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现任同济大学附属上海市第四人民医院内分泌代谢科主任,同济大学医学院教授。先后主持4项国家自然科学基金、上海市科委研发平台样本库专项课题和国际合作项目。先后入选上海市卫健委优秀学科带头人、上海市科委启明星及启明星追踪计划、上海市卫生局优秀青年医师培养计划。作为第一作者/通讯作者在Cell Discovery、Cell Metabolism、Diabetes、Diabetologia、J Colloid InterfaceSci、Cell Death Dis、Stem Cell Res Ther、Diabetes Technol Ther、Diabetes Res ClinPract等知名SCI收录杂志发表论文。授权发明专利3项,其中2项发明专利已成功转化。
本项目组与华东理工大学赵玉政教授课题组在代谢探针与糖代谢方向有长期合作,合作成果发表在Cell Metabolism上。本项目组与同济大学再生医学系孙毅教授课题组在干细胞治疗糖尿病等方面有长期合作,合作成果发表在Cell Discovery、Cell Death & Disease等杂志,授权发明专利2项。
1. 线粒体能量代谢紊乱与代谢性疾病(2025ZD0549902)科技创新2030重大专项。2025.8-2029.7。学术骨干。123万。
2. 糖尿病并发症智能化信息系统的建立及推广应用(2023ZD0509206)。科技创新2030重大专项。2024.8-2028.7。学术骨干。75万。
3. DCAF17-KIF11-RHOT1在m.3243A>G线粒体疾病中的作用机制研究。国家自然科学基金面上项目(82471893)。2025.1.1-2028.12.31。项目负责人49万。
4. 虹口区卫健委临床重点扶持专科建设项目(HKCFC202403),2024.1.1-2026.12.31。项目负责人60万。
5. 基于饮食运动深度强化学习的糖尿病个性化精准血糖管理。上海市科委国际合作项目(22410713200)。2022.9-2025.8,项目负责人40万。
1. Cao B, Fang L, Zhang Y, Lin C, Liu P, Zhang H, Fan O, Xu M*, Qin Z*, WangC*. MitoQ alleviates m.3243A>G-induced mitochondrial dysfunction bystabilizing PINK1 and enhancing mitophagy. J Genet Genomics. 2025 Aug22:S1673-8527(25)00229-2. doi: 10.1016/j.jgg.2025.08.007. Epub ahead of print. PMID: 40850503.
2. Zhang Y, Liu S, Cao B, Xu J*, Jia W, Wang C*. ComparingADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes inthe SHiDS study. Diabetes Res Clin Pract. 2025 Jan;219:111963. doi:10.1016/j.diabres.2024.111963. Epub 2024 Dec 18. PMID: 39706370.
3. Cao B, Lu H, Liu P, Zhang Y*, Wang C*. Serum metabolomicssignature of maternally inherited diabetes and deafness by gaschromatography-time of flight mass spectrometry. J Diabetes Investig. 2024 Oct31. doi: 10.1111/jdi.14334. Epub ahead of print. PMID: 39480690.
4. Cao B, Li Y, Xu J, ZhangY, Wang C*. Dynamic changes of complete blood cell countparameters among airport workers during the COVID-19 pandemic in Chongqing,China: A retrospective longitudinal study. Heliyon. 2024 Jun 8;10(12):e32734.doi: 10.1016/j.heliyon.2024.e32734. PMID: 39183824; PMCID: PMC11341334.
5. Hu K, Cao B, Lu H, Xu J, Zhang Y*, Wang C*. Changes inPM2.5-related diabetes risk under the implementation of the clean air act inShanghai. Diabetes Res Clin Pract. 2024 Jun;212:111716. doi:10.1016/j.diabres.2024.111716. Epub 2024 May 21. PMID: 38777130.
6. Wang Y, Yu H, Tang H, Zhu R, Shi Y, Xu C, Li Y, Wang H, Chen Y, Shen P, XuJ*, Wang C*, Liu Z*. Characterization of dynamical changes invital signs during allogeneic human umbilical cord-derived mesenchymal stemcells infusion. Regen Ther. 2023 Aug 2;24:282-287. doi:10.1016/j.reth.2023.07.007. PMID: 37559872; PMCID: PMC10407816.
7. Liu P#, Cao B#, Zhou Y, Zhang H, Wang C*.Human umbilical cord-derived mesenchymal stem cells alleviate oxidativestress-induced islet impairment via the Nrf2/HO-1 axis. J Mol Cell Biol. 2023May 27:mjad035. doi: 10.1093/jmcb/mjad035. Epub ahead of print. PMID: 37245063.
