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张国龙，同济大学教授，主任医师，博士研究生导师。同济大学附属皮肤病医院副院长，皮肤肿瘤诊疗中心常务副主任，美国密歇根大学访问学者。荣获上海市卫健委东方英才（拔尖项目）、上海市“医苑新星”杰出青年医学人才、首届上海市医学会“青年菁英”提名等。
现任国际光学与光子学协会会员、国际光动力医学协会（IPA）会员、中华医学会皮肤性病学分会皮肤肿瘤学组副组长、中华医学会激光医学分会第十届委员、中华医学会激光医学分会青年委员会副主任委员、中国医师协会皮肤科医师分会皮肤肿瘤专业委员会委员、中国康复医学会皮肤病康复专业委员会常委兼副秘书长、中国抗癌协会肿瘤光动力治疗专业委员会常委、中华预防医学会皮肤病与性病预防与控制专业委员会科普学组委员、中国医学装备协会皮肤病与皮肤美容分会委员、上海市医学会激光医学专科分会副主任委员、上海市医学会激光医学专科分会光动力与弱激光学组组长、上海市医学会皮肤性病学分会青年副主任委员、上海医药行业协会皮肤健康专委会副主任委员、上海市中医药学会皮肤病分会委员、上海市药理学会皮肤药理专业委员会委员、上海市医学会医学遗传学专科分会委员、上海市康复医学会皮肤康复学组委员、中国遗传学会皮肤病学遗传分会委员。
Dr. Zhang is professor, chief physician and Doctoral Student Supervisor of Dermatology and Venereology. He is the vice president of Shanghai Skin Disease Hospital of Tongji University,Executive Deputy Director of the skin cancer Center in Shanghai Skin Disease Hospital, visiting scholar of university of Michigan. Shanghai Municipal Health Commission Eastern Talent,the outstanding young medical talents of "rising star of Medical Academy" in Shanghai, nomination of the first term "young elite" of Shanghai Medical Association.
Member of the International Association of Optics and Photonics
Member of the International Association of Photodynamic Medicine (IPA)
Deputy Leader of the Skin Oncology Group of the Dermatology and Venereology Branch of the Chinese Medical Association
Tenth Committee Member of the Laser Medicine Branch of the Chinese Medical Association
Vice chairman of Youth Committee of laser medicine, Chinese Medical Association
Member of the professional committee of skin cancer, branch, Chinese dermatologist Association
Member of the standing committee and deputy General Secretary of Dermatology Rehabilitation Committee of China Rehabilitation Medical Association
Member of Photodynamic Therapy for Tumor Professional Committee of China Anti Cancer Association
Member of science popularization group of Dermatology and STD prevention and Control Professional Committee of Chinese Preventive Medicine Association
Member of dermatology and skin beauty Committee of China Medical Equipment Association
Vice Chairman of laser medicine branch of Shanghai Medical Association
Leader of photodynamic and low level laser group of laser medicine branch of Shanghai Medical Association
Vice chairman of Youth Committee of Dermatology and Venereology branch of Shanghai Medical Association
Vice Chairperson of the Skin Health Committee, Shanghai Pharmaceutical Industry Association
Member of the Dermatology Branch of the Shanghai Association of Traditional Chinese Medicine
Member of the Dermatopharmacology Committee, Shanghai Pharmacological Society
Member of medical genetics branch of Shanghai Medical Association
Member of skin rehabilitation group of Shanghai Rehabilitation Medical Association
Member of the Dermatogenetics Branch of the Chinese Society of Genetics
上海市皮肤病医院/同济大学附属皮肤病医院光学医治疗科简介
1. 国家自然科学基金面上项目，82573467，ALA-PDT通过LT/LTBR通路促进肿瘤相关高内皮静脉形成重塑肿瘤免疫微环境治疗皮肤鳞癌的效应与机制研究，2026/01-2029/12，49万，在研，主持
