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徐美东，外科学博士，主任医师，教授，博士生导师。现任同济大学附属东方医院副院长，消化内科及消化内镜中心主任。上海市第十六届人大代表、上海市工会代表。获国家级百千万人才工程“有突出贡献中青年专家”、上海市五一劳动奖章、上海市优秀学术带头人、上海领军人才、上海工匠、上海市科技精英（提名奖）、上海市医务工匠、浦东新区科技精英、浦东工匠。
主要从事消化内镜微创治疗，是国内最早开展ESD治疗消化道早癌及癌前病变、POEM治疗贲门失弛缓症的专家之一，是我国乃至世界消化内镜切除技术迅速发展的推动者和引领者之一。2011年在国际上首创STER术治疗各种消化道黏膜下肿瘤，该术式极大地提高了内镜切除手术的安全性，被作为治疗黏膜下肿瘤的标准安全手术方式写入国内及国际多个指南。多次应邀出席参加美国、意大利、西班牙、德国、荷兰、希腊、印度等世界各地举办的国际消化内镜学术大会，通过大会主题演讲及手术操作演示，在世界各地推广以STER为代表的内镜切除新技术。目前STER已经在临床广泛开展应用，并被业界称之为“徐氏手术”，造福了数以万计的患者。同时在国内率先开展了多项内镜诊疗新技术：如国内第一例急性完全性大肠梗阻的导管和支架治疗、第一例经鼻胃镜置管和支架术、第一例超声胃镜引导下胃空肠吻合术等、第一例自控式防狭窄水囊防治食管狭窄。
近年来主持科研课题10余项，其中国家级课题4项，省部级课题7项。第一/通讯发表SCI论文50余篇，包括《Gastroenterology》、《Gut》、《American Journal of Gastroenterology》、《Annalsof Surgery》、《Gastrointestinal Endoscopy》、《Endoscopy》等世界顶级消化内镜或外科学杂志，总影响因子300余分，被引用次数超过1000次。主编专著4部，参编10余部。作为主要完成人，荣获国家科技进步二等奖、上海市科技进步奖一等奖、华夏医学科技一等奖、教育部科技进步奖一等奖、上海市优秀发明奖银奖等多项省部级奖项及荣誉。现任中华医学会消化内镜学分会全国委员、消化内镜隧道技术协作组副组长，中国医师协会内镜医师分会常委，上海市医学会消化内镜分会委员兼秘书，上海市抗癌协会消化内镜专业委员会副主任委员等学术任职，《中华消化内镜杂志》、《中国内镜杂志》等杂志编委。
| 项目名称 | 项目种类 | 起止日期 |
| PSAT1 调控组蛋白甲基化增强ACSL1 基因转录在食管癌进展中的作用研究 | 国家自然科学基金面上项目 | 2021.01-2024.12 |
| 代谢组学在内镜诊治食管早癌中的应用价值 | 上海市优秀学术带头人 | 2020.10-2023.09 |
| 基于多模态图像精准对应的早期胃癌筛查人工智能模型探索与开发 | 上海市“科技创新行动计划”基础研究领域项目 | 2021.10-2023.09 |
| 代谢应激状态乙酰辅酶A合成酶2（ACSS2）增强表达及其促进食管早癌转移的机制研究 | 上海领军人才计划 | |
| 消化病学 | 浦东新区临床高峰学科 | 2021.12.1-2024.11.30 |
| 可注射性热致水凝胶系统在内镜黏膜下剥离术中的应用基础研究 | 国家自然科学基金面上项目 | 2016.01.01-2019.12.31 |
| 内镜黏膜下剥离术后食管狭窄：关键 miRNA 促进肌成纤维细胞表型转化在食管粘膜损伤及修复中的作用 | 国家自然科学基金面上项目 | 2014.01.01-2017.12.31 |
| 大肠息肉癌变诊断中形态学的统计分析 | 国家自然科学基金面上项目 | 2011.01.01-2013.12.31 |
| 由纳米粒子构筑的热致水凝胶负载TGF-β1单抗用于食管内镜黏膜下剥离术后的创面修复 | 上海市科委基础研究重点项目 | 2015.09.01-2018.08.31 |
| 应用于内镜黏膜下剥离术中的可注射性热致水凝胶 | 上海市科委项目 | 2014.07.01-2017.09.30 |
| 提高西藏日喀则地区消化道早期癌内镜规范化治疗水平 | 上海市科委项目 | 2015.07-2016.06 |
发表SCI文章（第一、通讯）：
1. Chen T, Wang GX, Lian JJ, XuAP, Leng ZY, Zhang L, Li SX, Wang XY, Xu MD. Submucosal Tunneling EndoscopicResection for Submucosal Tumors in the Proximal Esophagus. J Am Coll Surg 2022,234(6): 1127-1135.