8. Zhang Y, Bian Z, Lu H, Wang L, Xu J, Wang C*. Associationbetween tea consumption and glucose metabolism and insulin secretion in theShanghai High-risk Diabetic Screen (SHiDS) study. BMJ Open Diabetes Res Care.2023 Mar;11(2):e003266.
9. Zhao Q, Zhu J, Shen X, Lin C, Zhang Y, Liang Y, Cao B, Li J, Liu X*, RaoW*, Wang C*. Chinese diabetes datasets for data-driven machinelearning. Sci Data. 2023 Jan19;10(1):35.
10. Li X, Zhang Y, Xu L, Wang A, Zou Y, Li T, Huang L, Chen W, Liu S, JiangK, Zhang X, Wang D, ZhangL, Zhang Z, Zhang Z, Chen X, Jia W, Zhao A, Yan X, Zhou H, Zhu L, Ma X,Ju Z, Jia W, Wang C*,Loscalzo J, Yang Y*, Zhao Y*. Ultrasensitive sensors reveal thespatiotemporal landscape of lactate metabolism in physiology and disease. CellMetab. 2023 Jan 3;35(1):200-211.
11. Zhang Y, Bian Z, Chen Y, Jiang E, Chen T, Wang C*. Positive association between researchcompetitiveness of Chinese academic hospitals and the scale of their biobanks:A national survey. Clin Transl Sci. 2022 Dec;15(12):2909-2917.
12. Xuan Q, Hu C, Zhang Y, Wang Q, Zhao X, Liu X, Wang C*, JiaW*, Xu G*. Serum lipidomics profiles reveal potential lipid markers forprediabetes and type 2 diabetes in patients from multiple communities. FrontEndocrinol (Lausanne). 2022 Aug 15;13:966823.
13. Aierken A, Li B, Liu P, Cheng X, Kou Z, Tan N, Zhang M, Yu S, Shen Q, DuX, Enkhbaatar BB, Zhang J, Zhang R, Wu X, Wang R, He X, Li N, Peng S, Jia W*, Wang C*, Hua J*. Melatonintreatment improves human umbilical cord mesenchymal stem cell therapy in amouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway.Stem Cell Res Ther. 2022 Apr 12;13(1):164.
14. Le S, Zhang Y, Voutilainen A, Tan X, Laukkanen J*, Wang C*,Cheng S*. Differences in cardiometabolic risk profiles between Chinese andFinnish older adults with glucose impairment and central obesity. J EndocrinolInvest. 2022 Jul;45(7):1427-1437.
15. Gao H, Cao B, Dang N, Gu S, Xu M, Ji B, Shi Y, Liu S*, Wang C*.Comparison of factors influencing the willingness to donate biospecimens amongguardians of children with cancer and adult cancer patients. Cancer Med. 2022Mar;11(6):1524-1534.
16. Pan J, Yan X, Li F, Zhang Y, Jiang L, Wang C*. Association of glycemic variability assessed bycontinuous glucose monitoring with subclinical diabetic polyneuropathy in type2 diabetes. J Diabetes Investig. 2022 Feb;13(2):328-335.
17. Liu J, Wang J, Xu J, Xia H, Wang Y, Zhang C, Chen W, Zhang H, Liu Q, ZhuR, Shi Y, Shen Z, Xing Z, Gao W, Zhou L, Shao J, Shi J, Yang X, Deng Y, Wu L,Lin Q, Zheng C, Zhu W, Wang C*,Sun YE*, Liu Z*. Comprehensive investigations revealed consistentpathophysiological alterations after vaccination with COVID-19 vaccines. CellDiscov. 2021 Oct 26;7(1):99.
18. Fu Y, Liu P, Chen M, JinT, Wu H, Hei M, Wang C*, XuY, Qian X, Zhu W*. On-demand transdermal insulin delivery system for type 1diabetes therapy with no hypoglycemia risks. J Colloid Interface Sci. 2022 Jan;605:582-591.
19. Gao X, Jiang Z, Yan X,Liu J, Li F, Liu P, Li J, Wei Y, Sun YE*, Zhang Y*, Wang C*. ATF5, a putative therapeutic target for themitochondrial DNA 3243A > G mutation-related disease. Cell Death Dis. 2021 Jul 14;12(7):701.

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