2. 上海申康医院发展中心诊疗技术推广及优化管理市级医院新兴前沿技术联合攻关项目，SHDC12025123，ALA-PDT联合免疫治疗在局部晚期皮肤鳞癌中的临床应用推广研究，2025/06-2028/05，30万，在研，主持
3. 上海市东方英才拔尖项目（卫生平台），BJWS2024057，ALA-PDT通过LT_LTβR通路促进肿瘤相关高内皮静脉形成重塑肿瘤免疫微环境治疗皮肤鳞癌的效应与机制研究，2025/01-2027/12，20万，在研，主持
4. 同济大学“医学+X”交叉研究项目，2025-0650-YB-02，EGFR靶向纳米颗粒增效光动力治疗皮肤鳞癌，2025/01-2027/12，30万，在研，主持
5. 国家重点研发计划子课题，2023YFC2508200，基于光电免疫调控效应的常见慢性皮肤病临床试验研究和应用，2023/11-2026/10，138万，在研，分中心牵头人
6. 国家重点研发计划子课题，2022YFC2504705，皮肤恶性肿瘤个体化治疗新技术研发和新策略的制定，2022/11-2025/12，300万，在研，主要参与（子课题联络人）
7. 国家自然科学基金面上项目，82272761，ALA-PDT通过CXCL13促进三级淋巴结构形成打破皮肤鳞状细胞癌免疫逃逸的机制研究，2023/01-2026/12，52万，在研，主持
8. 上海申康医院发展中心研究型医师创新转化能力培训项目，SHDC2022CRT017，新型实时可控智能无痛光动力治疗仪的研发与转化，2022/01-2024/9，100万元，在研，高级助理（30万）
9. 上海市卫计委卓越项目，20224Z0018，ALA-光动力治疗遗传性皮肤病相关非黑素皮肤癌，2022/01-2024/12，30万元，在研，主持
10. 国家自然科学基金面上项目，82073016，基于单细胞测序发现TDO2促进皮肤鳞癌发展和免疫逃逸的机制研究，2021/01-2024/12，55万，在研，主持
11. 上海市自然科学基金项目，20ZR1449400，TDO2在皮肤鳞状细胞癌进展和免疫逃逸中的作用及机制研究，2020/07-2023/06，20万，在研，主持
12. 国家自然科学基金面上项目，81872512，ω-3多不饱和脂肪酸保护皮肤光老化的作用及机制研究，2019/1-2022/12，57万，在研，主要参与（第二）
13. 上海市皮肤病医院攀登人才培养计划-后备博导项目，17HBDS04，探索发现CXCL13对ALA-PDT治疗SCC疗效的影响，2018/01-2020/12，20万元，已结题，主持
14. 上海市卫计委重点课题项目， 201640016，咪喹莫特增强ALA-PDT治疗皮肤鳞癌的疗效研究，2017/01-2019/12，30万元，已结题，主持
15. 上海市科委西医引导类项目，16411961700，新型光医学技术序贯治疗痤疮的临床疗效研究，2016/7-2019/6，20万元，已结题，主持
16. 上海市皮肤病医院攀登人才培养计划-后备硕导项目，ALA-PDT治疗皮肤鳞状细胞癌上调CXCL13的表达研究，2015/9-2017/8，6万元，已结题，主持
17. 国家自然科学基金面上项目，81472538，Exosome介导ALA光动力抑制SCC生长的分子机制研究，2015/1-2018/12，72万元，已结题，主要参与（第二）
18. 国家自然科学基金青年项目，81201222，1型神经纤维病遗传资源库的建立及其发病分子机制研究，2013/1-2015/12，23万元，已结题，主持
19. 南京医科大学科技发展基金重点项目，2010NMUZ63，部分单基因遗传性皮肤病遗传资源的收集、保存与利用，2011/1-2013/12，5万元，已结题，主持
20. 南京医科大学科技发展基金面上项目，07NMUM092，家族性慢性良性天疱疮家系的致病基因突变研究，2008/1-2009/12，0.5万元，已结题、主持
从事皮肤性病学临床、教学和科研工作20余年，主要研究领域为光动力治疗、皮肤肿瘤、瘢痕以及遗传性皮肤病。先后主持国家自然科学基金项目4项、上海市科委项目2项、上海市卫计委重点项目和卓越项目各1项，并参与多项科技部重点研发专项和国自然项目的研究。发表学术论文近200篇，其中以第一作者或通讯作者发表SCI论文50余篇，参编皮肤病相关著作9部。先后获中国康复医学会科技一等奖2项、上海市科技进步三等奖1项、华夏医学科技奖二等奖1项。
Dr. Zhang has been engaged in clinical, teaching and scientific research of dermatology and venereal diseases for more than 20 years. His main research interests are photodynamic therapy, skin cancer, scar, and genodermatoses. Currently, he has five research projects under study. He has hosted series of financial supports from National Natural Science Foundations, Shanghai Science and Technology Commissions and Shanghai Health and Health Commission, and participated in many development projects of the Ministry of science and technology and other national natural projects. He has published almost 200 professional papers, including more than 50 papers in SCI journals as the first or corresponding author, and participated in the editing of many dermatological works. He won two first prize of scientific and technological progress of China Rehabilitation Medical Association, one third prize of Shanghai Scientific and technological progress and one second prize of Huaxia Medical Science and technology award.
