | 上海市科委自然科学基金 | 2023-04~2026-03 | 20万元 | 课题负责人 |
| 92059112 | 基于膀胱灌注双靶向金纳米探针实现膀胱微小病灶可视化诊疗的研究 | 国家自然科学基金委重大研发计划培育项目 | 2021-01~2023-12 | 60万元 | 课题负责人 |
| 82072821 | 肿瘤来源Wnt7a重塑转移小生境成纤维细胞促进膀胱癌肺转移的机制研究 | 国家自然科学基金委员会面上项目 | 2021-01~2024-12 | 55万元 | 课题负责人 |
| 20SJKJGG250 | 肿瘤来源Wnt7a活化肺成纤维细胞促进膀胱癌肺转移的机制研究 | 2020年度松江区科技攻关（医疗卫生类）项目 | 2020-07~2023-06 | 8万元 | 课题负责人 |
| ZHYY-ZXYJHZX-1-201705 | 膀胱灌注化疗联合厚朴通闭汤干预膀胱癌术后患者的临床研究 | 上海市综合医院中西医结合专项 | 2018-01~2019-12 | 80万元 | 课题负责人 |
| 320.6750.16051 | B型单氨氧化酶在膀胱癌细胞转移的分子机制研究 | 吴阶平医学基金会临床科研专项资助基金 | 2016-07~2019-06 | 10万元 | 课题负责人 |
| 81470116 | 和厚朴酚通过调控EZH2/microRNAs抑制膀胱癌肿瘤干细胞的分子机制研究 | 国家自然科学基金委员会面上项目 | 2015-01~2016-12 | 30万元 | 课题负责人 |
| 14ZR1433200 | 和厚朴酚抑制膀胱癌肿瘤干细胞的分子机制研究 | 上海市科委自然科学基金 | 2014-07~2017-06 | 10万元 | 课题负责人 |
1. Yilin Yan#, Zhengnan Huang#, Jinming Cai, Pengfei Tang, Fang Zhang*, Mingyue Tan*, Bing Shen*.Identification of a novel immune microenvironment signature predicting survival and therapeutic options for bladder cancer. Aging 2021, Vol. 13, No. 2.2780-2802.
2. Zhengnan Huang# ,Yilin Yan#, Pengfei Tang, Jinming Cai, Xiangqian Cao, Zeyi Wang, Fang Zhang*, Bing Shen*. TEAD4 as a Prognostic Marker Promotes Cell Migration and Invasion of Urinary Bladder Cancer via EMT. OncoTargets and Therapy. 2021:14 937–949.
3. Shenyi Wang#, Jinming Cai#, Si Zhang, Mingwei Dong, Li Zhang,Yingying Xu*, Bing Shen*,She Chen*.Loss of polarity protein Par3, via transcription factor Snail,promotes bladder cancer metastasis. Cancer Science. 2021;00:1–17.
4. Zhengnan Huang #, Yilin Yan #, Zhen Zhu #, Jiakuan Liu, Xiao He, Sumiya Dalangood, Meiqian Li, Mingyue Tan, Jinming Cai, Pengfei Tang, Ruimin Huang, Bing Shen*, Jun Yan*. CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling. Cell Death Dis. 2021 May 25;12(6):537. doi: 10.1038/s41419-021-03819-0.
5. Yilin Yan#, Jinming Cai#, Zhengnan Huang , Xiangqian Cao, Pengfei Tang , Zeyi Wang , Fang Zhang*, Shujie Xia* and Bing Shen*.A Novel Ferroptosis-related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer. Front Cell Dev Biol. 2021 Aug 20;9:712230. doi: 10.3389/fcell.2021.712230. eCollection 2021.
6. Zhengnan Huang#; Jiakuan Liu#; Jiale Yang; Yilin Yan; Chenkai Yang; Xiao He; Ruimin Huang; Mingyue Tan; Denglong Wu*, Jun Yan* and Bing Shen*. PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7. Frontiers in Cell and Developmental Biology, 2021, 9(712230)
7. Yilin Yan#, Xiangqian Cao#, Zeyi Wang, Zhengnan Huang , Jinming Cai , Pengfei Tang , Chenkai Yang , Fang Zhang*, Shujie Xia* and Bing Shen*. Pyroptosis-Related Patterns Predict Tumor Immune Landscape and Immunotherapy Response in Bladder Cancer. Front Mol Biosci. 2022 Apr 26;9:815290. doi: 10.3389/fmolb.2022.815290. eCollection 2022.
8. Zhengnan Huang#, Yilin Yan#, Tengjiao Wang#, Zeyi Wang， Jinming Cai, Xiangqian Cao, Chenkai Yang, Fang Zhang*, Gang Wu* and Bing Shen*.Identifcation of ENO1 as a prognostic biomarker and molecular target among ENOs in bladder cancer. Journal of Translational Medicine (2022) 20:315 https://doi.org/10.1186/s12967-022-03509-1.
9. Jinming Cai#, Zhiwen Xie#, Yilin Yan , Zhengnan Huang , Pengfei Tang, Xiangqian Cao, Zeyi Wang, Chenkai Yang, Mingyue Tan*, Fang Zhang* and Bing Shen*. Establishment of an optimized orthotopic bladder cancer model in mice. BMC Urology (2022)22:142. https://doi.org/10.1186/s12894-022-01093-6.
10. Jinming Cai#, Haoran Xie#, Yilin Yan, Zhengnan Huang, Pengfei Tang, Xiangqian Cao, Zeyi Wang, Chenkai Yang, Jiling Wen*, Mingyue Tan*, Fang Zhang* and Bing Shen*. A novel cuproptosis-related lncRNA signature predicts prognosis and therapeutic response in bladder cancer. Frontiers in Genetics, 04 January 2023, DOI 10.3389/fgene.2022.1082691.
11. Zeyi Wang#，Zhengnan Huang# , Xiangqian Cao#, Fang Zhang , Jinming Cai, Pengfei Tang, Chenkai Yang, Shengzhou Li, Dong Yu, Yilin Yan, Bing Shen*. A prognostic model based on necroptosis-related genes for prognosis and therapy in bladder cancer. BMC Urol, 2023 Jan 28;23(1):10. doi: 10.1186/s12894-023-01175-z.
12. Jingming Zhuang#, Jiahang Mo#, Zhengnan Huang, Yilin Yan, Zeyi Wang, Xiangqian Cao, Chenkai Yang, Bing Shen* and Fang Zhang*. Mechanisms of Xiaozheng decoction for anti-bladder cancer efects via afecting the GSK3β/β-catenin signaling pathways: a network pharmacology-directed experimental investigation. Chinese Medicine, 2023 18:104: doi.org/10.1186/s13020-023-00818-5
13. Xiangqian Cao#, Chenkai Yang#, Xiaodong Zhu#, Mengxin Zhao, Yilin Yan, Zhengnan Huang, Jinming Cai, Jingming Zhuang, Shengzhou Li, Wei Li*, Bing Shen*. Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters. Available online 13 October 2023, 109199
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