2. Sun MC, Fang K, Li ZX, Chu Y,Xu AP, Zhao ZY, Leng ZY, Zhang YW, Zhang ZH, Zhang L, Chen T, Xu MD. ETV5overexpression promotes progression of esophageal squamous cell carcinoma byupregulating SKA1 and TRPV2. INT J MED SCI 2022, 19(6):1072-1081.
3. Zhang Z, Yan X, Duan B, Leng Z,Zhang H, Li J, Zhu Y, Xu M, Xu Q. A New Preparation Method for PeroralEndoscopic Myotomy in Patients with Achalasia Can Effectively Reduce theEsophageal Residual Contents: A Comparative Retrospective Study. Gastroenterol Res Pract 2022, 2022: 6953166.
4. Chen T, Xu M. Transcolonicnatural orifice transluminal endoscopic surgery (NOTES) is a promisingtechnique for but not limited to periappendiceal lesions. GUT 2022.
5. Lian J, Chu Y, Chen T, Li F, XuA, Zhang H, Xu M. Outcome of a novel self-control stricture-preventing waterballoon for complete circular esophageal endoscopic submucosal dissection. SURGENDOSC 2022.
6. Zhang Z, Leng Z, Fang K, Sun M,Li Z, Kang L, Chen T, Xu M. Global research trend of esophageal squamous cellcarcinoma from 2012 to 2022: a bibliometric analysis. FRONT ONCOL 2022, 12: 977935.
7. Chen T, Xu A, Lian J, Chu Y,Zhang H, Xu M. Transcolonic endoscopic appendectomy: a novel natural orificetransluminal endoscopic surgery (NOTES) technique for the sessile serratedlesions involving the appendiceal orifice. GUT 2021, 70(10):1812-1814.
8. Yan X, Hu X, Duan B, Zhang X,Pan J, Fu J, Xu M, Xu Q. Exploration of endoscopic findings and risk factors ofearly gastric cancer after eradication of Helicobacter pylori. Scand JGastroenterol 2021, 56(3): 356-362.
9. Chen T, Xu A, Lian J, Chu Y,Zhao Z, Zhang L, Xu M. Endoscopic Submucosal Dissection for SuperficialPharyngeal Carcinoma Is Effective and Safe. Surg Laparosc Endosc Percutan Tech2021, 32(2): 217-222.
10. Zhu Y, Xu M, Xu C, Zhang X,Chen S, Zhong Y, Zhang Y, Chen W, Chen T, Xu J, Yao L, Li Q, Zhou P.Microscopic positive tumor margin does not increase the rate of recurrence inendoscopic resected gastric mesenchymal tumors compared to negative tumormargin. Surgical Endoscopy 2020, 34(1): 159-169.
11. Li H, Li Q, Lian J, Chu Y, FangK, Xu A, Chen T, Xu M. MLL2 promotes cancer cell lymph node metastasis byinteracting with RelA and facilitating STC1 transcription. CELL SIGNAL 2020, 65:109457.
12. Wang G, Yu G, Xiang Y, Miu Y,Wang H, Xu M. Submucosal tunneling endoscopic resection for large symptomaticsubmucosal tumors of the esophagus: A clinical analysis of 24 cases. TheTurkish Journal of Gastroenterology 2020, 31(1): 42-48.
13. Fang K, Chu Y, Zhao Z, Li Q, LiH, Chen T, Xu M. Enhanced expression of asparagine synthetase underglucose-deprived conditions promotes esophageal squamous cell carcinomadevelopment. INT J MED SCI 2020, 17(4): 510-516.
14. Lian J, Xu A, Chu Y, Chen T, XuM. Early primary anorectal malignant melanoma treated with endoscopicsubmucosal dissection: a case report. INT J COLORECTAL DIS 2020, 35(5):959-961.
15. Chu Y, Xu M. A Real-WorldPromising Result of Endoscopic Full-Thickness Resection: It's Time forEndoscopic Full-Thickness Resection to Be Widely Used. AM J GASTROENTEROL 2020,115(12): 1972-1973.
16. Chu Y, Chen T, Li H, Zhou P,Zhang Y, Chen W, Zhong Y, Yao L, Xu M. Long-term efficacy and safety ofintralesional steroid injection plus oral steroid administration in preventingstricture after endoscopic submucosal dissection for esophageal epithelial neoplasms.SURG ENDOSC 2019, 33(4): 1244-1251.
17. Ferreira Cardoso M, Cai MY, XuMD. Endoscopic full‐thickness resection of a colonic schwannoma. DIGESTENDOSC 2019, 31(3).