1. 2024年，上海市卫健委东方英才（拔尖项目）
2. 2021年，上海市“医苑新星”青年医学杰出人才（卓越项目）
3. 2021年，难治性皮肤疾病的5-氨基酮戊酸光动力诊疗与康复体系的创建与应用，中国康复医学会科技进步一等奖（排名第八），中国康复医学会，证书编号：KXJS-2020-1-3-P1108
——王秀丽、王宏伟、石磊、张玲琳、周忠霞、张海艳、张云凤、张国龙、王佩茹、柳小婧、曹智
4. 2021年，上海市医学会首届“青年菁英”提名奖
5. 2020年，皮肤恶性肿瘤5-氨基酮戊酸光动力诊疗与康复体系的创建与应用，中国康复医学会科技进步一等奖（排名第四），中国康复医学会，证书编号：KXJS-2020-1-3-P1104
——王秀丽、方方、李智铭、张国龙、王宏伟、黄鹏、石磊、张玲琳、周忠霞、王佩茹、张海艳
6. 2018年，5-氨基酮戊酸光动力治疗中重度痤疮的技术创新与临床应用，上海市科技进步三等奖（排名第七），上海市人民政府，证书编号：20184115-3-07
——王秀丽，鞠强，张玲琳，王宏伟，石磊，王佩茹，张国龙
7. 2017年，5-氨基酮戊酸光动力治疗难治性皮肤病关键技术的建立及推广应用，华夏医学科技奖二等奖（排名第六）, 中国医疗保健国际交流促进会，证书编号：201702091P0906
——王秀丽、王宏伟、石磊、张玲琳、张海艳、张国龙、王佩茹、张云凤、吉杰
8. 2012年，部分单基因遗传性皮肤病遗传资源的收集保存和利用，获无锡市科技进步奖1项（第一完成人）
9. 2010年，南京医科大学无锡临床医学院青年教师双语讲课竞赛中获优秀讲师奖
10.《Photodiagnosis and Photodynamic Therapy》、《The Journal of the European Academy of Dermatology and Venereology》、《Journal of Dermatological Science》、《Clinical and Experimental Dermatology》、《European Journal of Dermatology》、《中华皮肤科杂志》、《中国麻风皮肤科杂志》审稿人
1. Chen D, Wang B, Li C, Wang X*, Zhang G*, Zeng Q*. Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma. Cell Rep Med. 2025 Jul 15;6(7):102239. Q1: 10.6
2. Chen Y, Wu Y, Zhao Z, Wen L, Wu M, Song D, Zeng Q, Liu Y, Yan G*, Zhang G*. Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma. PeerJ. 2025 May 7;13:e19398. Q3: 2.3
3. Li Z, Lu F, Zhou F, Song D, Chang L, Liu W, Yan G*, Zhang G*. From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments. Front Immunol. 2025 Jan 24;16:1518633. Q1: 7.30
4. Hu C, Liu X, Wu M, Liao C, Zhao Y, Xu M, Lai Y*, Zhang G*. Case Report: Comprehensive management of trichilemmal carcinoma of the lower leg in an elderly patient with comorbidities: a case study on integrated ALA-PDT and surgical excision. Front Med (Lausanne). 2025 Mar 14;12:1546359. Q3: 3.9
5. Lu F, Yan G, Zhao Z, Zheng Z, Wu Y, Wen L, Liu Y, Zeng Q*, Zhang G*. TDO2 + cancer-associated fibroblasts mediate cutaneous squamous cell carcinoma immune escape via impeding infiltration of CD8 + T cells. Cancer Immunol Immunother. 2025 Jan 3;74(2):67. Q2: 4.86
6. Yan G, Wang X, Zhang G*. Unraveling the landscape of non-melanoma skin cancer through single-cell RNA sequencing technology. Front Oncol. 2024 Nov 4;14:1500300. Q2: 3.08
7. Xi N, Xu X, Xu M, Wu N, Wu Y, Chen J, Liu S, Jiang L, Yan G*, Zhang G*, Liu Y*. The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease. Front Immunol. 2024 Nov 15;15:1435629. Q1: 5.31
8. Chen Y, Wu M, Chen L, Li Z, Zhou Z, Li W*, Zhang G*. ALA-PDT combined with CO2 laser in the treatment of malignant hidroacanthoma simplex: A case report. Photodiagnosis Photodyn Ther. 2024 Oct; 49: 104299. Q3: 3.1
