近5年主持的科研项目：

1. 国家重点研发计划子课题-项目编号：2021YFB3201400；项目名称：高性能高选择离子敏元件和传感器研制及应用验证

2. 上海市市级科技重大专项“重大突发传染病防控关键核心技术研究”方向三子任务 “多来源适用检测技术” ZXS003R2-2-1

3. 国家自然科学基金面上项目《免疫抑制受体SIRL-1调控吞噬细胞固有免疫应答促进RA发病的作用及机》 81971535

4. 国家自然科学基金面上项目《PADI4调控巨噬细胞极化和增殖在RA关节滑膜病变中的作用及分子机制》81671599

5. 上海市科委基础研究重大专项《微流控芯片及其在临床病原体检测中的应用》 子课题17JC1401002

6. 国家科技重大专项《突发急性传染病诊断试剂的研制》20182x10732401子课题《基于微流控芯片的现场快速诊断试剂的研制》  2018ZX10732401

7. 上海市科委生物医药领域科技支撑项目《呼吸道病毒高通量检测系统研发》编号17441902400

近5年获奖及主要代表性论文：

科技成果：《新型冠状病毒感染实验室高效诊断体系建立与应用》上海市科技进步二等奖，第一完成单位、完成人

代表性论文：

1.  YuSS, Lu Y, Zong M, Tan Q, Fan LY*. Hypoxia-induced miR-191-C/EBPβ signaling regulatescell proliferation and apoptosis of fibroblast-like synoviocytes from patients withrheumatoid arthritis. Arthritis Research & Therapy 2019,21:78   

2. Ye Z, ·Ma M,·Guo Y, ·Zong M, ·Ding ML, ·Fan LY*. Determinationof Phthalate and Metabolites in Human Urine by Lithiu Bis(trifluoromethanesulfonyl)imideEnhanced Dual Microextraction Method Optimized by Central Composite Design. Chromatographia (2020) 83:397–408  

3. Chen CC, Zong M, Lu Y, Guo Y, Lv H, Xie L, Fu Z,Cheng Y,  Si Y, Ye B, Fan L*.Differentially expressed lnc-NOS2P3-miR-939-5p axis in chronic heart failureinhibits myocardial and endothelial cells apoptosis via iNOS/TNFα pathway. JCell Mol Med. 2020;24:11381–11396.  

4. Zong M,  ZhouL,  Guan Q,  Lin D, Zhao J,  Qi H,  Harriman D, Fan L,  Zeng H,  Du C. Comparison of Surface-Enhanced RamanScattering Properties of Serum and Urine for the Detection of Chronic KidneyDisease in Patients. Appl Spectrosc 2020 Oct 29.  

5. Cheng Y,  Si Y, Wang L,  Ding M,  Yu S, Lu L,  Guo Y,  Zong M,  Fan L*. The regulation of macrophagepolarization by hypoxia-PADI4 coordination in Rheumatoid arthritis. IntImmunopharmacol 2021 Oct;99  

6.Nianzhen Chen · Yuying Si · Gen Li ·Ming Zong · Wenyan Zhang · Yangqin Ye· Lieying Fan*.  Development of aloop‑mediated isothermal amplification assay for the rapiddetection of six common respiratory viruses. European Journal ofClinical Microbiology & Infectious Diseases. 2021 Dec;40(12)

7.   Si Y, Zhang T, Chen N, Cheng Y, Wang L, Yuan J,Li G, Zong M, Sui G, Fan L*. A LAMP-based system for rapid detection ofeight common pathogens causing lower respiratory tract infections. J MicrobiolMethods. 2021 Nov;190:106339.  

8.  Xu F, Yu S, Han J, Zong M, Tan Q, Zeng X, Fan L. Detectionof Circulating Tumor DNA Methylation in Diagnosis of Colorectal Cancer. ClinTransl Gastroenterol. 2021 Aug 12;12(8):e00386.     

9. Zhang T, Zhao W, Zhao W, Si Y, Chen N, Chen X, Zhang X, Fan L*, Sui G*. Universally Stable and Precise CRISPR-LAMP DetectionPlatform for Precise Multiple Respiratory Tract Virus Diagnosis IncludingMutant SARS-CoV‑2 Spike N501Y. Anal. Chem. 2021, 93, 16184-16193   

10 .ChenN, Li G, Si Y, Zhang W, Ye Y, Wang Y, Wang K, Zong M*, Fan L*.Evaluation of LAMP assay using phenotypic tests and PCR for detection of blaKPCgene among clinical samples. J Clin Lab Anal. 2022 ;36(4):e24310.

11.Li G, Ye Z, Zhang W, Chen N, Ye Y, Wang Y, Wu F, Wang K, Fan L*. RapidLC-MS/MS detection of diferent carbapenemase types in carbapenemase-producingEnterobacterales. Eur J Clin Microbiol Infect Dis  2022,41:815-825.  

12.  Lu Y,Jiang Z, Wang K, Yu S, Hao C, Ma Z, Fu X, Qin M, Xu Z, Fan L*. Blockade of theamino acid transporter SLC6A14 suppresses tumor growth in colorectalCancer.  BMC Cancer 2022, 22:833 

13.  Wang L,Yuan J, Cheng Y, Xu Z, Ding M, Li J, Si Y, Zong M, Fan L*. Signal inhibitoryreceptor on leukocytes-1 regulates the formation of the neutrophilextracellular trap in rheumatoid arthritis. Molecular Immunology 2022,151242–251.

14.  Ding M,Cheng Y, Xu Z, Lu Y, Li J, Lu L, Zong M, Fan L*. Hypoxia Inhibits Osteogenesisand Promotes Adipogenesis of Fibroblast-like Synoviocytes via Upregulation ofLeptin in Patients with Rheumatoid Arthritis. Journal of Immunology Research,2022, Article ID 1431399,

15. Chen N,Li G, Si Y, Ye Y, Zhang T, Chi D, Zhang W, Pan L, QuG, Lu Y, Zong M, Sui G, Fan L*. Development and evaluation of a centrifugal disksystem for the rapid detection of multiple pathogens and their antibioticresistance genes in urinary tract infection. Front Microbiol 2023;14:1157403.  

16. Zong M, Cheng Y, Ye B,Chen S, Yu S, Ding M, Lu L, Fan L*. Preparation of mesoporous silicananocarriers targeting glucose-6-phosphate isomerase inhibition and applicationin the treatment of rheumatoid arthritis. .Preparationof mesoporous silica nanocarriers targeting glucose-6-phosphate isomeraseinhibition and application in the treatment of rheumatoid arthritis  Clin Exp Immunol. 2023 Jan; 211(1): 46–56.