18. Zhang Y, Ding H, Chen T, ZhangX, Chen W, Li Q, Yao L, Korrapati P, Jin X, Zhang Y, Xu M, Zhou P. Outcomes ofEndoscopic Submucosal Dissection vs Esophagectomy for T1 Esophageal SquamousCell Carcinoma in a Real-World Cohort. CLIN GASTROENTEROL H 2019, 17(1):73-81.
19. Chen H, Li B, Li L,Vachaparambil CT, Lamm V, Chu Y, Xu M, Cai Q. Current Status of EndoscopicResection of Gastric Subepithelial Tumors. The American Journal ofGastroenterology 2019, 114(5): 718-725.
20. Li Q, Xu A, Chu Y, Chen T, LiH, Yao L, Zhou P, Xu M. Rap1A promotes esophageal squamous cell carcinomametastasis through the AKT signaling pathway. ONCOL REP 2019, 42(5):1815-1824.
21. Chen T, Lin Z, Zhang Y, Chen W,Zhong Y, Wang Q, Yao L, Zhou P, Xu M. Submucosal Tunneling Endoscopic Resectionvs Thoracoscopic Enucleation for Large Submucosal Tumors in the Esophagus andthe Esophagogastric Junction. J AM COLL SURGEONS 2017, 225(6):806-816.
22. Zhang Y, Chen T, Zhang C, Li Q,Chen W, Yao L, Zhou P, Xu M. Endoscopic Submucosal Dissection for SuperficialProximal Esophageal Neoplasia is Highly Successful. ANN SURG 2017, 266(6):995-999.
23. Chen T, Zhang Y, Chen W, Hou Y,Yao L, Zhong Y, Xu M, Zhou P. Efficacy and safety of additional surgery afternon-curative endoscopic submucosal dissection for early colorectal cancer. BMCGASTROENTEROL 2017, 17(1): 134.
24. Hu J, Ge L, Zhou P, Li Q, ZhangY, Chen W, Chen T, Yao L, Xu M, Chu Y. A novel grasp-and-loop closure methodfor defect closure after endoscopic full-thickness resection (with video).Surgical Endoscopy 2017, 31(10): 4275-4282.
25. Chen T, Zhou P, Chu Y, Zhang Y,Chen W, Ji Y, Yao L, Xu M. Long-term Outcomes of Submucosal TunnelingEndoscopic Resection for Upper Gastrointestinal Submucosal Tumors. ANN SURG2017, 265(2): 363-369.
26. Cao L, Li Q, Zhang C, Wu H, YaoL, Xu M, Yu L, Ding J. Safe and Efficient Colonic Endoscopic SubmucosalDissection Using an Injectable Hydrogel. ACS BIOMATER SCI ENG 2016, 2(3):393-402.
27. Xu M, Cai Q. Editorial:Endoscopic Resection of Upper Gastrointestinal Subepithelial Tumors: PromisingNew Endoscopic Techniques—Are They Here to Stay? AM J GASTROENTEROL 2016, 111(6):797-799.
28. Li Q, He M, Xu M. An UnusualCause of Dysphagia and Melena. GASTROENTEROLOGY 2016, 151(4):e7-e8.
29. Li Q, Chen W, Zhang X, Cai M,Zhang Y, Hu J, He M, Yao L, Zhou P, Xu M. Submucosal Tunneling EndoscopicSeptum Division: A Novel Technique for Treating Zenker's Diverticulum.GASTROENTEROLOGY 2016, 151(6): 1071-1074.
30. Chen T, Zhang C, Yao L, Zhou P,Zhong Y, Zhang Y, Chen W, Li Q, Cai M, Chu Y, Xu M. Management of thecomplications of submucosal tunneling endoscopic resection for uppergastrointestinal submucosal tumors. ENDOSCOPY 2016, 48(02):149-155.
31. Du N, Wang X, Guo J, Xu M.Attraction Propagation: A User-Friendly Interactive Approach for PolypSegmentation in Colonoscopy Images. PLOS ONE 2016, 11(5):e155371.
32. Zhang C, Hu JW, Chen T, ZhouPH, Zhong YS, Zhang YQ, Chen WF, Li QL, Yao LQ, Xu MD. Submucosal tunnelingendoscopic resection for upper gastrointestinal multiple submucosal tumorsoriginating from the muscular propria layer: a feasibility study. INDIAN JCANCER 2015, 51 Suppl 2: e52-e55.
33. Li QL, Chen WF, Zhang C, Hu JW,Zhou PH, Zhang YQ, Zhong YS, Yao LQ, Xu MD. Clinical impact of submucosaltunneling endoscopic resection for the treatment of gastric submucosal tumorsoriginating from the muscularis propria layer (with video). SURG ENDOSC 2015, 29(12):3640-3646.