9. Fang S, Zhang L, Wang P, Shi L, Zhang H, Liao C, Zhao Z, Zhou Z, Zhao Y, Yan G, Wu Y, Wu Y, Zheng Z, Wang R, Liu Y, Zhang G, Wang X. Real-world data of 5-aminolaevulinic acid-mediated photodynamic therapy for Bowen disease: a 10-year retrospective study in patients with darker-coloured skin (2011-2021). Clin Exp Dermatol. 2024 Sep 18;49(10):1190-1196. Q4: 3.88
10. Kang Z, Wang P, Wang B, Yan Y, Zhao Z, Li C, Wen L, Wu M, Yan G, Wang X*, Zhang G*, Zeng Q*. Echinatin suppresses cutaneous squamous cell carcinoma by targeting GSTM3-mediated ferroptosis. Phytomedicine. 2024 May 26;131:155752. Q1：6.58
11. Chen Y, Wu Y, Yan G, Zhang G*. Tertiary lymphoid structures in cancer: maturation and induction. Front Immunol. 2024 Apr 16;15: 1369626. Q1: 7.30
12. Jiang L, Xu X, Yan G, Wu Y, Xi N, Lai Y*, Zhang G*, Liu Y*. Untargeted metabolomics yields insight into extramammary Paget's disease mechanisms. Front Oncol. 2024 Jan 29;14:1319819. Q2: 3.17
13. Zeng Q, Chen C, Chen D, Zhang G*, Wang X*. Non-Surgical Therapeutic Strategies for Non-Melanoma Skin Cancers. Curr Treat Options Oncol. 2023 Dec;24(12): 1978-1993. Q2: 3.84
14. Liao C, Wu M, Liu Y, Wang X*, Zhang G*. Advanced treatment of giant proliferating trichilemmal tumor: limited resection combined with neoadjuvant ALA-PDT. Photodiagnosis Photodyn Ther. 2023 Oct 28:103870. Q3: 3.3
15. Zheng J, Liu W, Zhou Z, Cao Z, Zhao Z, Wang X, Li M, Zhang G*. Successful treatment of non-melanoma skin cancer in three patients with Xeroderma Pigmentosum by modified ALA-PDT. Photodiagnosis Photodyn Ther. 2023 Jul 6;43:103694. Q3: 3.3
16. Zheng Z, Yan G, Xi N, Xu X, Zeng Q, Wu Y, Zheng Y*, Zhang G*, Wang X*. Triptolide induces apoptosis and autophagy in cutaneous squamous cell carcinoma via Akt/mTOR pathway. Anticancer Agents Med Chem. 2023;23(13):1596-1604. Q4: 2.527
17. Wu M, Liao C, Zhao Z, Zhou Z, Liu Y, Wang X*, Zhang G*. Local narrow margin excision sequential with modified ALA-PDT for successful treatment of an 86-year-old patient with malignant proliferating trichilemmal tumor. Photodiagnosis Photodyn Ther. 2023 Mar 23;42:103524. Q3: 3.631
18. Zhou Z, Yang Y, Zhang L, Zhang H, Sun X, Zhao Y, Zeng K, Zhang G*, Wang X*. Topical ALA-PDT with novel approach successfully treated refractory deep male urethral condyloma acuminata: A retrospective case series. J Am Acad Dermatol. 2022 Dec 10: S0190-9622(22)03180-2. Q1: 19.36
19. Wu Y, Wen L, Wang P, Wang X*, Zhang G*. Case Report: Diverse phenotypes of congenital poikiloderma associated with FAM111B mutations in codon 628: A case report and literature review. Front Genet. 2022 Aug 25;13:926451. Q1: 4.25
20. Wu YH, Wu F, Yan GR, Zeng QY, Jia N, Zheng Z, Fang S, Liu YQ, Zhang GL*, Wang XL*. Features and clinical significance of tertiary lymphoid structure in cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol. 2022 Nov;36(11):2043-2050. Q1: 9.228
