吴德升，主任医师、教授、医学博士、博士生导师，同济大学附属东方医院脊柱外科主任，上海市医学会骨科分化脊柱学组组长，著名脊柱外科专家，长期从事脊柱退变性疾病临床治疗和基础研究。现有脊柱外科南、北两院包括主任医师、副主任医师等在内的医疗团队20人，以及包括硕士研究生、博士研究生、副研究员等在内的科研团队数人。现已培养硕士、博士研究生40余人，指导学生获得研究生国家奖学金、学业奖学金等多项奖励，并与NYU、UPenn等多所世界名校进行博士研究生联合培养。现有包括国家自然科学基金在内的在研科研项目数项，近三年发表SCI论文20余篇。

1. 国家自然科学基金面上项目, 82272537，单细胞测序鉴定KLF4+小鼠纤维环干细胞及TGF-β/Smad信号轴在椎间盘损伤修复中的机制研究，2023-01-01 至 2026-12-31，55万元，在研，主持

2. 国家自然科学基金面上项目, 81972106, 小分子化合物Kartogenin联合骨髓间充质干细胞促进退变椎间盘修复及其机制研究, 2020-01-01 至 2023-12-31, 55万元, 结题, 主持

3. 国家自然科学基金面上项目，8167090208，水通道蛋白在介导尼古丁诱导椎间盘退变过程中的作用机制，2017.01-2020.12，60万元，结题，主持

4. 国家自然科学基金面上项目，81371994，瘦素调控椎体软骨终板的机制研究，2014.01-2017.12，55万元，结题，主持

5. 上海市科委医学创新研究项目，自体脂肪间充质干细胞治疗椎间盘源性腰痛的临床研究，30万元，在研，主持

6. 上海市东方医院临床研究项目，椎间盘退变性疾病的生物学修复治疗，40万元，在研，主持

7. 浦东新区重点学科建设，PWZxk2017-08， 80万，结题，主持

8. 上海市科委医药重点项目，12411951202，腰椎后外侧融合椎弓根钉置入对固定及相邻节段椎间盘影响的基础及临床应用研究，20万，结题，主持

9. 上海市卫计委重点课题，201440016，新型颈椎后路椎板成型融合器的应用基础研究，2015.1.1-2017.12.31，10万，结题，主持

10. 浦东新区卫计委重点学科脊柱外科附带课题，PWZx2014-02，颈椎前路手术干预优化的临床应用研究，18万，结题，主持

11. 浦东新区卫生局，PW11-4，椎管静脉丛内炎性介质在对腰椎管狭窄症形成机制中的临床研究，1.8万，结题，主持

12. 浦东新区科委，PK00-1，颈椎前路椎体间融合方式改进的基础与临床应用研究，7万，结题，主持

13. 浦东新区社发局，PW04-3，PDN人工髓核置换术治疗下腰痛的临床应用研究，4万，结题，主持

14. 浦东新区社发局，PW03-2，陆家嘴地区金融从业人员颈椎病现状的流行病学调查和预防对策，4万，结题，主持

1. 国家自然科学基金面上项目, 82272537，单细胞测序鉴定KLF4+小鼠纤维环干细胞及TGF-β/Smad信号轴在椎间盘损伤修复中的机制研究，2023-01-01 至 2026-12-31，55万元，在研，主持

2. 国家自然科学基金面上项目, 81972106, 小分子化合物Kartogenin联合骨髓间充质干细胞促进退变椎间盘修复及其机制研究, 2020-01-01 至 2023-12-31, 55万元, 结题, 主持

3. 国家自然科学基金面上项目，8167090208，水通道蛋白在介导尼古丁诱导椎间盘退变过程中的作用机制，2017.01-2020.12，60万元，结题，主持

4. 国家自然科学基金面上项目，81371994，瘦素调控椎体软骨终板的机制研究，2014.01-2017.12，55万元，结题，主持

1. Guo K, Zeng J, Lu J, Guo Y, Shan P, Huang Y, et al. The clinicalsignificance of the Neutrophil-to-Lymphocyte Ratio as a novel inflammatorybiomarker for assessing the severity of intervertebral disc degeneration. FrontMed (Lausanne). 2024;11:1446124.

2. Lu J, Guo K, Liu EZ, Braun C, Huang Y, WuD. The Impact of Preoperative Adaptive Training on Postoperative Outcomes inLumbar Spine Fusion Surgery for Lumbar Disc Herniation: A RetrospectiveAnalysis. J Pain Res. 2024;17:73-81.

3. Shen B, Gao Z, Wang B, Huang Y, Wu D.Relationship between intervertebral disc height and post operative dysphagiasecondary to single-level anterior cervical discectomy and fusion- aretrospective study. BMC Musculoskelet Disord. 2024;25(1):369.

4. Zhao HH, Xu HW, Wang SJ, Hu T, Wu DS.Anterior cervical discectomy and fusion with a zero-profile VA spacer device: aclinical and radiological study with two-year follow-up. J Orthop Surg Res.2024;19(1):51.