34. Li QL, Gao WD, Zhang C, ZhouPH, Zhong YS, Chen WF, Zhang YQ, Yao LQ, Xu MD. Is endoscopic sphincterotomyplus large-balloon dilation a better option than endoscopic large-balloondilation alone in removal of large bile duct stones? A retrospective comparisonstudy. INDIAN J CANCER 2015, 51 Suppl 2(5): e13.
35. Li S, Yuan C, Xu M. Twodifferent endoscopic long intestinal tube placements for small bowelobstruction: Transnasal ultrathin endoscopy versus conventional endoscopy. JCANCER RES THER 2015, 11(8): 248.
36. Li S, Xu M, Yuan C. Twoendoscopic submucosal dissection procedures for stripping huge segment of thegastric mucosa to treat early gastric signet ring cell carcinoma. J CANCER RESTHER 2015, 11(8): 253.
37. Hu JW, Zhang C, Chen T, ZhouPH, Zhong YS, Zhang YQ, Chen WF, Li QL, Yao LQ, Xu MD. Submucosal tunnelingendoscopic resection for the treatment of rectal submucosal tumors originatingfrom the muscular propria layer. J CANCER RES THER 2014, 10 Suppl: 281-286.
38. Wang XY, Xu MD, Yao LQ, ZhouPH, Pleskow D, Li QL, Zhang YQ, Chen WF, Zhong YS. Submucosal tunnelingendoscopic resection for submucosal tumors of the esophagogastric junctionoriginating from the muscularis propria layer: a feasibility study (withvideos). SURG ENDOSC 2014, 28(6): 1971-1977.
39. Lu W, Xu MD, Zhou PH, Zhang YQ,Chen WF, Zhong YS, Yao LQ. Endoscopic submucosal dissection of esophagealgranular cell tumor. WORLD J SURG ONCOL 2014, 12(1): 1-7.
40. Xu M, Wang X, Zhou P, Li Q,Zhang Y, Zhong Y, Chen W, Ma L, Ishaq S, Qin W, Hu J, Yao L. Endoscopicfull-thickness resection of colonic submucosal tumors originating from themuscularis propria: an evolving therapeutic strategy. ENDOSCOPY 2013, 45(09):770-773.
41. Xu M, Wang X, Li Q, Zhou P, ZhangY, Zhong Y, Chen W, Ma L, Qin W, Hu J, Yao L. Colorectal lateral spreadingtumor subtypes: clinicopathology and outcome of endoscopic submucosaldissection. INT J COLORECTAL DIS 2013, 28(1): 63-72.
42. Xu M, Cai M, Zhou P, Qin X,Zhong Y, Chen W, Hu J, Zhang Y, Ma L, Qin W, Yao L. Submucosal tunnelingendoscopic resection: a new technique for treating upper GI submucosal tumorsoriginating from the muscularis propria layer (with videos). GASTROINTESTENDOSC 2012, 75(1): 195-199.
43. Shi Q, Xu M, Zhong Y, Zhou P,Wu H, Yao L. The Laparoscopic-Endoscopic Cooperative Surgery for the ColonicCalcifying Fibrous Tumor: One Case Report. J LAPAROENDOSC ADV S 2012, 22(10):996-998.
44. Xu M, Zhong Y, Yao L, Xu J,Zhou P, Wang P, Wang H. Endoscopic decompression using a transanal drainagetube for acute obstruction of the rectum and left colon as a bridge to curativesurgery. COLORECTAL DIS 2009, 11(4): 405-409.
45. Yao LQ, Zhang YQ, Zhou PH, GaoWD, He GJ, Xu MD. Endoscopic sphincterotomy or papillary balloon dilatation forcholedocholithiasis. Hepatobiliary Pancreat Dis Int 2002, 1(1):101-105.
专著：
| 专著名字 | 发表/出版时间 | 出版社期刊名称 |
| 幽门螺杆菌图谱：形态、结构与感染特征 | 2021-04 | 科学出版社 |
| 隧道内镜治疗学 | 2017-04 | 复旦大学出版社 |
| 实用消化内镜手术学 | 2013-03 | 华中科技大学出版社 |
| 消化系统疑难及少见病例临床荟萃 | 2018-08 | 科学技术文献出版社 |
专利：
| 专利名称 | 专利类型 |
| 一种多功能高频切开刀 | 发明专利 |
| 一种多功能高频切开刀 | 实用新型专利 |
| 用于预防食管狭窄的自控型水囊导管 | 实用新型专利 |
| 依附内镜使用的止血吸引导管 | 实用新型专利 |
| 多用途内镜抓钳 | 实用新型专利 |
| 兼具载药和塑形的食道支架装置 | 实用新型专利 |
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同济大学