21. Fang S, Wu Y, Zhang H, Zeng Q, Wang P, Zhang L, Yan G*, Zhang G*, Wang X*. Molecular characterization of gene expression changes in murine cutaneous squamous cell carcinoma after 5-aminolevulinic acid photodynamic therapy. Photodiagnosis Photodyn Ther. 2022 May 12:102907. Q3: 3.631
22. Qingyu Zeng#, Jiayi Yang#, Jie Ji, Peiru Wang, Linglin Zhang, Guorong Yan, Yuhao Wu, Qi Chen, Jia Liu, Guolong Zhang*, Xiuli Wang*. PD-L1 blockade potentiates the antitumor effects of ALA-PDT and optimizes the tumor microenvironment in cutaneous squamous cell carcinoma. OncoImmunology, 2022 Apr 3;11(1):2061396. Q1: 8.110
23. Wang PR#, Yan GR#, Xue H, Shen SZ, Cao YJ, Zhang GL*, Wang XL*. Proteomics and lipidomics reveal the protective mechanism of dietary n-3 PUFA supplementation for photoaging. Food & Function. 2021 June 26. Q1: 5.396
24. Yan G#, Li L#, Zhu S#, Wu Y, Liu Y, Zhu L, Zhao Z, Wu F, Jia N, Liao C, Jiang L, Zeng Q, Wang P, Shi L, Zheng Z, Fang S, Zhang G*, Tang Y*, Wang X*. Single-cell transcriptomic analysis reveals the critical molecular pattern of UV-induced cutaneous squamous cell carcinoma. Cell Death Dis. 2021 Dec 21;13(1):23. Q1: 8.713
25. Wang P#, Zhang G#, Zhang L, Zhou Z, Shi L, Zeng Q, Zhu L, Wang X. 5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma. Photodiagnosis Photodyn Ther. 2021 Sep;35:102321. Q3: 3.631
26. Zhao Z#, Wu Y#, Zhou Z, Zhao Y, Sun X, Hu C, Wang X*, Zhang G*. ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis. Photodiagnosis Photodyn Ther. 2021 Jun 11;35:102395. Q3: 3.631
27. Chen Q#, Jiang L#, Shi L, Li C, Wu Y, Yang J, Zhang G*, Wang X*. Successful treatment of upper-left eyelid squamous cell carcinoma in an epidermodysplasia verruciformis patient by ALA-PDT/holmium laser combination therapy. Photodiagnosis Photodyn Ther. 2021 Jun;34:102277. Q3: 3.631
28. Zhang G#, Yan G#, Fu Z, Wu Y, Wu F, Zheng Z, Fang S, Gao Y, Bao X, Liu Y*, Wang X*, Zhu S*. Loss of retinoic acid receptor-related receptor alpha (Rorα) promotes the progression of UV-induced cSCC. Cell Death Dis. 2021 Mar 4;12(3):247. Q1: 8.713
29. Zhang H#, Zhang G#, Zhang Y, Wen L, Zhang M, Pan J, Wang P, Wang X, Cheng Q*, Wang X*. Quantitatively assessing port-wine stains using a photoacoustic imaging method: A pilot study. J Am Acad Dermatol. 2021 Jan 29: S0190-9622(20)33183-2. Q1: 11.527
30. Zhang L#, Zhang Y#, Liu X, Shi L, Wang P, Zhang H, Zhou Z, Zhao Y, Zhang G*, Wang X*. Conventional versus daylight photodynamic therapy for acne vulgaris: A randomized and prospective clinical study in China. Photodiagnosis Photodyn Ther. 2020 Sep; 31: 101796. Q3: 2.894