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7. Guo Y, Zhou Y, Zhao H, Hu T, Wu D. Serumantioxidant enzymes in spinal stenosis patients with lumbar disc herniation:correlation with degeneration severity and spinal fusion rate. BMCMusculoskelet Disord. 2023;24(1):782.

8. Zeng J, Xiong S, Zhou J, Wei P, Guo K,Wang F, et al. Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 toRecruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote BoneRegeneration in Bone Defects. Int J Nanomedicine. 2023;18:3509-34.

9. Shen B, Ba Z, Huang Y, Wu D.Intramedullary spinal cord metastasis from esophageal squamous cell carcinoma:case report and literature review. BMC Neurol. 2023;23(1):100.

10. Song X, Ren D, Zhang F, Han S, Wu D, WangJ. Percutaneous versus open posterior stabilization and decompression inAOSpine-type A3 thoracolumbar fractures with neurological deficit. BMCMusculoskelet Disord. 2023;24(1):385.

11. Wang F, Guo K, Nan L, Wang S, Lu J, WangQ, et al. Kartogenin-loaded hydrogel promotes intervertebral disc repair viaprotecting MSCs against reactive oxygen species microenvironment byNrf2/TXNIP/NLRP3 axis. Free Radic Biol Med. 2023;204:128-50.

12. Wang Q, Gao Z, Guo K, Lu J, Wang F, HuangY, et al. ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNAsignaling pathway. J Orthop Surg Res. 2022;17(1):455.

13. Wang Q, Gao Z, Guo K, Wang F, Wu D.Effect of sagittal screw angle and distance of screw apex to superior endplateon adjacent segment disease after posterolateral lumbar fusion: a retrospectivestudy. J Orthop Surg Res. 2022;17(1):486.

14. Zhou N, Shen B, Bai C, Ma L, Wang S, WuD. Nutritional deficiency induces nucleus pulposus cell apoptosis via theATF4-PKM2-AKT signal axis. BMC Musculoskelet Disord. 2022;23(1):946.

15. Guo Y, Guo K, Hu T, Wu D. Correlationbetween serum angiotensin-converting enzyme (ACE) levels and intervertebraldisc degeneration. Peptides. 2022;157:170867.

16. Guo Y, Li C, Shen B, Chen X, Hu T, Wu D.Is intervertebral disc degeneration associated with reduction in serumferritin? Eur Spine J. 2022.

17. Chen H, Yi YY, Zhang SB, Xu HW, Fang XY,Tao H, et al. Sarcopenic obesity defined by visceral adiposity was associatedwith osteoporotic vertebral fracture. Arch Osteoporos. 2022;17(1):41.

18. Guo Y, Zhao H, Lu J, Xu H, Hu T, Wu D.Preoperative Lymphocyte to Monocyte Ratio as a Predictive Biomarker for DiseaseSeverity and Spinal Fusion Failure in Lumbar Degenerative Diseases PatientsUndergoing Lumbar Fusion. J Pain Res. 2022;15:2879-91.

19. Guo Y, Zhao H, Xu H, Gu H, Cao Y, Li K,et al. Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker forSpinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar SpinalFusion. J Clin Med. 2022;11(16).

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21. Wang F, Wang S, Nan L, Lu J, Zhu Z, YangJ, et al. Conductive Adhesive and Antibacterial Zwitterionic Hydrogel Dressingfor Therapy of Full-Thickness Skin Wounds. Front Bioeng Biotechnol.2022;10:833887.

22. Wang F, Wang SG, Yang Q, Nan LP, Cai TC,Wu DS, et al. In Reply to the Letter to the Editor Regarding "Cytotoxicityand Effect of Topical Application of Tranexamic Acid on Human Fibroblast inSpine Surgery". World Neurosurg. 2022;157:261.

23. Wang Q, Gao Z, Guo K, Lu J, Wang F, Wu T,et al. Human Umbilical Cord Wharton Jelly Cells Treatment Prevents OsteoporosisInduced by D-Galactose. Int J Clin Pract. 2022;2022:4593443.

24. Wu T, Jia X, Zhu Z, Guo K, Wang Q, Gao Z,et al. Inhibition of miR-130b-3p restores autophagy and attenuatesintervertebral disc degeneration through mediating ATG14 and PRKAA1. Apoptosis.2022;27(5-6):409-25.

25. Yu B, Zhu Z, Hu T, Lu J, Shen B, Wu T, etal. Construction of a circular RNA-based competing endogenous RNA network toscreen biomarkers related to intervertebral disc degeneration. BMCMusculoskelet Disord. 2022;23(1):675.

26. Yu B, Zhu Z, Shen B, Lu J, Guo K, Zhao W,et al. MicroRNA-137 inhibits the inflammatory response and extracellular matrixdegradation in lipopolysaccharide-stimulated human nucleus pulposus cells bytargeting activin a receptor type I. Bioengineered. 2022;13(3):6396-408.