31. Meng L#, Yang X#, Wu Y, Zhao Z, Yang L, Li M, Wang X*, Zhang G*. A novel frameshift mutation in the FERMT1 gene in a Chinese patient with Kindler syndrome. Exp Ther Med. 2020 Nov;20(5):103. Q4: 1.785
32. Zhang GL#, Keyal U#, Shi L, Wang PR, Zhang LL, Bhatta AK, Wu YH, Fang S, Wang XL*. Photodynamic therapy as an alternative treatment in patients with invasive cutaneous SCC where surgery is not feasible: single center experience. Photodiagnosis Photodyn Ther. 2020 Dec;32:101980. Q3: 2.894
33. Zhang GL#, Cao Z#, Wang PR, Zhu LD, Zhang LL, Zhou ZX, Shi L, Wang XL*. Comparison of efficacy, adverse effects and costs between 20% ALA-PDT and 10% ALA-PDT for the treatment of actinic keratosis in Chinese patients. Photodiagnosis Photodyn Ther. 2019 Nov 28:101605. Q3: 2.589
34. Ji J, Wang P, Zhou Q, Zhu L, Zhang H, Zhang Y, Zheng Z, Bhatta AK, Zhang G*, Wang X*. CCL8 enhances sensitivity of cutaneous squamous cell carcinoma to photodynamic therapy by recruiting M1 macrophages. Photodiagnosis Photodyn Ther. 2019 Jun;26:235-243. Q3: 2.589
35. Bhatta AK#, Wang P#, Keyal U, Zhao Z, Ji J, Zhu L, Wang X*, Zhang G*. Therapeutic effect of Imiquimod enhanced ALA-PDT on cutaneous squamous cell carcinoma. Photodiagnosis Photodyn Ther. 2018 Sep;23:273-280. Q3: 2.589
36. Gu Y#, Bhatta AK#, Du X, Shao M, Keyal U, Zhang G*, Hua Y*. Identification of one Novel complex delins mutation and one recurrent mutation of ERCC8 gene in a Chinese family with Cockayne Syndrome A. J Eur Acad Dermatol Venereol. 2017 Sep; 31(9): e394-e395. Q1: 3.029
37. Zhou Q, Wang P, Zhang L, Wang B, Shi L, Keyal U, Bhatta AK, Zhang G*, Wang X*. Pemphigus vulgaris induced by 5-aminolaevulinic acid-based photodynamic therapy. Photodiagnosis Photodyn Ther. 2017 Sep;19:156-158. Q3: 2.589
38. Qian Zhou#, Ling Lin Zhang#, Yun Feng Zhang, Hao Luo, Lu De Zhu, Pei Ru Wang, Guo Long Zhang*, Xiu Li Wang*. Two novel ADAR1 gene mutations in patients with dyschromatosis symmetrica hereditaria since birth: one patient died of congenital heart disease. Molecular Medicine Reports. Mol Med Rep. 2017 Jun;15(6):3715-3718. Q3: 1.559
39. Liu YQ#, Zhang GL#, Mo XH#, Wang B, Wu F, Chen J, Luo H, Zhu LD, Xu MY, Zhou Q, Cai QL*, Wang XL*. A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient. J Eur Acad Dermatol Venereol. 2017 Nov;31(11):e504-e505. Q1: 3.029
40. Lude Zhu, Lei Shi, Mingye Bi, Haifeng Huang, Jie Pu, Linglin Zhang, Yunfeng Zhang, Xiuli Wang*, Guolong Zhang*. Novel mutations in one allele in a Chinese family with neurofibromatosis type 1: Including a complex insertion-deletion mutation. The Journal of Dermatology. 2016 Nov;43(11):1332-1335.Q2: 2.252
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